Gene: GH1

2688
GH|GH-N|GHB5|GHN|IGHD1B|hGH-N
growth hormone 1
protein-coding
17q23.3
Ensembl:ENSG00000259384 MIM:139250 Vega:OTTHUMG00000172293 UniprotKB:P01241
NG_011676.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.062e-1 (AD)  9.497e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRL0.854
CGA0.774
LHB0.61
POMC0.576
TSHB0.514
FSHB0.407
UGT1A70.388
PRM20.368
PRM10.36
GKN10.34

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK15-0.261
MYF6-0.234
RASGEF1B-0.232
MYPN-0.225
ZNF518B-0.225
ZC3H11B-0.221
FNDC8-0.221
TNNT3-0.221
MYH7-0.216
L3MBTL3-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]"17027146
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]"17027146
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA"19327374
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA"19327374
C0439582-butanol2-butanol affects the folding of GH1 protein11064379
C0230353,4,5,3',4'-pentachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA"19327374
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
C1114204-hydroxybutyric acid4-hydroxybutyric acid results in increased secretion of GH1 protein10657535
C1114204-hydroxybutyric acidCocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein]10657535
C0415944-nonylphenol4-nonylphenol results in increased expression of GH1 mRNA19145065|1946369
C0415944-nonylphenol4-nonylphenol results in increased expression of GH1 protein19145065
C0415944-nonylphenol4-nonylphenol results in increased secretion of GH1 protein19463694
C0415944-nonylphenolfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]19145065|1946369
C0415944-nonylphenolfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]19145065
C0415944-nonylphenolfulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]19463694
C0804174-octylphenol4-octylphenol results in increased expression of GH1 mRNA19463694
C0804174-octylphenol4-octylphenol results in increased secretion of GH1 protein19463694
C0804174-octylphenolfulvestrant inhibits the reaction [4-octylphenol results in increased expression of GH1 mRNA]19463694
C0804174-octylphenolfulvestrant inhibits the reaction [4-octylphenol results in increased secretion of GH1 protein]19463694
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of GH1 mRNA19145065
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of GH1 protein19145065
C1052604-tert-octylphenolfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 mRNA]19145065
C1052604-tert-octylphenolfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 protein]19145065
C027696acipimoxacipimox promotes the reaction [GHRH protein results in increased secretion of GH1 protein]8923850
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of GH1 protein12471042
D000255Adenosine Triphosphateoxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]12471042
D000255Adenosine Triphosphate"Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]"12471042
D000255Adenosine TriphosphateNCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]12471042
D000255Adenosine Triphosphateoxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]12471042
D000324Adrenocorticotropic HormoneAdrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein]3008584
C016601afimoxifeneafimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
C103303alitretinoinalitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
C103303alitretinoinalitretinoin results in increased expression of GH1 mRNA10720163|1524099
C103303alitretinoinPentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
C103303alitretinoinPentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]10720163
C103303alitretinoinPentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
C103303alitretinoinTriiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]10720163
C103303alitretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
C103303alitretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
C103303alitretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]]10720163
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [GH1 protein results in increased expression of IGF1 mRNA]"22067323
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]"18388193
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]"29079362
C011512alpha-naphthoflavone[Tetrachlorodibenzodioxin co-treated with alpha-naphthoflavone] affects the expression of GH1 mRNA16188257
D006710HomocysteineGH1 protein results in decreased abundance of Homocysteine17311540|1732460
D000638AmiodaroneAmiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]2910914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GH1 mRNA16483693
D001058ApomorphineApomorphine results in increased expression of GH1 protein8889285
D001058ApomorphineApomorphine results in increased secretion of GH1 protein993808
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased activity of MMP9 protein]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of BCL2 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of CDH1 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of MMP2 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of MMP9 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of PLAU mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of PLAUR mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of TERT mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in increased expression of BAX mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in increased expression of CDKN2A mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in increased expression of MYC mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in increased expression of PMAIP1 mRNA]23851143
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in increased expression of TP53 mRNA]23851143
C006632arsenic trioxideGH1 protein results in increased susceptibility to arsenic trioxide23851143
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of GH1 protein]18602937
D001280Atrazine[Atrazine binds to GHRHR protein] which results in decreased expression of GH1 mRNA20529762
D001280AtrazineAtrazine results in decreased expression of GH1 mRNA20529762
C547126AZM551248AZM551248 results in increased expression of GH1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [Sulpiride results in decreased expression of GH1 protein]26466350
D004958Estradiol[Estradiol co-treated with Progesterone] inhibits the reaction [GH1 protein results in increased susceptibility to Methylnitrosourea]15528971
D004958EstradiolEstradiol inhibits the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased secretion of GH1 protein15772906
D004958EstradiolEstradiol affects the reaction [Dieldrin results in decreased expression of GH1 mRNA]23041725
D004958EstradiolEstradiol results in increased expression of GH1 mRNA16188257|1782345
D004958EstradiolEstradiol results in increased expression of GH1 mRNA15240998|1946369
D004958EstradiolEstradiol results in increased expression of GH1 protein11408345|1586055
D004958EstradiolEstradiol results in increased secretion of GH1 protein19463694
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of GH1 mRNA]19463694
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased secretion of GH1 protein]19463694
D004958EstradiolGH1 protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]22067323
D004958EstradiolNOG protein promotes the reaction [GH1 protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D001663BilirubinGH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Bilirubin]9185964
C006780bisphenol A[bisphenol A co-treated with GH1 protein] results in increased activity of GHR1 protein20467862
C006780bisphenol A[bisphenol A co-treated with GH1 protein] results in increased activity of GHR protein20467862
C006780bisphenol AESR1 protein inhibits the reaction [[bisphenol A co-treated with GH1 protein] results in increased activity of GHR1 protein]20467862
C006780bisphenol AESR1 protein inhibits the reaction [[bisphenol A co-treated with GH1 protein] results in increased activity of GHR protein]20467862
C006780bisphenol Abisphenol A results in decreased expression of GH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GH1 mRNA19463694
C006780bisphenol Abisphenol A results in increased expression of GH1 protein19145065|2284222
C006780bisphenol Abisphenol A results in increased methylation of GH1 gene28505145
C006780bisphenol Abisphenol A results in increased secretion of GH1 protein19463694
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 mRNA]19463694
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 protein]19145065
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased secretion of GH1 protein]19463694
D001971BromocriptineBromocriptine results in decreased expression of GH1 protein19420816|3226523
D001971BromocriptineBromocriptine results in increased expression of GH1 protein772175
D0200011-Butanol1-Butanol affects the folding of GH1 protein11064379
D020148Butyric AcidButyric Acid inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]2211641
D019256Cadmium Chloride"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]"17027146
D019256Cadmium Chloride"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]"17027146
D019256Cadmium ChlorideGenistein inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]17027146
D019256Cadmium ChlorideGenistein inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]17027146
D019256Cadmium ChlorideGH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]17027146
D019256Cadmium ChlorideGH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]17027146
D019256Cadmium ChlorideGH1 protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]17027146
D019256Cadmium ChlorideGH1 protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]17027146
D019256Cadmium ChlorideGH1 protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of STAT5 protein]17027146
D019256Cadmium ChlorideThapsigargin inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]17027146
D019256Cadmium ChlorideThapsigargin inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]17027146
D019256Cadmium ChlorideCadmium Chloride affects the expression of GH1 protein20652474
D002110CaffeineGH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]11907490
D002211CapsaicinCapsaicin results in increased expression of GH1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D002220CarbamazepineCarbamazepine results in decreased expression of GH128267586
C033394CGP 12177GH1 protein promotes the reaction [CGP 12177 results in increased metabolism of Lipids]14981226
D002712ChloridesGH1 protein affects the transport of [Sodium co-treated with Chlorides]18388193
D002712Chloridespegvisomant inhibits the reaction [GH1 protein results in increased transport of [Sodium co-treated with Chlorides]]18388193
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of GH1 protein]18602937
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of GH1 protein18602937
D003000ClonidineClonidine results in increased secretion of GH1 protein6248808
D003000ClonidineClonidine results in increased expression of GH1707001
D003000ClonidineClonidine results in increased expression of GH1 protein2568210|3007707|
D003000ClonidineClonidine results in increased secretion of GH1 protein17889730
D003000ClonidineL 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]2568210
D003000ClonidineClonidine results in increased secretion of GH1 protein15099682
D003000ClonidineCocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]15099682
C018021cobaltous chloridecobaltous chloride results in decreased expression of GH1 mRNA21167956
D003042CocaineCocaine results in increased expression of GH1 mRNA17622340
D003042CocaineMelatonin affects the reaction [Cocaine affects the expression of GH1 mRNA]17622340
D003042CocaineCocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein]10657535
D003042CocaineCocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein]9413023
D003042CocaineCocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]15099682
D005576ColforsinColforsin results in increased secretion of GH1 protein19952226
D005576ColforsinGH1 protein promotes the reaction [Colforsin results in increased metabolism of Lipids]14981226
C029892cupric chloridecupric chloride results in increased expression of GH1 mRNA19616320
C029892cupric chloridecupric chloride results in increased expression of GH1 protein19616320
D003533CyproheptadineCyproheptadine results in increased expression of GH1 protein642945
C017180decamethrindecamethrin results in decreased expression of GH1 mRNA20647053
D003687Dehydroepiandrosterone[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein15161484
C007262deoxynivalenol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C007262deoxynivalenol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C007262deoxynivalenoldeoxynivalenol results in decreased expression of and results in decreased secretion of GH1 protein26141394
C007262deoxynivalenoldeoxynivalenol results in decreased expression of GH1 mRNA26141394
C007262deoxynivalenolfarnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C007262deoxynivalenolfarnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C007262deoxynivalenolpyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C007262deoxynivalenolpyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C007262deoxynivalenolSB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C007262deoxynivalenolSB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
D003907DexamethasoneDexamethasone results in decreased expression of GH1 protein12670838
D003907DexamethasoneDexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]15240998
D003907DexamethasoneDexamethasone results in decreased expression of GH1 mRNA15240998
C068327diallyl sulfoneGH1 protein inhibits the reaction [diallyl sulfone results in increased expression of CYP2B1 mRNA]8390837
C068327diallyl sulfoneGH1 protein inhibits the reaction [diallyl sulfone results in increased expression of CYP2B2 mRNA]8390837
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of GH1 mRNA17056472
D004026DieldrinDieldrin results in decreased expression of GH1 mRNA23041725
D004026DieldrinEstradiol affects the reaction [Dieldrin results in decreased expression of GH1 mRNA]23041725
D004041Dietary FatsDietary Fats results in decreased expression of GH1 mRNA18721800
D002117CalcitriolGH1 protein affects the reaction [CYP27B1 protein affects the abundance of Calcitriol]11316734
D0151279,10-Dimethyl-1,2-benzanthracene"GH1 gene mutant form results in decreased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"12082019
D004221DisulfiramGH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]8390837
D004221DisulfiramGH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]8390837
D004280DobutamineGH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids]14981226
D007980LevodopaLevodopa results in increased expression of GH1 protein8867520
D007980LevodopaLevodopa results in increased expression of GH1 protein6122169
D004317Doxorubicin[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]20051877
D004317Doxorubicin[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]20051877
D004317Doxorubicin[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]20051877
D004492Edetic AcidEdetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D004656EnalaprilGH1 protein results in increased susceptibility to Enalapril12883983
D004726EndosulfanEndosulfan results in decreased expression of GH1 mRNA20471459
D004726EndosulfanEndosulfan results in increased expression of GH1 protein20471459
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of GH1 protein21323755
C015854estradiol valerateestradiol valerate results in increased expression of GH1 protein10843175
D004964EstriolEstriol results in increased expression of GH1 mRNA15240998
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in increased expression of GH1 protein"10843175
D000431EthanolEthanol affects the folding of GH1 protein11064379
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of GH1 protein11172797
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GH1 protein10843175
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GH1 mRNA18000313
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GH1 mRNA17222921
C004912ethylbenzeneGH1 protein inhibits the reaction [ethylbenzene results in increased expression of CYP2E1 protein]11884239
D019855Ethylene GlycolEthylene Glycol affects the folding of GH1 protein11064379
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D005230Fatty Acids, Nonesterified"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"838844
D005230Fatty Acids, Nonesterified"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein"838844
D005230Fatty Acids, Nonesterified"3-Hydroxybutyric Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
D005230Fatty Acids, Nonesterified"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein"1890151
D005230Fatty Acids, Nonesterified"Oleic Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
D005230Fatty Acids, Nonesterified"GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Fatty Acids, Nonesterified]"9185964
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified affects the reaction [GHRH protein results in increased secretion of GH1 protein]"8923850
D005485FlutamideFlutamide results in increased expression of GH1 mRNA17222921
D005557FormaldehydeFormaldehyde results in increased expression of GH1 mRNA12679049
C070081fulvestrantfulvestrant results in increased expression of GH1 mRNA16188257
C070081fulvestrantfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]19145065|1946369
C070081fulvestrantfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]19145065
C070081fulvestrantfulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]19463694
C070081fulvestrantfulvestrant inhibits the reaction [4-octylphenol results in increased expression of GH1 mRNA]19463694
C070081fulvestrantfulvestrant inhibits the reaction [4-octylphenol results in increased secretion of GH1 protein]19463694
C070081fulvestrantfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 mRNA]19145065
C070081fulvestrantfulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 protein]19145065
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 mRNA]19463694
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 protein]19145065
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased secretion of GH1 protein]19463694
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of GH1 mRNA]19463694
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased secretion of GH1 protein]19463694
D019833GenisteinGenistein inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]17027146
D019833GenisteinGenistein inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]17027146
D005947GlucoseGH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein]21559284
D005947Glucose"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"838844
D005947GlucoseGH1 protein inhibits the reaction [Lipopolysaccharides results in decreased abundance of Glucose]9185964
D005947Glucose[INS protein results in decreased abundance of Glucose] which results in increased secretion of GH1 protein1890151
D016316GuanfacineGuanfacine results in increased expression of GH1 protein6150000
C086184hexarelinhexarelin results in increased secretion of GH1 protein7673411
D006854HydrocortisoneHydrocortisone results in increased expression of GH1 protein15833589
D0201553-Hydroxybutyric Acid"3-Hydroxybutyric Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
D012978Sodium OxybateCocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein]9413023
D012978Sodium OxybateSodium Oxybate results in increased expression of GH1 protein9413023
C027299hydroxymaprotilinhydroxymaprotilin results in increased secretion of GH1 protein8364347
D019329IdazoxanIdazoxan results in decreased expression of GH1 protein6150737
D007213IndomethacinIndomethacin results in increased expression of GH1 mRNA28201806
D015759IonomycinIonomycin results in increased secretion of GH1 protein12471042
C054290L 657743L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]2568210
C017461lead nitratelead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]12022635
C017461lead nitratelead nitrate results in decreased secretion of GH1 protein12022635
D008055LipidsGH1 protein promotes the reaction [CGP 12177 results in increased metabolism of Lipids]14981226
D008055LipidsGH1 protein promotes the reaction [Colforsin results in increased metabolism of Lipids]14981226
D008055LipidsGH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids]14981226
D008070LipopolysaccharidesGH1 protein inhibits the reaction [Lipopolysaccharides results in decreased abundance of Glucose]9185964
D008070LipopolysaccharidesGH1 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of INS protein]9185964
D008070LipopolysaccharidesGH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Bilirubin]9185964
D008070Lipopolysaccharides"GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Fatty Acids, Nonesterified]"9185964
D008070LipopolysaccharidesGH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Urea]9185964
D008070LipopolysaccharidesGH1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]9185964
D017706Lisinopril[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]20051877
D017706Lisinopril[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]20051877
D017706Lisinopril[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]20051877
C005095malachite greenESR1 protein inhibits the reaction [[malachite green co-treated with GH1 protein] results in increased activity of GHR1 protein]20467862
C005095malachite greenESR1 protein inhibits the reaction [[malachite green co-treated with GH1 protein] results in increased activity of GHR protein]20467862
C005095malachite green[malachite green co-treated with GH1 protein] results in increased activity of GHR1 protein20467862
C005095malachite green[malachite green co-treated with GH1 protein] results in increased activity of GHR protein20467862
D008550MelatoninMelatonin affects the reaction [Cocaine affects the expression of GH1 mRNA]17622340
D008617MephenytoinGH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]11907490
D008748MethylcholanthreneMethylcholanthrene results in decreased activity of GH1 protein22978700
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GH1 mRNA26011545
D008770Methylnitrosourea[Estradiol co-treated with Progesterone] inhibits the reaction [GH1 protein results in increased susceptibility to Methylnitrosourea]15528971
D008770MethylnitrosoureaGH1 protein results in increased susceptibility to Methylnitrosourea15528971
D008770MethylnitrosoureaGH1 gene mutant form results in decreased susceptibility to Methylnitrosourea12082019
D009020MorphineMorphine results in increased secretion of GH1 protein7201058
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D009525Niacin"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"838844
D009525Niacin"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein"838844
D009525Niacin"3-Hydroxybutyric Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
D009525Niacin"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein"1890151
D009525Niacin"Oleic Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
C038405nivalenolnivalenol results in decreased expression of and results in decreased secretion of GH1 protein26141394
C038405nivalenolnivalenol results in decreased expression of GH1 mRNA26141394
C009074N-n-propylnorapomorphineN-n-propylnorapomorphine affects the secretion of GH1 protein1107835
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of GH1 protein11172797
D019301Oleic Acid"Oleic Acid inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]"1890151
D015282OctreotideOctreotide affects the expression of GH1 protein16449332
D015282OctreotideOctreotide results in decreased expression of GH1 protein1516598|1518433|
D015282OctreotideOctreotide results in decreased secretion of GH1 protein1561523|1683947|
D015282OctreotideOctreotide binds to and results in increased activity of GH1 protein9351990
C016340o,p'-DDT"o,p'-DDT results in increased expression of GH1 mRNA"16188257
C029341oxophenylarsineoxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]12471042
C029341oxophenylarsineoxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]12471042
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA"19327374
C406545pegvisomantpegvisomant inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]18388193
C406545pegvisomantpegvisomant inhibits the reaction [GH1 protein results in increased transport of [Sodium co-treated with Chlorides]]18388193
D004369Pentetic AcidPentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidPentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]10720163
D004369Pentetic AcidZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D026023PermethrinGH1 protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]14722249
D010634PhenobarbitalGH1 protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]14722249
C006253pirinixic acidpirinixic acid results in increased expression of GH1 mRNA19162173
D011075Polybrominated BiphenylsPolybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]22201216
D011075Polybrominated BiphenylsPolybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]22201216
D011374Progesterone[Estradiol co-treated with Progesterone] inhibits the reaction [GH1 protein results in increased susceptibility to Methylnitrosourea]15528971
D011374ProgesteroneProgesterone results in decreased expression of GH1 protein21323755
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased secretion of GH1 protein15772906
D011374ProgesteroneProgesterone results in increased secretion of GH1 protein15772906
D011374ProgesteroneGH1 protein promotes the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
D011374ProgesteroneGH1 protein inhibits the reaction [BMP4 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneGH1 protein inhibits the reaction [BMP6 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneGH1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneGH1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]22067323
D011374ProgesteroneGH1 protein promotes the reaction [[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneGH1 protein promotes the reaction [[FSHB protein results in increased expression of HSD3B2 mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneGH1 protein promotes the reaction [[FSHB protein results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneNOG protein promotes the reaction [GH1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011372ProgestinsProgestins results in increased expression of GH18751273
D019946Propylene GlycolPropylene Glycol affects the folding of GH1 protein11064379
D0198402-Propanol2-Propanol affects the folding of GH1 protein11064379
D0004331-Propanol1-Propanol affects the folding of GH1 protein11064379
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]"12471042
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
D011732Pyridoxal PhosphatePyridoxal Phosphate results in decreased secretion of GH1 protein16690808
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]17272397
C059514resveratrolresveratrol inhibits the reaction [GHRH protein results in increased secretion of GH1 protein]23292070
C059514resveratrolresveratrol results in decreased expression of GH1 mRNA23292070
C059514resveratrolresveratrol results in decreased secretion of GH1 protein23292070
C059514resveratrolSIRT1 mutant form affects the reaction [resveratrol results in decreased expression of GH1 mRNA]23292070
C059514resveratrolSIRT1 mutant form inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]23292070
C059514resveratrolsirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]23292070
C093642SB 203580SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]26141394
C093642SB 203580SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]26141394
C093642SB 203580SB 203580 inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D012834SilverSilver analog results in decreased expression of GH1 mRNA22727896
D012835Silver NitrateSilver Nitrate results in decreased expression of GH1 mRNA22727896
C439060sirtinolsirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]23292070
C439060sirtinolsirtinol results in increased expression of GH1 mRNA23292070
C439060sirtinolsirtinol results in increased secretion of GH1 protein23292070
D012964SodiumGH1 protein results in increased abundance of Sodium17311540|1732460
D012964SodiumGH1 protein affects the transport of Sodium18388193
D012964SodiumGH1 protein affects the transport of [Sodium co-treated with Chlorides]18388193
D012964Sodium[GH1 protein co-treated with IGF1 protein] affects the transport of Sodium18388193
D012964Sodiumpegvisomant inhibits the reaction [GH1 protein results in increased transport of [Sodium co-treated with Chlorides]]18388193
D013469SulpirideBenzo(a)pyrene affects the reaction [Sulpiride results in decreased expression of GH1 protein]26466350
D013469SulpirideSulpiride results in decreased expression of GH1 protein26466350
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein]22150557
D014284Triiodothyroninealitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D014284TriiodothyronineAmiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]2910914
D014284TriiodothyronineButyric Acid inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]2211641
D014284TriiodothyronineDexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]15240998
D014284TriiodothyronineEdetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D014284TriiodothyronineP4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]22201216
D014284TriiodothyronineP4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]22201216
D014284TriiodothyroninePentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D014284TriiodothyroninePentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D014284TriiodothyroninePentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
D014284TriiodothyroninePentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D014284TriiodothyroninePentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D014284TriiodothyroninePolybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]22201216
D014284TriiodothyroninePolybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]22201216
D014284TriiodothyronineTretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D014284TriiodothyronineTriiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]10720163
D014284TriiodothyronineTriiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]10720163
D014284TriiodothyronineTriiodothyronine results in increased expression of GH1 mRNA10720163|1524099
D014284TriiodothyronineTriiodothyronine results in increased expression of GH1 protein22201216
D014284TriiodothyronineZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D014284TriiodothyronineZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D014284TriiodothyronineZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]]10720163
D014284TriiodothyronineZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]10720163
D014284TriiodothyronineZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D013605T-2 Toxin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 Toxin3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 ToxinAKNA protein affects the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 Toxin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]"29079362
D013605T-2 Toxinfarnesylthiosalicylic acid inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 ToxinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 ToxinSB 203580 inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]29079362
D013605T-2 ToxinT-2 Toxin results in decreased expression of and results in decreased secretion of GH1 protein26141394
D013605T-2 ToxinT-2 Toxin results in decreased expression of GH1 mRNA26141394|2907936
D013629TamoxifenTamoxifen promotes the reaction [SST protein results in decreased secretion of GH1 protein]1350760
D013629TamoxifenTamoxifen results in decreased secretion of GH1 protein1350760
D020002tert-Butyl Alcoholtert-Butyl Alcohol affects the folding of GH1 protein11064379
D013739Testosterone[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein15161484
D013739TestosteroneTestosterone results in increased expression of GH1 protein21084444
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with alpha-naphthoflavone] affects the expression of GH1 mRNA16188257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GH1 mRNA16188257
D019284ThapsigarginThapsigargin inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNA mRNA]]17027146
D019284ThapsigarginThapsigargin inhibits the reaction [GH1 protein promotes the reaction [Cadmium Chloride results in increased expression of MTNB mRNA]]17027146
D013853ThioacetamideGH1 protein affects the susceptibility to Thioacetamide11255791
D013974ThyroxineGH1 protein results in decreased abundance of Thyroxine17311540|1732460
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GH1 protein27793746
D014212TretinoinPentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D014212TretinoinPentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]10720163
D014212TretinoinPentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D014212TretinoinTretinoin affects the expression of GH1 protein1630583
D014212TretinoinTretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]10720163
D014212TretinoinTretinoin results in increased expression of GH1 mRNA10720163|1524099
D014212TretinoinTriiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]10720163
D014212TretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D014212TretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D014212TretinoinZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]10720163
C011559tributyltintributyltin affects the expression of GH1 mRNA26418422
D014236TrichlorfonTrichlorfon results in decreased expression of GH1 mRNA20570226
D014270TrifluoroethanolTrifluoroethanol affects the folding of GH1 protein11064379
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GH1 mRNA"26512412|2764616
D014508UreaGH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Urea]9185964
D014635Valproic AcidValproic Acid results in increased methylation of GH1 gene29154799
D014801Vitamin AGH1 protein promotes the reaction [Vitamin A affects the expression of and affects the activity of CYP2C11 protein]15963505
D015032ZincZinc promotes the reaction [GH1 protein binds to PRLR protein]12915731
D015032ZincGH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]10985758
D015032ZincGH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR protein]10985758
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]10720163
D015032ZincZinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]10720163
D019287Zinc SulfateZinc Sulfate results in decreased expression of GH1 mRNA21167956

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005131growth hormone receptor binding-IBA21873635  
GO:0005131growth hormone receptor binding-IDA6303755  
GO:0005131growth hormone receptor binding-IPI1549776  2825030  8943276  9571026  
GO:0005148prolactin receptor binding-IDA10890569  
GO:0005148prolactin receptor binding-IPI7984244  
GO:0005179hormone activity-IBA21873635  
GO:0005179hormone activity-IEA-  
GO:0005515protein binding-IPI8943276  9353194  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-IPI9360546  
GO:0046872metal ion binding-IEA-  
GO:0070186growth hormone activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002092positive regulation of receptor internalizationNOTIDA9360546  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010536positive regulation of activation of Janus kinase activity-IDA8063815  12552091  
GO:0010828positive regulation of glucose transmembrane transport-IDA9144201  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA7782332  
GO:0031667response to nutrient levels-IBA21873635  
GO:0032355response to estradiol-IDA12552091  
GO:0040018positive regulation of multicellular organism growth-IDA7565946  20110402  
GO:0040018positive regulation of multicellular organism growth-IMP8496314  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA8923468  12552091  
GO:0043406positive regulation of MAP kinase activity-TAS8063815  
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathway-IDA7565946  
GO:0045927positive regulation of growth-IBA21873635  
GO:0046427positive regulation of JAK-STAT cascade-IBA21873635  
GO:0046427positive regulation of JAK-STAT cascade-IDA8063815  8923468  
GO:0048513animal organ development-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA7782332  
GO:0060396growth hormone receptor signaling pathway-IBA21873635  
GO:0060396growth hormone receptor signaling pathway-IDA8063815  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO:0070977bone maturation-IDA20110402  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11549663  
GO:0031904endosome lumen-TAS-  
GO:0070195growth hormone receptor complex-IDA1549776  8943276  9571026  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1170546Prolactin receptor signalingIEA
R-HSA-1170546Prolactin receptor signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS
R-HSA-982772Growth hormone receptor signalingTAS
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20168335Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer. (2010 Mar)Gao CMJ Hum Genet