Gene: MLH3

27030
HNPCC7
mutL homolog 3
protein-coding
14q24.3
Ensembl:ENSG00000119684 MIM:604395 Vega:OTTHUMG00000171766 UniprotKB:Q9UHC1
NG_008649.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.133e-2 (AD)  4.997e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PWWP2A0.89
PTK20.876
DMTF10.87
FANCL0.866
MON20.864
FAR10.864
NXPE30.861
U2SURP0.861
USP480.86
ZZZ30.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.526
OR4F29-0.525
OR4F16-0.268
PLA2G5-0.264
WNT7B-0.243
NKX6-1-0.231
MTRNR2L10-0.229
MTRNR2L6-0.224
MTRNR2L9-0.223
TTLL10-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MLH3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MLH3 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MLH3 mRNA"21346803
C0944114-phenylcoumarin4-phenylcoumarin analog results in increased expression of MLH3 mRNA27773722
D000082AcetaminophenAcetaminophen affects the expression of MLH3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MLH3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MLH3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MLH3 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MLH3 mRNA22082530
D004958EstradiolEstradiol results in increased expression of MLH3 mRNA23804311
C006780bisphenol Abisphenol A affects the methylation of MLH3 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of MLH3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MLH3 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MLH3 mRNA23741332
C018021cobaltous chloridecobaltous chloride results in increased expression of MLH3 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of MLH3 mRNA19549813
C014347decitabinedecitabine results in increased expression of MLH3 mRNA22082530
C000944dicrotophosdicrotophos results in decreased expression of MLH3 mRNA28302478
C039281furanfuran results in decreased expression of MLH3 mRNA22507866
C071834glycidamideglycidamide affects the expression of MLH3 protein21978862
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MLH3 mRNA26846883
C045463leflunomideleflunomide results in decreased expression of MLH3 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MLH3 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MLH3 mRNA"26251327
C005246myristicinmyristicin results in decreased expression of MLH3 mRNA24792648
C016030pantogabpantogab results in decreased expression of MLH3 mRNA17379144
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MLH3 mRNA19710929
D011374ProgesteroneProgesterone results in increased expression of MLH3 mRNA23012394
C547185riccardin Driccardin D results in increased expression of MLH3 mRNA24069304
D012834SilverSilver results in decreased expression of MLH3 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of MLH3 mRNA23804311
D012999SomanSoman results in decreased expression of MLH3 mRNA19281266
D014028Tobacco Smoke PollutionMLH3 gene polymorphism affects the susceptibility to Tobacco Smoke Pollution22623965
D014520UrethaneUrethane results in decreased expression of MLH3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MLH3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MLH3 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003696satellite DNA binding-TAS10615123  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0005515protein binding-IPI20603073  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0019237centromeric DNA binding-IEA-  
GO:0030983mismatched DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-NAS12095912  
GO:0007130synaptonemal complex assembly-IEA-  
GO:0007131reciprocal meiotic recombination-NAS12095912  
GO:0007140male meiotic nuclear division-IEA-  
GO:0007144female meiosis I-IEA-  
GO:0008104protein localization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001673male germ cell nucleus-IEA-  
GO:0005634nucleus-IDA-  
GO:0032300mismatch repair complex-IBA21873635  
GO:0032389MutLalpha complex-IBA21873635  
KEGG ID KEGG Term
hsa03430Mismatch repair
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29775861Screening methylation of DNA repair genes in the oral mucosa of chronic smokers. (2018 May 1)Carta CFLArch Oral Biol