Gene: GJA1

2697
AVSD3|CMDR|CX43|EKVP|EKVP3|GJAL|HLHS1|HSS|ODDD|PPKCA
gap junction protein alpha 1
protein-coding
6q22.31
Ensembl:ENSG00000152661 MIM:121014 Vega:OTTHUMG00000015479 UniprotKB:P17302
NG_008308.1
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.065e-1 (AD)  9.950e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
METTL7A0.963
SLC1A30.95
SLC39A120.937
PBXIP10.934
NTRK20.928
SOX90.926
SPON10.921
TP53BP20.92
LRP40.914
STOX10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.43
DUSP27-0.408
OR4F29-0.398
COL13A1-0.369
TYRP1-0.362
ZNF860-0.348
COL22A1-0.348
HTR7-0.347
LGI2-0.346
LAMB3-0.345

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01136CarvedilolSmall Molecule72956-09-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]"22813906
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [antofine results in decreased expression of GJA1 protein]"23403203
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]"15685554
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased expression of GJA1 mRNA"26921789
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 mRNA29170806
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 protein29170806
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased degradation of and results in decreased expression of GJA1 protein28329830
C0512461-methylanthracene1-methylanthracene results in increased degradation of and results in decreased expression of GJA1 protein28329830
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein24079413
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholineAG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]24079413
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholineresveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]24079413
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GJA1 mRNA"28712647
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane affects the localization of GJA1 protein]12807735
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane results in increased phosphorylation of GJA1 protein]12807735
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [bromoxynil octanoate results in decreased activity of GJA1 protein]20510257
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [ioxynil analog results in decreased activity of GJA1 protein]20510257
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog affects the phosphorylation of GJA1 protein]20510257
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of GJA1 protein]26926986
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane results in increased phosphorylation of GJA1 protein]15194225
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [muconaldehyde results in increased phosphorylation of GJA1 protein]15690152
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]18445782
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]11532878
C0122802,2'-dichlorobiphenyl"2,2'-dichlorobiphenyl results in increased phosphorylation of GJA1 protein"16751230
C0010422',3-dimethyl-4-aminobiphenyl"2',3-dimethyl-4-aminobiphenyl results in increased expression of GJA1 mRNA"7955049
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of GJA1 mRNA22193206
C0185662,4,5,2',4',5'-hexabromobiphenyl"[Dieldrin co-treated with 2,4,5,2',4',5'-hexabromobiphenyl] results in decreased expression of GJA1 protein"8820588
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein"8820588
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Dieldrin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein"8820588
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the localization of GJA1 protein"18832185
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [MAPK1 protein results in increased phosphorylation of GJA1 protein]"18832185
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [MAPK3 protein results in increased phosphorylation of GJA1 protein]"18832185
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of GJA1 protein"11767051|1883218
C0140242,4,5,2',4',5'-hexachlorobiphenyl"SPHK1 protein affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of GJA1 protein]"27318803
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of GJA1 mRNA"20713471
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]16091010
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]"23452621
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA"27052460
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]"27052460
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of GJA1 protein15082077
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of GJA1 protein modified form15082077
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein"16091010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"BMS453 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GJA1 mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [TNF protein results in decreased expression of GJA1 protein]25268939
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]23270704
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein]23270704
C0325384-cresol"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]"22813906
C0325384-cresol4-cresol results in decreased phosphorylation of GJA1 protein22813906
C0325384-cresolPRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]22813906
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of GJA1 protein15082077
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of GJA1 mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of GJA1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of and results in increased phosphorylation of GJA1 protein26912412
D000082AcetaminophenAcetaminophen results in increased expression of GJA1 mRNA26912412
D000082AcetaminophenGJA1 protein affects the susceptibility to Acetaminophen26912412
D000082Acetaminophen[GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IFNG protein26912412
D000082Acetaminophen[GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IL10 protein26912412
D000082Acetaminophen[GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IL1B protein26912412
D000082Acetaminophen[GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of TNF protein26912412
C056165acetovanilloneacetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]23270704
C056165acetovanilloneacetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein]23270704
C063261acetylleucyl-leucyl-norleucinalacetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA]17559834
D020106AcrylamideAcrylamide results in increased expression of GJA1 protein24928766
D000255Adenosine TriphosphateGJA1 protein mutant form results in increased export of Adenosine Triphosphate17687502
D000255Adenosine TriphosphateGJA1 protein results in increased export of Adenosine Triphosphate17687502
C016601afimoxifeneafimoxifene results in decreased expression of GJA1 protein29180066
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GJA1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GJA1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GJA1 mRNA23630614
C412373AG 1879AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]24079413
C430898AGN 194204AGN 194204 results in decreased expression of GJA1 mRNA16339527
C104223aluminum lactatealuminum lactate affects the localization of GJA1 protein12397369
C100057ametryneametryne results in decreased expression of GJA1 mRNA26310382
D000638AmiodaroneAmiodarone results in decreased expression of GJA1 mRNA15520326
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GJA1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride inhibits the reaction [antofine results in decreased expression of GJA1 protein]23403203
D000661AmphetamineAmphetamine results in increased expression of GJA1 mRNA15194466
D000661AmphetamineAmphetamine results in increased expression of GJA1 protein15194466
D000661AmphetamineMAPK8 protein promotes the reaction [Amphetamine results in increased expression of GJA1 protein]15194466
D000661Amphetaminepyrazolanthrone inhibits the reaction [Amphetamine results in increased expression of GJA1 protein]15194466
C090450anastrozoleanastrozole results in decreased expression of GJA1 protein29180066
C473343antofine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [antofine results in decreased expression of GJA1 protein]"23403203
C473343antofineAmmonium Chloride inhibits the reaction [antofine results in decreased expression of GJA1 protein]23403203
C473343antofineantofine results in decreased expression of GJA1 protein23403203
C473343antofinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [antofine results in decreased expression of GJA1 protein]23403203
C006632arsenic trioxideacetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA]17559834
C006632arsenic trioxidearsenic trioxide results in decreased expression of GJA1 mRNA15070760|1576101
C006632arsenic trioxideleupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA]17559834
C015001arsenitearsenite results in decreased expression of GJA1 mRNA23974009
D001241AspirinAspirin results in decreased expression of GJA1 mRNA12800193
C005948astaxanthine2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]16091010
C005948astaxanthine"astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C005948astaxanthineastaxanthine results in increased expression of GJA1 protein16091010
D001262AtenololAtenolol results in increased expression of GJA1 protein16448880
D001280AtrazineAtrazine results in increased expression of GJA1 mRNA22153302
D001374AzacitidineAzacitidine results in decreased expression of GJA1 mRNA20823114
D001374AzacitidineAzacitidine results in increased expression of GJA1 protein18037191
C044946benazeprilbenazepril promotes the reaction [Thyroxine results in increased expression of GJA1 mRNA]21545815
C044946benazeprilbenazepril promotes the reaction [Thyroxine results in increased expression of GJA1 protein]21545815
D001554BenzeneBenzene results in increased expression of GJA1 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJA1 mRNA22316170
D001564Benzo(a)pyrene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 mRNA29170806
D001564Benzo(a)pyrene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 protein29170806
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GJA1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene affects the localization of GJA1 protein19874837
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJA1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJA1 protein19874837|2917080
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GJA1 mRNA20713471|2222880
D001564Benzo(a)pyreneGJA1 mutant form promotes the reaction [Benzo(a)pyrene results in increased activity of CASP3 protein]19874837
D001564Benzo(a)pyreneGJA1 mutant form promotes the reaction [Benzo(a)pyrene results in increased activity of CASP7 protein]19874837
D001564Benzo(a)pyreneGJA1 protein affects the susceptibility to Benzo(a)pyrene19874837
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GJA1 mRNA26358852
D001585Benzoyl Peroxide"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] affects the expression of GJA1 protein"7586191
D001585Benzoyl Peroxide"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased expression of GJA1 mRNA"7586191
D001585Benzoyl PeroxideBenzoyl Peroxide results in increased expression of GJA1 mRNA8597533
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [antofine results in decreased expression of GJA1 protein]23403203
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]20510257
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]20510257
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]15685554
C038328BEP protocolBEP protocol results in increased expression of GJA1 mRNA18987330
D019207beta Carotene"beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
D019207beta Carotenebeta Carotene results in increased expression of GJA1 protein16091010
D019207beta CaroteneRo 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]16091010
D019207beta Carotenebeta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
D019207beta Carotenebeta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GJA1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of GJA1 mRNA15849065|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of GJA1 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of GJA1 mRNA19484750|2314475
D004958EstradiolEstradiol affects the expression of GJA1 mRNA20004189
D004958EstradiolEstradiol affects the expression of GJA1 protein20004189
D004958EstradiolTamoxifen inhibits the reaction [Estradiol affects the expression of GJA1 mRNA]20004189
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]16352648|1844578
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of GJA1 protein]15685554
C006780bisphenol Abisphenol A results in increased expression of GJA1 mRNA22045264
C006780bisphenol Abisphenol A results in decreased expression of GJA1 mRNA27022677
C006780bisphenol Abisphenol A results in decreased expression of and affects the localization of GJA1 protein19497385
C006780bisphenol Abisphenol A results in decreased expression of and results in decreased phosphorylation of GJA1 protein20921394
C006780bisphenol Abisphenol A results in decreased expression of GJA1 protein15082077
C006780bisphenol Abisphenol A results in increased expression of GJA1 mRNA25181051|2808731
C006780bisphenol Abisphenol A results in increased expression of GJA1 protein19782717
C006780bisphenol Abisphenol A results in increased methylation of GJA1 gene28505145
C402892BMS453"BMS453 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GJA1 mRNA22079614
C006826bromoxynilbromoxynil results in decreased activity of GJA1 protein20510257
C028382bromoxynil octanoate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [bromoxynil octanoate results in decreased activity of GJA1 protein]20510257
C028382bromoxynil octanoatebromoxynil octanoate results in decreased activity of GJA1 protein20510257
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein7586169
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein7586169
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GJA1 mRNA15336504
D020148Butyric AcidButyric Acid results in decreased expression of GJA1 mRNA12800193
D002104CadmiumCadmium results in decreased expression of GJA1 mRNA21120746
D002104CadmiumCadmium affects the localization of GJA1 protein26165643
D002104CadmiumCadmium results in decreased expression of GJA1 mRNA26165643
D002104CadmiumCadmium results in decreased expression of GJA1 protein15082077
D002104CadmiumCadmium results in increased expression of GJA1 mRNA28829631
D002104CadmiumThioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]26165643
D002104CadmiumThioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]26165643
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNA19840844
D002110Caffeinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
D002110CaffeineCaffeine results in decreased expression of GJA1 protein26304238
D002110CaffeineChloroquine inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
D002110Caffeineleupeptin inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
D002110CaffeineCaffeine results in decreased expression of GJA1 mRNA28087314
C006889capsanthincapsanthin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
C006889capsanthincapsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D002229CarbenoxoloneGJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate]26926986
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GJA1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GJA1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GJA1 protein15685554
C043211carvedilolcarvedilol results in decreased degradation of GJA1 protein16448880
C043211carvedilolcarvedilol results in increased expression of GJA1 mRNA16448880
C043211carvedilolcarvedilol results in increased expression of GJA1 protein16448880
C043211carvedilolcarvedilol affects the localization of GJA1 protein17445419
C043211carvedilolcarvedilol results in decreased phosphorylation of GJA1 protein16563290
C043211carvedilolcarvedilol results in increased expression of GJA1 mRNA19478468
C043211carvedilolcarvedilol results in increased expression of GJA1 protein16448880|1897157
C043211carvedilolcarvedilol results in increased phosphorylation of GJA1 protein19478468
C019290chaetoglobosinschaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]18040759
C019290chaetoglobosinschaetoglobosins inhibits the reaction [Lindane results in decreased phosphorylation of GJA1 protein]18040759
D002697Chloral HydrateChloral Hydrate results in decreased expression of GJA1 mRNA21243523
D002697Chloral HydrateChloral Hydrate results in decreased expression of GJA1 protein21243523
D002697Chloral HydrateChloral Hydrate results in increased expression of GJA1 protein21243523
D002706ChlordanChlordan results in decreased activity of GJA1 protein20510257
D002706ChlordanChlordan results in increased phosphorylation of GJA1 protein11532878
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GJA1 mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of GJA1 mRNA26352163
D002737ChloropreneChloroprene results in decreased expression of GJA1 mRNA23125180
D002738ChloroquineChloroquine inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
D002738ChloroquineChloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]8824497
D002738ChloroquineChloroquine inhibits the reaction [Lindane results in increased degradation of GJA1 protein modified form]8824497
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GJA1 mRNA20938992
D002857ChromiumChromium affects the localization of GJA1 protein23357549
C013883chrysarobinchrysarobin results in increased expression of GJA1 mRNA8597533
D003024ClozapineClozapine results in increased expression of GJA1 protein18585900
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of GJA1 protein24708733
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of GJA1 protein]24708733
C018021cobaltous chloridecobaltous chloride results in decreased expression of GJA1 mRNA19320972|1937684
D003078ColchicineColchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]8824497
D003078ColchicineColchicine inhibits the reaction [Lindane results in increased degradation of GJA1 protein modified form]8824497
D003300CopperCopper results in increased expression of GJA1 mRNA22465980
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D003520CyclophosphamideCyclophosphamide affects the expression of GJA1 mRNA10859244
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]15685554
C077420Cys(11)-Cys(15)-endothelin-1 (11-21)Cys(11)-Cys(15)-endothelin-1 (11-21) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]15685554
D000069439DasatinibDasatinib promotes the reaction [lead acetate results in decreased expression of GJA1 protein]26926986
D003634DDTDDT results in decreased expression of GJA1 mRNA27894940
D003634DDT"[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein"8820588
D003634DDTDDT results in decreased expression of GJA1 protein8820588
D003634DDTChloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]8824497
D003634DDTColchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]8824497
D003634DDTDDT results in decreased expression of and results in increased phosphorylation of GJA1 protein8285856
D003634DDTDDT results in decreased expression of GJA1 protein15082077
D003634DDTDDT results in decreased expression of GJA1 protein modified form15082077
D003634DDTDDT results in increased degradation of GJA1 protein8313522
D003634DDTDDT results in increased degradation of GJA1 protein modified form8824497
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GJA1 mRNA28572024
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GJA1 protein28572024
C014347decitabinedecitabine affects the expression of GJA1 mRNA17306607
C014347decitabinedecitabine affects the expression of GJA1 protein17306607
C014347decitabinedecitabine results in decreased expression of GJA1 mRNA19222872
D013759DronabinolDronabinol results in increased expression of GJA1 mRNA28087314
D003907DexamethasoneDexamethasone results in increased expression of GJA1 protein15685554
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GJA1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GJA1 mRNA21266533
D003994BucladesineBucladesine results in increased expression of GJA1 protein11741589|1671868
D003994BucladesineGJA1 promotes the reaction [Bucladesine results in increased expression of CDKN1A protein]16718685
D003994BucladesineTolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]11741589
D002945CisplatinCisplatin results in decreased expression of GJA1 mRNA21151649
D002945CisplatinCisplatin results in decreased expression of GJA1 protein24449132
D002945CisplatinCisplatin results in increased phosphorylation of GJA1 protein22006019
D002945CisplatinCisplatin results in decreased expression of GJA1 protein15082077
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of GJA1 mRNA27894940
D004008DiclofenacDiclofenac results in increased expression of GJA1 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GJA1 mRNA26924002
D004026Dieldrin"[Dieldrin co-treated with 2,4,5,2',4',5'-hexabromobiphenyl] results in decreased expression of GJA1 protein"8820588
D004026Dieldrin"[Dieldrin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein"8820588
D004026DieldrinDieldrin results in decreased expression of GJA1 protein8820588
D004026Dieldrinchaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]18040759
D004026DieldrinDieldrin results in decreased expression of GJA1 mRNA8068183
D004026DieldrinDieldrin results in decreased expression of GJA1 protein15082077
D004026DieldrinDieldrin results in decreased expression of GJA1 protein modified form15082077
D004026DieldrinDieldrin results in decreased phosphorylation of GJA1 protein18040759|8068183
D004041Dietary FatsDietary Fats results in increased expression of GJA1 mRNA22609946|2726046
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
D004041Dietary FatsThioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
D004041Dietary FatsDietary Fats results in increased expression of GJA1 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GJA1 protein19344669
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GJA1 protein20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GJA1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of GJA1 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GJA1 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GJA1 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GJA1 protein25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GJA1 mRNA16636312
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of GJA1 mRNA16507463
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] affects the expression of GJA1 protein"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased expression of GJA1 mRNA"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of GJA1 protein"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GJA1 mRNA"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA"25447408
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 protein"25447408
D0151279,10-Dimethyl-1,2-benzanthracene"A gene mutant form affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA]"25447408
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA"24269759
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 protein"24269759
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GJA1 protein"24269759
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of GJA1 protein15736408
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GJA1 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of GJA1 mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GJA1 mRNA22193206
D004237DiuronDiuron results in increased expression of GJA1 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of GJA1 mRNA16243910|2589636
D004317DoxorubicinDoxorubicin results in decreased expression of GJA1 protein24291741
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA]18089841
C042986ebselenebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]12958040
C042986ebselenebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]12958040
D004726EndosulfanEndosulfan results in decreased expression of GJA1 mRNA28108160
D004726EndosulfanEndosulfan results in decreased expression of GJA1 protein28108160
D004726EndosulfanEndosulfan affects the localization of GJA1 protein8020150
D004726EndosulfanEndosulfan results in decreased expression of GJA1 protein11767051
D004726EndosulfanEndosulfan results in decreased phosphorylation of GJA1 protein8020150
D004726EndosulfanEndosulfan results in increased phosphorylation of GJA1 protein8020150
D004996EthidiumGJA1 protein results in increased uptake of Ethidium26926986
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GJA1 protein]10633228
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GJA1 protein10633228
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GJA1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GJA1 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJA1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GJA1 mRNA12075121|1265503
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GJA1 mRNA16174780|1735126
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GJA1 exon16155213
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GJA1 gene15548583|1672432
D005047EtoposideGJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]23978459
D005047EtoposideGJA1 protein results in increased susceptibility to Etoposide23978459
D005047EtoposideTetradecanoylphorbol Acetate affects the reaction [GJA1 protein results in increased susceptibility to Etoposide]23978459
D015025ZearalenoneZearalenone results in decreased expression of GJA1 mRNA26386189
C000499ferric oxideferric oxide analog results in increased expression of GJA1 mRNA25086211
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 mRNA29170806
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in decreased expression of GJA1 protein29170806
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased degradation of and results in decreased expression of GJA1 protein28329830
C007738fluoranthenefluoranthene results in increased degradation of and results in decreased expression of GJA1 protein28329830
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GJA1 mRNA17187413
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GJA1 protein15133858
D005472FluorouracilGJA1 protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilGJA1 protein affects the susceptibility to Fluorouracil16531325
D005473FluoxetineFluoxetine results in increased expression of GJA1 protein18585900
D005485FlutamideFlutamide results in decreased expression of GJA1 mRNA24136188
D005485FlutamideFlutamide affects the expression of GJA1 mRNA20961722
D005492Folic AcidFolic Acid affects the expression of GJA1 mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GJA1 mRNA20938992
C025164fucoxanthinfucoxanthin results in increased expression of GJA1 mRNA19737546
C025164fucoxanthinfucoxanthin results in increased expression of GJA1 protein19737546
C070081fulvestrantbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C070081fulvestrantfulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]29180066
C070081fulvestrantfulvestrant results in decreased expression of GJA1 mRNA29180066
C070081fulvestrantfulvestrant results in decreased expression of GJA1 protein29180066
C070081fulvestrantMAP2K3 promotes the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C070081fulvestrantMAP2K6 promotes the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C070081fulvestrantSB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]29180066
C070081fulvestrantSB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 mRNA]29180066
C070081fulvestrantSB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C039281furanfuran results in increased expression of GJA1 mRNA27387713
C039281furanfuran results in increased methylation of GJA1 gene22079235
C045345gastrodingastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 mRNA]23783886
C045345gastrodingastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 protein]23783886
C045345gastrodingastrodin inhibits the reaction [Rotenone results in increased phosphorylation of GJA1 protein]23783886
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D019833GenisteinGenistein results in increased expression of GJA1 mRNA15901920
D005897GlafenineGlafenine results in increased expression of GJA1 mRNA24136188
D005947GlucoseGlucose results in decreased expression of GJA1 protein20578705
D005947GlucoseGlucose results in increased degradation of GJA1 protein20578705
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]20578705
D005947GlucoseGlucose results in increased expression of GJA1 mRNA17178593
D005976GlutaralGlutaral results in decreased expression of GJA1 protein19932693
D006072GossypolGossypol results in decreased expression of GJA1 protein15082077
D006118GriseofulvinGriseofulvin results in increased expression of and results in increased localization of GJA1 protein23329179
D006118GriseofulvinGriseofulvin results in increased expression of GJA1 mRNA23329179
D006220HaloperidolHaloperidol results in decreased expression of GJA1 protein18585900
D006533HeptachlorHeptachlor results in decreased expression of GJA1 protein8738476
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of GJA1 protein8738476
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of and results in decreased phosphorylation of GJA1 protein11246134
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of GJA1 mRNA8068183
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased phosphorylation of GJA1 protein8068183
D019850HeptanolHeptanol results in decreased phosphorylation of GJA1 protein16563290
D017313FenretinideFenretinide results in increased expression of GJA1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GJA1 mRNA15761015
D006861Hydrogen Peroxidebeta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
D006861Hydrogen Peroxidebeta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D006861Hydrogen Peroxidecapsanthin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
D006861Hydrogen Peroxidecapsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GJA1 mRNA27154496
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of GJA1 protein19720069|2715449
D006861Hydrogen PeroxidePlant Extracts inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
D006861Hydrogen PeroxidePlant Extracts inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D006861Hydrogen Peroxideresveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]19720069
D002112CalcifediolCalcifediol deficiency results in decreased expression of GJA1 mRNA17293106
C014290hydroxyflutamidehydroxyflutamide results in decreased expression of and affects the localization of GJA1 protein26437446
C014290hydroxyflutamide[Testosterone co-treated with hydroxyflutamide] results in decreased expression of GJA1 protein26437446
C014290hydroxyflutamidewortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein]26437446
C082359imidaclopridimidacloprid results in decreased expression of GJA1 mRNA27792329
C082359imidaclopridimidacloprid results in increased expression of GJA1 mRNA27444676
C082359imidaclopridimidacloprid results in decreased expression of GJA1 mRNA27792329
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GJA1 mRNA25613284
C008161ioxynil2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [ioxynil analog results in decreased activity of GJA1 protein]20510257
C008161ioxynil2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog affects the phosphorylation of GJA1 protein]20510257
C008161ioxynilbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]20510257
C008161ioxynilbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]20510257
C008161ioxynilioxynil affects the localization of GJA1 protein20510257
C008161ioxynilioxynil analog affects the localization of GJA1 protein20510257
C008161ioxynilioxynil analog results in decreased activity of GJA1 protein20510257
C008161ioxynilioxynil analog results in decreased expression of and affects the phosphorylation of GJA1 protein20510257
C008161ioxynilioxynil results in decreased activity of GJA1 protein20510257
C008161ioxynilioxynil results in decreased expression of and affects the phosphorylation of GJA1 protein20510257
C081309irbesartanirbesartan promotes the reaction [Thyroxine results in increased expression of GJA1 mRNA]21545815
C081309irbesartanirbesartan promotes the reaction [Thyroxine results in increased expression of GJA1 protein]21545815
C051890irinotecanirinotecan analog affects the expression of GJA1 mRNA18927307
C051890irinotecanirinotecan results in increased expression of GJA1 mRNA20097248
C549713isocarbophosisocarbophos results in increased expression of GJA1 protein26818681
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA]18089841
D007545IsoproterenolIsoproterenol results in decreased expression of GJA1 mRNA18089841|2000320
D007545Isoproterenol[Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein20215810
D007545IsoproterenolIsoproterenol results in increased expression of GJA1 mRNA16352648|2021581
D007545IsoproterenolIsoproterenol results in increased expression of GJA1 protein16352648|2021581
C008261lead acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of GJA1 protein]26926986
C008261lead acetateDasatinib promotes the reaction [lead acetate results in decreased expression of GJA1 protein]26926986
C008261lead acetateGJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate]26926986
C008261lead acetateGJA1 protein results in increased uptake of lead acetate26926986
C008261lead acetatelead acetate results in decreased expression of GJA1 protein26926986|2891632
C008261lead acetatelead acetate results in increased expression of GJA1 protein20932874
C045463leflunomideleflunomide results in increased expression of GJA1 mRNA19751817
C045463leflunomideleflunomide results in increased expression of GJA1 mRNA24136188
C067431letrozoleletrozole results in decreased expression of GJA1 protein29180066
C032854leupeptinleupeptin inhibits the reaction [Caffeine results in decreased expression of GJA1 protein]26304238
C032854leupeptinleupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA]17559834
D001556LindaneLindane results in decreased phosphorylation of GJA1 protein17620312
D001556Lindane2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane affects the localization of GJA1 protein]12807735
D001556Lindane2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane results in increased phosphorylation of GJA1 protein]12807735
D001556LindaneLindane affects the localization of GJA1 protein11532877|1280773
D001556LindaneLindane results in decreased expression of GJA1 protein11532877
D001556LindaneLindane results in increased phosphorylation of GJA1 protein12807735
D001556Lindane2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lindane results in increased phosphorylation of GJA1 protein]15194225
D001556Lindanechaetoglobosins inhibits the reaction [Lindane results in decreased phosphorylation of GJA1 protein]18040759
D001556LindaneChloroquine inhibits the reaction [Lindane results in increased degradation of GJA1 protein modified form]8824497
D001556LindaneColchicine inhibits the reaction [Lindane results in increased degradation of GJA1 protein modified form]8824497
D001556LindaneLindane affects the localization of GJA1 protein15194225
D001556LindaneLindane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]15749814
D001556LindaneLindane promotes the reaction [GJA1 protein binds to TJP1 protein]15194225
D001556LindaneLindane results in decreased expression of GJA1 mRNA7530866
D001556LindaneLindane results in decreased expression of GJA1 protein7530866
D001556LindaneLindane results in decreased phosphorylation of GJA1 protein18040759
D001556LindaneLindane results in increased degradation of GJA1 protein modified form8824497
D001556LindaneLindane results in increased phosphorylation of GJA1 protein15194225
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of GJA1 mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GJA1 mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GJA1 mRNA20423518|2733941
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of GJA1 mRNA]20423518
D008094LithiumLithium results in decreased expression of GJA1 protein18585900
D018021Lithium ChlorideLithium Chloride affects the localization of GJA1 protein21177194
D018021Lithium Chloride[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein18972237
D018021Lithium ChlorideLithium Chloride results in increased expression of GJA1 protein21177194
D019808LosartanLosartan results in increased expression of GJA1 protein18971572
C015329lycopenelycopene results in increased expression of GJA1 protein16091010
D008244LysophosphatidylcholinesLysophosphatidylcholines affects the localization of and results in increased phosphorylation of GJA1 protein23973256
D008244LysophosphatidylcholinesLysophosphatidylcholines results in increased ubiquitination of GJA1 protein23973256
D008244LysophosphatidylcholinesPRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]23973256
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GJA1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of GJA1 mRNA26378955
D061965Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase Inhibitors inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]27818224
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of GJA1 mRNA20843944
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GJA1 mRNA18409822
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GJA1 protein18409822
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GJA1 mRNA20938992
D008731MethoxychlorMethoxychlor affects the expression of GJA1 mRNA20829426
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GJA1 mRNA20713471
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of GJA1 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of GJA1 mRNA21664453
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GJA1 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GJA1 mRNA"23747752
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GJA1 protein"23747752
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GJA1 mRNA"28087314
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased phosphorylation of GJA1 protein"23747752
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GJA1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJA1 mRNA19840844
C008493methylselenic acidmethylselenic acid results in increased expression of GJA1 mRNA18548127
D008790Metoprolol[Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein20215810
D008790MetoprololMetoprolol affects the localization of GJA1 protein17445419
D008790MetoprololMetoprolol results in increased expression of GJA1 protein20215810
D015735MifepristoneMifepristone results in increased expression of GJA1 mRNA17584828
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GJA1 mRNA22321834
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of GJA1 mRNA16507463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GJA1 mRNA26924002
C523799MRK 003GJA1 results in increased susceptibility to MRK 00319903844
C034476muconaldehyde2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [muconaldehyde results in increased phosphorylation of GJA1 protein]15690152
C034476muconaldehydemuconaldehyde results in decreased expression of GJA1 protein19932693
C034476muconaldehydemuconaldehyde results in increased degradation of GJA1 protein15690152
C034476muconaldehydemuconaldehyde results in increased phosphorylation of GJA1 protein15690152
D009151Mustard GasMustard Gas results in increased expression of GJA1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of GJA1 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GJA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GJA1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GJA1 mRNA20551477|2538013
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of GJA1 mRNA19812364
C010723N-ethyl-N-(4-hydroxybutyl)nitrosamineN-ethyl-N-(4-hydroxybutyl)nitrosamine results in increased expression of GJA1 mRNA7955049
C028007nickel monoxidenickel monoxide results in increased expression of GJA1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of GJA1 mRNA22714537
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of GJA1 mRNA10397678
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of GJA1 protein10397678|1185696
D009569Nitric OxideNitric Oxide results in decreased expression of GJA1 protein20004189
C007350nitrofennitrofen affects the expression of GJA1 protein16720372
C007350nitrofennitrofen results in increased expression of GJA1 mRNA16720372
C007350nitrofennitrofen results in decreased expression of GJA1 mRNA22325386
C007350nitrofennitrofen results in increased expression of GJA1 mRNA16292552
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in decreased expression of GJA1 mRNA]22325386
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in increased expression of GJA1 mRNA]16292552
C025589ochratoxin Aochratoxin A results in increased phosphorylation of GJA1 protein11711124
C025589ochratoxin Aochratoxin A affects the phosphorylation of GJA1 protein11711124
C025589ochratoxin Aochratoxin A results in decreased expression of GJA1 mRNA16857307
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GJA1 mRNA19840844
D019319Okadaic AcidOkadaic Acid results in increased expression of GJA1 mRNA8597533
C542870onabotulinumtoxinAGJA1 gene affects the susceptibility to onabotulinumtoxinA17584988
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GJA1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GJA1 mRNA25729387
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D010100OxygenOxygen deficiency results in decreased expression of GJA1 mRNA18665255
D010100OxygenOxygen deficiency results in decreased expression of GJA1 protein18665255
D010100OxygenOxygen deficiency results in increased expression of GJA1 mRNA23452621
D010100OxygenOxygen deficiency results in increased phosphorylation of GJA1 protein18665255
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D010100Oxygen4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]23270704
D010100Oxygen4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein]23270704
D010100Oxygenacetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]23270704
D010100Oxygenacetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein]23270704
D010100Oxygenebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]12958040
D010100Oxygenebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]12958040
D010100OxygenOxygen deficiency results in decreased expression of GJA1 mRNA23270704
D010100OxygenOxygen deficiency results in decreased expression of GJA1 protein23270704
D010100OxygenOxygen deficiency results in increased expression of GJA1 mRNA12958040
D010100OxygenOxygen deficiency results in increased expression of GJA1 protein12958040
D010100OxygenRotenone inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]12958040
D010100OxygenRotenone inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]12958040
D010269ParaquatParaquat results in decreased expression of GJA1 mRNA12595580
D052638Particulate MatterParticulate Matter results in decreased expression of GJA1 mRNA22178795
D010455PeptidesPeptides results in decreased activity of GJA1 protein28687253
C076994perfluorooctane sulfonic acidMatrix Metalloproteinase Inhibitors inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]27818224
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein23761298
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GJA1 mRNA23948355
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GJA1 protein27818224
C076994perfluorooctane sulfonic acidSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]23761298
C076994perfluorooctane sulfonic acidSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]27818224
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GJA124169556
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GJA1 mRNA23948355
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GJA1 protein25743374
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of GJA1 mRNA]20423518
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of GJA1 mRNA17616710
D010634PhenobarbitalPhenobarbital affects the expression of GJA1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of GJA1 mRNA19270015
D019800PhenolPhenol results in increased expression of GJA1 mRNA15094358
D019800PhenolPhenol results in increased expression of GJA1 protein15094358
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]18445782
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]16352648|1844578
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
D010656PhenylephrineGJA1 protein affects the susceptibility to Phenylephrine18593691
D010656PhenylephrinePhenylephrine results in increased expression of GJA1 mRNA16352648|1844578
D010656PhenylephrinePhenylephrine results in increased expression of GJA1 protein16352648|1844578
D010656PhenylephrineSB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]18445782
D010656PhenylephrineSB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
D010795Phthalic AcidsPhthalic Acids analog results in decreased expression of GJA1 protein22936646
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GJA1 mRNA15728792
D010862PilocarpinePilocarpine affects the localization of GJA1 protein21177194
D010862PilocarpinePilocarpine results in increased expression of GJA1 protein21177194
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of GJA1 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of GJA1 mRNA20059764
C006253pirinixic acidpirinixic acid results in increased expression of GJA1 mRNA18445702
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of GJA1 mRNA]20059764
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
D010936Plant ExtractsPlant Extracts results in decreased expression of GJA1 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]27154496
D010936Plant ExtractsPlant Extracts inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]27154496
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of GJA1 mRNA21334430
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in decreased expression of GJA1 protein23085979
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GJA1 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of GJA1 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of GJA1 protein21558462
D011374ProgesteroneGJA1 protein affects the secretion of Progesterone17379658
D011374ProgesteroneProgesterone results in increased expression of GJA1 mRNA20726854
D011433PropranololPropranolol affects the localization of GJA1 protein17445419
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Amphetamine results in increased expression of GJA1 protein]15194466
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of GJA1 mRNA15761015
C059514resveratrolresveratrol results in decreased expression of GJA1 mRNA24305840
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]20578705
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]23452621
C059514resveratrol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C059514resveratrolpyrazolanthrone inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
C059514resveratrolresveratrol results in decreased expression of GJA1 mRNA22610192
C059514resveratrolresveratrol results in increased expression of GJA1 mRNA24449132
C059514resveratrolresveratrol results in increased expression of GJA1 protein24449132
C059514resveratrolSB 203580 inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C059514resveratrolresveratrol affects the phosphorylation of and affects the localization of GJA1 protein17520802
C059514resveratrolresveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]24079413
C059514resveratrolresveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]19720069
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]10973802
C059514resveratrolresveratrol promotes the reaction [CHRM3 protein binds to GJA1 protein]17520802
