Gene: GJA4

2701
CX37
gap junction protein alpha 4
protein-coding
1p34.3
Ensembl:ENSG00000187513 MIM:121012 Vega:OTTHUMG00000004050 UniprotKB:P35212
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.044e-2 (AD)  6.840e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEYL0.839
GPR40.835
LRRC320.789
EPHA20.783
ITPRIP0.781
PEAR10.775
NID10.769
DOCK60.765
TINAGL10.764
ADAMTS10.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.573
MARCH4-0.551
PPEF1-0.544
SLC7A4-0.537
PTPRR-0.535
KCNB2-0.533
NDST3-0.527
NEUROD6-0.527
GLRA3-0.524
GPR61-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GJA4 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GJA4 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of GJA4 mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of GJA4 mRNA16084531
D000452AldrinAldrin results in decreased expression of GJA4 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GJA4 mRNA16483693
D001151ArsenicArsenic affects the methylation of GJA4 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of GJA4 protein17559834
C015001arsenitearsenite results in increased methylation of GJA4 promoter23974009
D001262AtenololAtenolol results in increased expression of GJA4 protein16448880
D001280AtrazineAtrazine results in decreased expression of GJA4 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GJA4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJA4 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GJA4 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of GJA4 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of GJA4 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of GJA4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GJA4 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GJA4 mRNA17484886
C043211carvedilolcarvedilol results in increased expression of GJA4 protein16448880
D002737ChloropreneChloroprene results in decreased expression of GJA4 mRNA23125180
D004041Dietary FatsDietary Fats results in increased expression of GJA4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GJA4 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of GJA4 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GJA4 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased methylation of GJA4 promoter25374375
D002117CalcitriolCalcitriol results in increased expression of GJA4 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the reaction [A gene mutant form results in decreased expression of GJA4 protein]"25447408
D0151279,10-Dimethyl-1,2-benzanthracene"[A gene mutant form co-treated with 9,10-Dimethyl-1,2-benzanthracene] affects the expression of GJA4 protein"25447408
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA4 mRNA"24269759
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA4 protein"24269759
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GJA4 mRNA"24269759
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GJA4 protein"24269759
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GJA4 mRNA25380136
C118739entinostatentinostat results in decreased expression of GJA4 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of GJA4 mRNA16084531
D015025ZearalenoneZearalenone results in decreased expression of GJA4 mRNA26386189
D004397FonofosFonofos results in increased methylation of GJA4 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of GJA4 mRNA19167457
D017313FenretinideFenretinide results in increased expression of GJA4 mRNA28973697
C015329lycopenelycopene results in decreased expression of GJA4 mRNA16886892
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of GJA4 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of GJA4 mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of GJA4 mRNA17400583
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GJA4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GJA4 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GJA4 mRNA25380136
D009532NickelNickel results in increased expression of GJA4 mRNA24768652
D009538NicotineNicotine results in increased expression of GJA4 mRNA28087314
D010100OxygenOxygen deficiency results in decreased expression of GJA4 mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of GJA4 mRNA18042831
C016030pantogabpantogab results in increased expression of GJA4 mRNA17379144
D010278ParathionParathion results in increased methylation of GJA4 promoter22847954
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GJA4 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased methylation of GJA4 promoter25374375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GJA4 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GJA4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of GJA4 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of GJA4 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GJA4 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of GJA4 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of GJA4 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of GJA4 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of GJA4 mRNA18692832
C010313pseudocumenepseudocumene results in increased expression of GJA4 protein17337753
D011691Puromycin[Tretinoin co-treated with Puromycin] results in increased expression of GJA4 mRNA15977162
C059514resveratrolresveratrol results in increased expression of GJA4 mRNA25905778
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of GJA4 mRNA19564919
C009250sevofluranesevoflurane affects the expression of GJA4 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GJA4 mRNA23806026
C012568terbufosterbufos results in increased methylation of GJA4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GJA4 mRNA21215274
D013849ThimerosalThimerosal results in decreased expression of GJA4 mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of GJA4 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with Puromycin] results in increased expression of GJA4 mRNA15977162
D014212TretinoinTretinoin results in increased expression of GJA4 mRNA20488242
C057693troglitazonetroglitazone results in increased expression of GJA4 mRNA17569031
C022884undecaneundecane results in increased expression of GJA4 protein17337753
D014635Valproic AcidValproic Acid affects the expression of GJA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GJA4 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of GJA4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GJA4 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of GJA4 mRNA19015723
D014800VitalliumVitallium analog results in decreased expression of GJA4 mRNA23825117
C111237vorinostatvorinostat results in decreased expression of GJA4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23840749  
GO ID GO Term Qualifier Evidence PubMed
GO:0001568blood vessel development-IEA-  
GO:0003158endothelium development-IEA-  
GO:0006816calcium ion transport-IEA-  
GO:0007043cell-cell junction assembly-TAS7680674  
GO:0007267cell-cell signaling-IEA-  
GO:0048265response to pain-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS7680674  
GO:0005921gap junction-TAS7680674  
GO:0005922connexin complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-190828Gap junction traffickingTAS
R-HSA-190861Gap junction assemblyTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22481247Risky communication in atherosclerosis and thrombus formation. (2012 Apr 5)Meens MJSwiss Med Wkly