Gene: GGT1

2678
CD224|D22S672|D22S732|GGT|GGT 1|GTG
gamma-glutamyltransferase 1
protein-coding
22q11.23
Ensembl:ENSG00000100031 MIM:612346 Vega:OTTHUMG00000030859 UniprotKB:P19440
NG_008111.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.300e-1 (AD)  6.505e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF10.768
FUK0.743
MICALL20.731
LRCH40.731
NPEPL10.73
TAZ0.728
RNPEPL10.725
USP400.722
TTLL30.719
GUSB0.717

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.377
OR4F29-0.362
BEND4-0.306
ADAMTS5-0.277
CHAC2-0.266
FAM216B-0.256
SYT16-0.249
RAB39A-0.247
GRPR-0.241
FBP2-0.239

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of GGT1 mRNA"19784758
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein]28414158
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GGT1 mRNA"25614096
C0697112,5-dichloro-3-(glutathionyl-S-yl)-1,4-benzoquinone"GGT1 protein affects the susceptibility to 2,5-dichloro-3-(glutathionyl-S-yl)-1,4-benzoquinone"1678558
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GGT1 mRNA"12376462
C0571052-gluthionyl-3,5,6-trichloro-1,4-benzoquinone"GGT1 protein affects the susceptibility to 2-gluthionyl-3,5,6-trichloro-1,4-benzoquinone"1678558
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGT1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of GGT1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGT1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GGT1 mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of GGT1 mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of GGT1 mRNA19784758
C069744acetaminophen cysteine[GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophen15629191
C069744acetaminophen cysteineGGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione]15629191
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in increased secretion of GGT1 protein]24634002
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]24485406
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of GGT1 protein]12030384
D000111AcetylcysteineAcetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GGT1 mRNA22129741
D000111AcetylcysteineSelenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
C006303acivicinacivicin results in decreased activity of GGT1 protein15629191
C006303acivicinacivicin results in decreased activity of GGT1 protein15629191
C006303acivicin[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione19419996
C006303acivicinacivicin results in decreased activity of GGT1 protein1673268|1678558|
D020106AcrylamideAcrylamide results in increased expression of GGT1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GGT1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GGT1 mRNA19770486
D000498Allyl CompoundsAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
C006578anetholeanethole analog results in decreased activity of GGT1 protein20171274
D000814Aniline CompoundsGGT1 protein affects the metabolism of Aniline Compounds analog6149445
C030610argemone oilargemone oil results in increased expression of GGT1 protein15981203
D001151ArsenicGGT1 mRNA results in decreased susceptibility to Arsenic17976673
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in increased secretion of GGT1 protein]24634002
C006632arsenic trioxidearsenic trioxide results in increased secretion of GGT1 protein24634002
C006632arsenic trioxidearsenic trioxide results in increased activity of GGT1 protein18801422
C006632arsenic trioxidearsenic trioxide results in increased expression of GGT1 mRNA18801422
D001194AsbestosAsbestos results in decreased expression of GGT1 mRNA22076105
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]16298753
D001241AspirinAspirin analog results in decreased activity of GGT1 protein20171274
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GGT1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of GGT1 protein18057710
D001564Benzo(a)pyreneQuercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of GGT1 protein]18057710
D001585Benzoyl PeroxideBenzoyl Peroxide results in decreased activity of GGT1 protein1354260
D004958EstradiolEstradiol results in increased expression of GGT1 mRNA19484750
C099952bifenthrinbifenthrin results in increased expression of GGT1 mRNA26071804
C006780bisphenol Abisphenol A affects the expression of GGT1 mRNA25181051
D001888Boric AcidsBoric Acids analog results in decreased activity of GGT1 protein6149445
C014369bromfenvinphos[bromfenvinphos co-treated with Methoxychlor] results in increased activity of GGT1 protein8106090
C014369bromfenvinphosbromfenvinphos results in increased activity of GGT1 protein8106090
D002087ButyratesButyrates results in increased expression of and results in increased activity of GGT1 protein12030384
D002087ButyratesButyrates results in increased expression of GGT1 mRNA alternative form12030384
D002104CadmiumCadmium results in increased activity of GGT1 protein17165624
D002104CadmiumCadmium results in increased expression of GGT1 protein23193971
D002104Cadmiumkutkin inhibits the reaction [Cadmium results in increased activity of GGT1 protein]17165624
D002104Cadmiumpectin inhibits the reaction [Cadmium results in increased expression of GGT1 protein]23193971
D019256Cadmium ChlorideCadmium Chloride results in increased activity of GGT1 protein23961183
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GGT1 protein23750309
D019256Cadmium ChloridePlant Extracts inhibits the reaction [Cadmium Chloride results in increased activity of GGT1 protein]23961183
D019256Cadmium Chloridetelmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein]23750309
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GGT1 mRNA27746196
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GGT1 mRNA19784758
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of GGT1 protein15700767
D002251Carbon TetrachlorideMelatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein]15700767
C004659chlorobenzilatechlorobenzilate results in increased activity of GGT1 protein2387028
D020111Chlorodiphenyl (54% Chlorine)Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]16298753
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein15955608|1629875
D020111Chlorodiphenyl (54% Chlorine)Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]16298753
D002737ChloropreneChloroprene results in increased expression of GGT1 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion results in decreased activity of GGT1 protein15980013
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GGT1 mRNA28472532
C030973cupric oxide[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein28212817
C030973cupric oxide[cupric oxide co-treated with lead oxide] results in increased activity of GGT1 protein28212817
D003474CurcuminCurcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D003474CurcuminCurcumin results in increased expression of GGT1 mRNA18299980
C057862cyanoginosin LRcyanoginosin LR results in increased expression of GGT1 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of GGT1 mRNA19770486
D016572CyclosporineCyclosporine affects the expression of GGT1 protein11589784
D016572CyclosporineSirolimus promotes the reaction [Cyclosporine affects the expression of GGT1 protein]11589784
C515055darinaparsindarinaparsin results in increased expression of GGT1 mRNA19417148
D003634DDTDDT results in decreased activity of GGT1 protein9475050
D003634DDTDDT results in increased activity of GGT1 protein2387028
C014347decitabinedecitabine results in increased expression of GGT1 mRNA19194470
D003980DiazooxonorleucineDiazooxonorleucine results in decreased activity of GGT1 protein6149445
D015946Ethylene DibromideEthylene Dibromide results in increased activity of GGT1 protein12628311
D015946Ethylene DibromidePhentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]12628311
D015946Ethylene DibromidePhenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]12628311
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GGT1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GGT1 mRNA27392435
D004008Diclofenac"[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein"23939143
D004010DicofolDicofol results in increased activity of GGT1 protein2387028
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GGT1 mRNA27746196
D004052DiethylnitrosamineAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GGT1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased activity of GGT1 protein15563447
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GGT1 mRNA19638242
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GGT1 protein19126423
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GGT1 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA22129741
D004052Diethylnitrosamine[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA22687989
D004052DiethylnitrosaminePlant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of GGT1 protein]15563447
D004052DiethylnitrosamineSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GGT1 mRNA"12376462
D004317DoxorubicinDoxorubicin results in decreased secretion of GGT1 protein28885000
D004391DustDust results in increased expression of GGT1 mRNA17805423
D004726EndosulfanEndosulfan results in increased activity of GGT1 protein8588293
C118739entinostatentinostat results in increased expression of GGT1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GGT1 mRNA"27188386
C031365epomediol[Ethinyl Estradiol co-treated with epomediol] results in increased activity of GGT1 protein12071332
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GGT1 mRNA14976129
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GGT1 mRNA14976129
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GGT1 mRNA17942748
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with epomediol] results in increased activity of GGT1 protein12071332
D004997Ethinyl EstradiolEthinyl Estradiol results in increased activity of GGT1 protein12071332
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GGT1 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GGT1 gene16724327
C033789fenarimolfenarimol results in increased activity of GGT1 protein2387028
C017690fenvaleratefenvalerate affects the expression of GGT112479040
C082360fipronilfipronil results in increased expression of GGT1 mRNA23962444
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GGT1 mRNA17187413
D0150732-AcetylaminofluoreneAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein15554553
D0150732-AcetylaminofluoreneSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
D005492Folic AcidFolic Acid affects the activity of GGT1 protein16967759
D005557FormaldehydeFormaldehyde results in increased expression of GGT1 mRNA23649840
C039281furanfuran results in increased expression of GGT1 mRNA27387713
C497432gamma-glutamylcysteinylacetominophen[GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophen15629191
D005978Glutathione[GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophen15629191
D005978Glutathione[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione19419996
D005978GlutathioneGGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione]15629191
D005978Glutathione[hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione19419996
D005978GlutathioneGGT1 results in increased metabolism of Glutathione19419996
C412815GW 4064GW 4064 results in increased expression of GGT1 mRNA26655953
C033550hexylglutathione[hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione19419996
C033550hexylglutathionehexylglutathione results in decreased activity of GGT1 protein19419996
C016517indole-3-carbinolindole-3-carbinol affects the expression of GGT1 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GGT1 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA22129741
C051890irinotecanirinotecan analog results in decreased expression of GGT1 mRNA18927307
C038267isopropyl 4,4'-dibromobenzilate"isopropyl 4,4'-dibromobenzilate results in increased activity of GGT1 protein"2387028
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GGT1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GGT1 mRNA26752646
C057463kutkinkutkin inhibits the reaction [Cadmium results in increased activity of GGT1 protein]17165624
C047365lead oxide[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein28212817
C047365lead oxide[cupric oxide co-treated with lead oxide] results in increased activity of GGT1 protein28212817
C047365lead oxide[lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein28212817
C047365lead oxidelead oxide results in increased activity of GGT1 protein28212817
D001556LindaneLindane results in increased activity of GGT1 protein11349524
D001556LindanePlant Extracts inhibits the reaction [Lindane results in increased activity of GGT1 protein]11349524
D001556LindaneLindane affects the activity of GGT1 protein8519523
D001556LindaneLindane results in decreased activity of GGT1 protein9475050
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein"23939143
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GGT1 mRNA26378955
D008550MelatoninMelatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein]15700767
D008627Mercuric ChlorideAcetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]24485406
D008627Mercuric ChlorideAcetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GGT1 protein24485406
D008627Mercuric ChlorideSelenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]24485406
D008627Mercuric ChlorideSelenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
D008628MercuryMercury results in decreased expression of GGT1 mRNA19937285
D008727Methotrexate18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein]28414158
D008727MethotrexateMethotrexate results in increased activity of GGT1 protein28414158
D008731Methoxychlor[bromfenvinphos co-treated with Methoxychlor] results in increased activity of GGT1 protein8106090
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GGT1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GGT1 protein24941299
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GGT1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GGT1 mRNA"22076105
C031721naphthalenenaphthalene analog results in increased expression of GGT1 mRNA24976557
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of GGT1 mRNA18187559
D009525NiacinNiacin results in increased expression of GGT1 mRNA20303128
C029938nickel sulfatenickel sulfate results in increased activity of GGT1 protein24112957
C029938nickel sulfatetroxerutin inhibits the reaction [nickel sulfate results in increased activity of GGT1 protein]24112957
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of GGT1 mRNA19784758
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of and results in increased activity of GGT1 protein9144455
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of GGT1 mRNA16049373|9144455
D009675NovobiocinNovobiocin results in increased activity of GGT1 protein1739614
C025589ochratoxin Aochratoxin A results in decreased activity of GGT1 protein2569870
C025589ochratoxin Aochratoxin A results in decreased expression of GGT1 mRNA12700408|1625148
D009853Omeprazole[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA22687989
D009966OrphenadrineOrphenadrine affects the expression of GGT1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GGT1 mRNA25729387
C030121pectinpectin inhibits the reaction [Cadmium results in increased expression of GGT1 protein]23193971
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of GGT1 mRNA22790973
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of GGT1 mRNA20118188
D026023PermethrinPermethrin results in increased activity of GGT1 protein2902710
D010634PhenobarbitalPhenobarbital results in increased expression of GGT1 mRNA2563599
D010646PhentolaminePhentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]12628311
D010656PhenylephrinePhenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]12628311
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GGT1 mRNA22008526
D010936Plant ExtractsPlant Extracts inhibits the reaction [Lindane results in increased activity of GGT1 protein]11349524
D010936Plant ExtractsPlant Extracts inhibits the reaction [Cadmium Chloride results in increased activity of GGT1 protein]23961183
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of GGT1 protein]15563447
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GGT1 mRNA19162173
C045362prochlorazprochloraz results in increased expression of GGT1 mRNA25182419
D011411PropanilPropanil affects the activity of GGT1 protein18973941
D011794QuercetinQuercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of GGT1 protein]18057710
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of GGT1 mRNA25905778
C005705sanguinarinesanguinarine results in increased expression of GGT1 protein15981203
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of GGT1 mRNA19244175
D012643SeleniumAcetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
D012643SeleniumSelenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]24485406
D012643SeleniumSelenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]24485406
C518471silybin-phytosomesilybin-phytosome inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D020123SirolimusSirolimus promotes the reaction [Cyclosporine affects the expression of GGT1 protein]11589784
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of GGT1 mRNA25905778
D013311StreptozocinStreptozocin results in decreased expression of GGT1 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein]19634143
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GGT1 mRNA26378955
D013440SulfidesSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]15554553
C061133tamibarotenetamibarotene results in increased expression of GGT1 mRNA15498508
C084178telmisartantelmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein]23750309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GGT1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GGT1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GGT1 mRNA19770486
D013853ThioacetamideCurcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GGT1 mRNA28943392
D013853Thioacetamidesilybin-phytosome inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D013853ThioacetamideThioacetamide results in decreased expression of GGT1 mRNA19784758
D013853ThioacetamideThioacetamide results in increased expression of GGT1 mRNA23411599
D013853ThioacetamideThioacetamide results in increased expression of GGT1 protein24704557
D013853ThioacetamideThioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D008063Thioctic AcidThioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]24704557
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GGT1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in decreased expression of GGT1 mRNA26489853
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GGT1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of GGT1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of GGT1 mRNA16788091
D014212TretinoinTretinoin results in increased expression of GGT1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GGT1 mRNA28973375
C012589trichostatin Atrichostatin A results in increased activity of GGT1 protein12030384
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein]19634143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GGT1 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased activity of GGT1 protein24685621
C005865troxerutintroxerutin inhibits the reaction [nickel sulfate results in increased activity of GGT1 protein]24112957
D014635Valproic AcidValproic Acid results in increased methylation of GGT1 gene29154799
D014640VancomycinVancomycin results in increased expression of GGT1 mRNA18930951
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of GGT1 mRNA19244175
D014810Vitamin EVitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]16298753
D024483Vitamin K 3Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of GGT1 protein]12030384
D024483Vitamin K 3Vitamin K 3 results in decreased expression of GGT1 mRNA alternative form12030384
D024483Vitamin K 3Vitamin K 3 results in increased expression of and results in increased activity of GGT1 protein12030384
D015034Zinc Oxide[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein28212817
D015034Zinc Oxide[lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein28212817
C088658zoledronic acidzoledronic acid results in decreased expression of GGT1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000048peptidyltransferase activity-IDA21447318  
GO:0002951leukotriene-C(4) hydrolase-IDA21447318  
GO:0002951leukotriene-C(4) hydrolase-IMP14754911  
GO:0005515protein binding-IPI15528406  
GO:0036374glutathione hydrolase activity-EXP9080  17924658  
GO:0036374glutathione hydrolase activity-IDA20622017  23682772  24047895  
GO:0036374glutathione hydrolase activity-TAS-  
GO:0102953hypoglycin A gamma-glutamyl transpeptidase activity-IEA-  
GO:0103068leukotriene C4 gamma-glutamyl transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002682regulation of immune system process-ISS-  
GO:0006412translation-IEA-  
GO:0006508proteolysis-IMP14754911  
GO:0006520cellular amino acid metabolic process-IDA14754911  
GO:0006536glutamate metabolic process-IDA24047895  
GO:0006631fatty acid metabolic process-IDA21447318  
GO:0006691leukotriene metabolic process-TAS-  
GO:0006750glutathione biosynthetic process-ISS-  
GO:0006750glutathione biosynthetic process-TAS-  
GO:0006751glutathione catabolic process-IDA17924658  21447318  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0007283spermatogenesis-ISS-  
GO:0019344cysteine biosynthetic process-ISS-  
GO:0031638zymogen activation-IDA23682772  
GO:0050727regulation of inflammatory response-ISS-  
GO:1901750leukotriene D4 biosynthetic process-IDA21447318  
GO:1901750leukotriene D4 biosynthetic process-IMP14754911  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005886plasma membrane-IDA23682772  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA20458337  23533145  
KEGG ID KEGG Term
hsa00430Taurine and hypotaurine metabolism
hsa00460Cyanoamino acid metabolism
hsa00480Glutathione metabolism
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-1643685DiseaseTAS
R-HSA-174403Glutathione synthesis and recyclingTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-5423646Aflatoxin activation and detoxificationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579022Defective GGT1 causes Glutathionuria (GLUTH)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9035968Defective GGT1 causes Glutathionuria (GLUTH)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23462328Variation in the gamma-glutamyltransferase 1 gene and risk of chronic pancreatitis. (2013 Jul)Brand HPancreas
21715529Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)O'Shaughnessy PJJ Clin Endocrinol Metab