Gene: INVS

27130
INV|NPH2|NPHP2
inversin
protein-coding
9q31.1
Ensembl:ENSG00000119509 MIM:243305 Vega:OTTHUMG00000020364 UniprotKB:Q9Y283
NG_008316.1
PubMed
0   ANCO-SNPs
ND
1   
2.962e-2 (AD)  2.746e-2 (ND)   (Frontal_Cortex)
4.882e-2 (AD)  3.534e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAF10.848
ZNF8410.841
LRCH30.839
DIP2A0.831
NKTR0.829
MAML10.818
ZSCAN300.815
ZFC3H10.815
ANKHD10.813
RBM50.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.436
OR4F29-0.4
NANOGNB-0.289
KLRC2-0.265
PAGE4-0.221
MUC12-0.211
AVP-0.205
OXT-0.197
LCN1-0.189
PLA2G5-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in decreased expression of INVS mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of INVS mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of INVS mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of INVS mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of INVS gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INVS mRNA20064835|2010694
C006780bisphenol Abisphenol A affects the expression of INVS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of INVS mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of INVS mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of INVS mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INVS mRNA28628672
D019327Copper SulfateCopper Sulfate results in decreased expression of INVS mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of INVS mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of INVS mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INVS mRNA28628672
D004041Dietary FatsDietary Fats affects the expression of INVS mRNA19680557
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INVS mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of INVS mRNA17606305
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of INVS mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INVS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of INVS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of INVS mRNA28628672
D008727MethotrexateMethotrexate results in increased expression of INVS mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of INVS mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of INVS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of INVS mRNA"25620056
C006253pirinixic acidpirinixic acid results in decreased expression of INVS mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INVS mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of INVS mRNA22079256
C017947sodium arsenitesodium arsenite results in decreased expression of INVS mRNA28595984
C013698tallowtallow affects the expression of INVS mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to INVS promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INVS mRNA22298810
D014635Valproic AcidValproic Acid results in decreased methylation of INVS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of INVS mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of INVS gene25560391
D015032ZincZinc deficiency results in decreased expression of INVS mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18371931  21565611  21602787  
GO:0005516calmodulin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA18371931  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005819spindle-IEA-  
GO:0005874microtubule-IEA-  
GO:0005929cilium-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2420315Recurrent choroidal neovascularization after argon laser photocoagulation for neovascular maculopathy. Macular Photocoagulation Study Group. (1986 Apr)-Arch Ophthalmol