Gene: AGO2

27161
CASC7|EIF2C2|LINC00980|PPD|Q10
argonaute 2, RISC catalytic component
protein-coding
8q24.3
Ensembl:ENSG00000123908 MIM:606229 Vega:OTTHUMG00000164232 UniprotKB:Q9UKV8
NC_000008.11
PubMed
0   ANCO-SNPs
OD|CD|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.762e-1 (AD)  2.732e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2640.786
LONRF30.768
ZNF4600.766
ELMSAN10.751
RNF1690.75
KDM5A0.749
GNL3L0.744
ZNF8050.741
IGF2R0.737
CDK120.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.257
CLPSL1-0.254
MYCNOS-0.245
OR4F29-0.24
SNX22-0.234
RBM34-0.224
CT45A1-0.209
RERGL-0.207
KLRC3-0.206
ALG1L-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of AGO2 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AGO2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGO2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGO2 mRNA"27188386
C5692129,10-dimethoxy-3,3-dimethyl-7,7a,13,13atetrahydro-3H-chromeno(3,4-b)pyrano(2,3-h)chromen-7-ol"9,10-dimethoxy-3,3-dimethyl-7,7a,13,13atetrahydro-3H-chromeno(3,4-b)pyrano(2,3-h)chromen-7-ol results in decreased expression of AGO2 protein"21535412
D000082AcetaminophenAcetaminophen promotes the reaction [MIR122 mRNA binds to AGO2 protein]26489516
D000082AcetaminophenAcetaminophen promotes the reaction [MIR885 mRNA binds to AGO2 protein]26489516
D000082AcetaminophenAcetaminophen results in increased expression of AGO2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of AGO2 mRNA17562736
C000188alachloralachlor results in increased expression of AGO2 mRNA12419858
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of AGO2 mRNA21298039
D000841AnisomycinAnisomycin results in increased phosphorylation of AGO2 protein18476811
D001151ArsenicArsenic affects the methylation of AGO2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of AGO2 protein25419056
D001205Ascorbic AcidAscorbic Acid results in decreased expression of AGO2 mRNA15372504
D001280AtrazineAtrazine results in increased expression of AGO2 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AGO2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AGO2 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AGO2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGO2 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGO2 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of AGO2 mRNA23019147
D004958EstradiolEstradiol results in decreased expression of AGO2 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of AGO2 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO2 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of AGO2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of AGO2 mRNA29097150
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AGO2 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AGO2 mRNA15336504
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
C584509C646 compoundC646 compound results in increased expression of AGO2 mRNA26191083
D002118CalciumCalcium affects the reaction [PICK1 protein binds to AGO2 protein]28404816
D002118CalciumCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]]28404816
D002220CarbamazepineCarbamazepine affects the expression of AGO2 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AGO2 mRNA27339419
C026690cerous chloridecerous chloride results in increased expression of AGO2 mRNA23573234
D002737ChloropreneChloroprene results in increased expression of AGO2 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AGO2 mRNA27858113
D007464Clioquinol[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA22415087
D007464Clioquinol[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein22415087
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR181A1 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR369 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR376A mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR376C mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR384 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR467B mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]20643829
D003042CocaineAGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]20643829
D003042CocaineAGO2 protein affects the susceptibility to Cocaine20643829
D003300CopperCopper results in increased expression of AGO2 mRNA24403277
D019327Copper SulfateCopper Sulfate results in increased expression of AGO2 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of AGO2 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of AGO2 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of AGO2 mRNA16597638
D003703DemecolcineDemecolcine results in decreased expression of AGO2 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AGO2 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of AGO2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AGO2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AGO2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of AGO2 mRNA27392435|2759478
D004008DiclofenacDiclofenac affects the expression of AGO2 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of AGO2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AGO2 mRNA26924002
D002117CalcitriolCalcitriol results in increased expression of AGO2 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AGO2 mRNA29097150
D018690Excitatory Amino Acid AgonistsCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]]28404816
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]28404816
D005557FormaldehydeFormaldehyde results in decreased expression of AGO2 mRNA20655997
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
C492448ICG 001ICG 001 results in increased expression of AGO2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AGO2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGO2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AGO2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AGO2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AGO2 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride results in increased expression of AGO2 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AGO2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGO2 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AGO2 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AGO2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AGO2 mRNA"25554681
D009532NickelNickel results in increased expression of AGO2 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of AGO2 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of AGO2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of AGO2 mRNA]22629407
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of AGO2 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of AGO2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of AGO2 mRNA23091169
D011794QuercetinQuercetin results in increased expression of AGO2 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of AGO2 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA19059307
