Gene: AMPD1

270
MAD|MADA|MMDD
adenosine monophosphate deaminase 1
protein-coding
1p13.2
Ensembl:ENSG00000116748 MIM:102770 Vega:OTTHUMG00000011892 UniprotKB:P23109
NG_008012.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.159e-1 (AD)  3.954e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XIRP20.871
TTN0.815
MYL10.768
MYH10.765
KLHL410.762
LMOD20.76
NEB0.743
TNNI10.737
MYH20.714
MYLPF0.712

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KPTN-0.3
MIER2-0.298
CCDC151-0.296
HDDC3-0.294
PSPN-0.288
TRAF2-0.287
CCL27-0.286
ZNF575-0.283
FADD-0.283
KLK14-0.282

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AMPD1 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in increased expression of AMPD1 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AMPD1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMPD1 mRNA16483693
D001507BeclomethasoneBeclomethasone results in increased expression of AMPD1 mRNA23656298
C006780bisphenol Abisphenol A affects the expression of AMPD1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of AMPD1 mRNA24376830
D002509CephaloridineCephaloridine results in increased expression of AMPD1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of AMPD1 mRNA18804290
D003471CuprizoneCuprizone results in increased expression of AMPD1 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AMPD1 mRNA24317228
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of AMPD1 mRNA28085963
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AMPD1 mRNA22079256
D005419FlavonoidsFlavonoids results in increased expression of AMPD1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of AMPD1 mRNA24793618
C039281furanfuran results in decreased methylation of AMPD1 gene22079235
D006108GraphiteGraphite results in increased expression of AMPD1 mRNA27440207
C082359imidaclopridimidacloprid results in decreased expression of AMPD1 mRNA27782041
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AMPD1 mRNA21889194
D008694MethamphetamineMethamphetamine results in increased expression of AMPD1 mRNA19564919
D008727MethotrexateAMPD1 gene polymorphism affects the susceptibility to Methotrexate16947783|1753070
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of AMPD1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AMPD1 mRNA26011545
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AMPD1 mRNA27935865
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of AMPD1 mRNA23948077
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AMPD1 mRNA27935865
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AMPD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AMPD1 mRNA22079256
C009495titanium dioxidetitanium dioxide results in decreased expression of AMPD1 mRNA23557971|2776080

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003876AMP deaminase activity-EXP1429593  7287721  9857047  
GO:0032036myosin heavy chain binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010033response to organic substance-IEA-  
GO:0032264IMP salvage-IEA-  
GO:0043101purine-containing compound salvage-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-74217Purine salvageTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17530705A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. (2007 Jun)Wessels JAArthritis Rheum
26864064Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease. (2016 Feb 11)Safranow KPostepy Hig Med Dosw (Online)