Gene: DKK4

27121
DKK-4
dickkopf WNT signaling pathway inhibitor 4
protein-coding
8p11.21
Ensembl:ENSG00000104371 MIM:605417 Vega:OTTHUMG00000164167 UniprotKB:Q9UBT3
NC_000008.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.202e-1 (AD)  8.134e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL250.498
SPO110.465
CRYBA40.457
DMBX10.457
BEND30.451
LRRC150.449
C2orf700.445
MAP2K30.443
COL6A50.442
CALCA0.44

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE11A-0.267
ADARB2-0.231
POU2AF1-0.227
SLCO1A2-0.222
CTNNA3-0.22
ERMN-0.22
PAIP2B-0.218
MYH15-0.216
MOBP-0.21
SNX22-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DKK4 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of DKK4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DKK4 mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DKK4 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of DKK4 mRNA25181051|2717856
D019256Cadmium ChlorideCadmium Chloride affects the expression of DKK4 mRNA20478370
D019327Copper SulfateCopper Sulfate results in decreased expression of DKK4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of DKK4 mRNA21632981|2556210
C107676deguelindeguelin results in increased expression of DKK4 mRNA19861542
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of DKK4 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of DKK4 mRNA19680557
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of DKK4 mRNA24535843
D002117CalcitriolCalcitriol inhibits the reaction [CTNNB1 protein results in increased expression of DKK4 mRNA]20043299
D005472FluorouracilFluorouracil results in increased expression of DKK4 mRNA16584549
C410337K 7174K 7174 results in decreased expression of DKK4 mRNA24086573
D009151Mustard GasMustard Gas results in increased expression of DKK4 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DKK4 mRNA"25926378
D000073878Palm OilPalm Oil affects the expression of DKK4 mRNA19680557
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DKK4 mRNA"25510870
D011192Potassium DichromatePotassium Dichromate results in increased expression of DKK4 mRNA23608068
D011794QuercetinQuercetin results in decreased expression of DKK4 mRNA21632981
D013629TamoxifenTamoxifen results in decreased expression of DKK4 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKK4 mRNA21632981
D014520UrethaneUrethane results in decreased expression of DKK4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DKK4 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DKK4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0039706co-receptor binding-IBA21873635  
GO:0048019receptor antagonist activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-NAS10570958  
GO:0061170negative regulation of hair follicle placode formation-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-IEA-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26457595Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer. (2015 Dec)Yilmaz MJ Investig Med
27457487Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility. (2016 Jul 26)Wu JBMC Gastroenterol