Gene: CHIA

27159
AMCASE|CHIT2|TSA1902
chitinase, acidic
protein-coding
1p13.2
Ensembl:ENSG00000134216 MIM:606080 Vega:OTTHUMG00000011165 UniprotKB:Q9BZP6
NC_000001.11
PubMed|SNP Mapped
2   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.925e-2 (AD)  1.019e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4839122chr1:111311585 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4240530chr1:111310959 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGC0.692
PGA30.68
LIPF0.671
C2orf830.648
ATP4B0.633
MTRNR2L30.617
GKN20.607
RNF1860.582
PRR90.582
OR1J10.561

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIST3H2A-0.357
CCDC157-0.356
ABHD14A-0.351
SP9-0.347
TMEM240-0.345
LRFN4-0.345
FAM207A-0.344
CHST5-0.341
ZNF771-0.341
YJEFN3-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of CHIA mRNA18544908
D000082AcetaminophenAcetaminophen results in increased expression of CHIA mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CHIA gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of CHIA mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of CHIA mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CHIA mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CHIA mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CHIA mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHIA mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of CHIA mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CHIA mRNA27858113
D003471CuprizoneCuprizone results in increased expression of CHIA mRNA27523638
D004026DieldrinDieldrin results in increased expression of CHIA mRNA20438755
D004642EmodinEmodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]22484343
C029310lardlard results in increased expression of CHIA mRNA26115784
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHIA mRNA"25554681
D010047OvalbuminEmodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]22484343
D010047OvalbuminOvalbumin results in increased expression of CHIA mRNA22484343
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CHIA mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CHIA mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CHIA mRNA19162173
D011441PropylthiouracilPropylthiouracil affects the expression of CHIA mRNA24780913
D011791QuartzQuartz results in increased expression of CHIA mRNA19836432
D013739TestosteroneTestosterone results in decreased expression of CHIA mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHIA mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of CHIA mRNA19464567
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CHIA mRNA18087596
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHIA protein27818348
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CHIA mRNA16141432
D014635Valproic AcidValproic Acid results in decreased methylation of CHIA gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CHIA gene25560391
C025643vinclozolinvinclozolin affects the expression of CHIA mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003796lysozyme activity-NAS11085997  
GO:0004568chitinase activity-IBA21873635  
GO:0004568chitinase activity-IDA11085997  19435888  
GO:0004568chitinase activity-NAS10548734  
GO:0004568chitinase activity-TAS-  
GO:0005515protein binding-IPI18824549  
GO:0008061chitin binding-IBA21873635  
GO:0008061chitin binding-TAS11085997  
GO:0019900kinase binding-IPI18824549  
GO:0030246carbohydrate binding-NAS11085997  
GO ID GO Term Qualifier Evidence PubMed
GO:0000272polysaccharide catabolic process-IEA-  
GO:0002532production of molecular mediator involved in inflammatory response-IDA18824549  
GO:0006030chitin metabolic process-NAS10548734  
GO:0006032chitin catabolic process-IBA21873635  
GO:0006032chitin catabolic process-IDA19435888  
GO:0006032chitin catabolic process-NAS11085997  
GO:0006037cell wall chitin metabolic process-TAS11085997  
GO:0006915apoptotic process-IEA-  
GO:0006955immune response-NAS11085997  
GO:0007586digestion-NAS11085997  
GO:0009620response to fungus-TAS11085997  
GO:0044245polysaccharide digestion-TAS-  
GO:0090197positive regulation of chemokine secretion-IDA18824549  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IC11085997  
GO:0005615extracellular space-IDA18824549  
GO:0005737cytoplasm-ISS-  
GO:0005737cytoplasm-NAS10548734  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
Reactome ID Reactome Term Evidence
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17482959Inducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma risk. (2007 May)Shen CHUrology
14992310Lifetime exposure to environmental tobacco smoke and cervical intraepithelial neoplasms among nonsmoking Taiwanese women. (2003 Jun)Wu MTArch Environ Health