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]21852083
C084904Ro 41-5253"Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]"16091010
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]16091010
D012402Rotenonegastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 mRNA]23783886
D012402Rotenonegastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 protein]23783886
D012402Rotenonegastrodin inhibits the reaction [Rotenone results in increased phosphorylation of GJA1 protein]23783886
D012402RotenoneRotenone affects the localization of GJA1 protein19232380
D012402RotenoneRotenone inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]12958040
D012402RotenoneRotenone inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]12958040
D012402RotenoneRotenone results in increased expression of GJA1 mRNA23783886
D012402RotenoneRotenone results in increased expression of GJA1 protein19232380|2378388
D012402RotenoneRotenone results in increased phosphorylation of GJA1 protein19232380|2378388
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of GJA1 mRNA21427059
C541923sandostatinLARsandostatinLAR results in increased expression of GJA1 mRNA17210224
C057354sarafotoxins s6sarafotoxins s6 results in increased expression of GJA1 protein15685554
C093642SB 203580SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]29180066
C093642SB 203580SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 mRNA]29180066
C093642SB 203580SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]29180066
C093642SB 203580SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]23761298
C093642SB 203580SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]27818224
C093642SB 203580SB 203580 inhibits the reaction [resveratrol results in increased expression of GJA1 protein]24449132
C093642SB 203580SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]18445782
C093642SB 203580SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]18445782
D012822Silicon DioxideSilicon Dioxide results in increased expression of GJA1 mRNA23221170
D012834SilverSilver results in increased expression of GJA1 mRNA28959546
D019821SimvastatinGJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]23978459
D019821SimvastatinSimvastatin affects the localization of and results in decreased phosphorylation of GJA1 protein23978459
C009277sodium arsenatesodium arsenate results in decreased expression of GJA1 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of GJA1 mRNA12727804|1650746
C017947sodium arsenitesodium arsenite results in increased expression of GJA1 mRNA22714537
D012969Sodium Fluoride[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of GJA1 protein27237588
D012969Sodium FluorideSodium Fluoride results in decreased expression of GJA1 mRNA27237588
D012969Sodium FluorideSodium Fluoride results in decreased expression of GJA1 protein27237588
D012999SomanSoman results in increased expression of GJA1 mRNA19281266
D053260SootSoot analog results in increased expression of GJA1 protein24932759
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GJA1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of GJA1 mRNA26378955
D013458Sulfur Dioxide[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of GJA1 protein27237588
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of GJA1 protein27237588
D014284TriiodothyronineTriiodothyronine results in increased expression of GJA1 protein15685554
D014284TriiodothyronineTriiodothyronine results in decreased expression of GJA1 mRNA21523860
D013629TamoxifenTamoxifen affects the expression of GJA1 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of GJA1 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of GJA1 mRNA25123088
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol affects the expression of GJA1 mRNA]20004189
D013739Testosterone[Testosterone co-treated with hydroxyflutamide] results in decreased expression of GJA1 protein26437446
D013739TestosteroneTestosterone results in decreased expression of GJA1 protein26437446
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GJA1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of and results in decreased activity of GJA1 protein19121332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GJA1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of GJA1 protein19121332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GJA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GJA1 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GJA1 protein23085979
D013755Tetradecanoylphorbol AcetateEthinyl Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GJA1 protein]10633228
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GJA1 protein10633228
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein11711124
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of GJA1 protein"7586191
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GJA1 mRNA"7586191
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJA1 mRNA19840844
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the reaction [GJA1 protein results in increased susceptibility to Etoposide]23978459
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GJA1 mRNA7586191|8597533
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GJA1 protein7586191
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein7586169
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GJA1 mRNA25613284
D013755Tetradecanoylphorbol Acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]11532878
D013755Tetradecanoylphorbol Acetatebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]15685554
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of GJA1 protein]15685554
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]10973802
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of GJA1 protein8020150
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of GJA1 mRNA8068183
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of GJA1 protein8285856
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and results in decreased activity of GJA1 protein20510257
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of GJA1 protein15685554
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein10973802|1153287
D008063Thioctic AcidThioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]27260466
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]26165643
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]26165643
D013974Thyroxinebenazepril promotes the reaction [Thyroxine results in increased expression of GJA1 mRNA]21545815
D013974Thyroxinebenazepril promotes the reaction [Thyroxine results in increased expression of GJA1 protein]21545815
D013974Thyroxineirbesartan promotes the reaction [Thyroxine results in increased expression of GJA1 mRNA]21545815
D013974Thyroxineirbesartan promotes the reaction [Thyroxine results in increased expression of GJA1 protein]21545815
D013974ThyroxineThyroxine results in increased expression of GJA1 mRNA21545815
D013974ThyroxineThyroxine results in increased expression of GJA1 protein21545815
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of GJA1 protein]24708733
C078041tin sulfidetin sulfide results in increased expression of GJA1 mRNA29069489
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GJA1 mRNA27480279|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GJA1 mRNA20133372
D014044TolbutamideGJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]16718685
D014044TolbutamideTolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]11741589
D014044TolbutamideTolbutamide results in increased expression of GJA1 protein11741589|1671868
D014050TolueneToluene affects the expression of GJA1 mRNA22166486
D019772TopotecanGJA1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GJA1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GJA1 mRNA25729387
D014112ToxapheneToxaphene results in decreased expression of GJA1 protein8820588
D014212TretinoinTretinoin results in decreased expression of GJA1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of GJA1 protein16959971
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in decreased expression of GJA1 mRNA]22325386
D014212TretinoinTretinoin results in increased expression of GJA1 mRNA22325386
C011559tributyltintributyltin results in decreased expression of GJA1 protein28707438
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GJA1 gene27618143
C104274tris(4-chlorophenyl)methanoltris(4-chlorophenyl)methanol results in decreased expression of GJA1 protein11869875
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GJA1 mRNA"18930950
D014520UrethaneUrethane affects the expression of GJA1 mRNA16926031
C406224valdecoxibvaldecoxib results in increased expression of GJA1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of GJA1 mRNA29154799
D014635Valproic AcidValproic Acid analog results in decreased expression of GJA1 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of GJA1 mRNA20546886|2142705
D014639VanadiumVanadium results in increased expression of GJA1 mRNA15159208
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GJA1 gene25560391
C025643vinclozolinvinclozolin affects the expression of GJA1 mRNA19015723
C025643vinclozolinvinclozolin results in increased phosphorylation of and affects the localization of GJA1 protein27413106
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in increased expression of GJA1 mRNA]16292552
D014801Vitamin AVitamin A results in increased expression of GJA1 mRNA12031251
D002762CholecalciferolCholecalciferol results in increased expression of GJA1 protein15685554
D024483Vitamin K 3Vitamin K 3 affects the expression of GJA1 mRNA20829426
C009687wortmanninwortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein]26437446
C066436zardaverinezardaverine results in decreased localization of GJA1 protein15082077
D015032ZincZinc deficiency results in increased expression of GJA1 mRNA19111725
D015032ZincZinc deficiency results in increased expression of GJA1 protein18224284
D015032ZincZinc results in decreased expression of GJA1 mRNA17074742
D015032ZincZinc results in increased expression of GJA1 mRNA15159208
D019287Zinc SulfateZinc Sulfate results in decreased expression of GJA1 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005243gap junction channel activity-IDA1696265  16790700  23348765  
GO:0005515protein binding-IPI9707407  15709751  16944923  21220045  25910212  
GO:0015075ion transmembrane transporter activity-IDA1696265  
GO:0017124SH3 domain binding-IEA-  
GO:0030165PDZ domain binding-IEA-  
GO:0048487beta-tubulin binding-IEA-  
GO:0071253connexin binding-IEA-  
GO:0086075gap junction channel activity involved in cardiac conduction electrical coupling-NAS1696265  
GO:0097110scaffold protein binding-IEA-  
GO:0097718disordered domain specific binding-IEA-  
GO:1903763gap junction channel activity involved in cell communication by electrical coupling-IDA1696265  
GO:1990782protein tyrosine kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001764neuron migration-IEA-  
GO:0001937negative regulation of endothelial cell proliferation-IEA-  
GO:0001947heart looping-IEA-  
GO:0002070epithelial cell maturation-IEA-  
GO:0002088lens development in camera-type eye-IEA-  
GO:0002544chronic inflammatory response-IEA-  
GO:0002931response to ischemia-IEA-  
GO:0003104positive regulation of glomerular filtration-IEA-  
GO:0003158endothelium development-IEA-  
GO:0003294atrial ventricular junction remodeling-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006936muscle contraction-TAS7715640  
GO:0007165signal transduction-IDA1696265  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007267cell-cell signaling-IDA1696265  
GO:0007507heart development-TAS7715640  
GO:0007512adult heart development-IEA-  
GO:0009749response to glucose-IEA-  
GO:0010232vascular transport-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0010643cell communication by chemical coupling-IEA-  
GO:0010644cell communication by electrical coupling-IDA1696265  16790700  23348765  
GO:0010652positive regulation of cell communication by chemical coupling-IEA-  
GO:0015867ATP transport-IEA-  
GO:0016264gap junction assembly-TAS15709751  
GO:0022898regulation of transmembrane transporter activity-IEA-  
GO:0030308negative regulation of cell growth-ISS-  
GO:0030500regulation of bone mineralization-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0034220ion transmembrane transport-IDA1696265  
GO:0034405response to fluid shear stress-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-HMP12761501  
GO:0043403skeletal muscle tissue regeneration-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0045844positive regulation of striated muscle tissue development-IEA-  
GO:0045907positive regulation of vasoconstriction-IEA-  
GO:0046697decidualization-IEA-  
GO:0046850regulation of bone remodeling-IEA-  
GO:0048514blood vessel morphogenesis-IEA-  
GO:0048812neuron projection morphogenesis-IEA-  
GO:0051259protein complex oligomerization-IEA-  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0060044negative regulation of cardiac muscle cell proliferation-IEA-  
GO:0060156milk ejection reflex-IEA-  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IEA-  
GO:0060371regulation of atrial cardiac muscle cell membrane depolarization-IEA-  
GO:0060373regulation of ventricular cardiac muscle cell membrane depolarization-IEA-  
GO:0061045negative regulation of wound healing-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071374cellular response to parathyroid hormone stimulus-IEA-  
GO:0071467cellular response to pH-IEA-  
GO:0086014atrial cardiac muscle cell action potential-TAS23348765  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-NAS1696265  
GO:0097755positive regulation of blood vessel diameter-IEA-  
GO:1905867epididymis development-IEA-  
GO:2000279negative regulation of DNA biosynthetic process-IEA-  
GO:2000810regulation of bicellular tight junction assembly-IEA-  
GO:2000987positive regulation of behavioral fear response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA15919068  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005764lysosome-IEA-  
GO:0005769early endosome-IEA-  
GO:0005771multivesicular body-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-IEA-  
GO:0005882intermediate filament-IEA-  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS15709751  
GO:0005916fascia adherens-IEA-  
GO:0005921gap junction-IDA1696265  23348765  
GO:0005921gap junction-ISS-  
GO:0005922connexin complex-ISS15044680  
GO:0005925focal adhesion-HDA21423176  
GO:0014704intercalated disc-IDA22889254  23381804  
GO:0014704intercalated disc-ISS-  
GO:0016324apical plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
GO:0030054cell junction-IDA-  
GO:0030660Golgi-associated vesicle membrane-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0043292contractile fiber-IEA-  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
hsa04540Gap junction
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-157858Gap junction trafficking and regulationIEA
R-HSA-190704Oligomerization of connexins into connexonsIEA
R-HSA-190827Transport of connexins along the secretory pathwayIEA
R-HSA-190828Gap junction traffickingTAS
R-HSA-190828Gap junction traffickingIEA
R-HSA-190840Microtubule-dependent trafficking of connexons from Golgi to the plasma membraneTAS
R-HSA-190861Gap junction assemblyTAS
R-HSA-190861Gap junction assemblyIEA
R-HSA-190872Transport of connexons to the plasma membraneTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-191647c-src mediated regulation of Cx43 function and closure of gap junctionsTAS
R-HSA-191647c-src mediated regulation of Cx43 function and closure of gap junctionsIEA
R-HSA-191650Regulation of gap junction activityTAS
R-HSA-191650Regulation of gap junction activityIEA
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5653656Vesicle-mediated transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28714806Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. (2017 Sep)de Paiva Lima CJ Neurogenet