Gene: ABL2

27
ABLL|ARG
ABL proto-oncogene 2, non-receptor tyrosine kinase
protein-coding
1q25.2
Ensembl:ENSG00000143322 MIM:164690 Vega:OTTHUMG00000035199 UniprotKB:P42684
NG_028242.1
PubMed
0   ANCO-SNPs
ND
2   
8.426e-1 (AD)  8.858e-1 (ND)   (Frontal_Cortex)
8.336e-1 (AD)  4.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP1G10.915
ANKRD170.91
CBLL10.903
FOXJ30.903
GAPVD10.903
ZC3H140.902
CSNK1G10.895
CHD80.893
PRR14L0.892
KPNA60.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.492
OR4F29-0.462
PLA2G5-0.348
NKX6-1-0.312
S100A1-0.307
KLRC2-0.3
SLC22A6-0.298
S100A14-0.295
NXNL1-0.295
ASB4-0.293

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB05184XL228Small Molecule-InvestigationalTarget
DB076645-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABL2 mRNA28329830
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABL2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABL2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ABL2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ABL2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABL2 mRNA19770486
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ABL2 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ABL2 mRNA"18687144|2535159
D001507BeclomethasoneBeclomethasone results in increased expression of ABL2 mRNA23656298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABL2 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of ABL2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ABL2 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of ABL2 mRNA26079696
D002104CadmiumCadmium results in increased expression of ABL2 mRNA21120746
C037123cadmium sulfatecadmium sulfate results in increased expression of ABL2 mRNA12064557|1467641
D002220CarbamazepineCarbamazepine affects the expression of ABL2 mRNA24752500
C018021cobaltous chloridecobaltous chloride results in increased expression of ABL2 mRNA24612858
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ABL2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of ABL2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ABL2 mRNA20106945
D000069439DasatinibDasatinib binds to ABL2 protein17684099|1818038
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ABL2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ABL2 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of ABL2 mRNA24752500
D004298DopamineDopamine results in decreased expression of ABL2 mRNA21983523
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ABL2 mRNA22079256
D018818FenoldopamFenoldopam results in increased expression of ABL2 mRNA21983523
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABL2 mRNA28329830
C069837fullerene C60fullerene C60 results in decreased expression of ABL2 mRNA19167457
D000068877Imatinib MesylateImatinib Mesylate binds to ABL2 protein21417343
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ABL2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ABL2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ABL2 mRNA27392435
D007854LeadLead results in decreased expression of ABL2 mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides affects the reaction [IL4 protein results in increased expression of ABL2 mRNA]22024136
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL4] results in increased expression of ABL2 mRNA22024136
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABL2 mRNA22024136
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ABL2 mRNA23103053
D009532NickelNickel results in increased expression of ABL2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of ABL2 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ABL2 mRNA20971185
D010634PhenobarbitalPhenobarbital affects the expression of ABL2 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABL2 mRNA"27188386
D010938Plant OilsPlant Oils results in increased expression of ABL2 mRNA23370395
C545373ponatinibponatinib results in decreased activity of ABL2 protein19878872
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ABL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ABL2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ABL2 mRNA23608068
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ABL2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ABL2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ABL2 mRNA25351596
C009277sodium arsenatesodium arsenate results in decreased expression of ABL2 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of ABL2 mRNA12760830
D013654TaurineTaurine results in increased expression of ABL2 mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABL2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABL2 mRNA21296121
D013806TheophyllineTheophylline results in decreased expression of ABL2 mRNA16083514
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ABL2 mRNA28065790
D017973Tungsten CompoundsTungsten Compounds results in increased expression of ABL2 mRNA28666766
C029297vinylidene chloridevinylidene chloride results in increased expression of ABL2 mRNA26682919
C484810VX680VX680 binds to ABL2 protein21417343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA15886098  
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0003785actin monomer binding-TAS20841568  
GO:0004672protein kinase activity-TAS2198571  
GO:0004713protein tyrosine kinase activity-IDA15886098  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS20841568  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI12893824  15886098  16273093  17474147  19380743  20598684  
24658140  24728074  25241761  26420826  
GO:0005524ATP binding-IEA-  
GO:0030145manganese ion binding-IDA15886098  
GO:0051015actin filament binding-TAS20841568  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS2198571  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS2198571  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IMP24367707  
GO:0010506regulation of autophagy-TAS20841568  
GO:0010863positive regulation of phospholipase C activity-IMP24367707  
GO:0010976positive regulation of neuron projection development-IMP17910947  
GO:0018108peptidyl-tyrosine phosphorylation-IDA15886098  
GO:0030100regulation of endocytosis-TAS20841568  
GO:0030154cell differentiation-IBA21873635  
GO:0030155regulation of cell adhesion-TAS20841568  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0045087innate immune response-IBA21873635  
GO:0051353positive regulation of oxidoreductase activity-IDA12893824  
GO:0071300cellular response to retinoic acid-IMP17910947  
GO:2000145regulation of cell motility-TAS20841568  
GO:2000249regulation of actin cytoskeleton reorganization-TAS20841568  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-TAS20841568  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27859136KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer. (2017 Feb 15)Nagy AInt J Cancer
16945033Periodontal disease and coronary heart disease. (2006 Sep)Geismar KJ Periodontol