Gene: GHR

2690
GHBP|GHIP
growth hormone receptor
protein-coding
5p13.1-p12
Ensembl:ENSG00000112964 MIM:600946 Vega:OTTHUMG00000094791 UniprotKB:P10912
NG_011688.1
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.101e-1 (AD)  4.618e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN3A0.648
ZNF518B0.647
FNBP1L0.611
ZXDA0.609
RFX70.603
DYRK20.602
ESR10.59
PGAP10.588
TOM1L10.583
LYST0.582

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.292
DRD4-0.273
OR4F29-0.27
NXNL1-0.247
HIST1H3J-0.245
LCN1-0.245
PACSIN3-0.226
FAM229A-0.222
PYY-0.221
CDKN2C-0.219

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00052SomatotropinBiotechDrug12629-01-5Approved|InvestigationalTarget
DB00082PegvisomantBiotechDrug218620-50-9ApprovedTarget
DB09098SomatremBiotechDrug82030-87-3Approved|Investigational|WithdrawnTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GHR mRNA"15302862
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GHR mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GHR mRNA19933214
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in decreased expression of GHR mRNA"19101654
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GHR mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of GHR mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GHR mRNA"20959002
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GHR mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GHR mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of GHR mRNA27638505
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of GHR mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GHR mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of GHR mRNA17562736
D000082AcetaminophenGHR gene mutant form results in increased susceptibility to Acetaminophen16713617
D000082AcetaminophenAcetaminophen results in increased expression of GHR mRNA17088403
D000082AcetaminophenAcetaminophen results in increased expression of GHR protein17088403
D000082AcetaminophenGHR protein affects the susceptibility to Acetaminophen17088403
D000082AcetaminophenN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in increased expression of GHR mRNA]17088403
D020106AcrylamideAcrylamide results in decreased expression of GHR mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GHR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GHR mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GHR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GHR mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GHR mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of GHR mRNA22750116
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GHR mRNA16483693
C015001arsenitearsenite results in decreased expression of GHR mRNA18191166
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of GHR mRNA"25351596
C547126AZM551248AZM551248 results in decreased expression of GHR mRNA22323515
D001414BacitracinBacitracin affects the expression of GHR mRNA18289764
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GHR mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GHR mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GHR mRNA22228805
D004958EstradiolEstradiol results in decreased expression of GHR mRNA20467862
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of GHR mRNA21323755
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GHR mRNA19619570
D004958EstradiolEstradiol results in decreased expression of GHR mRNA19619570|2118537
D004958EstradiolEstradiol results in decreased expression of GHR mRNA21703268
D004958EstradiolEstradiol results in decreased expression of GHR protein21703268
D004958EstradiolEstradiol results in decreased expression of GHR mRNA19101654
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of GHR mRNA15912405
C006780bisphenol A[bisphenol A co-treated with GH1 protein] results in increased activity of GHR protein20467862
C006780bisphenol Abisphenol A results in decreased expression of GHR mRNA20467862
C006780bisphenol AESR1 protein inhibits the reaction [[bisphenol A co-treated with GH1 protein] results in increased activity of GHR protein]20467862
C006780bisphenol Abisphenol A affects the expression of GHR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GHR mRNA12075121
D000069286BortezomibBortezomib results in increased expression of GHR mRNA17895889
D002065BuspironeBuspirone results in decreased expression of GHR mRNA24136188
D002104CadmiumGHR gene mutant form results in decreased susceptibility to Cadmium16713617
D019256Cadmium ChlorideCadmium Chloride affects the expression of GHR mRNA22110744
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GHR mRNA20360939
D002118CalciumCalcium affects the expression of GHR mRNA15913539
D002118Calcium[Calcium co-treated with Calcitriol] affects the expression of GHR mRNA15913539
D002211CapsaicinCapsaicin results in increased expression of GHR protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GHR mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GHR mRNA27339419
D002713ChlorineChlorine results in decreased expression of GHR mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of GHR mRNA18636392
D002716ChlormequatChlormequat results in decreased expression of GHR mRNA28214531
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GHR mRNA18178546
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GHR mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of GHR mRNA18353800
D002994ClofibrateClofibrate affects the expression of GHR mRNA16081524
D003471CuprizoneCuprizone results in decreased expression of GHR mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GHR mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of GHR mRNA19770486
C093628cyproconazolecyproconazole results in decreased expression of GHR mRNA22334560
D003561CytarabineCytarabine results in decreased expression of GHR mRNA21198554
D003671DEET[fipronil co-treated with DEET] results in decreased expression of GHR mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of GHR mRNA12670838
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GHR mRNA28628672
D002945CisplatinCisplatin results in increased expression of GHR mRNA21151649
D002945CisplatinCisplatin results in decreased expression of GHR mRNA18289764
D004008DiclofenacDiclofenac affects the expression of GHR protein26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GHR mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of GHR mRNA22715380
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GHR mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GHR mRNA19638242
D002117Calcitriol[Calcium co-treated with Calcitriol] affects the expression of GHR mRNA15913539
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GHR mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of GHR mRNA17072980|2538013
C024629dimethyl phthalatedimethyl phthalate affects the expression of GHR mRNA26924002
D004237DiuronDiuron results in decreased expression of GHR mRNA21551480|2515243
D004317DoxorubicinDoxorubicin results in increased expression of GHR mRNA15033991
D004726EndosulfanEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GHR mRNA]26159488
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of GHR mRNA12655031
C109476epoxiconazoleepoxiconazole results in decreased expression of GHR mRNA22334560
C074283estradiol 3-benzoateestradiol 3-benzoate affects the expression of GHR mRNA21323755
C074283estradiol 3-benzoateProgesterone inhibits the reaction [estradiol 3-benzoate results in increased expression of GHR mRNA]21323755
D000431EthanolEthanol results in decreased expression of GHR mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GHR mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GHR mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GHR mRNA17222921
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GHR mRNA12075121
C024565ethylene dichlorideethylene dichloride results in decreased expression of GHR mRNA28189721
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of GHR mRNA27091632
D005485FlutamideFlutamide results in decreased expression of GHR mRNA17222921
D005485FlutamideFlutamide results in decreased expression of GHR mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GHR mRNA20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of GHR mRNA16221962
C039281furanfuran results in decreased expression of GHR mRNA25539665|2619464
D019833GenisteinGenistein results in increased expression of GHR mRNA12075121
D005839GentamicinsGentamicins results in decreased expression of GHR mRNA18289764
D005897GlafenineGlafenine results in decreased expression of GHR mRNA24136188
D006533HeptachlorHeptachlor results in decreased expression of GHR mRNA19101654
D017313FenretinideFenretinide results in decreased expression of GHR mRNA28973697
D006861Hydrogen PeroxideGHR gene mutant form results in decreased susceptibility to Hydrogen Peroxide15701676|1671361
D006861Hydrogen PeroxideGHR protein affects the susceptibility to Hydrogen Peroxide19786089
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GHR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GHR mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GHR mRNA"20371263
C005095malachite greenESR1 protein inhibits the reaction [[malachite green co-treated with GH1 protein] results in increased activity of GHR protein]20467862
C005095malachite green[malachite green co-treated with GH1 protein] results in increased activity of GHR protein20467862
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GHR mRNA20938992
D008731MethoxychlorMethoxychlor affects the expression of GHR mRNA20829426
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of GHR mRNA22978700|2316961
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GHR protein23169610
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GHR mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GHR mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GHR mRNA"19285098
D015735MifepristoneMifepristone results in decreased expression of GHR mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GHR mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of GHR mRNA18955075
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in increased expression of GHR mRNA]17088403
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GHR mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GHR mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of GHR mRNA25380136
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
C051752nefazodonenefazodone results in decreased expression of GHR mRNA24136188
D009532NickelNickel results in decreased expression of GHR mRNA25583101
C012655nimesulidenimesulide results in decreased expression of GHR mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of GHR mRNA18417182
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GHR mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of GHR mRNA18636392
D010269ParaquatGHR gene mutant form results in decreased susceptibility to Paraquat15701676|1671361
D010269ParaquatGHR gene mutant form results in increased susceptibility to Paraquat12384824
D010269ParaquatGHR protein affects the susceptibility to Paraquat19786089
D052638Particulate MatterParticulate Matter results in increased expression of GHR mRNA19699283
D052638Particulate MatterParticulate Matter results in increased expression of GHR protein19699283
C406545pegvisomantpegvisomant binds to and results in decreased activity of GHR protein18388193
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of GHR mRNA28973697
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of GHR mRNA23602845
D010634PhenobarbitalPhenobarbital results in decreased expression of GHR mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GHR mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of GHR mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GHR mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of GHR mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of GHR mRNA16221962|2081375
C006253pirinixic acidpirinixic acid results in increased expression of GHR mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of GHR mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GHR mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GHR mRNA19162173
D011374ProgesteroneProgesterone affects the expression of GHR mRNA21323755
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of GHR mRNA21323755
D011374ProgesteroneProgesterone inhibits the reaction [estradiol 3-benzoate results in increased expression of GHR mRNA]21323755
D011374ProgesteroneProgesterone results in increased expression of GHR mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of GHR mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of GHR mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GHR mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of GHR mRNA16202921
C059514resveratrolresveratrol results in increased expression of GHR mRNA25061707
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of GHR mRNA25905778
C059514resveratrolresveratrol results in decreased expression of GHR mRNA25905778
C010327salinomycinsalinomycin results in decreased expression of GHR mRNA19682730
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GHR mRNA22300531|2535159
C017947sodium arsenitesodium arsenite affects the methylation of GHR gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of GHR mRNA21396911
C016104sodium bichromatesodium bichromate affects the expression of GHR mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of GHR mRNA25993096
D018038Sodium SeleniteSodium Selenite results in decreased expression of GHR mRNA18175754
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of GHR mRNA25905778
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of GHR mRNA16214533
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GHR mRNA"20371263
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein]22150557
D013629TamoxifenTamoxifen affects the expression of GHR mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of GHR mRNA20600201|2166921
D013739TestosteroneTestosterone results in increased expression of GHR mRNA21703268
D013739TestosteroneTestosterone results in increased expression of GHR protein21703268
D013749TetrachlorodibenzodioxinEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GHR mRNA]26159488
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GHR mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GHR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GHR mRNA19619570|2010694
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GHR mRNA]22978700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GHR mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GHR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GHR mRNA18796159|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GHR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GHR mRNA18178546|1879615
D013853ThioacetamideThioacetamide results in decreased expression of GHR mRNA12679928
D013853ThioacetamideThioacetamide results in decreased expression of GHR protein12679928
C009495titanium dioxidetitanium dioxide affects the expression of GHR mRNA23557971
C423915TO-901317TO-901317 results in decreased expression of GHR mRNA15302862
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GHR mRNA25729387
D014212TretinoinTretinoin results in increased expression of GHR mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GHR mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GHR mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of GHR mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GHR mRNA19042947
C406224valdecoxibvaldecoxib results in decreased expression of GHR mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GHR mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of GHR mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of GHR gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GHR mRNA24383497|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GHR gene25560391
C025643vinclozolinvinclozolin results in decreased expression of GHR mRNA20566332
C025643vinclozolinvinclozolin results in increased expression of GHR mRNA22570695
C029297vinylidene chloridevinylidene chloride results in decreased expression of GHR mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of GHR mRNA20829426
D015032ZincGH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]10985758
D015032ZincGH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR protein]10985758
D015032ZincZinc deficiency results in decreased expression of GHR mRNA10985758|7722689
D015032ZincZinc deficiency results in decreased expression of GHR protein10985758|7722689
D015034Zinc OxideZinc Oxide affects the expression of GHR mRNA28648595
D019287Zinc SulfateZinc Sulfate results in decreased expression of GHR mRNA9685221

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004896cytokine receptor activity-IEA-  
GO:0004903growth hormone receptor activity-IBA21873635  
GO:0005515protein binding-IPI8943276  9353194  10502458  10866662  12907755  17474147  
19167335  25241761  
GO:0017046peptide hormone binding-IBA21873635  
GO:0017046peptide hormone binding-IPI1549776  2825030  8943276  9571026  
GO:0019838growth factor binding-IBA21873635  
GO:0019901protein kinase binding-ISS-  
GO:0019955cytokine binding-IBA21873635  
GO:0042802identical protein binding-IPI16116438  
GO:0042803protein homodimerization activity-IDA1549776  8137822  8943276  
GO:0070064proline-rich region binding-ISS2825030  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-ISS-  
GO:0000255allantoin metabolic process-ISS-  
GO:0006101citrate metabolic process-ISS-  
GO:00061032-oxoglutarate metabolic process-ISS-  
GO:0006105succinate metabolic process-ISS-  
GO:0006107oxaloacetate metabolic process-ISS-  
GO:0006549isoleucine metabolic process-ISS-  
GO:0006573valine metabolic process-ISS-  
GO:0006600creatine metabolic process-ISS-  
GO:0006631fatty acid metabolic process-ISS-  
GO:0006897endocytosis-IEA-  
GO:0007259JAK-STAT cascade-ISS-  
GO:0019221cytokine-mediated signaling pathway-IEA-  
GO:0019530taurine metabolic process-ISS-  
GO:0032870cellular response to hormone stimulus-IMP7565946  
GO:0040014regulation of multicellular organism growth-ISS-  
GO:0040018positive regulation of multicellular organism growth-IMP2813379  
GO:0042445hormone metabolic process-IMP8137822  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-ISS2825030  
GO:0042976activation of Janus kinase activity-ISS-  
GO:0046427positive regulation of JAK-STAT cascade-IBA21873635  
GO:0046449creatinine metabolic process-ISS-  
GO:0048009insulin-like growth factor receptor signaling pathway-IMP7565946  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0060396growth hormone receptor signaling pathway-IBA21873635  
GO:0060396growth hormone receptor signaling pathway-IMP7565946  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA8137822  
GO:0005615extracellular space-IMP2825030  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA8137822  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009986cell surface-IDA8137822  
GO:0016021integral component of membrane-IDA1549776  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA8137822  
GO:0070195growth hormone receptor complex-IBA21873635  
GO:0070195growth hormone receptor complex-IDA1549776  8137822  8943276  9571026  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1170546Prolactin receptor signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-982772Growth hormone receptor signalingTAS
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24093007Ghrelin and ghrelin receptor modulation of psychostimulant action. (2013 Sep 25)Wellman PJFront Neurosci
21392542Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference. (2011 Aug 1)Landgren SBehav Brain Res
20445798Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. (2009)Van Dyke ALJ Cancer Epidemiol
18299312Lung cancer risk associated with Thr495Pro polymorphism of GHR in Chinese population. (2008 Apr)Cao GJpn J Clin Oncol
21309944Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. (2012 Jan)Landgren SAddict Biol
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res