Gene: NOX1

27035
GP91-2|MOX1|NOH-1|NOH1
NADPH oxidase 1
protein-coding
Xq22.1
Ensembl:ENSG00000007952 MIM:300225 Vega:OTTHUMG00000022007 UniprotKB:Q9Y5S8
NG_012567.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALML40.637
CRLS10.543
LIN7C0.536
CCDC580.532
DGUOK0.526
SUPV3L10.519
TIMM230.514
PSMG20.511
LEFTY10.508
MNAT10.508

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FER1L6-0.311
OR4F5-0.301
KRT73-0.292
ATP2A3-0.287
CXCL17-0.287
STRA6-0.284
ZAN-0.282
AVPR1A-0.279
LAMC3-0.279
KRTAP9-3-0.279

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09140OxygenSmall Molecule7782-44-7ApprovedTarget
ID Drug Name Action PubMed
C5495001-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea inhibits the reaction [AGT protein modified form results in increased expression of NOX1 mRNA]27678262
C5398271-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid"1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NOX1 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]19293636
C5847872-acetylphenothiazine2-acetylphenothiazine results in decreased activity of NOX1 protein25617244
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NOX1 protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NOX1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1"20715105
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of NOX1 mRNA25088246
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of NOX1 mRNA24835767
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of NOX1 protein24835767
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of NOX1 mRNA24835767
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of NOX1 protein24835767
C056165acetovanilloneacetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]26522475
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D012794Sialic AcidsSialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein]24973090
C058956acteosideacteoside results in decreased activity of NOX1 protein16393473
D052242Adiponectin"Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]]"20832062
C010845aluminum chloridealuminum chloride results in increased expression of NOX1 mRNA28826906
D017311AmlodipineAmlodipine promotes the reaction [candesartan results in decreased expression of NOX1]21107329
C530884anacetrapibanacetrapib results in increased expression of NOX1 mRNA25617244
D016718Arachidonic AcidArachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein20832062
D016718Arachidonic Acid"Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]]"20832062
D001151ArsenicArsenic results in increased expression of NOX1 protein22552367
D001151ArsenicArsenic results in increased expression of NOX1 protein22552367
D001205Ascorbic AcidAscorbic Acid results in increased expression of NOX1 protein21570463
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [AGT protein results in increased expression of NOX1 protein]19451411
D001507BeclomethasoneBeclomethasone results in increased expression of NOX1 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NOX1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NOX1 mRNA26001963
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of NOX1 mRNA"28987381
C006780bisphenol Abisphenol A results in decreased expression of NOX1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NOX1 mRNA26079696
D002118Calcium"1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
D002118CalciumNOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]24912985
D002118Calcium"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
C081643candesartanAmlodipine promotes the reaction [candesartan results in decreased expression of NOX1]21107329
C081643candesartancandesartan results in decreased expression of NOX121107329
C081643candesartanHydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1]21107329
C043211carvedilolcarvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D000068579CelecoxibCelecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
D000068579CelecoxibCelecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
C060894CGP 42112ACGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]25446015
C060894CGP 42112ACGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]25446015
C060894CGP 42112APD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]25446015
C060894CGP 42112APD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]25446015
D008078Cholesterol, LDL"Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]]"20832062
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of NOX1 protein21742780|2255236
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of NOX1 protein22552367
C018021cobaltous chloridecobaltous chloride results in increased expression of NOX1 mRNA16507596
C018021cobaltous chloridecobaltous chloride results in increased expression of NOX1 protein16507596
C018021cobaltous chloridecobaltous chloride results in increased expression of NOX1 mRNA23000094
C018021cobaltous chlorideGHRL protein modified form inhibits the reaction [cobaltous chloride results in increased expression of NOX1 mRNA]23000094
D003300CopperCopper deficiency results in increased expression of NOX1 mRNA26033743
C083069crenatosidecrenatoside results in decreased activity of NOX1 protein16393473
C411602dalcetrapibdalcetrapib results in increased expression of NOX1 protein25617244
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NOX1 mRNA23640034
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]27678262
D064791Desoxycorticosterone Acetate[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA27678262
D002945CisplatinCisplatin results in increased expression of NOX1 mRNA23603837
D002945CisplatinEicosanoids analog inhibits the reaction [Cisplatin results in increased expression of NOX1 mRNA]23603837
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of NOX1 mRNA25386960
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NOX1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of NOX1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of NOX1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of NOX1 mRNA26924002
C007517diphenyleneiodoniumdiphenyleneiodonium results in decreased activity of NOX1 protein16393473
C007517diphenyleneiodonium"[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
C007517diphenyleneiodonium"[diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22307971
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]24912985
C007517diphenyleneiodoniumdiphenyleneiodonium results in decreased activity of NOX1 protein15364949|2230797
D004317DoxorubicinDoxorubicin results in increased expression of NOX1 mRNA24072175
D004317Doxorubicinrhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24072175
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D004317Doxorubicincarvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D004317DoxorubicinDoxorubicin results in increased expression of NOX1 mRNA16213474|2407217
D004317Doxorubicinpyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D004317DoxorubicinQuercetin inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24902966
D004317DoxorubicinRazoxane inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D004317Doxorubicinrhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24072175
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NOX1 mRNA"23811387
D015777EicosanoidsEicosanoids analog inhibits the reaction [Cisplatin results in increased expression of NOX1 mRNA]23603837
D000431EthanolEthanol results in increased expression of NOX1 protein22872060
D000431Ethanol[sodium arsenite co-treated with Ethanol] results in increased expression of NOX1 protein22872060
D000431Ethanolsodium arsenite promotes the reaction [Ethanol results in increased expression of NOX1 protein]22872060
D000431Ethanolacetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]26522475
D000431EthanolEthanol results in increased expression of NOX1 protein26522475
C039281furanfuran results in increased expression of NOX1 mRNA27387713
C576694GKT137831GKT137831 results in decreased activity of NOX1 protein25617244
D005947GlucoseGlucose results in increased expression of and results in increased activity of NOX1 protein23731528
D005947GlucoseGlucose results in increased expression of NOX1 mRNA23731528
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of and results in increased activity of NOX1 protein]23731528
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of NOX1 mRNA]23731528
C041865glycylphenylalanine 2-naphthylamide"1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
C041865glycylphenylalanine 2-naphthylamideNOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]24912985
C041865glycylphenylalanine 2-naphthylamide"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
D006851Hydrochloric AcidNOX1 protein affects the susceptibility to Hydrochloric Acid21339339
D006852HydrochlorothiazideHydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1]21107329
D006861Hydrogen PeroxideNOX1 protein affects the reaction [Hydrogen Peroxide results in increased expression of ARPC2 protein]24152438
D003900Desoxycorticosterone[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein22431579
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NOX1 mRNA26752646
D007854LeadCelecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
D007854LeadLead results in increased expression of NOX1 mRNA25596430
D007854Leadrofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
D007854LeadSB 203580 inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of NOX1 mRNA"28987381
D008070LipopolysaccharidesCAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]24835767
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOX1 mRNA24835767|2666776
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOX1 protein24835767
D008070LipopolysaccharidesNOX1 protein affects the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]20715105
D008070LipopolysaccharidesNOX1 protein affects the reaction [Lipopolysaccharides affects the localization of RELA protein]20715105
D008070LipopolysaccharidesNOX1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]20715105
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]26667767
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]19293636
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of NOX1 protein19005069
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOX1 mRNA19293636
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOX1 protein24835767
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]19293636
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOX1 protein24973090
D008070LipopolysaccharidesSialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein]24973090
C545385MequindoxMequindox affects the expression of NOX1 mRNA21146578
C545385MequindoxMequindox results in increased expression of NOX1 mRNA20553828
D008627Mercuric ChlorideCelecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of NOX1 protein28987480
D008627Mercuric ChlorideMercuric Chloride results in increased expression of NOX1 mRNA21232032|2341568
D008627Mercuric Chloriderofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D008627Mercuric ChlorideSB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D008627Mercuric ChlorideU 0126 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NOX1 mRNA26011545
D008799Mevinphos[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]23824088
D008825MiconazoleMiconazole results in decreased expression of NOX1 mRNA22262564
C035133mirtazapinemirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein]28623179
D016686MonocrotalineMonocrotaline results in increased expression of NOX1 mRNA24947524
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NOX1 mRNA26924002
C024376NAADPNOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP]23940720
D009285NaphthoquinonesNaphthoquinones results in increased expression of NOX1 mRNA23811387
D000068577NebivololNebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein]16940222
C022838nickel chloridenickel chloride results in increased expression of NOX1 protein22648416
C007350nitrofennitrofen results in increased expression of NOX1 mRNA26534761
D005996NitroglycerinNitroglycerin results in decreased expression of NOX1 mRNA17493633
D019308Palmitic AcidPalmitic Acid results in increased expression of NOX1 mRNA24080574
D010269ParaquatParaquat results in increased expression of NOX1 mRNA29273418
D010269Paraquatpirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]29273418
D010269ParaquatParaquat results in increased expression of NOX1 mRNA23827392
D010269ParaquatParaquat results in increased expression of NOX1 protein23827392
D010269ParaquatPRKCD mutant form inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]23827392
D010269ParaquatPRKCD mutant form inhibits the reaction [Paraquat results in increased expression of NOX1 protein]23827392
D010269Paraquatrottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]23827392
D010269Paraquatrottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein]23827392
C073402PD 123319PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]25446015
C073402PD 123319PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]25446015
D010455PeptidesPeptides results in decreased expression of NOX1 protein28987480
C060836pioglitazonepioglitazone affects the activity of NOX1 protein21962020
C093844pirfenidonepirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]29273418
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]"24912985
D011794QuercetinQuercetin inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24902966
C004532quinonequinone results in increased expression of NOX1 protein25437431
C004532quinone[quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species25437431
D011929RazoxaneRazoxane inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]16213474
D017382Reactive Oxygen Species"[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
D017382Reactive Oxygen SpeciesNOX1 protein affects the abundance of Reactive Oxygen Species22307971
D017382Reactive Oxygen Species"NOX1 protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
D017382Reactive Oxygen Species[quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species25437431
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]26667767
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of and results in increased activity of NOX1 protein]23731528
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of NOX1 mRNA]23731528
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]19293636
C059514resveratrolresveratrol inhibits the reaction [Titanium results in increased expression of NOX1 mRNA]26878849
C059514resveratrolresveratrol results in decreased expression of NOX1 mRNA24322615
C059514resveratrolresveratrol results in decreased expression of NOX1 mRNA20081535
C059514resveratrolresveratrol results in decreased expression of NOX1 mRNA22857612
C009172rhodiolosiderhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24072175
C009172rhodiolosiderhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]24072175
C116926rofecoxibrofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
C116926rofecoxibrofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
C547390rossicaside Brossicaside B results in decreased activity of NOX1 protein16393473
D012402Rotenone[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA25446015
D012402Rotenone[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein25446015
D012402RotenoneCGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]25446015
D012402RotenoneCGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]25446015
D012402RotenonePD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]25446015
D012402RotenonePD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]25446015
D012402RotenoneRotenone results in increased expression of NOX1 mRNA25446015
D012402RotenoneRotenone results in increased expression of NOX1 protein25446015
C085746rottlerinrottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]23827392
C085746rottlerinrottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein]23827392
C093642SB 203580SB 203580 inhibits the reaction [Lead results in increased expression of NOX1 mRNA]25596430
C093642SB 203580SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NOX1 mRNA25895662
D012834SilverSilver results in increased expression of NOX1 mRNA19429238
C017947sodium arsenite[sodium arsenite co-treated with Ethanol] results in increased expression of NOX1 protein22872060
C017947sodium arsenitesodium arsenite promotes the reaction [Ethanol results in increased expression of NOX1 protein]22872060
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]27678262
D012965Sodium Chloride[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA27678262
D012965Sodium Chloride[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein22431579
D013481Superoxidesdiphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]24912985
D013481SuperoxidesNOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]23940720
D013481SuperoxidesNOX1 protein results in increased abundance of Superoxides24912985
D013481Superoxides[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]23824088
D013481SuperoxidesNOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]27816504
D016559TacrolimusTacrolimus results in increased expression of NOX1 mRNA17085464
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NOX1 mRNA21592394
D013853Thioacetamidemirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein]28623179
D013853ThioacetamideThioacetamide results in increased expression of NOX1 protein28623179
D014025Titaniumresveratrol inhibits the reaction [Titanium results in increased expression of NOX1 mRNA]26878849
D014025TitaniumTitanium results in increased expression of NOX1 mRNA26878849
D014028Tobacco Smoke PollutionNOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]27816504
C483909torcetrapibtorcetrapib results in increased expression of NOX1 mRNA25617244
C483909torcetrapibtorcetrapib results in increased expression of NOX1 protein25617244
C113580U 0126"U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]"22307971
C113580U 0126U 0126 results in decreased expression of NOX1 protein22307971
C113580U 0126U 0126 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]23415682
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NOX1 gene25560391
D024483Vitamin K 3Vitamin K 3 results in increased expression of NOX1 mRNA16507596
D024483Vitamin K 3Vitamin K 3 results in increased expression of NOX1 protein16507596
D015032ZincZinc deficiency results in decreased expression of NOX1 mRNA18356318
D015054ZymosanZymosan results in increased activity of NOX1 protein19005069

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005515protein binding-IPI16636067  
GO:0016175superoxide-generating NADPH oxidase activity-IC10485709  
GO:0016175superoxide-generating NADPH oxidase activity-IMP18023288  
GO:0016175superoxide-generating NADPH oxidase activity-TAS10485709  18347018  
GO:0046872metal ion binding-IEA-  
GO:0048365Rac GTPase binding-IPI16636067  
GO:0050661NADP binding-IC10485709  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IMP11805326  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IEA-  
GO:0006739NADP metabolic process-IC10485709  
GO:0006954inflammatory response-TAS18347018  
GO:0007165signal transduction-TAS17673675  
GO:0008217regulation of blood pressure-TAS18347018  
GO:0008284positive regulation of cell proliferation-IDA10485709  
GO:0010575positive regulation of vascular endothelial growth factor production-IEP11805326  
GO:0016477cell migration-IMP18023288  
GO:0030198extracellular matrix organization-IEA-  
GO:0034220ion transmembrane transport-IEA-  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0042554superoxide anion generation-IDA10485709  
GO:0042554superoxide anion generation-IMP18023288  
GO:0042743hydrogen peroxide metabolic process-IDA11331784  
GO:0045726positive regulation of integrin biosynthetic process-IMP18023288  
GO:0045730respiratory burst-TAS16636067  
GO:0046330positive regulation of JNK cascade-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-ISS10485709  
GO:0051454intracellular pH elevation-IDA10615049  
GO:0055114oxidation-reduction process-IDA10615049  
GO:0071455cellular response to hyperoxia-IEA-  
GO:0072592oxygen metabolic process-IEA-  
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1990451cellular stress response to acidic pH-IDA10615049  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA17673675  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0043020NADPH oxidase complex-IDA16636067  
GO:0071438invadopodium membrane-IDA19755710  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04380Osteoclast differentiation
hsa04670Leukocyte transendothelial migration
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5668599RHO GTPases Activate NADPH OxidasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24180474NADPH oxidases in vascular pathology. (2014 Jun 10)Konior AAntioxid Redox Signal
27816504NADPH oxidase (NOX) 1 mediates cigarette smoke-induced superoxide generation in rat vascular smooth muscle cells. (2017 Feb)Chang KHToxicol In Vitro
26677910Peroxisome Proliferator-Activated Receptor gamma Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. (2016 Jul)Yeligar SMAm J Respir Cell Mol Biol