Gene: SMC1B

27127
SMC1BETA|SMC1L2
structural maintenance of chromosomes 1B
protein-coding
22q13.31
Ensembl:ENSG00000077935 MIM:608685 Vega:OTTHUMG00000151334 UniprotKB:Q8NDV3
NC_000022.11
PubMed
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.281e-1 (AD)  2.590e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9614466chr22:45415482 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EZH20.521
HELLS0.47
NLRP140.469
SH3BP5-AS10.461
SAMD70.456
PAN30.453
SMC50.451
ZNF705G0.447
C4orf460.447
PMFBP10.442

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSE-0.28
PPP1R3G-0.265
MMD2-0.244
GDF11-0.243
KCNJ16-0.243
WNT7B-0.243
ACY3-0.239
TNNT1-0.226
DIO2-0.223
HPSE2-0.221

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SMC1B gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SMC1B mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of SMC1B mRNA22342234
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SMC1B mRNA24982889
D004041Dietary FatsDietary Fats results in decreased expression of SMC1B mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SMC1B mRNA25975992
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMC1B protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMC1B mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC1B mRNA17942748
D007854LeadLead results in decreased expression of SMC1B mRNA19921347
C008261lead acetatelead acetate results in decreased expression of SMC1B mRNA22609695
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMC1B mRNA16962184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC1B mRNA17942748
D014635Valproic AcidValproic Acid results in increased methylation of SMC1B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMC1B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007062sister chromatid cohesion-IEA-  
GO:0051321meiotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IEA-  
GO:0000800lateral element-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0030893meiotic cohesin complex-IDA21242291  
GO:0034991nuclear meiotic cohesin complex-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25127693A let-7 microRNA polymorphism in the KRAS 3'-UTR is prognostic in oropharyngeal cancer. (2014 Oct)De Ruyck KCancer Epidemiol