Gene: GNMT

27232
HEL-S-182mP
glycine N-methyltransferase
protein-coding
6p21.1
Ensembl:ENSG00000124713 MIM:606628 Vega:OTTHUMG00000014712 UniprotKB:Q14749
NG_008396.1
PubMed
0   ANCO-SNPs
ND
1   
8.744e-1 (AD)  8.707e-1 (ND)   (Frontal_Cortex)
8.191e-1 (AD)  5.616e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCR100.558
ING50.555
BRICD50.549
RBM480.543
ZNF6070.539
CES4A0.535
PRSS530.533
IFT200.532
FAHD2A0.531
RBM330.526

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PABPC4L-0.286
FOXL1-0.277
OR4F5-0.274
ASB9-0.269
SUCNR1-0.266
EREG-0.265
LUM-0.256
MTRNR2L10-0.254
ELF5-0.254
FAM124B-0.254

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB01752S-adenosyl-L-homocysteineSmall Molecule979-92-0ExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GNMT mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GNMT mRNA"28903501
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of GNMT mRNA"21920950
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GNMT mRNA"22100608
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNMT mRNA"20816883|2210060
C0581182'-deoxyadenosine2'-deoxyadenosine results in decreased activity of GNMT protein15181470
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of GNMT mRNA14600272
C0182583-deazaadenosine3-deazaadenosine results in decreased activity of GNMT protein15181470
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in decreased expression of GNMT mRNA14610520
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GNMT mRNA14600272
C0139195'-deoxy-5'-S-isobutylthioadenosine5'-deoxy-5'-S-isobutylthioadenosine results in decreased activity of GNMT protein15181470
C0059845-methyltetrahydrofolateGNMT protein binds to 5-methyltetrahydrofolate17158459
D000082AcetaminophenAcetaminophen results in decreased expression of GNMT mRNA26690555|2906747
D000082AcetaminophenAcetaminophen affects the expression of GNMT mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of GNMT mRNA19103213
D000082AcetaminophenAcetaminophen affects the expression of GNMT protein16687475
D000082AcetaminophenAcetaminophen results in decreased expression of GNMT mRNA18346771
D000212AcyclovirAcyclovir results in decreased activity of GNMT protein15181470
D000241AdenosineAdenosine results in decreased activity of GNMT protein15181470
D012435S-AdenosylhomocysteineS-Adenosylhomocysteine results in decreased activity of GNMT protein15181470
D012436S-AdenosylmethionineGNMT protein affects the metabolism of S-Adenosylmethionine15181470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GNMT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GNMT mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GNMT mRNA22100608
D016604Aflatoxin B1GNMT inhibits the reaction [Aflatoxin B1 results in increased abundance of aflatoxin B1-DNA adduct]19146867
D016604Aflatoxin B1GNMT protein affects the localization of Aflatoxin B119146867
D016604Aflatoxin B1GNMT results in decreased susceptibility to Aflatoxin B119146867
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GNMT mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GNMT mRNA14600272
C072611aflatoxin B1-DNA adductGNMT inhibits the reaction [Aflatoxin B1 results in increased abundance of aflatoxin B1-DNA adduct]19146867
D016607Aflatoxin M1GNMT results in increased secretion of Aflatoxin M119146867
C033759aflatoxin Q1GNMT results in decreased secretion of aflatoxin Q119146867
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of GNMT protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNMT mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of GNMT mRNA"22863853
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GNMT mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GNMT mRNA23912714
C026487benzo(e)pyrene[benzo(e)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA9261130
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of GNMT protein23542452
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GNMT mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased activity of GNMT protein20185185
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GNMT mRNA19892394|2018518
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNMT mRNA20106945|2210060
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNMT mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GNMT mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene binds to GNMT protein9261130
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA9261130
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 protein9261130
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [ARNT protein binds to GNMT protein]21445860
D001564Benzo(a)pyreneGNMT binds to Benzo(a)pyrene16545412
D001564Benzo(a)pyrene[GNMT protein binds to GNMT protein] which binds to Benzo(a)pyrene21445860
D001564Benzo(a)pyreneGNMT protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]21445860
D004958EstradiolEstradiol results in decreased expression of GNMT mRNA20106945
C006780bisphenol Abisphenol A affects the expression of GNMT mRNA27101439
C006780bisphenol Abisphenol A results in decreased expression of GNMT mRNA27474941
C006780bisphenol Abisphenol A results in increased expression of GNMT mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of GNMT protein27474941
C006780bisphenol Abisphenol A affects the expression of GNMT mRNA21786754
C032036bromobenzenebromobenzene metabolite binds to GNMT protein17305373
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of GNMT mRNA12082028
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GNMT mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GNMT mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GNMT mRNA18346771
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GNMT mRNA18178546
D002737ChloropreneChloroprene results in increased expression of GNMT mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GNMT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA]17585979
D003300CopperCopper results in decreased expression of GNMT mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of GNMT mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of GNMT mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of GNMT mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GNMT mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in decreased expression of GNMT mRNA23726867
D003907DexamethasoneDexamethasone results in increased expression of GNMT mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GNMT mRNA]20032058
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GNMT mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GNMT mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of GNMT mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of GNMT mRNA22609946
D004041Dietary FatsDietary Fats results in increased expression of GNMT mRNA17164430
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GNMT mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GNMT mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GNMT mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of GNMT mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GNMT mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of GNMT mRNA14600272
D004147DioxinsDioxins affects the expression of GNMT mRNA20463971
D004147DioxinsDioxins results in decreased expression of GNMT mRNA22100608
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GNMT mRNA26159488
D004726EndosulfanEndosulfan results in decreased expression of GNMT mRNA26159488
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GNMT mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GNMT mRNA12082028
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) results in decreased activity of GNMT protein15181470
D011345FenofibrateFenofibrate results in decreased expression of GNMT mRNA25572481
D018120FinasterideFinasteride results in decreased expression of GNMT mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of GNMT mRNA18035473
D005485FlutamideFlutamide results in decreased expression of GNMT mRNA24136188
D005492Folic AcidFolic Acid affects the activity of GNMT protein16632891
D005492Folic AcidFolic Acid inhibits the reaction [Streptozocin results in increased activity of GNMT protein]16835399
C056933fumonisin B1fumonisin B1 results in decreased expression of GNMT mRNA16221962
C039281furanfuran results in decreased expression of GNMT mRNA25539665
C419708gefitinib[gefitinib co-treated with naphthalene] affects the expression of GNMT mRNA20935109
D019833GenisteinGenistein results in decreased expression of GNMT mRNA12075121
D005897GlafenineGlafenine results in decreased expression of GNMT mRNA24136188
D005912GliotoxinGliotoxin results in decreased expression of GNMT mRNA18346771
D017313FenretinideFenretinide results in increased expression of GNMT mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of GNMT mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GNMT mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GNMT mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GNMT mRNA27392435
C045463leflunomideleflunomide results in decreased expression of GNMT mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GNMT mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GNMT mRNA"18346771
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of GNMT mRNA22100608
D008748Methylcholanthrene[Methylcholanthrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA9261130
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GNMT mRNA23103053
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GNMT mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GNMT mRNA22100608
D015741MetriboloneMetribolone results in increased expression of GNMT mRNA17010675
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of GNMT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GNMT mRNA"25554681
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Polyethylene Glycols] results in increased expression of GNMT protein"28807745
C031721naphthalene[gefitinib co-treated with naphthalene] affects the expression of GNMT mRNA20935109
C051752nefazodonenefazodone results in decreased expression of GNMT mRNA24136188
C012655nimesulidenimesulide results in decreased expression of GNMT mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of GNMT mRNA17483316
D010126OzoneOzone results in increased expression of GNMT mRNA25838073
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of GNMT mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GNMT mRNA18692542
D010634PhenobarbitalPhenobarbital results in decreased expression of GNMT mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of GNMT mRNA12082028
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of GNMT mRNA22484513
C014153pirimiphos methylpirimiphos methyl results in increased expression of GNMT mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of GNMT mRNA16221962|2081375
C006253pirinixic acidpirinixic acid results in decreased expression of GNMT protein15226431
C006253pirinixic acidpirinixic acid results in decreased expression of GNMT mRNA17164430|1916217
D011092Polyethylene Glycols"[Nanotubes, Carbon co-treated with Polyethylene Glycols] results in increased expression of GNMT protein"28807745
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GNMT mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GNMT mRNA19162173
C045362prochlorazprochloraz results in increased expression of GNMT mRNA21470553
D011374ProgesteroneProgesterone results in decreased expression of GNMT mRNA23018184
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of GNMT mRNA25626140
D011794QuercetinQuercetin results in decreased expression of GNMT mRNA21632981
C488333Ro 65-7199Ro 65-7199 affects the expression of GNMT mRNA14610520
D012643SeleniumSelenium affects the activity of GNMT protein16632891
C009237senecioninesenecionine results in increased expression of GNMT mRNA26100227
C016104sodium bichromatesodium bichromate results in decreased expression of GNMT mRNA22561333|2599309
D013311StreptozocinFolic Acid inhibits the reaction [Streptozocin results in increased activity of GNMT protein]16835399
D013311StreptozocinStreptozocin results in increased activity of GNMT protein16835399
D013311StreptozocinStreptozocin results in increased expression of GNMT mRNA16835399
D013311StreptozocinStreptozocin results in increased expression of GNMT protein16835399
D013467SulindacSulindac results in decreased expression of GNMT mRNA24136188
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GNMT mRNA21592394
D013739TestosteroneTestosterone results in increased expression of GNMT mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GNMT mRNA]20032058
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GNMT mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNMT mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNMT mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of GNMT mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GNMT mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNMT mRNA18796159|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNMT mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNMT mRNA16054898|2121527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GNMT mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GNMT mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of GNMT mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of GNMT mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GNMT mRNA28111298
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of GNMT mRNA]27469509
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GNMT mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GNMT mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of GNMT mRNA25572481
D014520UrethaneUrethane results in decreased expression of GNMT mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of GNMT mRNA24136188
D014640VancomycinVancomycin results in increased expression of GNMT mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of GNMT mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of GNMT mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  21988832  26871637  27107014  
GO:0005542folic acid binding-IEA-  
GO:0016594glycine binding-IDA15340920  
GO:0017174glycine N-methyltransferase activity-IDA15340920  
GO:0017174glycine N-methyltransferase activity-TAS-  
GO:0042802identical protein binding-IPI16189514  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0005977glycogen metabolic process-IEA-  
GO:0006111regulation of gluconeogenesis-IEA-  
GO:0006464cellular protein modification process-NAS10843803  
GO:0006555methionine metabolic process-IEA-  
GO:0006730one-carbon metabolic process-IEA-  
GO:0032259methylation-IEA-  
GO:0034641cellular nitrogen compound metabolic process-TAS-  
GO:0046500S-adenosylmethionine metabolic process-IDA15340920  
GO:0051289protein homotetramerization-IPI15340920  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29288362Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)Goonesekere NCWJ Cancer Res Clin Oncol