Gene: NBEA

26960
BCL8B|LYST2
neurobeachin
protein-coding
13q13.3
Ensembl:ENSG00000172915 MIM:604889 Vega:OTTHUMG00000016724 UniprotKB:Q8NFP9
NG_028156.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.053e-1 (AD)  7.409e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7332116chr13:35504290 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYCBP20.98
FRMPD40.977
ATP8A20.974
SLC4A100.969
MYT1L0.968
SYNJ10.967
SCN8A0.966
INPP4A0.966
FAXC0.965
DMXL20.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.605
ROM1-0.58
HEY2-0.579
RNF135-0.578
CSAG1-0.576
COPZ2-0.571
MYL3-0.57
CHST14-0.555
AGTRAP-0.548
FLT3LG-0.544

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of NBEA mRNA"23829299
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NBEA mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of NBEA mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NBEA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NBEA mRNA21632981|2164198
D000393Air PollutantsAir Pollutants analog results in decreased expression of NBEA mRNA21757418
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of NBEA mRNA15894712
C015001arsenitearsenite results in decreased expression of NBEA mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NBEA mRNA20106945|2163298
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of NBEA mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NBEA mRNA15894712|1977048
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NBEA mRNA19619570
D004958EstradiolEstradiol results in increased expression of NBEA mRNA19619570
C006780bisphenol Abisphenol A results in increased expression of NBEA mRNA29275510
C006780bisphenol Abisphenol A affects the expression of NBEA mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NBEA mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NBEA mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of NBEA mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NBEA mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of NBEA mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of NBEA mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NBEA mRNA25562108|2798913
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NBEA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NBEA mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of NBEA mRNA21852083
D005947GlucoseGlucose results in decreased expression of NBEA mRNA17178593
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NBEA mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NBEA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NBEA mRNA24796395
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NBEA mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NBEA mRNA"26251327
D009532NickelNickel results in decreased expression of NBEA mRNA24768652|2558310
D011794QuercetinQuercetin results in decreased expression of NBEA mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of NBEA mRNA19167446
C059514resveratrolresveratrol results in decreased expression of NBEA mRNA25888808
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of NBEA mRNA21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NBEA mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NBEA mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of NBEA mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of NBEA gene28589171
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NBEA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NBEA mRNA19619570
D019284ThapsigarginThapsigargin results in increased expression of NBEA protein24648495
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NBEA mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of NBEA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NBEA mRNA29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of NBEA mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008104protein localization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005802trans-Golgi network-ISS-  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0012505endomembrane system-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal