Gene: NSG1

27065
D4S234|D4S234E|NEEP21|P21
neuronal vesicle trafficking associated 1
protein-coding
4p16.3
Ensembl:ENSG00000168824 MIM:607645 Vega:OTTHUMG00000160002 UniprotKB:P42857
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.054e-4 (AD)  4.339e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3792686chr4:4391341 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAM0.937
INPP5F0.936
EID20.934
BTBD100.929
NECAP10.928
CISD10.925
GABARAPL10.924
ATP1A10.923
FAM49B0.923
PARM10.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.471
HEY2-0.463
RAI14-0.459
YES1-0.433
REST-0.419
OR4F29-0.418
MYOM1-0.412
MTRNR2L6-0.402
CTNNA3-0.399
MBNL3-0.397

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NSG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NSG1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NSG1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NSG1 gene27153756
D000447AldehydesAldehydes results in increased expression of NSG1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NSG1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NSG1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of NSG1 mRNA25929836
D001554BenzeneBenzene results in increased expression of NSG1 mRNA12928149
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NSG1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NSG1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NSG1 mRNA22610609
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of NSG1 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of NSG1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of NSG1 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NSG1 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of NSG1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of NSG1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NSG1 gene20938992
D013759DronabinolDronabinol results in decreased expression of NSG1 mRNA12237329
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NSG1 promoter23359474
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NSG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NSG1 mRNA27392435
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NSG1 promoter23359474
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of NSG1 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NSG1 mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NSG1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of NSG1 mRNA28937961
C069837fullerene C60fullerene C60 results in decreased expression of NSG1 mRNA19167457
C039281furanfuran results in decreased methylation of NSG1 gene27387713
C039281furanfuran results in increased expression of NSG1 mRNA27387713
C016527isoquercitrinisoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]25129099
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NSG1 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of NSG1 mRNA11578147
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NSG1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of NSG1 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NSG1 mRNA28001369
D009151Mustard GasMustard Gas results in increased expression of NSG1 mRNA15674844
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NSG1 mRNA19074003
D016627Oxidopamineisoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]25129099
D016627OxidopamineOxidopamine results in decreased expression of NSG1 mRNA25129099
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]25129099
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NSG1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of NSG1 mRNA25729387
C046012pentanalpentanal results in increased expression of NSG1 mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of NSG1 mRNA12832660
D010795Phthalic AcidsPhthalic Acids results in increased expression of NSG1 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of NSG1 mRNA12832660
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of NSG1 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of NSG1 mRNA26079696
D012431RutinRutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]25129099
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NSG1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NSG1 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of NSG1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of NSG1 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NSG1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NSG1 mRNA25729387
D014192TrapidilTrapidil affects the reaction [PTH protein affects the expression of NSG1 mRNA]18635661
D014212TretinoinTretinoin results in decreased expression of NSG1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of NSG1 mRNA24935251
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of NSG1 mRNA28934090
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NSG1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NSG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NSG1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NSG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0032051clathrin light chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001881receptor recycling-ISS-  
GO:0001921positive regulation of receptor recycling-IEA-  
GO:0006915apoptotic process-IMP20599942  
GO:0007212dopamine receptor signaling pathway-IEA-  
GO:0016197endosomal transport-IBA21873635  
GO:0042982amyloid precursor protein metabolic process-ISS-  
GO:0048268clathrin coat assembly-IBA21873635  
GO:0098814spontaneous synaptic transmission-ISS-  
GO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane-IEA-  
GO:0099627neurotransmitter receptor cycle-ISS-  
GO:0099630postsynaptic neurotransmitter receptor cycle-ISS-  
GO:1900271regulation of long-term synaptic potentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9013775  
GO:0005737cytoplasm-TAS9013775  
GO:0005768endosome-IBA21873635  
GO:0005768endosome-ISS-  
GO:0005770late endosome-ISS-  
GO:0005783endoplasmic reticulum-IDA20599942  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016328lateral plasma membrane-IEA-  
GO:0030425dendrite-ISS-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031901early endosome membrane-ISS-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0032585multivesicular body membrane-IEA-  
GO:0032588trans-Golgi network membrane-ISS-  
GO:0036477somatodendritic compartment-ISS-  
GO:0043202lysosomal lumen-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0055038recycling endosome membrane-ISS-  
GO:0098845postsynaptic endosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17295719Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. (2007 Mar)Wang JAlcohol Clin Exp Res