Gene: IL17C

27189
CX2|IL-17C
interleukin 17C
protein-coding
16q24.2
Ensembl:ENSG00000124391 MIM:604628 Vega:OTTHUMG00000173241 UniprotKB:Q9P0M4
NC_000016.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.240e-1 (AD)  7.482e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPX60.542
OR7A170.516
OR12D10.485
HOXD120.472
CARD180.469
HOXD110.465
OR5D140.443
MMP100.442
NAT20.437
CWH430.435

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KY-0.267
CYP2A6-0.253
CNGB1-0.243
ERVMER34-1-0.238
KIF26B-0.237
SHANK1-0.237
C16orf47-0.23
CCDC148-0.229
MCHR2-0.228
TRIQK-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IL17C mRNA"18648102
C496492abrineabrine results in increased expression of IL17C mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of IL17C mRNA22230336
D001280AtrazineAtrazine results in increased expression of IL17C mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to IL17C promoter]19654925
D004958EstradiolEstradiol results in increased expression of IL17C mRNA25210133
C546611brevetoxin 2brevetoxin 2 results in increased expression of IL17C mRNA20498034
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of IL17C mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of IL17C mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IL17C mRNA26011545
C059539midostaurinmidostaurin results in increased expression of IL17C mRNA20980353
D010269ParaquatParaquat results in increased expression of IL17C mRNA22938100
D010936Plant ExtractsPlant Extracts results in decreased expression of IL17C mRNA23557933
C059514resveratrolresveratrol results in decreased expression of IL17C mRNA23224687
D014635Valproic AcidValproic Acid results in increased methylation of IL17C gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS10639155  
GO:0007267cell-cell signaling-TAS10639155  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0097400interleukin-17-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics