Gene: GHRHR

2692
GHRFR|GRFR|IGHD1B
growth hormone releasing hormone receptor
protein-coding
7p14.3
Ensembl:ENSG00000106128 MIM:139191 Vega:OTTHUMG00000152801 UniprotKB:Q02643
NG_021416.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.898e-1 (AD)  4.014e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAPK30.565
PDLIM30.549
PDLIM50.529
GATM0.523
TNS30.523
FAH0.522
SLC2A100.52
TSPAN120.519
A2ML10.519
MCC0.515

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKD2L1-0.464
RASGRP1-0.462
RXFP1-0.456
TRPV6-0.453
OCA2-0.45
ADTRP-0.446
HS3ST2-0.444
RHO-0.438
IGFBP2-0.43
NPBWR2-0.426

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00010SermorelinBiotechDrug86168-78-7Approved|WithdrawnTarget
DB08869TesamorelinSmall Molecule218949-48-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GHRHR mRNA"20406850
D000082AcetaminophenGHRHR gene mutant form results in decreased susceptibility to Acetaminophen17521389
D000082AcetaminophenGHRHR protein affects the reaction [NR1I2 protein affects the susceptibility to Acetaminophen]17521389
D000082AcetaminophenGHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Acetaminophen]17521389
D019386AlendronateAlendronate affects the expression of GHRHR mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GHRHR mRNA16483693
D001280AtrazineAtrazine binds to GHRHR protein20529762
D001280Atrazine[Atrazine binds to GHRHR protein] which results in decreased expression of GH1 mRNA20529762
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of GHRHR mRNA20404318
D004958EstradiolEstradiol results in increased expression of GHRHR protein16015026
C006780bisphenol Abisphenol A results in decreased expression of GHRHR mRNA25181051
C032036bromobenzeneGHRHR gene mutant form results in decreased susceptibility to bromobenzene17521389
C018475butyraldehydebutyraldehyde results in decreased expression of GHRHR mRNA26079696
D002251Carbon TetrachlorideGHRHR gene mutant form results in increased susceptibility to Carbon Tetrachloride17521389
D004041Dietary FatsDietary Fats results in increased expression of GHRHR mRNA25016146
D004052DiethylnitrosamineGHRHR protein mutant form results in decreased susceptibility to Diethylnitrosamine11698349
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GHRHR mRNA16079270
D005419FlavonoidsFlavonoids results in increased expression of GHRHR mRNA18035473
C501461MZ-J-7-118MZ-J-7-118 binds to and results in decreased activity of GHRHR protein18629632
D010758PhosphorusPhosphorus results in decreased expression of GHRHR mRNA17715259
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GHRHR mRNA16079270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GHRHR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GHRHR mRNA22808131
D013849ThimerosalThimerosal results in increased expression of GHRHR mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of GHRHR mRNA29128614
C057693troglitazonetroglitazone results in increased expression of GHRHR mRNA21515302
D015034Zinc OxideZinc Oxide affects the expression of GHRHR mRNA28648595
D015049ZoxazolamineGHRHR gene mutant form results in decreased susceptibility to Zoxazolamine17521389
D015049ZoxazolamineGHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Zoxazolamine]17521389

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IC7680413  
GO:0005515protein binding-IPI1333056  7680413  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0016520growth hormone-releasing hormone receptor activity-IBA21873635  
GO:0016520growth hormone-releasing hormone receptor activity-IMP7680413  
GO:0017046peptide hormone binding-IBA21873635  
GO:0017046peptide hormone binding-IPI7680413  
GO:0019838growth factor binding-IBA21873635  
GO:0019838growth factor binding-IPI7680413  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA1333056  7680413  
GO:0007190activation of adenylate cyclase activity-IEA-  
GO:0007420brain development-IBA21873635  
GO:0007595lactation-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA12867592  
GO:0008340determination of adult lifespan-IEA-  
GO:0019933cAMP-mediated signaling-IMP7680413  
GO:0030104water homeostasis-IEA-  
GO:0030252growth hormone secretion-IEA-  
GO:0032868response to insulin-IMP17356054  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0033143regulation of intracellular steroid hormone receptor signaling pathway-IEA-  
GO:0040018positive regulation of multicellular organism growth-IMP8528260  
GO:0042445hormone metabolic process-IEA-  
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathway-NAS11773624  
GO:0043627response to estrogen-IDA9482665  
GO:0046010positive regulation of circadian sleep/wake cycle, non-REM sleep-IEA-  
GO:0048469cell maturation-IEA-  
GO:0048609multicellular organismal reproductive process-NAS15944917  
GO:0051246regulation of protein metabolic process-IEA-  
GO:0051384response to glucocorticoid-IDA9482665  
GO:0060124positive regulation of growth hormone secretion-NAS11773624  
GO:0060133somatotropin secreting cell development-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005637nuclear inner membrane-IDA10461027  
GO:0005640nuclear outer membrane-IDA10461027  
GO:0005737cytoplasm-IDA10461027  
GO:0005886plasma membrane-IDA10461027  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA1333056  
GO:0016021integral component of membrane-IDA1333056  
GO:0016363nuclear matrix-IDA10461027  
GO:0030141secretory granule-IDA10461027  
GO:0042383sarcolemma-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22449891Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. (2012 Jun)Wong MLMol Psychiatry
29797719Immunological and microbiological periodontal profiles in isolated growth hormone deficiency. (2018 May 25)Araujo IMPJ Periodontol