Gene info: ID 2677

Gene: GGCX

GENE ID: 2677

Synonyms: VKCFD1

Description: gamma-glutamyl carboxylase

Gene type: protein-coding

Location: 2p11.2

dbXrefs: Ensembl:ENSG00000115486 MIM:137167 Vega:OTTHUMG00000130173 UniprotKB:P38435

RefSeq: NG_011811.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : 3.017e-1 (AD) 2.555e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.671e-1 (AD) 2.323e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASXL1	0.878
SLC22A23	0.873
SYVN1	0.872
QSOX2	0.869
UGGT1	0.868
DCAF5	0.868
SEC24C	0.867
SART3	0.867
ZNF384	0.866
GLG1	0.864

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.57
OR4F29	-0.525
KLRC2	-0.301
MTRNR2L6	-0.271
MTRNR2L9	-0.258
MTRNR2L10	-0.258
OR4F16	-0.25
HMHB1	-0.241
OR6C74	-0.235
TRDN	-0.233

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00036	Coagulation factor VIIa Recombinant Human	BiotechDrug	102786-61-8	Approved	Target
DB00055	Drotrecogin alfa	BiotechDrug	98530-76-8	Approved\|Investigational\|Withdrawn	Target
DB00100	Coagulation Factor IX (Recombinant)	BiotechDrug	181054-95-5	Approved\|Investigational	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00170	Menadione	Small Molecule	58-27-5	Approved\|Nutraceutical	Target
DB01022	Phylloquinone	Small Molecule	84-80-0	Approved\|Investigational	Target
DB01125	Anisindione	Small Molecule	117-37-3	Approved	Target
DB09332	Kappadione	Small Molecule	131-13-5	Approved	Target
DB13152	Coagulation Factor IX Human	BiotechDrug	9001-28-9	Approved	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GGCX mRNA"	21394737
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of GGCX mRNA"	17547211
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GGCX mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGCX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGCX mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of GGCX mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GGCX mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GGCX mRNA	16483693
C006780	bisphenol A	bisphenol A affects the expression of GGCX mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased activity of GGCX protein	28903499
D002065	Buspirone	Buspirone results in decreased expression of GGCX mRNA	24136188
C584509	C646 compound	C646 compound results in increased expression of GGCX mRNA	26191083
D002220	Carbamazepine	Carbamazepine affects the expression of GGCX mRNA	25979313
C084597	chlorcyclizine	chlorcyclizine results in increased expression of GGCX mRNA	21058326
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GGCX mRNA	20938992
D002857	Chromium	Chromium results in decreased expression of GGCX mRNA	17547211
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GGCX mRNA	19376846
D016572	Cyclosporine	Cyclosporine results in decreased expression of GGCX mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of GGCX mRNA	19770486
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GGCX mRNA	21266533
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of GGCX mRNA	17547211
D004317	Doxorubicin	GGCX protein affects the susceptibility to Doxorubicin	16217747
D000431	Ethanol	Ethanol results in decreased expression of GGCX mRNA	17920746
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GGCX mRNA	20938992
D005897	Glafenine	Glafenine results in increased expression of GGCX mRNA	24136188
D017313	Fenretinide	Fenretinide results in decreased expression of GGCX mRNA	28973697
C492448	ICG 001	ICG 001 results in increased expression of GGCX mRNA	26191083
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of GGCX mRNA	20353558
D008628	Mercury	Mercury results in decreased expression of GGCX mRNA	17547211
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GGCX mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of GGCX mRNA	24449571
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GGCX mRNA"	25620056
C022838	nickel chloride	nickel chloride results in decreased expression of GGCX mRNA	17547211
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of GGCX mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of GGCX mRNA	25729387
D052638	Particulate Matter	Particulate Matter results in increased expression of GGCX mRNA	24769257
D010634	Phenobarbital	Phenobarbital affects the expression of GGCX mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGCX mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of GGCX mRNA	26272509
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GGCX mRNA	17547211
D015474	Isotretinoin	Isotretinoin results in decreased expression of GGCX mRNA	20436886
D012834	Silver	Silver results in decreased expression of GGCX mRNA	27131904
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in decreased expression of GGCX mRNA"	26680231
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GGCX mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GGCX mRNA	19770486
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of GGCX mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of GGCX mRNA	25729387
C080163	trovafloxacin	trovafloxacin results in decreased expression of GGCX mRNA	24136188
C406224	valdecoxib	valdecoxib results in decreased expression of GGCX mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of GGCX mRNA	23179753\|2519280
D014747	Vinblastine	GGCX protein affects the susceptibility to Vinblastine	16217747
D014859	Warfarin	Warfarin results in increased expression of GGCX mRNA	25094061
D014859	Warfarin	GGCX gene polymorphism affects the susceptibility to Warfarin	17049586\|1749616
D014859	Warfarin	GGCX gene polymorphism results in decreased susceptibility to Warfarin	16676068
D014859	Warfarin	GGCX gene SNP affects the susceptibility to Warfarin	21195460\|2132631
D014859	Warfarin	GGCX polymorphism affects the susceptibility to Warfarin	22161100\|2504272
D014859	Warfarin	GGCX protein results in increased susceptibility to Warfarin	17049586\|1749616

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008488	gamma-glutamyl carboxylase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006464	cellular protein modification process	-	TAS	1749935
GO:0007596	blood coagulation	-	TAS	9845520
GO:0017187	peptidyl-glutamic acid carboxylation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016020	membrane	-	TAS	1749935
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-159740	Gamma-carboxylation of protein precursors	TAS
R-HSA-159740	Gamma-carboxylation of protein precursors	IEA
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	TAS
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	IEA
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	TAS
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-597592	Post-translational protein modification	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21110013	Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)	Geisen C	Eur J Clin Pharmacol
22629463	Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians. (2012)	Rathore SS	PLoS One
28049362	Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. (2018 Mar)	Gaikwad T	Clin Appl Thromb Hemost