Gene: GK

2710
GK1|GKD
glycerol kinase
protein-coding
Xp21.2
Ensembl:ENSG00000198814 MIM:300474 Vega:OTTHUMG00000021328 UniprotKB:P32189
NG_008178.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP150.82
DIS30.807
EDEM10.796
SEC23IP0.791
SLC30A70.788
PTPN20.787
MTF20.785
IREB20.782
ZMYM60.782
PHTF20.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.37
OR4F29-0.34
OLIG1-0.281
NR0B1-0.278
HIGD1B-0.277
MTRNR2L6-0.277
WSCD1-0.263
LYPD1-0.261
MTRNR2L10-0.258
MUSTN1-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0638951-butyrylglycerol1-butyrylglycerol promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
C0638951-butyrylglycerolGK protein results in increased metabolism of 1-butyrylglycerol9606984
C0436582,3-dihydroxypropyl dichloroacetate"2,3-dihydroxypropyl dichloroacetate results in decreased activity of GK protein"6091865
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GK mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GK mRNA"29216392
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GK mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GK mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GK mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GK mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of GK protein16538041
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]25449180
D000393Air PollutantsAir Pollutants analog results in decreased expression of GK mRNA21757418
C000188alachloralachlor affects the expression of GK mRNA19425180
C029620alpha-glycerophosphoric acid1-butyrylglycerol promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
C029620alpha-glycerophosphoric acid[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid9606984
C029620alpha-glycerophosphoric acidmonoacetin promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GK mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GK mRNA"25757056
C547126AZM551248AZM551248 results in increased expression of GK mRNA22323515
D001554BenzeneBenzene results in increased expression of GK mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GK mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GK mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GK mRNA"20382639
D004958EstradiolEstradiol affects the expression of GK mRNA22574217
D004958EstradiolEstradiol results in increased expression of GK mRNA18709148
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GK mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of GK mRNA15912405
C006780bisphenol Abisphenol A results in increased expression of GK mRNA29275510
C006780bisphenol Abisphenol A affects the expression of GK mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GK mRNA22079614
D002104CadmiumCadmium results in decreased expression of GK mRNA24376830
D000074262Canola OilCanola Oil metabolite results in decreased expression of GK mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GK mRNA12734012
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GK gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GK mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of GK mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of GK mRNA18353800
D003010ClorgylineClorgyline results in increased expression of GK mRNA19691856
C018021cobaltous chloridecobaltous chloride results in decreased expression of GK mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of GK mRNA19549813
C030123coumarincoumarin results in decreased expression of GK mRNA18480146
D016572CyclosporineCyclosporine affects the expression of GK mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of GK mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of GK mRNA19770486
C014347decitabinedecitabine results in decreased expression of GK mRNA19194470
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of GK mRNA18709148
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GK mRNA28628672
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of GK mRNA23428407
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GK mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GK mRNA27392435
D002945CisplatinCisplatin results in increased expression of GK mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of GK mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of GK mRNA16357043
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GK mRNA24535843
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of GK mRNA25380136
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased activity of GK protein"12736183
D004280DobutamineDobutamine results in increased activity of GK protein12736183
D011345FenofibrateFenofibrate results in increased expression of GK mRNA25572481
D018120FinasterideFinasteride results in increased expression of GK mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of GK mRNA18035473
D005485FlutamideFlutamide results in decreased expression of GK mRNA21126777
D005485FlutamideFlutamide results in decreased expression of GK mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GK gene20938992
D005897GlafenineGlafenine results in decreased expression of GK mRNA24136188
D005990Glycerol1-butyrylglycerol promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
D005990Glycerol[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid9606984
D005990Glycerolmonoacetin promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of GK mRNA24680724
D017313FenretinideFenretinide results in increased expression of GK mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GK mRNA28628672
D007213IndomethacinIndomethacin affects the expression of GK mRNA17546600
C051890irinotecanirinotecan analog results in decreased expression of GK mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GK mRNA28628672
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of GK mRNA23428407
D007545IsoproterenolIsoproterenol results in increased activity of GK protein12736183
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GK mRNA27392435
C410337K 7174K 7174 results in increased expression of GK mRNA24086573
C008261lead acetatelead acetate results in increased expression of GK mRNA11578147
D008294MalathionAcetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]25449180
D008294MalathionMalathion results in increased activity of GK protein25449180
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GK gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GK mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GK mRNA23649840
C038923monoacetinGK protein results in increased metabolism of monoacetin9606984
C038923monoacetinmonoacetin promotes the reaction [[GK protein results in increased metabolism of Glycerol] which results in increased chemical synthesis of alpha-glycerophosphoric acid]9606984
C500085muraglitazarmuraglitazar results in increased expression of GK mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GK mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GK mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of GK mRNA25380136
C012655nimesulidenimesulide results in decreased expression of GK mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GK protein19716841
D009638NorepinephrineNorepinephrine results in increased activity of GK protein12736183
D009638NorepinephrineNorepinephrine results in increased expression of GK mRNA12736183
C464660obeticholic acidobeticholic acid results in decreased expression of GK mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of GK mRNA12700408
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of GK mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of GK mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GK mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GK mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GK mRNA21723365
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GK mRNA21723365|2356731
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GK mRNA21723365|2851185
D010634PhenobarbitalPhenobarbital affects the expression of GK mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GK mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of GK mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of GK mRNA16357043|1830175
C006253pirinixic acidpirinixic acid results in increased expression of GK mRNA16940010
D010936Plant ExtractsPlant Extracts results in increased expression of GK mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of GK mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of GK mRNA18070364
D011372ProgestinsProgestins results in increased expression of GK mRNA19609016
D011433PropranololPropranolol results in decreased activity of GK protein12736183
D015474IsotretinoinIsotretinoin results in decreased expression of GK mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of GK mRNA17245590
C089730rosiglitazonerosiglitazone results in increased expression of GK mRNA19211718|2151530
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GK mRNA25351596
C016104sodium bichromatesodium bichromate results in decreased expression of GK mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of GK protein28918527
D013311StreptozocinStreptozocin results in decreased expression of GK mRNA25905778
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of GK mRNA16214533
C025462sulindac sulfidesulindac sulfide results in increased expression of GK mRNA16184548
C501413tesaglitazartesaglitazar results in increased expression of GK mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GK mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GK mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GK mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GK gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GK mRNA16611356|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GK mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GK mRNA21215274
C011559tributyltintributyltin results in increased expression of GK mRNA23322813
D014241TrichloroethyleneTrichloroethylene results in increased expression of GK mRNA19448997
C012589trichostatin Atrichostatin A affects the expression of GK mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GK mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of GK mRNA21515302
D014520UrethaneUrethane results in decreased expression of GK mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GK mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of GK mRNA23179753|2627250
D014640VancomycinVancomycin results in increased expression of GK mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GK gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GK mRNA26682919
D015032ZincZinc deficiency results in increased expression of GK mRNA12672911|1567121
C088658zoledronic acidzoledronic acid results in increased expression of GK mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004370glycerol kinase activity-IBA21873635  
GO:0004370glycerol kinase activity-IMP8651297  
GO:0004370glycerol kinase activity-NAS8401584  
GO:0004370glycerol kinase activity-TAS-  
GO:0005515protein binding-IPI21988832  
GO:0005524ATP binding-IEA-  
GO:0016773phosphotransferase activity, alcohol group as acceptor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006071glycerol metabolic process-IBA21873635  
GO:0006071glycerol metabolic process-IMP8499898  
GO:0006641triglyceride metabolic process-IBA21873635  
GO:0006641triglyceride metabolic process-IMP8651297  
GO:0016310phosphorylation-IBA21873635  
GO:0016310phosphorylation-IEA-  
GO:0019432triglyceride biosynthetic process-TAS-  
GO:0019563glycerol catabolic process-IEA-  
GO:0046167glycerol-3-phosphate biosynthetic process-IBA21873635  
GO:0046167glycerol-3-phosphate biosynthetic process-IMP8651297  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75109Triglyceride biosynthesisTAS
R-HSA-8979227Triglyceride metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19179283Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. (2009 Feb 10)Carneiro AMProc Natl Acad Sci U S A