D012402RotenoneRotenone results in decreased expression of AGO2 mRNA23186747
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased localization of AGO2 protein]18476811
D012834SilverSilver affects the expression of AGO2 mRNA27131904
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased localization of AGO2 protein]18476811
C017947sodium arsenitesodium arsenite results in increased expression of AGO2 mRNA21457566
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased localization of AGO2 protein18476811
D013629TamoxifenTamoxifen affects the expression of AGO2 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGO2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGO2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of AGO2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of AGO2 mRNA24977338
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AGO2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of AGO2 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of AGO2 mRNA23179753|2800136
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of AGO2 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of AGO2 mRNA18042343|2303416
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 mRNA]"24792773
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AGO2 protein]"24792773
C111237vorinostatvorinostat results in decreased expression of AGO2 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of AGO2 mRNA18593933
C016837zinc chloride[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA22415087
C016837zinc chloride[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein22415087

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000340RNA 7-methylguanosine cap binding-IDA17524464  
GO:0000993RNA polymerase II core binding-IDA25336585  
GO:0001047core promoter binding-IMP25336585  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IDA19966796  
GO:0003727single-stranded RNA binding-IDA19966796  
GO:0003743translation initiation factor activity-NAS10534406  
GO:0004521endoribonuclease activity-EXP16271386  
GO:0004521endoribonuclease activity-IDA18178619  
GO:0004521endoribonuclease activity-TAS-  
GO:0005515protein binding-IPI14749716  15766526  16289642  16424907  16699599  16756390  
17400507  17507929  17531811  17891150  17932509  18178619  
19167051  19324964  19383768  19716330  19801630  19820710  
19838187  19955415  20616046  20671708  21525958  21840310  
21903422  21981923  22366686  22484317  22915799  23085987  
23090477  23125361  23361462  23409027  23622242  23636329  
23661684  23741051  24043833  24550003  24862572  24981741  
25336585  25446899  25697406  26496610  27157137  28877994  
GO:0008022protein C-terminus binding-IPI19820710  
GO:0035197siRNA binding-IDA17495927  
GO:0035197siRNA bindingcontributes_toIDA15973356  19701182  
GO:0035198miRNA binding-IDA15260970  19966796  
GO:0035198miRNA binding-TAS19820710  
GO:0046872metal ion binding-IEA-  
GO:0070551endoribonuclease activity, cleaving siRNA-paired mRNA-IDA15260970  17524464  
GO:0090624endoribonuclease activity, cleaving miRNA-paired mRNA-IDA15260970  
GO:0090624endoribonuclease activity, cleaving miRNA-paired mRNA-IMP22795694  
GO:0098808mRNA cap binding-IPI23409027  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006412translation-NAS10534406  
GO:0006413translational initiation-IEA-  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0009791post-embryonic development-IEA-  
GO:0010501RNA secondary structure unwinding-IDA19966796  
GO:0010501RNA secondary structure unwinding-IMP22795694  
GO:0010586miRNA metabolic process-TAS-  
GO:0030422production of siRNA involved in RNA interference-TAS-  
GO:0031047gene silencing by RNA-ISS-  
GO:0031054pre-miRNA processing-IDA16424907  17671087  18178619  19966796  
GO:0035087siRNA loading onto RISC involved in RNA interference-IC19701182  
GO:0035087siRNA loading onto RISC involved in RNA interference-IDA19966796  
GO:0035194posttranscriptional gene silencing by RNA-TAS-  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IDA19966796  23661684  
GO:0035278miRNA mediated inhibition of translation-IDA17671087  19801630  
GO:0035278miRNA mediated inhibition of translation-IMP18771919  
GO:0035279mRNA cleavage involved in gene silencing by miRNA-IDA15260970  17524464  
GO:0035279mRNA cleavage involved in gene silencing by miRNA-IMP18771919  
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA-IDA18178619  19966796  
GO:0045766positive regulation of angiogenesis-IDA27208409  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP25336585  
GO:0045947negative regulation of translational initiation-IDA17524464  19801630  
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening-ISS-  
GO:0060964regulation of gene silencing by miRNA-TAS-  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:0090625mRNA cleavage involved in gene silencing by siRNA-IDA15260970  
GO:0090625mRNA cleavage involved in gene silencing by siRNA-IMP22795694  
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-ISS-  
GO:1901165positive regulation of trophoblast cell migration-IMP27208409  
GO:1905618positive regulation of miRNA mediated inhibition of translation-IDA23409027  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IDA20616046  22915799  23125361  
GO:0005634nucleus-IC25336585  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA15260970  20014101  
GO:0005829cytosol-TAS-  
GO:0005844polysome-IDA17932509  
GO:0005845mRNA cap binding complex-IDA17524464  
GO:0005845mRNA cap binding complexcolocalizes_withIDA23409027  
GO:0016020membrane-HDA19946888  
GO:0016442RISC complex-IC19701182  
GO:0016442RISC complex-IDA15260970  19966796  20616046  
GO:0030054cell junction-IDA-  
GO:0030425dendrite-IEA-  
GO:0035068micro-ribonucleoprotein complex-IDA17531811  17671087  17932509  
GO:0070062extracellular exosome-IDA28159509  
GO:0070578RISC-loading complex-IDA15973356  17531811  18178619  19820710  19966796  23661684  
GO:1990904ribonucleoprotein complex-IDA17932509  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-426486Small interfering RNA (siRNA) biogenesisTAS
R-HSA-426496Post-transcriptional silencing by small RNAsTAS
R-HSA-5578749Transcriptional regulation by small RNAsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943723Regulation of PTEN mRNA translationTAS
R-HSA-8948700Competing endogenous RNAs (ceRNAs) regulate PTEN translationTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26944283Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. (2017 Apr)Sadakierska-Chudy AMol Neurobiol
23927484Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. (2015 Jan)Garcia-Perez DAddict Biol
20643829Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. (2010 Aug 30)Schaefer AJ Exp Med
28118842Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. (2017 Jan 25)Coleman LG JrJ Neuroinflammation
25495208Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. (2015 Mar)Gedik HDNA Cell Biol