Gene: DKK2

27123
DKK-2
dickkopf WNT signaling pathway inhibitor 2
protein-coding
4q25
Ensembl:ENSG00000155011 MIM:605415 Vega:OTTHUMG00000131216 UniprotKB:Q9UBU2
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.971e-1 (AD)  5.038e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSPAN20.752
SLC13A40.741
SLC22A80.741
MYOCD0.741
ITIH30.718
SLC6A200.714
CDC20B0.711
ACTA2-AS10.709
OGN0.706
SLC22A20.7

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN2C-0.407
SALL3-0.406
S100A1-0.399
C16orf74-0.396
GPR143-0.394
PLIN4-0.392
SLC7A10-0.39
PIPOX-0.387
NTSR2-0.386
GPT-0.38

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DKK2 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of DKK2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DKK2 protein20106945
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of DKK2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of DKK2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of DKK2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DKK2 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of DKK2 mRNA"20382639
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of DKK2 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of DKK2 mRNA19484750|2521013
D004958EstradiolEstradiol results in increased expression of DKK2 mRNA23144751
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter23359474
D002064Buserelin[Buserelin co-treated with CGB3 protein] results in decreased expression of DKK2 mRNA19955106
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene20938992
C107676deguelindeguelin results in decreased expression of DKK2 mRNA19861542
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter23359474
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter23359474
D004237DiuronDiuron results in decreased expression of DKK2 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of DKK2 mRNA16404146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DKK2 mRNA23550701
D015025ZearalenoneZearalenone results in decreased expression of DKK2 mRNA27862621
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene20938992
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DKK2 mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides affects the expression of DKK2 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of DKK2 mRNA]28070326
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene20938992
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DKK2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DKK2 mRNA"25554681
D009532NickelNickel results in decreased expression of DKK2 mRNA25583101
D052638Particulate MatterParticulate Matter results in increased expression of DKK2 mRNA17450221
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DKK2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DKK2 mRNA19710929
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of DKK2 mRNA]28070326
D011794QuercetinQuercetin results in increased expression of DKK2 mRNA23117658
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of DKK2 mRNA19429434
C017947sodium arsenitesodium arsenite affects the methylation of DKK2 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of DKK2 mRNA27862939
C004648testosterone enanthatetestosterone enanthate affects the expression of DKK2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DKK2 promoter]19654925
D014212TretinoinTretinoin results in increased expression of DKK2 mRNA23724009
C032910triadimefontriadimefon results in decreased expression of DKK2 mRNA26790661
C012589trichostatin Atrichostatin A results in increased expression of DKK2 mRNA24935251
D014403TubocurarineTubocurarine results in decreased expression of DKK2 mRNA19728367
D014635Valproic AcidValproic Acid results in increased expression of DKK2 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of DKK2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DKK2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of DKK2 mRNA26682919
D015032ZincZinc deficiency results in decreased expression of DKK2 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0039706co-receptor binding-IBA21873635  
GO:0039706co-receptor binding-IEA-  
GO:0048019receptor antagonist activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA11742004  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP23587485  
GO:0090090negative regulation of canonical Wnt signaling pathway-NAS24431302  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA12857724  
GO:0090263positive regulation of canonical Wnt signaling pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11742004  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20332099A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (2010 Jun 15)Kalsi GHum Mol Genet
26457595Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer. (2015 Dec)Yilmaz MJ Investig Med
27457487Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility. (2016 Jul 26)Wu JBMC Gastroenterol
24117450Association study of DKK2 polymorphisms with alcohol dependence and alcohol-related harm. (2014 Feb)Kim JYAlcohol Clin Exp Res