Gene: GLS2

27165
GA|GLS|LGA|hLGA
glutaminase 2
protein-coding
12q13.3
Ensembl:ENSG00000135423 MIM:606365 Vega:OTTHUMG00000140379 UniprotKB:Q9UI32
NC_000012.12
PubMed
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.025e-1 (AD)  3.229e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACTL6B0.97
MAGEE10.97
SH3GL20.966
TMEM1300.965
CACNA2D30.965
ADAM230.965
RBFOX10.963
FBXL20.962
NSF0.962
L1CAM0.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.583
REST-0.561
TFPI2-0.559
YES1-0.558
WWTR1-0.545
FZD10-0.537
CNN2-0.532
HEY2-0.524
AJUBA-0.519
KLRB1-0.51

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB017637-thionicotinamide-adenine-dinucleotide phosphateSmall Molecule-ExperimentalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB09092XanthinolSmall Molecule2530-97-4Approved|WithdrawnTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB047895-methyltetrahydrofolic acidSmall Molecule134-35-0Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB06757ManganeseSmall Molecule7439-96-5Approved|NutraceuticalTarget
DB09092XanthinolSmall Molecule2530-97-4Approved|WithdrawnTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB09270UbidecarenoneSmall Molecule303-98-0Approved|Investigational|NutraceuticalTarget
DB00120L-PhenylalanineSmall Molecule63-91-2Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00166Lipoic AcidSmall Molecule1200-22-2Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03758RadicicolSmall MoleculeExperimentalTarget
DB03760Dihydrolipoic AcidSmall Molecule462-20-4ExperimentalTarget
DB00795SulfasalazineSmall Molecule599-79-1ApprovedTarget
DB00121BiotinSmall Molecule58-85-5Approved|Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB02338Nadph Dihydro-Nicotinamide-Adenine-DinucleotidephosphateSmall MoleculeExperimentalTarget
DB04207N-(5-Amino-5-Carboxypentyl)Glutamic AcidSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalTarget
DB01030TopotecanSmall Molecule123948-87-8Approved|InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00160L-AlanineSmall Molecule56-41-7Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00536GuanidineSmall Molecule113-00-8ApprovedTarget
DB00822DisulfiramSmall Molecule97-77-8ApprovedTarget
DB02115DaidzinSmall Molecule552-66-9ExperimentalTarget
DB04381CrotonaldehydeSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01677Fumaric AcidSmall Molecule110-17-8Experimental|InvestigationalTarget
DB03499Malate IonSmall MoleculeExperimentalTarget
DB03589Alpha-Ketomalonic AcidSmall MoleculeExperimentalTarget
DB03680TartronateSmall MoleculeExperimentalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
DB00160L-AlanineSmall Molecule56-41-7Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB00534ChlormerodrinSmall Molecule62-37-3Approved|WithdrawnTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB09092XanthinolSmall Molecule2530-97-4Approved|WithdrawnTarget
DB00148CreatineSmall Molecule57-00-1Approved|Investigational|NutraceuticalTarget
DB13191PhosphocreatineSmall Molecule67-07-2NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB04657CarboxinSmall Molecule5234-68-4Approved|Experimental|InvestigationalTarget
DB04795ThenoyltrifluoroacetoneSmall Molecule326-91-0ExperimentalTarget
DB08689UBIQUINONE-1Small MoleculeExperimentalTarget
DB09270UbidecarenoneSmall Molecule303-98-0Approved|Investigational|NutraceuticalTarget
DB00583L-CarnitineSmall Molecule541-15-1Approved|InvestigationalTarget
DB01074PerhexilineSmall Molecule6621-47-2Approved|InvestigationalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00756HexachloropheneSmall Molecule70-30-4Approved|WithdrawnTarget
DB04137Guanosine-5'-TriphosphateSmall Molecule86-01-1ExperimentalTarget
DB11081Aluminum chlorideSmall Molecule7446-70-0ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00149L-LeucineSmall Molecule61-90-5Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00648MitotaneSmall Molecule53-19-0ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00160L-AlanineSmall Molecule56-41-7Approved|NutraceuticalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB00780PhenelzineSmall Molecule51-71-8ApprovedTarget
DB01080VigabatrinSmall Molecule68506-86-5ApprovedTarget
DB01699(4e)-4-Aminohex-4-Enoic AcidSmall MoleculeExperimentalTarget
DB042354-Amino Hexanoic AcidSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB00129OrnithineSmall Molecule70-26-8Approved|NutraceuticalTarget
DB00155L-CitrullineSmall Molecule372-75-8Approved|Investigational|NutraceuticalTarget
DB02011N-(Phosphonoacetyl)-L-OrnithineSmall Molecule63446-55-9ExperimentalTarget
DB04185NorvalineSmall Molecule6600-40-4ExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTarget
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03680TartronateSmall MoleculeExperimentalTarget
DB00129OrnithineSmall Molecule70-26-8Approved|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB02068Delta-Amino Valeric AcidSmall MoleculeExperimentalTarget
DB02530gamma-Aminobutyric acidSmall Molecule56-12-2Approved|InvestigationalTarget
DB04185NorvalineSmall Molecule6600-40-4ExperimentalTarget
DB04454Alpha-Aminobutyric AcidSmall MoleculeExperimentalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB00135L-TyrosineSmall Molecule60-18-4Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03059Acetoacetyl-CoASmall Molecule1420-36-6ExperimentalTarget
DB036123-Hydroxybutyryl-Coenzyme ASmall MoleculeExperimentalTarget
DB01097LeflunomideSmall Molecule75706-12-6Approved|InvestigationalTarget
DB01117AtovaquoneSmall Molecule95233-18-4ApprovedTarget
DB02262Orotic AcidSmall Molecule65-86-1Experimental|InvestigationalTarget
DB02613Decylamine-N,N-Dimethyl-N-OxideSmall MoleculeExperimentalTarget
DB03247Flavin mononucleotideSmall Molecule146-17-8Approved|InvestigationalTarget
DB03480Brequinar AnalogSmall MoleculeExperimentalTarget
DB03523BrequinarSmall Molecule96187-53-0ExperimentalTarget
DB04147Lauryl Dimethylamine-N-OxideSmall MoleculeExperimentalTarget
DB042812-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-NaphthalenoneSmall MoleculeExperimentalTarget
DB045835-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acidSmall MoleculeExperimentalTarget
DB05125SC12267Small Molecule-InvestigationalTarget
DB06481ManitimusSmall Molecule202057-76-9InvestigationalTarget
DB07443(2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamideSmall MoleculeExperimentalTarget
DB07559(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamideSmall MoleculeExperimentalTarget
DB07561(2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamideSmall MoleculeExperimentalTarget
DB07646UNDECYLAMINE-N,N-DIMETHYL-N-OXIDESmall MoleculeExperimentalTarget
DB079752-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB079763-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB079773-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB079782-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB08006N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amineSmall MoleculeExperimentalTarget
DB080085-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amineSmall MoleculeExperimentalTarget
DB08169(2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamideSmall MoleculeExperimentalTarget
DB08172(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamideSmall MoleculeExperimentalTarget
DB082493,6,9,12,15-PENTAOXATRICOSAN-1-OLSmall MoleculeExperimentalTarget
DB08880TeriflunomideSmall Molecule163451-81-8ApprovedTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB027834'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-PhosphateSmall MoleculeExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB04036Coenzyme a PersulfideSmall MoleculeExperimentalTarget
DB00148CreatineSmall Molecule57-00-1Approved|Investigational|NutraceuticalTarget
DB13191PhosphocreatineSmall Molecule67-07-2NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00129OrnithineSmall Molecule70-26-8Approved|NutraceuticalTarget
DB02054GabaculineSmall Molecule87980-11-8ExperimentalTarget
DB02821CanalineSmall Molecule496-93-5ExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01436AlfacalcidolSmall Molecule41294-56-8Approved|NutraceuticalTarget
DB00121BiotinSmall Molecule58-85-5Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00121BiotinSmall Molecule58-85-5Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00121BiotinSmall Molecule58-85-5Approved|Investigational|NutraceuticalTarget
DB00161L-ValineSmall Molecule72-18-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00167L-IsoleucineSmall Molecule73-32-5Approved|Investigational|NutraceuticalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB01675Methacrylyl-Coenzyme ASmall Molecule6008-91-9ExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB01117AtovaquoneSmall Molecule95233-18-4ApprovedTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00262CarmustineSmall Molecule154-93-8Approved|InvestigationalTarget
DB016443,6-Dihydroxy-Xanthene-9-Propionic AcidSmall MoleculeExperimentalTarget
DB021533-SulfinoalanineSmall Molecule1115-65-7ExperimentalTarget
DB02553Glutathionylspermidine DisulfideSmall MoleculeExperimentalTarget
DB028953-(Prop-2-Ene-1-Sulfinyl)-Propene-1-ThiolSmall MoleculeExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB03310Glutathione disulfideSmall Molecule27025-41-8Approved|Experimental|InvestigationalTarget
DB03867Meta-Nitro-TyrosineSmall MoleculeExperimentalTarget
DB073932-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINESmall MoleculeExperimentalTarget
DB077146-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACIDSmall MoleculeExperimentalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTarget
DB00121BiotinSmall Molecule58-85-5Approved|Investigational|NutraceuticalTarget
DB074975-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANALSmall MoleculeExperimentalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00293RaltitrexedSmall Molecule112887-68-0Approved|InvestigationalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00149L-LeucineSmall Molecule61-90-5Approved|NutraceuticalTarget
DB00167L-IsoleucineSmall Molecule73-32-5Approved|Investigational|NutraceuticalTarget
DB02142Pyridoxamine-5'-PhosphateSmall Molecule529-96-4ExperimentalTarget
DB02635N-[O-Phosphono-Pyridoxyl]-IsoleucineSmall MoleculeExperimentalTarget
DB04074Alpha-ketoisovalerateSmall Molecule759-05-7ExperimentalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00648MitotaneSmall Molecule53-19-0ApprovedTarget
DB01011MetyraponeSmall Molecule54-36-4Approved|InvestigationalTarget
DB05667LevoketoconazoleSmall Molecule142128-57-2InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00125L-ArginineSmall Molecule74-79-3Approved|NutraceuticalTarget
DB00129OrnithineSmall Molecule70-26-8Approved|NutraceuticalTarget
DB03731S-2-(Boronoethyl)-L-CysteineSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03059Acetoacetyl-CoASmall Molecule1420-36-6ExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB06757ManganeseSmall Molecule7439-96-5Approved|NutraceuticalTarget
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTarget
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB09092XanthinolSmall Molecule2530-97-4Approved|WithdrawnTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00995AuranofinSmall Molecule34031-32-8Approved|InvestigationalTarget
DB03608DiminazeneSmall Molecule536-71-0ExperimentalTarget
DB03793Benzoic AcidSmall Molecule65-85-0Approved|InvestigationalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB05282MCCSmall Molecule-InvestigationalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB04741MyxothiazolSmall Molecule76706-55-3ExperimentalTarget
DB047995-n-undecyl-6-hydroxy-4,7-dioxobenzothiazoleSmall Molecule43152-58-5ExperimentalTarget
DB07401METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATESmall MoleculeExperimentalTarget
DB07763(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONESmall MoleculeExperimentalTarget
DB07778FAMOXADONESmall MoleculeExperimentalTarget
DB08330METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATESmall MoleculeExperimentalTarget
DB084532-NONYL-4-HYDROXYQUINOLINE N-OXIDESmall MoleculeExperimentalTarget
DB08690UBIQUINONE-2Small MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB03413Deoxyuridine-5'-DiphosphateSmall MoleculeExperimentalTarget
DB046851-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONESmall MoleculeExperimentalTarget
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
DB02078TriglymeSmall Molecule112-49-2ExperimentalTarget
DB081687-AMINO-4-METHYL-CHROMEN-2-ONESmall MoleculeExperimentalTarget
DB02217Dpb-TSmall MoleculeExperimentalTarget
DB04672cyclic 3',5'-thymidine monophosphateSmall Molecule-ExperimentalTarget
DB02910Octanoyl-Coenzyme ASmall MoleculeExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB034153-Thiaoctanoyl-Coenzyme ASmall MoleculeExperimentalTarget
DB02910Octanoyl-Coenzyme ASmall MoleculeExperimentalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB03889S-(N-Hydroxy-N-Bromophenylcarbamoyl)GlutathioneSmall MoleculeExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB03245S-4-Nitrobutyryl-CoaSmall MoleculeExperimentalTarget
DB02379Beta-D-GlucoseSmall Molecule492-61-5ExperimentalTarget
DB04352beta-D-Ribose-5-phosphateSmall Molecule34980-66-0ExperimentalTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB043102-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-AmideSmall Molecule13434-13-4ExperimentalTarget
DB04368Bb-3497Small Molecule235784-88-0ExperimentalTarget
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00756HexachloropheneSmall Molecule70-30-4Approved|WithdrawnTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB08689UBIQUINONE-1Small MoleculeExperimentalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB08689UBIQUINONE-1Small MoleculeExperimentalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB02731Ethylmercurithiosalicylic acidSmall Molecule148-61-8ExperimentalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB08689UBIQUINONE-1Small MoleculeExperimentalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB031876-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic AcidSmall MoleculeExperimentalTarget
DB03760Dihydrolipoic AcidSmall Molecule462-20-4ExperimentalTarget
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnTarget
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
DB00156L-ThreonineSmall Molecule72-19-5Approved|NutraceuticalTarget
DB00160L-AlanineSmall Molecule56-41-7Approved|NutraceuticalTarget
DB00166Lipoic AcidSmall Molecule1200-22-2Approved|Investigational|NutraceuticalTarget
DB00167L-IsoleucineSmall Molecule73-32-5Approved|Investigational|NutraceuticalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
DB00174L-AsparagineSmall Molecule70-47-3Approved|Investigational|NutraceuticalTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB03983(Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)Small MoleculeExperimentalTarget
DB045943-hydroxyglutaric acidSmall Molecule638-18-6ExperimentalTarget
DB02059Adenosine-5-DiphosphoriboseSmall Molecule-ExperimentalTarget
DB02701NicotinamideSmall Molecule98-92-0Approved|InvestigationalTarget
DB034782'-O-Acetyl Adenosine-5-DiphosphoriboseSmall MoleculeExperimentalTarget
DB04786SuraminSmall Molecule145-63-1Approved|InvestigationalTarget
DB05428motexafin gadoliniumSmall Molecule-InvestigationalTarget
DB00357AminoglutethimideSmall Molecule125-84-8Approved|InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB01194BrinzolamideSmall Molecule138890-62-7ApprovedTarget
DB033854-MethylimidazoleSmall MoleculeExperimentalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB073443,6,9,12,15-PENTAOXAHEPTADECAN-1-OLSmall MoleculeExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB073841-ACETYL-2-CARBOXYPIPERIDINESmall MoleculeExperimentalTarget
DB07394AUROVERTIN BSmall MoleculeExperimentalTarget
DB08399PICEATANNOLSmall MoleculeExperimentalTarget
DB08629N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINESmall MoleculeExperimentalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB073841-ACETYL-2-CARBOXYPIPERIDINESmall MoleculeExperimentalTarget
DB07394AUROVERTIN BSmall MoleculeExperimentalTarget
DB08399PICEATANNOLSmall MoleculeExperimentalTarget
DB08629N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINESmall MoleculeExperimentalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB073841-ACETYL-2-CARBOXYPIPERIDINESmall MoleculeExperimentalTarget
DB07394AUROVERTIN BSmall MoleculeExperimentalTarget
DB08399PICEATANNOLSmall MoleculeExperimentalTarget
DB08629N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINESmall MoleculeExperimentalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB047995-n-undecyl-6-hydroxy-4,7-dioxobenzothiazoleSmall Molecule43152-58-5ExperimentalTarget
DB07401METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATESmall MoleculeExperimentalTarget
DB07763(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONESmall MoleculeExperimentalTarget
DB07778FAMOXADONESmall MoleculeExperimentalTarget
DB08330METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATESmall MoleculeExperimentalTarget
DB084532-NONYL-4-HYDROXYQUINOLINE N-OXIDESmall MoleculeExperimentalTarget
DB08690UBIQUINONE-2Small MoleculeExperimentalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB047995-n-undecyl-6-hydroxy-4,7-dioxobenzothiazoleSmall Molecule43152-58-5ExperimentalTarget
DB07401METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATESmall MoleculeExperimentalTarget
DB07763(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONESmall MoleculeExperimentalTarget
DB07778FAMOXADONESmall MoleculeExperimentalTarget
DB08330METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATESmall MoleculeExperimentalTarget
DB084532-NONYL-4-HYDROXYQUINOLINE N-OXIDESmall MoleculeExperimentalTarget
DB08690UBIQUINONE-2Small MoleculeExperimentalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB047995-n-undecyl-6-hydroxy-4,7-dioxobenzothiazoleSmall Molecule43152-58-5ExperimentalTarget
DB07401METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATESmall MoleculeExperimentalTarget
DB076365-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONESmall MoleculeExperimentalTarget
DB07763(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONESmall MoleculeExperimentalTarget
DB07778FAMOXADONESmall MoleculeExperimentalTarget
DB08330METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATESmall MoleculeExperimentalTarget
DB084532-NONYL-4-HYDROXYQUINOLINE N-OXIDESmall MoleculeExperimentalTarget
DB08690UBIQUINONE-2Small MoleculeExperimentalTarget
DB074034-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDESmall MoleculeExperimentalTarget
DB08809Dichloroacetic AcidSmall Molecule79-43-6Approved|InvestigationalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB019295-Chloryl-2,4,6-QuinazolinetriamineSmall MoleculeExperimentalTarget
DB019585-[4-Tert-Butylphenylsulfanyl]-2,4-QuinazolinediamineSmall MoleculeExperimentalTarget
DB020015-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-QuinazolinediamineSmall MoleculeExperimentalTarget
DB024025-(4-Methoxyphenoxy)-2,4-QuinazolinediamineSmall MoleculeExperimentalTarget
DB041635-Phenylsulfanyl-2,4-QuinazolinediamineSmall MoleculeExperimentalTarget
DB043065-[(4-Methylphenyl)Sulfanyl]-2,4-QuinazolinediamineSmall MoleculeExperimentalTarget
DB078627-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINESmall MoleculeExperimentalTarget
DB082037-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINESmall MoleculeExperimentalTarget
DB12116Epigallocatechin GallateSmall Molecule989-51-5InvestigationalTarget
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
DB083564-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diolSmall MoleculeExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB03758RadicicolSmall MoleculeExperimentalTarget
DB03760Dihydrolipoic AcidSmall Molecule462-20-4ExperimentalTarget
DB086084-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILESmall MoleculeExperimentalTarget
DB08609(2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideSmall MoleculeExperimentalTarget
DB08610N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDESmall MoleculeExperimentalTarget
DB03297Benzylsulfinic AcidSmall MoleculeExperimentalTarget
DB044363-FluorotyrosineSmall Molecule403-90-7ExperimentalTarget
DB01969Trifluoroacetonyl Coenzyme ASmall MoleculeExperimentalTarget
DB01992Coenzyme ASmall Molecule85-61-0Investigational|NutraceuticalTarget
DB02637Oxaloacetate IonSmall MoleculeExperimentalTarget
DB03182Alpha-Fluoro-Carboxymethyldethia Coenzyme a ComplexSmall MoleculeExperimentalTarget
DB03499Malate IonSmall MoleculeExperimentalTarget
DB04230Nitromethyldethia Coenzyme ASmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB01717Bis(Adenosine)-5'-PentaphosphateSmall MoleculeExperimentalTarget
DB03366ImidazoleSmall Molecule288-32-4Experimental|InvestigationalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB02563Hexanoyl-CoASmall Molecule5060-32-2ExperimentalTarget
DB02910Octanoyl-Coenzyme ASmall MoleculeExperimentalTarget
DB03059Acetoacetyl-CoASmall Molecule1420-36-6ExperimentalTarget
DB041174-(N,N-Dimethylamino)Cinnamoyl-CoaSmall MoleculeExperimentalTarget
DB01727Isocitric AcidSmall Molecule320-77-4ExperimentalTarget
DB039644-Hydroxy-Aconitate IonSmall MoleculeExperimentalTarget
DB04072Alpha-Methylisocitric AcidSmall MoleculeExperimentalTarget
DB04351Aconitate IonSmall MoleculeExperimentalTarget
DB04562Tricarballylic AcidSmall MoleculeExperimentalTarget
DB01727Isocitric AcidSmall Molecule320-77-4ExperimentalTarget
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
DB02059Adenosine-5-DiphosphoriboseSmall Molecule-ExperimentalTarget
DB02930Adenosine 5'-[gamma-thio]triphosphateSmall Molecule35094-46-3ExperimentalTarget
DB02452Thymidine-5'-TriphosphateSmall MoleculeExperimentalTarget
DB025942'-DeoxycytidineSmall Molecule951-77-9Experimental|InvestigationalTarget
DB04485DeoxythymidineSmall Molecule50-89-5Experimental|InvestigationalTarget
DB06775Carglumic AcidSmall Molecule1188-38-1ApprovedTarget
DB08818Hyaluronic acidSmall Molecule9004-61-9ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
DB09328VayarinSmall MoleculeApproved|InvestigationalEnzyme
DB00435Nitric OxideSmall Molecule10102-43-9ApprovedEnzyme
DB00727NitroglycerinSmall Molecule55-63-0Approved|InvestigationalEnzyme
DB01612Amyl NitriteSmall Molecule8017-89-8ApprovedEnzyme
DB06770Benzyl alcoholSmall Molecule100-51-6ApprovedEnzyme
DB09117ParaldehydeSmall Molecule123-63-7Approved|InvestigationalEnzyme
DB09072Sodium oxybateSmall Molecule502-85-2ApprovedEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
DB00146CalcidiolSmall Molecule19356-17-3Approved|NutraceuticalEnzyme
DB00153ErgocalciferolSmall Molecule50-14-6Approved|NutraceuticalEnzyme
DB01285CorticotropinBiotechDrug12427-33-7Approved|InvestigationalEnzyme
DB11094Vitamin DSmall Molecule1406-16-2Approved|NutraceuticalEnzyme
DB00161L-ValineSmall Molecule72-18-4Approved|NutraceuticalEnzyme
DB00082PegvisomantBiotechDrug218620-50-9ApprovedEnzyme
DB00153ErgocalciferolSmall Molecule50-14-6Approved|NutraceuticalEnzyme
DB00169CholecalciferolSmall Molecule67-97-0Approved|NutraceuticalEnzyme
DB06410DoxercalciferolSmall Molecule54573-75-0ApprovedEnzyme
DB06777Chenodeoxycholic acidSmall Molecule474-25-9ApprovedEnzyme
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalEnzyme
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
DB09110Coenzyme MSmall Molecule3375-50-6Approved|InvestigationalEnzyme
DB11135SeleniumSmall Molecule7782-49-2Approved|InvestigationalEnzyme
DB11590ThimerosalSmall Molecule54-64-8ApprovedEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
DB06813PralatrexateSmall Molecule146464-95-1Approved|InvestigationalEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB00196FluconazoleSmall Molecule86386-73-4Approved|InvestigationalEnzyme
DB00252PhenytoinSmall Molecule57-41-0ApprovedEnzyme
DB00257ClotrimazoleSmall Molecule23593-75-1ApprovedEnzyme
DB00292EtomidateSmall Molecule33125-97-2ApprovedEnzyme
DB00421SpironolactoneSmall Molecule52-01-7ApprovedEnzyme
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalEnzyme
DB00741HydrocortisoneSmall Molecule50-23-7ApprovedEnzyme
DB01011MetyraponeSmall Molecule54-36-4Approved|InvestigationalEnzyme
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalEnzyme
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalEnzyme
DB01233MetoclopramideSmall Molecule364-62-5Approved|InvestigationalEnzyme
DB01388MibefradilSmall Molecule116644-53-2Investigational|WithdrawnEnzyme
DB04630AldosteroneSmall Molecule52-39-1Experimental|InvestigationalEnzyme
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
DB09374Indocyanine greenSmall Molecule3599-32-4Approved|InvestigationalEnzyme
DB13155EsculinSmall Molecule531-75-9ApprovedEnzyme
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalEnzyme
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
DB09326Ammonia N-13Small Molecule34819-78-8ApprovedEnzyme
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnEnzyme
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalEnzyme
DB06756Glycine betaineSmall Molecule107-43-7Approved|NutraceuticalEnzyme
DB00169CholecalciferolSmall Molecule67-97-0Approved|NutraceuticalEnzyme
DB00257ClotrimazoleSmall Molecule23593-75-1ApprovedEnzyme
DB00338OmeprazoleSmall Molecule73590-58-6Approved|InvestigationalEnzyme
DB00390DigoxinSmall Molecule20830-75-5ApprovedEnzyme
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalEnzyme
DB00857TerbinafineSmall Molecule91161-71-6Approved|InvestigationalEnzyme
DB00882ClomifeneSmall Molecule911-45-5Approved|InvestigationalEnzyme
DB00917DinoprostoneSmall Molecule363-24-6ApprovedEnzyme
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalEnzyme
DB01232SaquinavirSmall Molecule127779-20-8Approved|InvestigationalEnzyme
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalEnzyme
DB01396DigitoxinSmall Molecule71-63-6Approved|InvestigationalEnzyme
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitEnzyme
DB02901StanoloneSmall Molecule521-18-6Illicit|InvestigationalEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
DB13951Stanolone acetateSmall Molecule1164-91-6ExperimentalEnzyme
DB00292EtomidateSmall Molecule33125-97-2ApprovedEnzyme
DB00700EplerenoneSmall Molecule107724-20-9ApprovedEnzyme
DB00741HydrocortisoneSmall Molecule50-23-7ApprovedEnzyme
DB01011MetyraponeSmall Molecule54-36-4Approved|InvestigationalEnzyme
DB01233MetoclopramideSmall Molecule364-62-5Approved|InvestigationalEnzyme
DB01388MibefradilSmall Molecule116644-53-2Investigational|WithdrawnEnzyme
DB04630AldosteroneSmall Molecule52-39-1Experimental|InvestigationalEnzyme
DB06281TorcetrapibSmall Molecule262352-17-0InvestigationalEnzyme
DB01280NelarabineSmall Molecule121032-29-9Approved|InvestigationalEnzyme
DB08949Inositol nicotinateSmall Molecule6556-11-2Approved|WithdrawnEnzyme
DB06796MangafodipirSmall Molecule155319-91-8Approved|Investigational|WithdrawnEnzyme
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalEnzyme
DB11590ThimerosalSmall Molecule54-64-8ApprovedEnzyme
DB00300Tenofovir disoproxilSmall Molecule201341-05-1Approved|InvestigationalEnzyme
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalEnzyme
DB00300Tenofovir disoproxilSmall Molecule201341-05-1Approved|InvestigationalEnzyme
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalEnzyme
DB09072Sodium oxybateSmall Molecule502-85-2ApprovedEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GLS2 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GLS2 mRNA"16984957
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GLS2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GLS2 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of GLS2 mRNA14600272
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GLS2 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GLS2 mRNA"16984957|2095900
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GLS2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLS2 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GLS2 mRNA14600272
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLS2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GLS2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of GLS2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of GLS2 mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of GLS2 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of GLS2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GLS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLS2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GLS2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLS2 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLS2 mRNA22484513
D000638AmiodaroneAmiodarone affects the expression of GLS2 mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of GLS2 mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of GLS2 mRNA18355885
C006632arsenic trioxideGLS2 protein affects the susceptibility to arsenic trioxide24276018
D001507BeclomethasoneBeclomethasone results in increased expression of GLS2 mRNA23656298
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GLS2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLS2 mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of GLS2 mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of GLS2 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in increased expression of GLS2 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GLS2 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of GLS2 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of GLS2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GLS2 mRNA27339419
D002746ChlorpromazineChlorpromazine affects the expression of GLS2 mRNA25064622
D002995Clofibric AcidClofibric Acid affects the expression of GLS2 mRNA17602206
D002997ClomipramineClomipramine affects the expression of GLS2 mRNA18355885
D019327Copper SulfateCopper Sulfate results in decreased expression of GLS2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of GLS2 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of GLS2 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of GLS2 mRNA20106945|2556210
C093628cyproconazolecyproconazole results in decreased expression of GLS2 mRNA22334560
D002945CisplatinCisplatin results in increased expression of GLS2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of GLS2 mRNA22609946|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GLS2 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GLS2 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GLS2 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of GLS2 mRNA14600272|2538013
D004317DoxorubicinDoxorubicin results in increased expression of GLS2 mRNA28940058
C118739entinostatentinostat results in increased expression of GLS2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLS2 mRNA"27188386
C109476epoxiconazoleepoxiconazole results in decreased expression of GLS2 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GLS2 mRNA25064622
D005047EtoposideEtoposide results in increased expression of GLS2 mRNA21527772
D005419FlavonoidsFlavonoids results in decreased expression of GLS2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of GLS2 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of GLS2 mRNA24136188
D006861Hydrogen PeroxideGLS2 protein affects the susceptibility to Hydrogen Peroxide24276018
D007099ImipramineImipramine affects the expression of GLS2 mRNA18355885
D007654KetoconazoleKetoconazole affects the expression of GLS2 mRNA18355885
C045463leflunomideleflunomide results in decreased expression of GLS2 mRNA24136188
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of GLS2 mRNA26667767
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GLS2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GLS2 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of GLS2 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of GLS2 mRNA24136188
D009532NickelNickel results in decreased expression of GLS2 mRNA24768652
C012655nimesulidenimesulide results in decreased expression of GLS2 mRNA24136188
D010269ParaquatParaquat affects the expression of GLS2 mRNA25064622
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GLS2 mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GLS2 mRNA20452409
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GLS2 mRNA17097637
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GLS2 mRNA24535843
D010634PhenobarbitalPhenobarbital results in decreased expression of GLS2 mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of GLS2 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLS2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GLS2 mRNA23811191
C006253pirinixic acidpirinixic acid results in decreased expression of GLS2 mRNA17164430|1916217
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GLS2 mRNA23608068
D017035PravastatinPravastatin results in decreased expression of GLS2 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of GLS2 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GLS2 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of GLS2 mRNA22334560
D011441PropylthiouracilPropylthiouracil results in decreased expression of GLS2 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of GLS2 mRNA25626140
D011794QuercetinQuercetin results in increased expression of GLS2 mRNA21632981
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of GLS2 mRNA26667767
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GLS2 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of GLS2 mRNA25993096
D012999SomanSoman results in increased expression of GLS2 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GLS2 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLS2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLS2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLS2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLS2 mRNA16054898|1698495
D013752TetracyclineTetracycline affects the expression of GLS2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of GLS2 mRNA25064622
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GLS2 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of GLS2 mRNA23411599
C024746tobacco tartobacco tar results in decreased expression of GLS2 mRNA19559774
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GLS2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of GLS2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of GLS2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of GLS2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of GLS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GLS2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GLS2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GLS2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of GLS2 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of GLS2 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004359glutaminase activity-IBA21873635  
GO:0004359glutaminase activity-TAS-  
GO:0005515protein binding-IPI11163757  
GO ID GO Term Qualifier Evidence PubMed
GO:0006520cellular amino acid metabolic process-TAS10620514  
GO:0006537glutamate biosynthetic process-IBA21873635  
GO:0006543glutamine catabolic process-IBA21873635  
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO:0014047glutamate secretion-TAS-  
GO:0042981regulation of apoptotic process-IMP20351271  
GO:0072593reactive oxygen species metabolic process-IMP20351271  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA20351271  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa00471D-Glutamine and D-glutamate metabolism
hsa00910Nitrogen metabolism
hsa01100Metabolic pathways
hsa04964Proximal tubule bicarbonate reclamation
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal