Gene: FOXP1

27086
12CC4|HSPC215|MFH|QRF1|hFKH1B
forkhead box P1
protein-coding
3p13
Ensembl:ENSG00000114861 MIM:605515 Vega:OTTHUMG00000158803 UniprotKB:Q9H334
NG_028243.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.437e-1 (AD)  3.362e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WASF10.852
LGALS80.849
PPP3CA0.848
BRAF0.846
LMO70.843
PDP10.841
KIAA07530.841
PPP3R10.841
SORBS20.841
PDE1B0.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.44
OR4F29-0.427
MYL3-0.397
AQP5-0.397
ZNF114-0.393
S100A14-0.385
S100A1-0.383
MAPKAPK3-0.377
MBNL3-0.376
PHEX-0.375

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of FOXP1 mRNA"23829299
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FOXP1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of FOXP1 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FOXP1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXP1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA19191707
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of FOXP1 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FOXP1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FOXP1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of FOXP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FOXP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOXP1 mRNA19770486
C430898AGN 194204AGN 194204 results in increased expression of FOXP1 mRNA16339527
D001151ArsenicArsenic affects the methylation of FOXP1 gene25304211
D001151ArsenicArsenic results in increased methylation of FOXP1 promoter21291286
D001280AtrazineAtrazine results in increased expression of FOXP1 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of FOXP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXP1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXP1 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXP1 mRNA"20382639
D004958EstradiolEstradiol affects the expression of FOXP1 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of FOXP1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of FOXP1 gene22576693|2566393
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FOXP1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of FOXP1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of FOXP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FOXP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXP1 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FOXP1 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXP1 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FOXP1 mRNA23650126
D019327Copper SulfateCopper Sulfate results in increased expression of FOXP1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of FOXP1 mRNA25562108
D016572CyclosporineCyclosporine inhibits the reaction [Ionomycin promotes the reaction [FOXP1 protein binds to RCAN1 promoter]]21606195
D016572CyclosporineFOXP1 protein promotes the reaction [Cyclosporine inhibits the reaction [Ionomycin promotes the reaction [NFATC4 protein results in increased expression of RCAN1 mRNA]]]21606195
D013759DronabinolDronabinol results in decreased expression of FOXP1 mRNA21955143
D003703DemecolcineDemecolcine results in increased expression of FOXP1 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of FOXP1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FOXP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXP1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of FOXP1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FOXP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FOXP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FOXP1 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of FOXP1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of FOXP1 mRNA]19850644
D004237DiuronDiuron results in decreased expression of FOXP1 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FOXP1 mRNA22079256
D000431EthanolEthanol results in decreased expression of FOXP1 mRNA21955143
D005557FormaldehydeFormaldehyde results in increased expression of FOXP1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of FOXP1 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXP1 mRNA24763279
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of FOXP1 mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FOXP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOXP1 mRNA25613284
D015759IonomycinCyclosporine inhibits the reaction [Ionomycin promotes the reaction [FOXP1 protein binds to RCAN1 promoter]]21606195
D015759IonomycinFOXP1 protein inhibits the reaction [Ionomycin promotes the reaction [NFATC4 protein results in increased expression of RCAN1 mRNA]]21606195
D015759IonomycinFOXP1 protein promotes the reaction [Cyclosporine inhibits the reaction [Ionomycin promotes the reaction [NFATC4 protein results in increased expression of RCAN1 mRNA]]]21606195
D015759IonomycinIonomycin promotes the reaction [FOXP1 protein binds to NFATC4 protein]21606195
D015759IonomycinIonomycin promotes the reaction [FOXP1 protein binds to RCAN1 promoter]21606195
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FOXP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOXP1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FOXP1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of FOXP1 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FOXP1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FOXP1 mRNA26378955
D008731MethoxychlorMethoxychlor affects the expression of FOXP1 mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOXP1 mRNA28001369
D009020MorphineMorphine results in increased expression of FOXP1 mRNA21955143
C523799MRK 003FOXP1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXP1 mRNA"25554681
C000621033napabucasinnapabucasin results in decreased expression of FOXP1 mRNA25605917
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of FOXP1 mRNA19812364
D009538NicotineNicotine results in decreased expression of FOXP1 mRNA21955143
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FOXP1 mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of FOXP1 mRNA17987463
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FOXP1 mRNA"25510870
C410127PCB 180PCB 180 results in decreased expression of FOXP1 mRNA23829299
D010634PhenobarbitalPhenobarbital results in decreased expression of FOXP1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FOXP1 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased expression of FOXP1 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FOXP1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FOXP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of FOXP1 mRNA17426115
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of FOXP1 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FOXP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FOXP1 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of FOXP1 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of FOXP1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of FOXP1 mRNA21632981
D012293RifampinRifampin results in increased expression of FOXP1 mRNA24552687
D012834SilverSilver results in increased expression of FOXP1 mRNA26014281
D012834SilverSilver results in decreased expression of FOXP1 mRNA27131904
D020123SirolimusSirolimus results in decreased expression of FOXP1 protein25663935
D012906SmokeSmoke results in decreased expression of FOXP1 mRNA21095227
D018038Sodium SeleniteSodium Selenite results in increased expression of FOXP1 mRNA18175754
C040109stanolone benzoatestanolone benzoate affects the expression of FOXP1 mRNA25247470
C040109stanolone benzoatestanolone benzoate affects the expression of FOXP1 protein25247470
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FOXP1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FOXP1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXP1 mRNA24058054|2629044
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOXP1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of FOXP1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FOXP1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FOXP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FOXP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of FOXP1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of FOXP1 mRNA20488242
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FOXP1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FOXP1 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of FOXP1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of FOXP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FOXP1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of FOXP1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in decreased expression of FOXP1 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of FOXP1 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FOXP1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FOXP1 mRNA23034163
D014750VincristineVincristine results in increased expression of FOXP1 mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of FOXP1 mRNA20044591
C009687wortmanninwortmannin results in decreased expression of FOXP1 protein25663935

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI18347093  18640093  19907493  24893771  25027557  25609649  
26647308  
GO:0042802identical protein binding-IPI25609649  26647308  
GO:0043565sequence-specific DNA binding-IEA-  
GO:0043621protein self-association-IMP26647308  
GO:0046872metal ion binding-IEA-  
GO:0050681androgen receptor binding-IDA18640093  
GO ID GO Term Qualifier Evidence PubMed
GO:0002903negative regulation of B cell apoptotic process-IDA25267198  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0010595positive regulation of endothelial cell migration-IMP24023716  
GO:0030316osteoclast differentiation-IDA18799727  
GO:0032496response to lipopolysaccharide-IDA18799727  
GO:0032680regulation of tumor necrosis factor production-IDA18799727  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0035926chemokine (C-C motif) ligand 2 secretion-IDA18799727  
GO:0036035osteoclast development-IDA18799727  
GO:0042116macrophage activation-IDA18799727  
GO:0042117monocyte activation-IDA18799727  
GO:0042118endothelial cell activation-IMP24023716  
GO:0045655regulation of monocyte differentiation-IDA15286807  
GO:0045892negative regulation of transcription, DNA-templated-IDA20950788  
GO:0045892negative regulation of transcription, DNA-templated-IMP26647308  
GO:0048661positive regulation of smooth muscle cell proliferation-IMP24023716  
GO:0050706regulation of interleukin-1 beta secretion-IDA18799727  
GO:0050727regulation of inflammatory response-IDA18799727  
GO:0060766negative regulation of androgen receptor signaling pathway-IDA18640093  
GO:0061470T follicular helper cell differentiation-ISS-  
GO:0072619interleukin-21 secretion-ISS-  
GO:1900424regulation of defense response to bacterium-IDA18799727  
GO:1901256regulation of macrophage colony-stimulating factor production-IDA18799727  
GO:1901509regulation of endothelial tube morphogenesis-IMP24023716  
GO:2001182regulation of interleukin-12 secretion-IDA18799727  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25027557  26647308  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26377193A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus. (2015 Nov)Dai JYCancer Epidemiol Biomarkers Prev
23590301Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. (2013 Aug)Bahr TMAm J Respir Cell Mol Biol