Gene: MORC1

27136
CT33|MORC|ZCW6
MORC family CW-type zinc finger 1
protein-coding
3q13.13
Ensembl:ENSG00000114487 MIM:603205 Vega:OTTHUMG00000159209 UniprotKB:Q86VD1
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.182e-1 (AD)  1.708e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2044590chr3:109007137 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTGS10.658
LILRB40.655
CSF1R0.64
PLD40.638
SUSD30.634
LPAR50.633
TMEM1190.633
ITGAM0.631
ITGAX0.63
APBB1IP0.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM34-0.253
GPR148-0.252
C19orf73-0.252
NDP-0.239
IHH-0.232
GLI4-0.231
GLIS1-0.229
CRYBB2-0.226
ANKK1-0.225
HPR-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MORC1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MORC1 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of MORC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MORC1 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MORC1 mRNA28472532
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MORC1 mRNA28123099
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of MORC1 mRNA25270620
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MORC1 mRNA21889194
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MORC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MORC1 mRNA"25554681
D011192Potassium DichromatePotassium Dichromate results in increased expression of MORC1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of MORC1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MORC1 mRNA22298810
D014635Valproic AcidValproic Acid results in decreased methylation of MORC1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MORC1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0010529negative regulation of transposition-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0040029regulation of gene expression, epigenetic-IEA-  
GO:0043046DNA methylation involved in gamete generation-IEA-  
GO:0044026DNA hypermethylation-IEA-  
GO:2000143negative regulation of DNA-templated transcription, initiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal