Gene: CPAMD8

27151
ASGD8|K-CAP|VIP
C3 and PZP like, alpha-2-macroglobulin domain containing 8
protein-coding
19p13.11
Ensembl:ENSG00000160111 MIM:608841 Vega:OTTHUMG00000133549 UniprotKB:Q8IZJ3
NG_054892.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.300e-1 (AD)  7.649e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2353203chr19:16989170 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26652413chr19:17007057CPAMD81.360e-15Maternal smoking in pregnancy27040690
cg26652413chr19:17007057CPAMD81.120e-19Maternal smoking in pregnancy27040690
cg15159987chr19:17003890CPAMD81.740e-9Maternal smoking in pregnancy27040690
cg26652413chr19:17007057CPAMD89.000e-19Maternal smoking in pregnancy27040690
cg15159987chr19:17003890CPAMD88.950e-13Maternal smoking in pregnancy27040690
cg06418475chr19:17008851CPAMD84.900e-9Smoking27651444
cg15159987chr19:17003890CPAMD82.710e-11Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAV20.597
RASL120.589
STON10.558
TAGLN20.552
NAGS0.551
EVA1C0.546
IRAK30.545
GALNT150.544
BNC20.544
SPARC0.54

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA2-0.332
PTHLH-0.272
TAC3-0.264
WNT7A-0.263
ARSF-0.261
KIT-0.26
VIP-0.256
SCRT1-0.252
WIF1-0.251
ZNF98-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CPAMD8 mRNA"19095052
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CPAMD8 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPAMD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPAMD8 mRNA"27188386
C015001arsenitearsenite results in increased methylation of CPAMD8 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CPAMD8 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CPAMD8 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CPAMD8 mRNA26496021
C018475butyraldehydebutyraldehyde results in increased expression of CPAMD8 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of CPAMD8 mRNA27989131
C039281furanfuran results in decreased expression of CPAMD8 mRNA25539665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CPAMD8 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CPAMD8 mRNA26011545
D010100OxygenOxygen deficiency results in increased expression of CPAMD8 mRNA26516004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPAMD8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CPAMD8 mRNA26272509
C005556propionaldehydepropionaldehyde results in decreased expression of CPAMD8 mRNA26079696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPAMD8 mRNA17949056
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of CPAMD8 gene26756918
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CPAMD8 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CPAMD8 mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001654eye development-IMP27839872  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal