Gene: DKK3

27122
REIC|RIG
dickkopf WNT signaling pathway inhibitor 3
protein-coding
11p15.3
Ensembl:ENSG00000050165 MIM:605416 Vega:OTTHUMG00000165709 UniprotKB:Q9UBP4
NC_000011.10
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.355e-1 (AD)  3.631e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13024368chr11:12030088DKK34.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRNP0.948
APLP20.944
AMFR0.943
GRINA0.941
SRP680.94
CS0.94
AP3S20.94
PSAP0.938
PSMD20.938
UQCRC20.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.775
OR4F29-0.73
KLRB1-0.372
TFPI2-0.364
TBX21-0.345
FCRL1-0.337
KLRF1-0.334
FCRL3-0.331
GZMK-0.327
CD2-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DKK3 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of DKK3 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of DKK3 mRNA"20406850
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of DKK3 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
D000452AldrinAldrin results in decreased expression of DKK3 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DKK3 mRNA16483693
D001151ArsenicArsenic affects the methylation of DKK3 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of DKK3 mRNA20458559
C547126AZM551248AZM551248 results in increased expression of DKK3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DKK3 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DKK3 mRNA22228805
D004958EstradiolEstradiol results in increased expression of DKK3 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of DKK3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DKK3 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DKK3 mRNA17484886
C054133casticincasticin results in decreased expression of DKK3 mRNA27862857
C100187chloropicrinchloropicrin results in decreased expression of DKK3 mRNA26352163|2847649
D004390ChlorpyrifosChlorpyrifos results in increased expression of DKK3 mRNA18502319
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DKK320938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK3 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DKK3 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of DKK3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of DKK3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DKK3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DKK3 mRNA27989131
C014347decitabinedecitabine affects the expression of DKK3 mRNA23300844
C014347decitabinedecitabine results in increased expression of DKK3 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DKK3 mRNA28628672
D003976DiazinonDiazinon results in increased expression of DKK3 mRNA19130878
D002945CisplatinCisplatin affects the expression of DKK3 mRNA23300844
D002945CisplatinCisplatin affects the expression of DKK3 mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of DKK3 mRNA18042831
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA24690739
D004317DoxorubicinDKK3 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DKK3 mRNA18936297
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DKK3 mRNA17942748
D005047EtoposideDKK3 protein affects the susceptibility to Etoposide16217747
D005419FlavonoidsFlavonoids results in decreased expression of DKK3 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DKK320938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK3 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DKK3 mRNA20938992
C039281furanfuran results in increased expression of DKK3 mRNA27387713
C010176halofuginonehalofuginone results in increased expression of DKK3 mRNA17180598
D017313FenretinideFenretinide results in increased expression of DKK3 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DKK3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DKK3 mRNA28628672
C544151jinfukangjinfukang results in increased expression of DKK3 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of DKK3 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TRIM33 mutant form results in increased expression of DKK3 mRNA]27432991
D007854LeadLead affects the expression of DKK3 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DKK320938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK3 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DKK3 mRNA20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DKK3 mRNA24810058
D016685MitomycinDKK3 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DKK3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DKK3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DKK3 mRNA"25620056
D009281NaphthalenesNaphthalenes results in decreased expression of DKK3 protein17337753
D009532NickelNickel results in decreased expression of DKK3 mRNA24768652|2558310
D009532NickelNickel results in decreased expression of DKK3 mRNA19130878
D000073878Palm OilPalm Oil results in decreased expression of DKK3 mRNA18042831
C046012pentanalpentanal results in increased expression of DKK3 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of DKK3 mRNA23602845
D010578PetroleumPetroleum results in increased expression of DKK3 mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DKK3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DKK3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of DKK3 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of DKK3 mRNA21273126
C005556propionaldehydepropionaldehyde results in increased expression of DKK3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of DKK3 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of DKK3 protein17337753
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DKK3 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of DKK3 mRNA17879257
C001873sporidesminsporidesmin results in decreased expression of DKK3 mRNA28193462
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DKK3 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DKK3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKK3 mRNA28077779
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DKK3 mRNA28065790
D019772TopotecanDKK3 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of DKK3 mRNA23724009
D014212TretinoinTretinoin results in increased expression of DKK3 mRNA20488242
C011559tributyltintributyltin results in increased expression of DKK3 mRNA21683754
C012589trichostatin Atrichostatin A results in increased expression of DKK3 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of DKK3 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DKK3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DKK3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of DKK3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DKK3 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of DKK3 mRNA24896083
D014747VinblastineDKK3 protein affects the susceptibility to Vinblastine16217747
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of DKK3 mRNA18579281
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of DKK3 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0039706co-receptor binding-IBA21873635  
GO:0048019receptor antagonist activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0009653anatomical structure morphogenesis-TAS10570958  
GO:0016055Wnt signaling pathway-IEA-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-NAS24431302  
GO:0030325adrenal gland development-IEP12844346  
GO:0032348negative regulation of aldosterone biosynthetic process-IDA16981135  
GO:0045892negative regulation of transcription, DNA-templated-IDA16981135  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA12857724  
GO:1902613negative regulation of anti-Mullerian hormone signaling pathway-TAS24449494  
GO:2000065negative regulation of cortisol biosynthetic process-IDA16981135  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-TAS10570958  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26457595Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer. (2015 Dec)Yilmaz MJ Investig Med
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol
27457487Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility. (2016 Jul 26)Wu JBMC Gastroenterol