Gene: GHSR

2693
GHDP
growth hormone secretagogue receptor
protein-coding
3q26.31
Ensembl:ENSG00000121853 MIM:601898 Vega:OTTHUMG00000156946 UniprotKB:Q92847
NG_021159.1
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.859e-2 (AD)  6.929e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ISL10.862
LHX80.855
SLC5A70.846
SLC18A30.84
DDC0.831
DGKK0.823
SLITRK60.822
IRX10.811
AMBN0.796
GPR10.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.536
NEUROD2-0.488
SOHLH1-0.481
TNNT2-0.47
TESPA1-0.446
TBR1-0.436
GALNT9-0.421
EMX1-0.419
NXPH3-0.41
TMEM155-0.403

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12128UlimorelinSmall Molecule842131-33-3InvestigationalTarget
DB13074MacimorelinSmall Molecule381231-18-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GHSR mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GHSR mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GHSR mRNA]"29112739
C0112692,5-hexanedione"2,5-hexanedione affects the expression of GHSR mRNA"20616210
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GHSR gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GHSR mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GHSR mRNA16483693
C015001arsenitearsenite results in increased methylation of GHSR promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of GHSR mRNA25181051
D002330CarmustineCarmustine results in decreased expression of GHSR mRNA15980968
C099555CD 437CD 437 results in decreased expression of GHSR mRNA12958071
D003300CopperCopper deficiency results in increased expression of GHSR mRNA26033743
D004041Dietary FatsDietary Fats results in increased expression of GHSR mRNA18721800
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of GHSR mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GHSR mRNA29112739
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of GHSR mRNA]29112739
D005411Flame RetardantsFlame Retardants results in decreased expression of GHSR mRNA29112739
D005411Flame RetardantsFlame Retardants results in increased expression of GHSR mRNA29112739
D005839GentamicinsGentamicins results in decreased expression of GHSR mRNA22061828
D054439GhrelinGhrelin binds to GHSR protein23921150
C520836GHRP-6, Lys(3)-"GHRP-6, Lys(3)- results in decreased activity of GHSR protein"26529667
C086184hexarelinhexarelin results in increased expression of GHSR mRNA19931584
D007545IsoproterenolIsoproterenol results in increased expression of GHSR mRNA20572026
D007545IsoproterenolIsoproterenol results in increased expression of GHSR protein20572026
C569751N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide"N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide binds to and results in decreased activity of GHSR protein"23977009
D010269ParaquatParaquat results in decreased expression of GHSR mRNA17077588
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GHSR mRNA19162173
D012999SomanSoman results in increased expression of GHSR mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GHSR mRNA15977195
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA]"29112739
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA]"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of GHSR mRNA"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of GHSR mRNA"29112739
C528884ulimorelinulimorelin binds to and results in increased activity of GHSR protein22106937

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001616growth hormone secretagogue receptor activity-IDA8688086  
GO:0004930G-protein coupled receptor activity-IDA8688086  
GO:0016520growth hormone-releasing hormone receptor activity-IDA8688086  
GO:0017046peptide hormone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IDA8688086  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007283spermatogenesis-IEA-  
GO:0007611learning or memory-IEA-  
GO:0008154actin polymerization or depolymerization-IDA15232612  
GO:0008343adult feeding behavior-ISS-  
GO:0009725response to hormone-IDA15232612  
GO:0009755hormone-mediated signaling pathway-IDA8688086  
GO:0010700negative regulation of norepinephrine secretion-IEA-  
GO:0030252growth hormone secretion-TAS16511605  
GO:0032094response to food-IEA-  
GO:0032099negative regulation of appetite-IEA-  
GO:0032100positive regulation of appetite-ISS-  
GO:0032354response to follicle-stimulating hormone-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032691negative regulation of interleukin-1 beta production-IDA15232612  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0036321ghrelin secretion-IEA-  
GO:0040018positive regulation of multicellular organism growth-IMP16511605  
GO:0042536negative regulation of tumor necrosis factor biosynthetic process-IDA15232612  
GO:0043134regulation of hindgut contraction-IEA-  
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathway-IEA-  
GO:0045409negative regulation of interleukin-6 biosynthetic process-IDA15232612  
GO:0045923positive regulation of fatty acid metabolic process-IEA-  
GO:0046676negative regulation of insulin secretion-IEA-  
GO:0046697decidualization-IDA17494105  
GO:0050728negative regulation of inflammatory response-IDA15232612  
GO:0051963regulation of synapse assembly-IEA-  
GO:0051969regulation of transmission of nerve impulse-IEA-  
GO:0060123regulation of growth hormone secretion-IEA-  
GO:0060416response to growth hormone-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071548response to dexamethasone-IEA-  
GO:0090327negative regulation of locomotion involved in locomotory behavior-IEA-  
GO:0097067cellular response to thyroid hormone stimulus-IEA-  
GO:0120058positive regulation of small intestinal transit-IEA-  
GO:1903672positive regulation of sprouting angiogenesis-IEA-  
GO:1904000positive regulation of eating behavior-IEA-  
GO:1904008response to monosodium glutamate-IEA-  
GO:1904349positive regulation of small intestine smooth muscle contraction-IEA-  
GO:1904468negative regulation of tumor necrosis factor secretion-IEA-  
GO:1905333regulation of gastric motility-IEA-  
GO:1905564positive regulation of vascular endothelial cell proliferation-IEA-  
GO:1990314cellular response to insulin-like growth factor stimulus-IEA-  
GO:2000110negative regulation of macrophage apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA8688086  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IDA12890514  
GO:0045121membrane raft-IDA15232612  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-373076Class A/1 (Rhodopsin-like receptors)IEA
R-HSA-375276Peptide ligand-binding receptorsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16789978Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males. (2006 Jul)Poykko SMJ Intern Med
23977009Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. (2013)Suchankova PPLoS One
23579732Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence. (2013)Suchankova PPLoS One
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
26059200Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking. (2016 Mar)Suchankova PAddict Biol
20586762Genetic variation of the ghrelin signaling system in females with severe alcohol dependence. (2010 Sep 1)Landgren SAlcohol Clin Exp Res
21606657Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study. (2011)Landgren SNeuropsychobiology