Gene: GIP

2695
-
gastric inhibitory polypeptide
protein-coding
17q21.32
Ensembl:ENSG00000159224 MIM:137240 Vega:OTTHUMG00000161171 UniprotKB:P09681
NC_000017.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.675e-1 (AD)  3.609e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF6830.438
RPS170.41
KLRF20.406
OR2G20.376
FAM111B0.375
OR4N20.356
OR52Z10.355
CLEC2A0.354
SPACA5B0.335
MTRNR2L10.332

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOXF1-0.253
MATN4-0.251
ZNF771-0.231
ASGR1-0.231
WIF1-0.227
HMCN2-0.227
PNPLA5-0.226
HTR3A-0.224
C16orf92-0.22
CHST5-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GIP mRNA"27291303
D000242Cyclic AMP[GIP protein binds to and results in increased activity of GIPR protein] which results in increased chemical synthesis of Cyclic AMP25191754
D000242Cyclic AMP[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP9202216
D000242Cyclic AMPtriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP]9202216
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GIP gene28458013
D000393Air PollutantsAir Pollutants analog results in decreased expression of GIP mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GIP mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of GIP mRNA25181051
D002118Calcium[GIP protein co-treated with Glucose] results in increased abundance of Calcium9202216
D002118Calciumtriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose] results in increased abundance of Calcium]9202216
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GIP mRNA17032414
D002994ClofibrateClofibrate results in increased expression of GIP mRNA17585979
D003024ClozapineClozapine results in increased expression of GIP mRNA16402076
D003024ClozapineClozapine results in increased expression of GIP protein16402076
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GIP mRNA23640034
C007262deoxynivalenoldeoxynivalenol results in increased expression of GIP protein28633506
C001809diacetoxyscirpenoldiacetoxyscirpenol results in increased expression of and results in increased secretion of GIP protein28666375
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GIP mRNA17379624
D002945CisplatinCisplatin results in decreased expression of GIP mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GIP mRNA28412506
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GIP mRNA17032414
C118739entinostatentinostat results in increased expression of GIP mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GIP mRNA17108234
C039281furanfuran results in increased expression of GIP mRNA27387713
D019833GenisteinGenistein results in increased expression of GIP mRNA21782745
D005947Glucose[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP9202216
D005947Glucose[GIP protein co-treated with Glucose] results in increased abundance of Calcium9202216
D005947Glucose[Glucose co-treated with GIP protein] results in increased secretion of INS1 protein9202216
D005947Glucosetriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP]9202216
D005947Glucosetriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose] results in increased abundance of Calcium]9202216
D005947Glucosetriphenyltin chloride inhibits the reaction [[Glucose co-treated with GIP protein] results in increased secretion of INS1 protein]9202216
C012351HT-2 toxinHT-2 toxin results in increased expression of and results in increased secretion of GIP protein28666375
D0150561-Methyl-3-isobutylxanthine[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP9202216
D0150561-Methyl-3-isobutylxanthinetriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP]9202216
C544151jinfukangjinfukang results in increased expression of GIP mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of GIP mRNA12539871
D018021Lithium ChlorideLithium Chloride inhibits the reaction [HDAC1 protein binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride inhibits the reaction [TCF7L2 protein binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [CTNNB1 protein binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [LEF1 protein binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride results in increased expression of GIP mRNA19582394
D018021Lithium Chloride[[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNA19582394
D008787MetoclopramideMetoclopramide results in increased secretion of GIP protein20829521
C059539midostaurinmidostaurin results in increased expression of GIP mRNA20980353
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GIP protein results in increased secretion of INS1 protein]16837018
C016009neosolaniolneosolaniol results in increased expression of and results in increased secretion of GIP protein28666375
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GIP mRNA17616710
C055122orlistatorlistat results in decreased expression of GIP protein12915676
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GIP mRNA26794494
D010634PhenobarbitalPhenobarbital results in decreased expression of GIP mRNA19162173
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GIP mRNA25895662
D012834SilverSilver results in increased expression of GIP mRNA27131904
D012964Sodium[Sodium co-treated with GIP protein] results in increased secretion of INS1 protein16837018
D012964Sodiumtriphenyltin chloride inhibits the reaction [[Sodium co-treated with GIP protein] results in increased secretion of INS1 protein]16837018
C009277sodium arsenatesodium arsenate results in decreased expression of GIP mRNA23922661
D012969Sodium FluorideSodium Fluoride results in decreased expression of GIP mRNA27862939
D013605T-2 ToxinT-2 Toxin results in increased expression of and results in increased secretion of GIP protein28666375
D013629TamoxifenTamoxifen results in increased expression of GIP mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GIP mRNA27914987
D014118Toxins, Biological"Toxins, Biological affects the expression of GIP mRNA"19682533
C012594triphenyltin chloridetriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP]9202216
C012594triphenyltin chloridetriphenyltin chloride inhibits the reaction [[GIP protein co-treated with Glucose] results in increased abundance of Calcium]9202216
C012594triphenyltin chloridetriphenyltin chloride inhibits the reaction [GIP protein results in increased secretion of INS1 protein]16837018
C012594triphenyltin chloridetriphenyltin chloride inhibits the reaction [[Glucose co-treated with GIP protein] results in increased secretion of INS1 protein]9202216
C012594triphenyltin chloridetriphenyltin chloride inhibits the reaction [[Sodium co-treated with GIP protein] results in increased secretion of INS1 protein]16837018
D014635Valproic AcidValproic Acid affects the expression of GIP mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GIP mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IEA-  
GO:0005515protein binding-IPI17715056  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS2890159  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007565female pregnancy-IEA-  
GO:0007613memory-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0009749response to glucose-IEA-  
GO:0010269response to selenium ion-IEA-  
GO:0010447response to acidic pH-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010828positive regulation of glucose transmembrane transport-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0031018endocrine pancreas development-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0033993response to lipid-IEA-  
GO:0035640exploration behavior-IEA-  
GO:0042493response to drug-IEA-  
GO:0042594response to starvation-IEA-  
GO:0043200response to amino acid-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0043950positive regulation of cAMP-mediated signaling-IEA-  
GO:0048678response to axon injury-IEA-  
GO:0050796regulation of insulin secretion-TAS20081857  
GO:0055123digestive system development-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0070094positive regulation of glucagon secretion-IEA-  
GO:0070328triglyceride homeostasis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationIEA
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)TAS
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)IEA
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25074318DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study. (2014 Jul 30)Nakamura KCardiovasc Diabetol
26988157No change in serum incretins levels but rise of leptin levels after smoking cessation: a pilot study. (2016 Nov 8)Pankova APhysiol Res
29765988Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes. (2018)Ma XJ Diabetes Res