Gene: NPTN

27020
GP55|GP65|SDFR1|SDR1|np55|np65
neuroplastin
protein-coding
15q24.1
Ensembl:ENSG00000156642 MIM:612820 Vega:OTTHUMG00000137586 UniprotKB:Q9Y639
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.370e-1 (AD)  5.777e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16231923chr15:73923634NPTN1.630e-8Maternal smoking in pregnancy27040690
cg16231923chr15:73923634NPTN4.330e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTN10.981
PPP3R10.978
NAP1L20.977
PREPL0.975
MDH10.975
LRP110.974
ATP1B10.974
ATP6V1B20.973
SLC9A60.973
NSF0.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.601
OR4F29-0.563
CSAG1-0.474
CXCR2-0.445
KCNJ15-0.443
MAGEA12-0.434
TFPI2-0.432
RAI14-0.427
MYL3-0.427
FZD10-0.425

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NPTN mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NPTN mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NPTN mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NPTN mRNA"21346803
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPTN mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of NPTN protein25419056
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of NPTN gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPTN mRNA21839799
C044887beta-methylcholinebeta-methylcholine affects the expression of NPTN mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of NPTN mRNA29275510
C006780bisphenol Abisphenol A affects the expression of NPTN mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NPTN mRNA28628672
D003024ClozapineClozapine results in increased expression of NPTN mRNA18797397
D019327Copper SulfateCopper Sulfate results in increased expression of NPTN mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NPTN mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NPTN mRNA25562108
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of NPTN mRNA"22228705
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NPTN mRNA28628672
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NPTN protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NPTN mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of NPTN mRNA18035473
D005839GentamicinsGentamicins results in increased expression of NPTN mRNA22061828
D017313FenretinideFenretinide results in decreased expression of NPTN mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NPTN mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NPTN mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPTN mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NPTN mRNA28628672
D008727MethotrexateMethotrexate results in decreased expression of NPTN mRNA17400583
D009151Mustard GasMustard Gas results in increased expression of NPTN mRNA15674844
C076029olanzapineolanzapine results in increased expression of NPTN mRNA18797397
C006253pirinixic acidpirinixic acid results in increased expression of NPTN mRNA18301758|2381119
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of NPTN mRNA"22228705
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NPTN mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of NPTN protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NPTN mRNA19162173
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of NPTN mRNA"22228705
D018038Sodium SeleniteSodium Selenite results in decreased expression of NPTN mRNA18175754
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of NPTN mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPTN mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NPTN mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPTN mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of NPTN mRNA"19682533
D014212TretinoinTretinoin affects the expression of NPTN protein15789344
D014520UrethaneUrethane results in increased expression of NPTN mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NPTN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NPTN mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NPTN gene25560391
C025643vinclozolinvinclozolin results in increased expression of NPTN mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005105type 1 fibroblast growth factor receptor binding-ISS-  
GO:0044325ion channel binding-IEA-  
GO:0050839cell adhesion molecule binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-ISS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0008542visual learning-IEA-  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0045743positive regulation of fibroblast growth factor receptor signaling pathway-ISS-  
GO:0048170positive regulation of long-term neuronal synaptic plasticity-ISS-  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:1900273positive regulation of long-term synaptic potentiation-IEA-  
GO:1902683regulation of receptor localization to synapse-IEA-  
GO:1903829positive regulation of cellular protein localization-IEA-  
GO:1904861excitatory synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009986cell surface-HDA19581412  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0042734presynaptic membrane-ISS-  
GO:0060077inhibitory synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28722770Asbestos-associated genome-wide DNA methylation changes in lung cancer. (2017 Nov 15)Kettunen EInt J Cancer