Gene: DISC1

27185
C1orf136|SCZD9
DISC1 scaffold protein
protein-coding
1q42.2
Ensembl:ENSG00000162946 MIM:605210 Vega:OTTHUMG00000037835 UniprotKB:Q9NRI5
NG_011681.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.842e-1 (AD)  3.234e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARD80.8
MAP3K10.781
CCDC500.773
REST0.768
TP53INP10.766
KDELC20.76
LIMA10.753
PARP40.748
NEDD40.747
GAB30.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC73-0.588
HAS1-0.583
LRTM2-0.582
KCNB2-0.567
HIPK4-0.558
MYADML2-0.556
SPEF1-0.556
SLC45A1-0.552
CDH22-0.545
CYP46A1-0.545

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
D000242Cyclic AMPCyclic AMP inhibits the reaction [DISC1 protein binds to PDE4B protein]16293762
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DISC1 mRNA16483693
D003913DextroamphetamineDISC1 protein modified form results in increased susceptibility to Dextroamphetamine26754951
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DISC1 mRNA20064835|2231617
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DISC1 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of DISC1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of DISC1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of DISC1 gene28505145
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA]20360939
D003024ClozapineDISC1 gene mutant form results in decreased susceptibility to Clozapine20531374
D003024ClozapineDISC1 protein affects the susceptibility to Clozapine20531374
D019327Copper SulfateCopper Sulfate affects the expression of DISC1 mRNA19549813
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of DISC1 mRNA]21095227
D004041Dietary FatsDietary Fats results in increased expression of DISC1 mRNA25016146
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DISC1 mRNA20360939
D004298DopamineDISC1 protein modified form results in increased uptake of and affects the metabolism of Dopamine26754951
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DISC1 mRNA29097150
C039281furanfuran results in increased methylation of DISC1 gene22079235
C008261lead acetatelead acetate results in increased expression of DISC1 mRNA11578147
C045463leflunomideleflunomide results in increased expression of DISC1 mRNA28988120
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DISC1 mRNA"25510870
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DISC1 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DISC1 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of DISC1 mRNA26079696
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of DISC1 mRNA]21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DISC1 mRNA22903824
D014212TretinoinTretinoin results in increased expression of DISC1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of DISC1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DISC1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of DISC1 mRNA24935251|2627250
C111237vorinostatvorinostat results in increased expression of DISC1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12812986  15094396  17035248  17043677  17389905  18762586  
18955030  22228767  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP18955030  
GO:0001764neuron migration-IMP19502360  
GO:0002052positive regulation of neuroblast proliferation-IGI19303846  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IGI19303846  
GO:0032091negative regulation of protein binding-ISS-  
GO:1905515non-motile cilium assembly-IMP20531939  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA20880836  
GO:0005813centrosome-IDA18762586  18955030  20531939  
GO:0005874microtubule-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0045111intermediate filament cytoskeleton-IDA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0097546ciliary base-IDA20531939  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25218871Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine. (2014 Dec 15)Trossbach SVBehav Brain Res
26997180DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample. (2016 Mar)Fudalej SJ Stud Alcohol Drugs
26385055DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity. (2016 Apr)Gancarz ANeurosci Res
23855403Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. (2014 Sep)Xie PAddict Biol
25555482Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015 Mar 1)Gelernter JBiol Psychiatry
23388542Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia--a potential biomarker? (2013 May)Gadelha AJ Psychiatr Res