Gene: PDE7B

27115
bA472E5.1
phosphodiesterase 7B
protein-coding
6q23.3
Ensembl:ENSG00000171408 MIM:604645 Vega:OTTHUMG00000015641 UniprotKB:Q9NP56
NG_011994.1
SNP Mapped
2   ANCO-SNPs
AD
0   
6.634e-1 (AD)  8.932e-1 (ND)   (Frontal_Cortex)
1.385e-1 (AD)  4.158e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7765567chr6:136075736 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6921041chr6:136049520 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AUTS20.674
SESN30.669
THSD7A0.665
FAM210B0.65
CMYA50.645
DOCK40.643
RFX30.64
MYO1B0.636
CTNND10.635
SNRK0.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.459
OR4F29-0.416
IP6K3-0.35
NPFFR2-0.343
FIBCD1-0.331
NXPH4-0.328
LRP2-0.327
C7orf61-0.323
SLC5A11-0.322
LCE3C-0.32

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00651DyphyllineSmall Molecule479-18-5ApprovedTarget
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDE7B mRNA"23196670
D000082AcetaminophenAcetaminophen results in decreased expression of PDE7B mRNA29067470
D000242Cyclic AMP1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504|1087282
D000242Cyclic AMPDipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504|1087282
D000242Cyclic AMPE 4021 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
D000242Cyclic AMPPDE7B protein results in increased hydrolysis of Cyclic AMP10814504|1087282
D000242Cyclic AMPSCH 51866 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
D000242Cyclic AMPvinpocetine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
D000242Cyclic AMP1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442|1087282
D000242Cyclic AMPDipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442|1087282
D000242Cyclic AMPPapaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442
D000242Cyclic AMPPDE7B protein results in increased hydrolysis of Cyclic AMP10618442|1087282
D000242Cyclic AMPSCH 51866 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442
D000638AmiodaroneAmiodarone results in increased expression of PDE7B mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDE7B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PDE7B mRNA24449571
D001151ArsenicArsenic affects the methylation of PDE7B gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDE7B mRNA26705709
C487081belinostatbelinostat results in increased expression of PDE7B mRNA27188386
D001554BenzeneBenzene results in decreased expression of PDE7B mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE7B mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE7B mRNA"20382639
D004958EstradiolEstradiol results in increased expression of PDE7B mRNA25878060
C006780bisphenol Abisphenol A results in decreased expression of PDE7B mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PDE7B mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PDE7B mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PDE7B promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDE7B mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of PDE7B mRNA23125180
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDE7B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PDE7B mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of PDE7B mRNA25016146
D004176DipyridamoleDipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504|1087282
D004176DipyridamoleDipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442|1087282
C091517E 4021E 4021 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDE7B mRNA22079256
C024565ethylene dichlorideethylene dichloride results in decreased expression of PDE7B mRNA28189721
D017313FenretinideFenretinide results in increased expression of PDE7B mRNA28973697
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504|1087282
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442|1087282
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDE7B mRNA27392435
D007854LeadLead results in increased expression of PDE7B mRNA19921347
D008727MethotrexateMethotrexate results in increased expression of PDE7B mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDE7B mRNA"26251327
D009532NickelNickel results in decreased expression of PDE7B mRNA25583101
D010208PapaverinePapaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE7B mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PDE7B mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of PDE7B mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of PDE7B mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDE7B mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDE7B mRNA22079256
C045950propiconazolepropiconazole results in decreased expression of PDE7B mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of PDE7B mRNA24780913
C096501SCH 51866SCH 51866 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
C096501SCH 51866SCH 51866 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10618442
D012834SilverSilver results in increased expression of PDE7B mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of PDE7B mRNA29319823
C004648testosterone enanthatePDE7B protein results in increased hydrolysis of testosterone enanthate21383644
C004648testosterone enanthatePDE7B protein results in increased metabolism of testosterone enanthate21383644
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDE7B mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDE7B mRNA15034205
C012589trichostatin Atrichostatin A results in decreased expression of PDE7B mRNA27188386
C057693troglitazonetroglitazone results in decreased expression of PDE7B mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of PDE7B mRNA24383497
D014635Valproic AcidValproic Acid affects the expression of PDE7B mRNA17963808
D014638VanadatesVanadates results in increased expression of PDE7B mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PDE7B gene25560391
C013983vinpocetinevinpocetine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]10814504
C029297vinylidene chloridevinylidene chloride results in decreased expression of PDE7B mRNA26682919
D019287Zinc SulfateZinc Sulfate results in decreased expression of PDE7B mRNA27215404
C088658zoledronic acidzoledronic acid results in decreased expression of PDE7B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006198cAMP catabolic process-IEA-  
GO:0007165signal transduction-TAS10814504  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007268chemical synaptic transmission-TAS10814504  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal