Gene info: ID 27250

Gene: PDCD4

GENE ID: 27250

Synonyms: H731

Description: programmed cell death 4

Gene type: protein-coding

Location: 10q25.2

dbXrefs: Ensembl:ENSG00000150593 MIM:608610 Vega:OTTHUMG00000019048 UniprotKB:Q53EL6

RefSeq: NC_000010.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.946e-1 (AD) 6.855e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMARCE1	0.874
EIF4B	0.857
RARS2	0.852
CNOT8	0.852
PICALM	0.846
DEK	0.837
EIF3E	0.833
PRPF4B	0.832
DDX5	0.831
SF3B1	0.83

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.61
OR4F5	-0.594
WNT7B	-0.35
HES5	-0.284
ADAMTSL5	-0.281
ARSF	-0.271
SLC13A5	-0.263
PYGM	-0.259
HPSE2	-0.258
REN	-0.253

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PDCD4 mRNA"	18281256
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of PDCD4 mRNA	20566314
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PDCD4 mRNA]"	19414516
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PDCD4 mRNA"	19114083
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of PDCD4 mRNA"	19167446
C486182	2,3-bis(4-hydroxyphenyl)-propionitrile	"2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PDCD4 mRNA"	19264808
C486182	2,3-bis(4-hydroxyphenyl)-propionitrile	"2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein"	19264808
C486182	2,3-bis(4-hydroxyphenyl)-propionitrile	"ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein]"	19264808
C486182	2,3-bis(4-hydroxyphenyl)-propionitrile	"ESR2 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 mRNA]"	19264808
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]	17259349
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 mRNA	17259349
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 protein	17259349\|2327213
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of PDCD4 mRNA	21873647
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of PDCD4 mRNA"	19264808
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"ESR2 protein affects the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of PDCD4 mRNA]"	19264808
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of PDCD4 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of PDCD4 mRNA	19191707
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PDCD4 mRNA	21873647
C029370	4-toluidine	4-toluidine results in increased expression of PDCD4 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PDCD4 mRNA	17093179
D000082	Acetaminophen	Acetaminophen affects the expression of PDCD4 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]	27323401
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PDCD4 mRNA	21873647\|2715375
C430898	AGN 194204	AGN 194204 results in increased expression of PDCD4 mRNA	16339527
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of PDCD4 mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDCD4 mRNA	16483693
D001151	Arsenic	Arsenic results in increased methylation of PDCD4 gene	24525453
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PDCD4 mRNA	20458559\|2435693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PDCD4 protein	17259349\|2541905
C015001	arsenite	arsenite results in decreased expression of PDCD4 protein	22387281
C015001	arsenite	RELA mutant form inhibits the reaction [arsenite results in decreased expression of PDCD4 protein]	22387281
C547126	AZM551248	AZM551248 results in decreased expression of PDCD4 mRNA	22323515
C004456	beauvericin	beauvericin results in decreased expression of PDCD4 mRNA	29203277
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDCD4 mRNA	21873647\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PDCD4 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased methylation of PDCD4 promoter	28476633
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PDCD4 mRNA"	20018196
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA]	19264808
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 protein]	19264808
D004958	Estradiol	ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 mRNA]	20302909
D004958	Estradiol	ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 protein]	20302909
D004958	Estradiol	ESR2 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA]	19264808
D004958	Estradiol	Estradiol results in increased expression of PDCD4 mRNA	19167446\|1926480
D004958	Estradiol	Estradiol results in increased expression of PDCD4 protein	19264808\|2030290
D004958	Estradiol	MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of PDCD4 protein]	23052036
C006780	bisphenol A	bisphenol A results in increased expression of PDCD4 mRNA	22403704
C006780	bisphenol A	bisphenol A results in increased expression of PDCD4 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of PDCD4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PDCD4 gene	28505145
D002065	Buspirone	Buspirone results in decreased expression of PDCD4 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PDCD4 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of PDCD4 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of PDCD4 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PDCD4 mRNA	18560533
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PDCD4 mRNA	26472689
D002220	Carbamazepine	Carbamazepine affects the expression of PDCD4 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of PDCD4 mRNA	27339419
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PDCD4 mRNA	23650126
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of PDCD4 mRNA	20350560
C074702	chromium hexavalent ion	Acetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]	27323401
C074702	chromium hexavalent ion	CAT protein inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]	27323401
C074702	chromium hexavalent ion	CAT protein inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]	27344173
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of PDCD4	28881718
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of PDCD4 mRNA	27323401
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of PDCD4 protein	27323401\|2734417
C074702	chromium hexavalent ion	MIR21 mRNA affects the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]	27323401
C074702	chromium hexavalent ion	Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4]	28881718
C074702	chromium hexavalent ion	Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]	27344173
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of PDCD4 protein	27323401
D002994	Clofibrate	Clofibrate results in increased expression of PDCD4 mRNA	17585979
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD4 mRNA	17602206
D003000	Clonidine	Clonidine results in decreased expression of PDCD4 mRNA	21873647
D003035	Cobalt	Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
D003035	Cobalt	CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
D003035	Cobalt	[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein	23758151
D003035	Cobalt	U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PDCD4 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PDCD4 mRNA	24356939
C113861	corosolic acid	corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein]	26513295
D003375	Coumestrol	Coumestrol results in increased expression of PDCD4 mRNA	19167446
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of PDCD4 mRNA	21873647
D016572	Cyclosporine	Cyclosporine results in decreased expression of PDCD4 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of PDCD4 mRNA	20106945
D003634	DDT	DDT results in increased expression of PDCD4 mRNA	22403704
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA	25969534
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of PDCD4 protein	25969534
D003687	Dehydroepiandrosterone	[Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein	25969534
D064730	Dexrazoxane	Dexrazoxane results in decreased expression of PDCD4 mRNA	26873546
D003976	Diazinon	Diazinon results in increased expression of PDCD4 mRNA	24356939
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased methylation of PDCD4 promoter"	28476633
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDCD4 mRNA	21266533
D004008	Diclofenac	Diclofenac results in decreased expression of PDCD4 mRNA	21873647
D004008	Diclofenac	Diclofenac results in increased expression of PDCD4 mRNA	21873647
C000944	dicrotophos	dicrotophos results in decreased expression of PDCD4 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PDCD4 mRNA	26924002
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PDCD4 mRNA	17093179
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD4 mRNA	17602206
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of PDCD4 mRNA	27638505
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PDCD4 mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of PDCD4 protein	17259349
D004317	Doxorubicin	Doxorubicin results in decreased expression of PDCD4 mRNA	26873546
D004391	Dust	Dust results in decreased expression of PDCD4 mRNA	17805423
C118739	entinostat	entinostat results in decreased expression of PDCD4 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDCD4 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PDCD4 mRNA	26865667
C496966	Eudragit RSPO	Eudragit RSPO results in decreased expression of PDCD4 mRNA	22119964
D018120	Finasteride	Finasteride results in increased expression of PDCD4 mRNA	24136188
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA	24356939
C108339	fludioxonil	fludioxonil results in decreased expression of PDCD4 mRNA	23052036
C108339	fludioxonil	fludioxonil results in decreased expression of PDCD4 protein	23052036
C108339	fludioxonil	MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]	23052036
D005472	Fluorouracil	Fluorouracil results in decreased expression of PDCD4 mRNA	15109396
D005485	Flutamide	Flutamide results in decreased expression of PDCD4 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in increased expression of PDCD4 mRNA	23649840
D019833	Genistein	Genistein affects the expression of PDCD4 mRNA	26865667
D019833	Genistein	Genistein results in increased expression of PDCD4 mRNA	15256057
D005839	Gentamicins	Gentamicins results in increased expression of PDCD4 mRNA	22061828
C010974	glyphosate	glyphosate results in decreased expression of PDCD4 mRNA	26302742
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of PDCD4 mRNA	20566314
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PDCD4 mRNA	20044591\|2117940
C475919	hydroxytamoxifen	hydroxytamoxifen results in decreased expression of PDCD4 mRNA	16849584
C021304	hyperoside	MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]	25354548
C021304	hyperoside	MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]	25354548
C021304	hyperoside	[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA	25354548
C021304	hyperoside	[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein	25354548
C492448	ICG 001	ICG 001 results in increased expression of PDCD4 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDCD4 mRNA	25613284
D007657	Ketone Bodies	Ketone Bodies results in increased expression of PDCD4 mRNA	16807920
D007854	Lead	Lead affects the splicing of PDCD4 mRNA	28903495
C045463	leflunomide	leflunomide results in decreased expression of PDCD4 mRNA	28988120
C533894	LG 100815	LG 100815 results in increased expression of PDCD4 mRNA	16951191
D001556	Lindane	Lindane results in increased expression of PDCD4 mRNA	24356939
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PDCD4 mRNA	21641980
D008353	Mannitol	Mannitol results in decreased expression of PDCD4 mRNA	21873647
D008353	Mannitol	Mannitol results in increased expression of PDCD4 mRNA	21873647
C412811	maslinic acid	maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein]	26513295
D008466	Mechlorethamine	Mechlorethamine results in increased expression of PDCD4 mRNA	17107856
D008701	Methapyrilene	Methapyrilene results in decreased expression of PDCD4 mRNA	21873647
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to PDCD4 promoter]	20348232
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PDCD4 mRNA	28001369
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of PDCD4 mRNA	24810058
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of PDCD4 mRNA	20886546
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PDCD4 mRNA	26924002
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of PDCD4 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA	16357179
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of PDCD4 mRNA	24356939
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein]"	23052036
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 mRNA"	23052036
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein"	23052036
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of PDCD4 mRNA	11494140
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PDCD4 mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of PDCD4 mRNA	24136188
D009543	Nifedipine	Nifedipine results in decreased expression of PDCD4 mRNA	21873647
C012655	nimesulide	nimesulide results in decreased expression of PDCD4 mRNA	24136188
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of PDCD4 mRNA"	16951191
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of PDCD4 mRNA	25729387
D010126	Ozone	Ozone results in decreased expression of PDCD4 mRNA	12763052
C016030	pantogab	pantogab results in decreased expression of PDCD4 mRNA	17379144
C062258	Pasteurella multocida toxin	Pasteurella multocida toxin results in decreased expression of PDCD4 mRNA	26369790
C062258	Pasteurella multocida toxin	Pasteurella multocida toxin results in decreased expression of PDCD4 protein	26369790
C062258	Pasteurella multocida toxin	PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]	26369790
C062258	Pasteurella multocida toxin	Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 mRNA]	26369790
C062258	Pasteurella multocida toxin	Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 protein]	26369790
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PDCD4 mRNA	23948077
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of PDCD4 mRNA	23892564
D010634	Phenobarbital	Phenobarbital results in decreased expression of PDCD4 mRNA	21873647
D010634	Phenobarbital	Phenobarbital results in increased expression of PDCD4 mRNA	21873647
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PDCD4 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of PDCD4 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of PDCD4 mRNA	19270015\|1948288
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of PDCD4 mRNA	21873647
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of PDCD4 mRNA	21873647
C006253	pirinixic acid	pirinixic acid results in decreased expression of PDCD4 mRNA	21873647
C006253	pirinixic acid	pirinixic acid results in increased expression of PDCD4 mRNA	21873647
C006253	pirinixic acid	pirinixic acid results in decreased expression of PDCD4 mRNA	18445702
D010936	Plant Extracts	Plant Extracts results in increased expression of PDCD4 mRNA	23557933
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PDCD4 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PDCD4 protein	23718831
D011239	Prednisolone	Prednisolone results in increased expression of PDCD4 mRNA	24356939
D011374	Progesterone	Progesterone results in increased expression of PDCD4 mRNA	18497975
D011794	Quercetin	MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]	25354548
D011794	Quercetin	MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]	25354548
D011794	Quercetin	[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA	25354548
D011794	Quercetin	[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein	25354548
D011794	Quercetin	Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4]	28881718
D011794	Quercetin	Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]	27344173
C059514	resveratrol	PDCD4 protein affects the susceptibility to resveratrol	23272133
C059514	resveratrol	[resveratrol co-treated with Sirolimus] results in increased stability of PDCD4 protein	24304514
C059514	resveratrol	resveratrol results in increased expression of PDCD4 mRNA	15767336\|2327213
C059514	resveratrol	resveratrol results in increased expression of PDCD4 protein	20637737\|2327213
C059514	resveratrol	[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein	24304514
C059514	resveratrol	TSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]	24304514
C059514	resveratrol	resveratrol inhibits the reaction [Sirolimus results in increased stability of PDCD4 protein]	24304514
C059514	resveratrol	resveratrol results in decreased expression of PDCD4 mRNA	25905778
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in increased expression of PDCD4 mRNA	12818353
D020123	Sirolimus	[resveratrol co-treated with Sirolimus] results in increased stability of PDCD4 protein	24304514
D020123	Sirolimus	Sirolimus promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]	17259349
D020123	Sirolimus	Sirolimus results in increased expression of PDCD4 mRNA	17259349\|2435693
D020123	Sirolimus	Sirolimus results in increased expression of PDCD4 protein	17259349
D020123	Sirolimus	Sirolimus results in increased stability of PDCD4 protein	24304514
D020123	Sirolimus	PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]	26369790
D020123	Sirolimus	[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein	24304514
D020123	Sirolimus	Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 mRNA]	26369790
D020123	Sirolimus	Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 protein]	26369790
D020123	Sirolimus	Sirolimus results in increased expression of PDCD4 protein	26369790
D020123	Sirolimus	Sirolimus results in increased stability of PDCD4 protein	24304514
D020123	Sirolimus	TSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]	24304514
D020123	Sirolimus	resveratrol inhibits the reaction [Sirolimus results in increased stability of PDCD4 protein]	24304514
D020123	Sirolimus	Sirolimus results in increased stability of PDCD4 protein	24304514
C017947	sodium arsenite	sodium arsenite results in decreased expression of PDCD4 protein	27107786
D053260	Soot	Soot results in decreased expression of PDCD4 mRNA	22461453
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PDCD4 mRNA	21641980
D013605	T-2 Toxin	T-2 Toxin results in increased expression of PDCD4 mRNA	26141394
C004648	testosterone enanthate	testosterone enanthate affects the expression of PDCD4 mRNA	17440010
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of PDCD4 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PDCD4 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PDCD4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PDCD4 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDCD4 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 mRNA	21873647
D013755	Tetradecanoylphorbol Acetate	corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein]	26513295
D013755	Tetradecanoylphorbol Acetate	maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein]	26513295
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein	26513295
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDCD4 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PDCD4 mRNA	28111298
D014044	Tolbutamide	Tolbutamide results in decreased expression of PDCD4 mRNA	21873647
D014044	Tolbutamide	Tolbutamide results in increased expression of PDCD4 mRNA	21873647
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of PDCD4 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of PDCD4 mRNA	20530235
D014212	Tretinoin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]	17259349
D014212	Tretinoin	PDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein]	17259349
D014212	Tretinoin	PDCD4 protein promotes the reaction [Tretinoin results in increased expression of EIF4G2 protein]	17259349
D014212	Tretinoin	PDCD4 protein results in increased susceptibility to Tretinoin	17259349
D014212	Tretinoin	Sirolimus promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]	17259349
D014212	Tretinoin	Tretinoin affects the localization of PDCD4 protein	17259349
D014212	Tretinoin	Tretinoin results in increased expression of PDCD4 mRNA	17259349
D014212	Tretinoin	Tretinoin results in increased expression of PDCD4 protein	17259349
C057693	troglitazone	troglitazone results in decreased expression of PDCD4 mRNA	17569031
C002802	tungsten carbide	Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
C002802	tungsten carbide	CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
C002802	tungsten carbide	[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein	23758151
C002802	tungsten carbide	U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
C113580	U 0126	U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]	23758151
D014520	Urethane	Urethane results in increased expression of PDCD4 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PDCD4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of PDCD4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PDCD4 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of PDCD4 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of PDCD4 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PDCD4 mRNA	20044591
C009687	wortmannin	wortmannin results in increased expression of PDCD4 mRNA	17259349
C009687	wortmannin	wortmannin results in increased expression of PDCD4 protein	17259349
D015032	Zinc	Zinc deficiency results in decreased expression of PDCD4 protein	22689922
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of PDCD4 mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	12054647 16357133 17353931 18296639 19204291 21163940 24413684 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006915	apoptotic process	-	NAS	12054647
GO:0007569	cell aging	-	IDA	12054647
GO:0030509	BMP signaling pathway	-	IDA	18548003
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043508	negative regulation of JUN kinase activity	-	ISS	-
GO:0045786	negative regulation of cell cycle	-	NAS	12054647
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	16357133
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0050729	positive regulation of inflammatory response	-	ISS	-
GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development	-	ISS	-
GO:0071222	cellular response to lipopolysaccharide	-	ISS	-
GO:1900016	negative regulation of cytokine production involved in inflammatory response	-	ISS	-
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IMP	19946272
GO:1904706	negative regulation of vascular smooth muscle cell proliferation	-	IMP	28522568
GO:1904761	negative regulation of myofibroblast differentiation	-	IMP	20533548
GO:1905064	negative regulation of vascular smooth muscle cell differentiation	-	IDA	18548003
GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	-	IMP	28522568
GO:2000353	positive regulation of endothelial cell apoptotic process	-	IMP	24732886

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IMP	16357133
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IMP	16357133
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	12054647
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-447115	Interleukin-12 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	TAS
R-HSA-9020591	Interleukin-12 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26116372	MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)	Melnik BC	J Transl Med
19761702	Association of programmed cell death factor 4 (PDCD4) with hepatocellular carcinoma and smoking in a Chinese male population. (2009 Jul-Aug)	Jiang Y	J Int Med Res