Gene: VPS4A

27183
SKD1|SKD1A|SKD2|VPS4|VPS4-1
vacuolar protein sorting 4 homolog A
protein-coding
16q22.1
Ensembl:ENSG00000132612 MIM:609982 Vega:OTTHUMG00000175589 UniprotKB:Q9UN37
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
9.565e-1 (AD)  6.729e-1 (ND)   (Frontal_Cortex)
1.845e-1 (AD)  7.456e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11647864chr16:69321603 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF1670.965
GDI10.965
RANBP30.964
WBP20.963
CFL10.961
ALDOA0.96
MLF20.96
ARF10.96
COPS60.956
PKM0.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.864
OR4F29-0.84
KLRB1-0.277
TFPI2-0.249
IL18RAP-0.246
DNASE1L3-0.246
KLRF1-0.241
MTRNR2L6-0.241
GZMK-0.24
IFNG-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of VPS4A mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of VPS4A mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of VPS4A mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VPS4A mRNA16483693
D001241AspirinAspirin results in decreased expression of VPS4A mRNA15928584
C006780bisphenol Abisphenol A affects the expression of VPS4A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of VPS4A mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of VPS4A mRNA26191083
C037123cadmium sulfatecadmium sulfate results in decreased expression of VPS4A mRNA19274763
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of VPS4A mRNA23650126
D003042CocaineCocaine affects the expression of VPS4A mRNA20187946
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of VPS4A mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of VPS4A mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of VPS4A mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of VPS4A mRNA26924002
D005419FlavonoidsFlavonoids results in decreased expression of VPS4A mRNA18035473
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of VPS4A mRNA22634610
C492448ICG 001ICG 001 results in decreased expression of VPS4A mRNA26191083
C051890irinotecanirinotecan analog results in decreased expression of VPS4A mRNA18927307
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of VPS4A protein25809596
D010416PentachlorophenolPentachlorophenol results in increased expression of VPS4A mRNA23892564
C045362prochlorazprochloraz results in increased expression of VPS4A mRNA21470553
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of VPS4A mRNA21427059
D012643SeleniumSelenium results in increased expression of VPS4A mRNA19244175
D012645SelenomethionineSelenomethionine affects the expression of VPS4A mRNA17222674
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VPS4A mRNA21570461
D014520UrethaneUrethane results in increased expression of VPS4A mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of VPS4A mRNA21427059
D014810Vitamin EVitamin E results in increased expression of VPS4A mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11559748  11563910  14505570  14519844  16730941  17928862  
18385515  18997780  19129479  19129480  21543490  23105106  
24814515  
GO:0005524ATP binding-IMP10637304  
GO:0008022protein C-terminus binding-IPI17928862  
GO:0008568microtubule-severing ATPase activity-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO:0016887ATPase activity-IMP10637304  
GO:0016887ATPase activity-NAS28242692  
GO:0019904protein domain specific binding-IPI18606141  
GO:0042623ATPase activity, coupled-NAS16174732  
GO ID GO Term Qualifier Evidence PubMed
GO:0000916actomyosin contractile ring contraction-TAS28242692  
GO:0000920cell separation after cytokinesis-IMP20616062  
GO:0006622protein targeting to lysosome-IMP16973552  
GO:0006900vesicle budding from membrane-IMP15075231  
GO:0006997nucleus organization-IMP20616062  
GO:0006998nuclear envelope organization-TAS28242692  
GO:0007080mitotic metaphase plate congression-IMP20616062  
GO:0009838abscission-IMP24814515  
GO:0016192vesicle-mediated transport-IDA11563910  
GO:0016197endosomal transport-IMP10637304  11559748  
GO:0016236macroautophagy-NAS20588296  
GO:0019058viral life cycle-TAS-  
GO:0019076viral release from host cell-IMP16193069  
GO:0031122cytoplasmic microtubule organization-IBA21873635  
GO:0031468nuclear envelope reassembly-TAS28242692  
GO:0032367intracellular cholesterol transport-IMP10637304  
GO:0032466negative regulation of cytokinesis-IMP24814515  
GO:0032880regulation of protein localization-IDA18005716  
GO:0034058endosomal vesicle fusion-IMP15075231  
GO:0036258multivesicular body assembly-ISS-  
GO:0036258multivesicular body assembly-NAS20588296  
GO:0039702viral budding via host ESCRT complex-IGI24107264  
GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway-IMP22547407  
GO:0044878mitotic cytokinesis checkpoint-IMP24814515  
GO:0051301cell division-IDA17853893  
GO:0061640cytoskeleton-dependent cytokinesis-TAS28242692  
GO:0061738late endosomal microautophagy-ISS-  
GO:0072319vesicle uncoating-IMP15075231  
GO:0090611ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway-IMP22547407  
GO:1902188positive regulation of viral release from host cell-IMP11595185  
GO:1903076regulation of protein localization to plasma membrane-IMP24878737  
GO:1903543positive regulation of exosomal secretion-IMP22660413  
GO:1903774positive regulation of viral budding via host ESCRT complex-IMP17940959  24878737  
GO:1903902positive regulation of viral life cycle-IMP11595185  16193069  17940959  
GO:1904896ESCRT complex disassembly-NAS21118109  
GO:1904903ESCRT III complex disassembly-NAS20588296  28242692  
GO ID GO Term Qualifier Evidence PubMed
GO:0000815ESCRT III complexcolocalizes_withIDA18606141  
GO:0000922spindle pole-IDA20616062  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20616062  
GO:0005737cytoplasm-IDA11563910  15075231  20616062  
GO:0005764lysosome-IDA10637304  
GO:0005768endosome-IDA17940959  
GO:0005769early endosome-IDA10637304  15075231  
GO:0005770late endosome-IDA10637304  15075231  
GO:0005774vacuolar membrane-IDA10637304  
GO:0005813centrosome-IDA20616062  
GO:0005829cytosol-IDA10637304  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA17940959  
GO:0030496midbody-IDA17853893  19129479  24814515  
GO:0030496midbodycolocalizes_withTAS28242692  
GO:0031902late endosome membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA11563910  
GO:0070062extracellular exosome-HDA19199708  23533145  
GO:0090543Flemming body-IDA20616062  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-162587HIV Life CycleTAS
R-HSA-162588Budding and maturation of HIV virionTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-917729Endosomal Sorting Complex Required For Transport (ESCRT)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal