Gene: PELP1

27043
MNAR|P160
proline, glutamate and leucine rich protein 1
protein-coding
17p13.2
Ensembl:ENSG00000141456 MIM:609455 Vega:OTTHUMG00000177831 UniprotKB:Q8IZL8
NC_000017.11
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.113e-1 (AD)  6.920e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7215300chr17:4705327 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7225717chr17:4704757 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4790689chr17:4701905 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4790688chr17:4701773 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4790687chr17:4701339 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12451741chr17:4700735 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs906453chr17:4691670 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKCSH0.897
TAF150.896
SUPT5H0.895
GPS20.887
DUS1L0.882
PAF10.881
SART10.88
CTTN0.879
RING10.878
EWSR10.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.748
OR4F5-0.724
MTRNR2L9-0.242
PABPC4L-0.236
TTLL10-0.218
MTRNR2L6-0.218
CCL26-0.2
MOGAT2-0.2
TTLL10-AS1-0.199
MTRNR2L10-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PELP1 mRNA"21346803
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to PELP1 protein modified form]"28751236
D000082AcetaminophenAcetaminophen affects the expression of PELP1 mRNA17562736
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [AR protein binds to SRC protein binds to PELP1 protein]15466214
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PELP1 mRNA21298039
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to PELP1 protein]23665804
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PELP1 protein modified form]28751236
C006780bisphenol Abisphenol A results in increased expression of PELP1 mRNA25181051
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]28751236
C000944dicrotophosdicrotophos results in increased expression of PELP1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of PELP1 mRNA20438755
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of PELP1 mRNA24680724
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PELP1 mRNA25613284
D008731MethoxychlorMethoxychlor results in decreased expression of PELP1 mRNA21276474
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PELP1 mRNA"20188158
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]28751236
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PELP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PELP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PELP1 mRNA"25554681
C059514resveratrolresveratrol results in increased expression of PELP1 protein17804729
D012969Sodium FluorideSodium Fluoride results in increased expression of PELP1 mRNA27862939
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to PELP1 protein]23665804
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of PELP1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PELP1 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PELP1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of PELP1 mRNA27188386
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PELP1 gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of PELP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PELP1 gene25560391
C025643vinclozolinvinclozolin affects the expression of PELP1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA17505058  
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI16169070  20195357  20448663  21326211  
GO:0008134transcription factor binding-IPI17505058  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006364rRNA processing-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17505058  
GO:0071391cellular response to estrogen stimulus-IDA17505058  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0035327transcriptionally active chromatin-IDA17505058  
GO:0071339MLL1 complex-IDA15960975  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849473PTK6 ExpressionTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal