Gene info: ID 26999

Gene: CYFIP2

GENE ID: 26999

Synonyms: PIR121

Description: cytoplasmic FMR1 interacting protein 2

Gene type: protein-coding

Location: 5q33.3

dbXrefs: Ensembl:ENSG00000055163 MIM:606323 Vega:OTTHUMG00000163484 UniprotKB:Q96F07

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.466e-1 (AD) 2.841e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20541456	chr5:156696520	CYFIP2	Promoter	4.564e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PI4KA	0.969
ARHGEF9	0.965
VPS26B	0.965
SEPT3	0.964
PPP2R5D	0.962
RAB6B	0.962
DNAJC5	0.962
ATP6V0A1	0.961
PFKM	0.96
MAPT	0.96

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.625
OR4F29	-0.573
TFPI2	-0.495
RAI14	-0.468
BEST3	-0.445
SGMS2	-0.445
C9orf135	-0.439
CSAG1	-0.438
SH2D1A	-0.438
CD48	-0.435

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CYFIP2 mRNA	19933214
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CYFIP2 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYFIP2 mRNA"	20959002
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYFIP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYFIP2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of CYFIP2 mRNA	22230336
D020106	Acrylamide	Acrylamide results in increased expression of CYFIP2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CYFIP2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYFIP2 mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CYFIP2 gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of CYFIP2 mRNA	21757418
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CYFIP2 mRNA	28522335
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CYFIP2 mRNA	24449571
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CYFIP2 mRNA	15894607
D001280	Atrazine	Atrazine results in decreased expression of CYFIP2 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYFIP2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYFIP2 mRNA	19770486\|2171566
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYFIP2 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of CYFIP2 mRNA	20660070
C044887	beta-methylcholine	beta-methylcholine affects the expression of CYFIP2 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of CYFIP2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of CYFIP2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of CYFIP2 protein	24552547
C006780	bisphenol A	bisphenol A results in increased methylation of CYFIP2 gene	28505145
D002220	Carbamazepine	Carbamazepine affects the expression of CYFIP2 mRNA	25979313
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CYFIP2 mRNA	25270620
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYFIP2 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CYFIP2 mRNA	19320972
D003300	Copper	Copper results in decreased expression of CYFIP2 mRNA	26293553
D003375	Coumestrol	Coumestrol results in decreased expression of CYFIP2 mRNA	19167446
C029892	cupric chloride	cupric chloride results in decreased expression of CYFIP2 mRNA	17211630
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYFIP2 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of CYFIP2 mRNA	19159671\|2214713
D002945	Cisplatin	Cisplatin results in decreased expression of CYFIP2 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of CYFIP2 mRNA	27392435
D002945	Cisplatin	[Piroxicam co-treated with Cisplatin] results in decreased expression of CYFIP2 mRNA	21858171
D004041	Dietary Fats	Dietary Fats results in increased expression of CYFIP2 mRNA	18042831
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYFIP2 mRNA	22129741
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of CYFIP2 mRNA	27638505
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of CYFIP2 mRNA	23649840
D005472	Fluorouracil	CYFIP2 protein affects the susceptibility to Fluorouracil	16217747
D005472	Fluorouracil	Fluorouracil results in increased expression of CYFIP2 mRNA	17039268\|1798267
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in increased expression of CYFIP2 mRNA]	15016801
D005472	Fluorouracil	TP53 protein promotes the reaction [Fluorouracil results in increased expression of CYFIP2 mRNA]	17982676
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYFIP2 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of CYFIP2 mRNA	23649840
D005839	Gentamicins	Gentamicins results in increased expression of CYFIP2 mRNA	22061828
C000625835	HFPO2 compound	HFPO2 compound results in increased expression of CYFIP2 mRNA	27553808
C000625836	HFPO4 compound	HFPO4 compound results in increased expression of CYFIP2 mRNA	27553808
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of CYFIP2 mRNA	17183730
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYFIP2 mRNA	22129741
C045463	leflunomide	leflunomide results in increased expression of CYFIP2 mRNA	24136188
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYFIP2 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CYFIP2 protein	25809596
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CYFIP2 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of CYFIP2 mRNA	21664453
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of CYFIP2 mRNA	21664453
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CYFIP2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CYFIP2 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CYFIP2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CYFIP2 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of CYFIP2 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of CYFIP2 mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of CYFIP2 mRNA	19167457
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of CYFIP2 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of CYFIP2 mRNA	18042831
D010634	Phenobarbital	Phenobarbital results in increased expression of CYFIP2 mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYFIP2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of CYFIP2 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of CYFIP2 mRNA	19162173
D010894	Piroxicam	[Piroxicam co-treated with Cisplatin] results in decreased expression of CYFIP2 mRNA	21858171
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of CYFIP2 mRNA	22714537
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of CYFIP2 mRNA	20660070
D011374	Progesterone	Progesterone results in decreased expression of CYFIP2 mRNA	20864642
C005556	propionaldehyde	propionaldehyde results in increased expression of CYFIP2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CYFIP2 mRNA	24780913
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CYFIP2 mRNA	21427059
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYFIP2 mRNA]	19759094
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYFIP2 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CYFIP2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CYFIP2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYFIP2 mRNA	19759094\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYFIP2 mRNA	20959002\|2121527
D013853	Thioacetamide	Thioacetamide results in increased expression of CYFIP2 mRNA	23411599
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of CYFIP2 mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CYFIP2 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of CYFIP2 mRNA	15894607\|2372400
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYFIP2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of CYFIP2 mRNA	26272509
C012589	trichostatin A	trichostatin A results in decreased expression of CYFIP2 mRNA	15901671
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CYFIP2 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CYFIP2 mRNA"	26179874
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of CYFIP2 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of CYFIP2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CYFIP2 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased methylation of CYFIP2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CYFIP2 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYFIP2 mRNA	15901671
D014640	Vancomycin	Vancomycin results in increased expression of CYFIP2 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CYFIP2 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of CYFIP2 mRNA	23869203
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of CYFIP2 mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in decreased expression of CYFIP2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000340	RNA 7-methylguanosine cap binding	-	IBA	21873635
GO:0000340	RNA 7-methylguanosine cap binding	NOT	IBA	21873635
GO:0005515	protein binding	-	IPI	11438699 15048123 15048733 24658146

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IBA	21873635
GO:0006417	regulation of translation	-	IBA	21873635
GO:0006915	apoptotic process	-	IBA	21873635
GO:0006915	apoptotic process	-	IDA	10449408
GO:0007411	axon guidance	-	IBA	21873635
GO:0030031	cell projection assembly	-	IBA	21873635
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0045862	positive regulation of proteolysis	-	IDA	18387192
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	-	IEA	-
GO:0097202	activation of cysteine-type endopeptidase activity	-	IBA	21873635
GO:0097202	activation of cysteine-type endopeptidase activity	-	IDA	18387192
GO:0097484	dendrite extension	-	IEA	-
GO:0098609	cell-cell adhesion	-	IDA	15048733

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	11438699
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0030054	cell junction	-	IEA	-
GO:0031209	SCAR complex	-	IBA	21873635
GO:0031209	SCAR complex	NOT	IBA	21873635
GO:0043005	neuron projection	-	IBA	21873635
GO:0043005	neuron projection	-	IEA	-
GO:0045202	synapse	-	IBA	21873635
GO:0045202	synapse	-	IDA	11438699
GO:0048471	perinuclear region of cytoplasm	-	IDA	10449408
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145

KEGG ID	KEGG Term
hsa04810	Regulation of actin cytoskeleton

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	IEA
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	TAS
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26581503	Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. (2016 Feb)	Dickson PE	Psychopharmacology (Berl)