Gene: GJB2

2706
CX26|DFNA3|DFNA3A|DFNB1|DFNB1A|HID|KID|NSRD1|PPK
gap junction protein beta 2
protein-coding
13q12.11
Ensembl:ENSG00000165474 MIM:121011 Vega:OTTHUMG00000016513 UniprotKB:P29033
NG_008358.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.325e-1 (AD)  3.953e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMTM60.685
GNG120.674
DDR20.674
FSTL10.674
RREB10.669
RNF1350.667
INHBB0.665
SPTLC30.661
EPS80.659
VIM0.654

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEFF2-0.554
BCL11A-0.54
CNIH3-0.538
CLSTN2-0.532
ADTRP-0.528
CRTAC1-0.515
KCNB2-0.515
HAS1-0.513
VSTM5-0.513
FADS6-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GJB2 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GJB2 mRNA]"27071940
C0389831,3-dimethylthiourea"1,3-dimethylthiourea results in increased expression of GJB2 mRNA"8631141
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of GJB2 mRNA"19114083
C0010422',3-dimethyl-4-aminobiphenyl"2',3-dimethyl-4-aminobiphenyl results in increased expression of GJB2 mRNA"7955049
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GJB2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GJB2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of GJB2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of GJB2 protein26912412
D000082AcetaminophenAcetaminophen results in increased expression of GJB2 mRNA26912412
C099158acetyl-aspartyl-glutamyl-valyl-aspartalacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
C420218acetyl-leucyl-glutamyl-histidyl-aspartalacetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GJB2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GJB2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GJB2 mRNA19770486
D000447AldehydesAldehydes results in increased expression of GJB2 mRNA25014914
C015001arsenitearsenite results in increased methylation of GJB2 promoter23974009
D001280AtrazineAtrazine results in increased expression of GJB2 mRNA22153302
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJB2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GJB2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GJB2 mRNA21839799
D001585Benzoyl Peroxide"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] affects the expression of GJB2 protein"7586191
D001585Benzoyl PeroxideBenzoyl Peroxide results in increased expression of GJB2 mRNA8597533
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GJB2 mRNA20660070
D004958EstradiolEstradiol affects the expression of GJB2 mRNA15598610
D004958EstradiolEstradiol results in increased expression of GJB2 mRNA12370124|1528915
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of GJB2 mRNA26945725
D004958EstradiolEstradiol results in increased expression of GJB2 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of GJB2 mRNA22687993|2606340
C006780bisphenol Abisphenol A affects the expression of GJB2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GJB2 mRNA22079614
D020122tert-ButylhydroperoxideGJB2 protein results in decreased susceptibility to tert-Butylhydroperoxide18235030
C018475butyraldehydebutyraldehyde results in increased expression of GJB2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of GJB2 mRNA26191083
C037123cadmium sulfatecadmium sulfate results in decreased expression of GJB2 mRNA19274763
D002220CarbamazepineCarbamazepine affects the expression of GJB2 mRNA25979313
D002697Chloral HydrateChloral Hydrate results in decreased expression of GJB2 mRNA21243523
D002697Chloral HydrateChloral Hydrate results in increased expression of GJB2 protein21243523
C100187chloropicrinchloropicrin affects the expression of GJB2 mRNA26352163
C100187chloropicrinchloropicrin results in decreased expression of GJB2 mRNA28476498
D002738ChloroquineChloroquine results in decreased expression of GJB2 mRNA19393257
C013883chrysarobinchrysarobin results in increased expression of GJB2 mRNA8597533
D003042CocaineCocaine results in decreased expression of GJB2 mRNA12629581
C030123coumarincoumarin results in increased expression of GJB2 mRNA18480146
D016578Crack CocaineCrack Cocaine results in increased expression of GJB2 mRNA12629581
D003471CuprizoneCuprizone results in increased expression of GJB2 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of GJB2 mRNA20106945
D003634DDTDDT results in decreased expression of GJB2 mRNA27894940
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GJB2 mRNA21266533
D002945Cisplatinacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
D002945Cisplatinacetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
D002945Cisplatin[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]23747833
D002945Cisplatin[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]23747833
D002945Cisplatinoleylamide inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
D002945Cisplatinoleylamide inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
D002945CisplatinTretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
D002945CisplatinTretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of GJB2 mRNA23625948
D002945CisplatinCisplatin results in decreased expression of GJB2 mRNA22023808
D002945Cisplatin[GJB2 protein co-treated with GJB1 protein] results in increased susceptibility to Cisplatin23747833
D002945Cisplatinoleylamide inhibits the reaction [[GJB2 protein co-treated with GJB1 protein] results in increased susceptibility to Cisplatin]23747833
D002945CisplatinTretinoin promotes the reaction [[GJB2 protein co-treated with GJB1 protein] results in increased susceptibility to Cisplatin]23747833
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of GJB2 mRNA27894940
D004026DieldrinDieldrin results in decreased expression of GJB2 protein8068183
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of GJB2 mRNA25031359
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GJB2 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GJB2 protein25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GJB2 mRNA12370124|1528915
D002117CalcitriolCalcitriol results in decreased expression of GJB2 mRNA26485663
D002117CalcitriolCalcitriol results in increased expression of GJB2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GJB2 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] affects the expression of GJB2 protein"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of GJB2 protein"7586191
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GJB2 mRNA"7586191
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GJB2 mRNA8631141
C118739entinostatentinostat results in increased expression of GJB2 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GJB2 mRNA15576828|1755790
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GJB2 gene16724327
D015025ZearalenoneZearalenone results in increased expression of GJB2 mRNA17557909
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GJB2 mRNA22213190
D005485FlutamideFlutamide results in decreased expression of GJB2 mRNA24793618
D005485FlutamideFlutamide results in increased expression of GJB2 mRNA24136188
D004397FonofosFonofos results in increased methylation of GJB2 promoter22847954
D019833GenisteinGenistein results in increased expression of GJB2 mRNA12370124|1528915
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of GJB2 mRNA25031359
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of GJB2 protein8068183
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of GJB2 mRNA12117784
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of GJB2 protein12117784
D017313FenretinideFenretinide results in increased expression of GJB2 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of GJB2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GJB2 mRNA25613284
D019266Iron, Dietary"Iron, Dietary affects the expression of GJB2 mRNA"15637178
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GJB2 mRNA22904298
C017461lead nitratelead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]11891201
C008281limonenelimonene results in increased expression of GJB2 mRNA12815608
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GJB2 mRNA25613284
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GJB2 mRNA18409822
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GJB2 protein18409822
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of GJB2 mRNA15120970
D009151Mustard GasMustard Gas results in decreased expression of GJB2 mRNA25102026
D009151Mustard GasMustard Gas results in increased expression of GJB2 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GJB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GJB2 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of GJB2 mRNA24136188
C010723N-ethyl-N-(4-hydroxybutyl)nitrosamineN-ethyl-N-(4-hydroxybutyl)nitrosamine results in increased expression of GJB2 mRNA7955049
C570897NSC668394NSC668394 results in increased expression of GJB2 mRNA27137931
C025589ochratoxin Aochratoxin A results in decreased expression of GJB2 mRNA16857307
D019319Okadaic AcidOkadaic Acid results in increased expression of GJB2 mRNA8597533
C029407oleylamideoleylamide inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
C029407oleylamideoleylamide inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
C029407oleylamideoleylamide inhibits the reaction [[GJB2 protein co-treated with GJB1 protein] results in increased susceptibility to Cisplatin]23747833
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GJB2 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of GJB2 mRNA18754875
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
C016030pantogabpantogab results in increased expression of GJB2 mRNA17379144
D010278ParathionParathion results in increased methylation of GJB2 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of GJB2 mRNA22178795
C046012pentanalpentanal results in increased expression of GJB2 mRNA26079696
D010634PhenobarbitalGJB2 protein results in increased susceptibility to Phenobarbital18308698
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GJB2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GJB2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GJB2 protein17624652
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of GJB2 mRNA26945725
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GJB2 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of GJB2 protein21558462
D011374ProgesteroneProgesterone affects the expression of GJB2 mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of GJB2 mRNA22238285
C045950propiconazolepropiconazole results in increased expression of GJB2 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of GJB2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of GJB2 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of GJB2 mRNA12370124
C059514resveratrolresveratrol results in increased expression of GJB2 mRNA25888808
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of GJB2 mRNA17540011
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GJB2 mRNA25895662
D019821SimvastatinSimvastatin results in increased expression of GJB2 mRNA17428261
C017947sodium arsenitesodium arsenite results in increased expression of GJB2 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of GJB2 mRNA14691202
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of GJB2 mRNA12815608
D013629TamoxifenTamoxifen results in increased expression of GJB2 mRNA12370124
C012568terbufosterbufos results in increased methylation of GJB2 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GJB2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of GJB2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GJB2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GJB2 mRNA15591033|1879615
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of GJB2 protein"7586191
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GJB2 mRNA"7586191
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GJB2 mRNA7586191|8597533
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GJB2 protein7586191
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GJB2 mRNA25613284
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of GJB2 protein8068183
C009495titanium dioxidetitanium dioxide affects the expression of GJB2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GJB2 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GJB2 mRNA25729387
D014212TretinoinTretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]23747833
D014212TretinoinTretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]23747833
D014212TretinoinTretinoin results in increased expression of GJB2 mRNA16029656|2193413
D014212TretinoinTretinoin promotes the reaction [[GJB2 protein co-treated with GJB1 protein] results in increased susceptibility to Cisplatin]23747833
C012589trichostatin Atrichostatin A results in increased expression of GJB2 mRNA24935251
D014520UrethaneUrethane results in decreased expression of GJB2 mRNA16926031
D014520UrethaneUrethane results in decreased expression of GJB2 protein16926031
C406224valdecoxibvaldecoxib results in increased expression of GJB2 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GJB2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GJB2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GJB2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of GJB2 mRNA17292431
D014640VancomycinVancomycin results in increased expression of GJB2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GJB2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of GJB2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of GJB2 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of GJB2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042802identical protein binding-IPI17551008  19340074  
GO ID GO Term Qualifier Evidence PubMed
GO:0007267cell-cell signaling-TAS1324944  
GO:0007605sensory perception of sound-IEA-  
GO:0016264gap junction assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005922connexin complex-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157858Gap junction trafficking and regulationIEA
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-190704Oligomerization of connexins into connexonsIEA
R-HSA-190827Transport of connexins along the secretory pathwayIEA
R-HSA-190828Gap junction traffickingIEA
R-HSA-190828Gap junction traffickingTAS
R-HSA-190861Gap junction assemblyIEA
R-HSA-190861Gap junction assemblyTAS
R-HSA-190872Transport of connexons to the plasma membraneTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci