Gene info: ID 2729

Gene: GCLC

GENE ID: 2729

Synonyms: GCL|GCS|GLCL|GLCLC

Description: glutamate-cysteine ligase catalytic subunit

Gene type: protein-coding

Location: 6p12.1

dbXrefs: Ensembl:ENSG00000001084 MIM:606857 Vega:OTTHUMG00000160220 UniprotKB:P48506

RefSeq: NG_012071.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 12

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.298e-1 (AD) 1.406e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PSEN1	0.873
RFC1	0.866
CCDC88A	0.866
USP16	0.85
ARAP2	0.85
NBR1	0.838
FECH	0.837
TMEM87A	0.837
SCARB2	0.836
SMARCA5	0.834

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.558
OR4F29	-0.557
EPPIN	-0.273
RNF223	-0.264
MMP23B	-0.262
OR4F16	-0.243
MTRNR2L9	-0.233
TTLL10	-0.223
MTRNR2L6	-0.22
CELSR1	-0.213

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00151	L-Cysteine	Small Molecule	52-90-4	Approved\|Nutraceutical	Target
DB00163	Vitamin E	Small Molecule	59-02-9	Approved\|Nutraceutical	Enzyme
DB14001	alpha-Tocopherol succinate	Small Molecule	4345-03-3	Approved\|Nutraceutical	Enzyme
DB14002	D-alpha-Tocopherol acetate	Small Molecule	58-95-7	Approved\|Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA"	27178040
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA"	18617210\|1937162
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"Acetaminophen promotes the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA]"	19371629
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 protein affects the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA]"	19371629
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 protein affects the reaction [[Acetaminophen co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLC mRNA]"	19371629
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA]"	27071940
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of GCLC mRNA"	26198647
C050642	1,2-dihydroxynaphthalene	"1,2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA"	25807370
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GCLC mRNA"	19073213\|1940811
C049325	1,2-dithiol-3-thione	"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA"	22495766
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GCLC mRNA"	18367636\|2295992
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GCLC protein"	18367636
C049325	1,2-dithiol-3-thione	"NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased expression of GCLC mRNA]"	18367636
C049325	1,2-dithiol-3-thione	"NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased expression of GCLC protein]"	18367636
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased activity of GCLC protein"	12535742
C049325	1,2-dithiol-3-thione	"[1,2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein"	12535742
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GCLC mRNA"	15946642
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of GCLC mRNA	25596134
C033489	1,3-dichloro-2-propanol	"1,3-dichloro-2-propanol results in increased expression of GCLC mRNA"	26143167
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GCLC mRNA"	28903501
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"[ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"[verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
C118559	1-bromopropane	1-bromopropane results in increased expression of GCLC mRNA	20211940
C118559	1-bromopropane	NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]	20211940
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GCLC mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNA"	25659769
C511295	2,2',4,4'-tetrabromodiphenyl ether	"[Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNA]"	25659769
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]	24211276
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]	11909699
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of GCLC mRNA]	11909699
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of GCLC protein]	25201354
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of GCLC mRNA"	20702594
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased activity of GCLC protein"	7943345
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GCLC mRNA"	7943345
C063002	2,3-dimethoxy-1,4-naphthoquinone	"Cycloheximide inhibits the reaction [2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GCLC mRNA]"	7943345
C063002	2,3-dimethoxy-1,4-naphthoquinone	"Dactinomycin inhibits the reaction [2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GCLC mRNA]"	7943345
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GCLC mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]	26577515\|2668657
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]	19073151
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA	19073151
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]	25895139
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA]	20399244
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of GCLC mRNA"	21346803
C499326	2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide	2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide results in decreased expression of GCLC mRNA	20159942
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide results in increased expression of GCLC mRNA	22851183
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide analog results in increased expression of GCLC mRNA	22851183
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide results in increased expression of GCLC mRNA	22851183
C091423	2-chloromethylpyridine	2-chloromethylpyridine results in increased expression of GCLC mRNA	26198647
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLC mRNA"	22746536
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLC protein"	22746536
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"NFE2L2 gene mutant form inhibits the reaction [2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLC mRNA]"	22746536
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLC mRNA"	22746536
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLC protein"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLC mRNA"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLC protein"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"NFE2L2 gene mutant form inhibits the reaction [(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLC mRNA]"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLC mRNA"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLC protein"	22746536
C578079	2-cyclohexylselenazolidine-4-carboxylic acid	2-cyclohexylselenazolidine-4-carboxylic acid results in increased expression of GCLC mRNA	22807314
C578079	2-cyclohexylselenazolidine-4-carboxylic acid	NFE2L2 mutant form inhibits the reaction [2-cyclohexylselenazolidine-4-carboxylic acid results in increased expression of GCLC mRNA]	22807314
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of GCLC mRNA	14600272\|1589037
C055802	2-nonynoic acid methyl ester	2-nonynoic acid methyl ester results in increased expression of GCLC mRNA	20491607
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone affects the expression of GCLC mRNA	15946948
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GCLC mRNA	27178040
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased activity of GCLC protein	7955076
C018855	2-tert-butylhydroquinone	[2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione	7955076
C018855	2-tert-butylhydroquinone	[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	22250088
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GCLC mRNA	12007577\|1601473
C018855	2-tert-butylhydroquinone	Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]	24128855
C018855	2-tert-butylhydroquinone	NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]	19328227
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GCLC mRNA	10978506
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GCLC promoter	20810208
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GCLC mRNA"	23994337
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GCLC mRNA"	23196670
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of GCLC protein"	22649188
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	23535287
C047368	3-methylquercetin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]	24211276
C047368	3-methylquercetin	[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	24211276
C047368	3-methylquercetin	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]"	24211276
C047368	3-methylquercetin	rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]	24211276
C047368	3-methylquercetin	[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	24211276
C047368	3-methylquercetin	3-methylquercetin results in increased expression of GCLC mRNA	25716194
C047368	3-methylquercetin	3-methylquercetin results in increased expression of GCLC protein	25716194
C047368	3-methylquercetin	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA	25716194
C047368	3-methylquercetin	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein	25716194
C015392	3-nitropropionic acid	[naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA	22871521
C490257	3-O-caffeoyl-1-methylquinic acid	3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA	16631525
C490257	3-O-caffeoyl-1-methylquinic acid	Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA]	16631525
C000623021	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of GCLC mRNA	28790194
C000623021	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one	NFE2L2 protein affects the reaction [3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of GCLC mRNA]	28790194
C471109	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of GCLC mRNA"	20159942
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of GCLC mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GCLC mRNA	19191707
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GCLC protein	24291486
C027576	4-hydroxy-2-nonenal	NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]	24291486
C549066	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine results in decreased expression of GCLC mRNA"	20159942
C447639	4-(methylthio)-3-butenyl isothiocyanate	4-(methylthio)-3-butenyl isothiocyanate results in increased expression of GCLC mRNA	29155359
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GCLC mRNA	15890375
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
C090933	4-phenyl-3-furoxancarbonitrile	4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA	22851183
C090933	4-phenyl-3-furoxancarbonitrile	4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA	22851183
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in decreased phosphorylation of GCLC protein"	22558124
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GCLC protein"	19121294
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in decreased phosphorylation of GCLC protein"	22558124
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GCLC protein"	19121294
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]"	24211276
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
C111984	6-methylsulfinylhexyl isothiocyanate	6-methylsulfinylhexyl isothiocyanate results in increased expression of GCLC protein	21382770
C077646	7,12-benz(a)anthraquinone	"7,12-benz(a)anthraquinone results in increased expression of GCLC mRNA"	23684558
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of GCLC mRNA"	26238291
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA	18332871
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein	18332871
D000079	Acetaldehyde	Acetaldehyde results in increased expression of GCLC mRNA	11439094
D000082	Acetaminophen	Acetaminophen affects the expression of GCLC mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of GCLC mRNA	27761495
D000082	Acetaminophen	Acetaminophen results in increased expression of GCLC mRNA	21420995\|2588154
D000082	Acetaminophen	Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]	29136249
D000082	Acetaminophen	pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]	25881548
D000082	Acetaminophen	Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]	25881548
D000082	Acetaminophen	Acetaminophen affects the expression of GCLC mRNA	15606129\|1756273
D000082	Acetaminophen	[Acetaminophen co-treated with Tobacco Smoke Pollution] results in increased expression of GCLC mRNA	26452297
D000082	Acetaminophen	"Acetaminophen promotes the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA]"	19371629
D000082	Acetaminophen	Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]]	16840778
D000082	Acetaminophen	Acetaminophen results in decreased activity of GCLC protein	10915739
D000082	Acetaminophen	Acetaminophen results in decreased expression of GCLC mRNA	25818464
D000082	Acetaminophen	[Acetaminophen results in increased activity of and results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA	15122755
D000082	Acetaminophen	Acetaminophen results in increased expression of GCLC mRNA	10915739\|1793574
D000082	Acetaminophen	Acetaminophen results in increased expression of GCLC protein	10915739\|1793574
D000082	Acetaminophen	FAS protein affects the reaction [Acetaminophen results in increased expression of GCLC mRNA]	23628456
D000082	Acetaminophen	FAS protein affects the reaction [Acetaminophen results in increased expression of GCLC protein]	23628456
D000082	Acetaminophen	[GCLC protein binds to GCLM protein] which results in decreased susceptibility to Acetaminophen	16840778
D000082	Acetaminophen	GCLC protein results in decreased susceptibility to Acetaminophen	18642143\|2466121
D000082	Acetaminophen	[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of GCLC mRNA	22107450
D000082	Acetaminophen	[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GCLC protein	22107450
D000082	Acetaminophen	"NFE2L2 protein affects the reaction [[Acetaminophen co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLC mRNA]"	19371629
D000082	Acetaminophen	NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of GCLC mRNA]	17935745\|1937162
D000082	Acetaminophen	NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of GCLC protein]	17935745
D000082	Acetaminophen	OGT gene mutant form promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]	29325178
D000082	Acetaminophen	Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA]	18071297
D000082	Acetaminophen	sulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]	25818464
D000082	Acetaminophen	Acetaminophen results in decreased expression of GCLC mRNA	26767949
D000082	Acetaminophen	Acetaminophen results in increased expression of GCLC mRNA	11245408\|1177920
D000082	Acetaminophen	GCLC protein affects the susceptibility to Acetaminophen	17573345
D000082	Acetaminophen	Acetaminophen results in decreased expression of GCLC mRNA	25818464
D000082	Acetaminophen	[GCLC protein co-treated with GCLM protein] affects the susceptibility to Acetaminophen	17584759
D000082	Acetaminophen	sulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]	25818464
D000109	Acetylcholine	GCLC promoter SNP results in decreased susceptibility to Acetylcholine	12598062
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of GCLC protein]	14568351
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA]	16631525
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]	25263748
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]	25263748
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of GCLC protein]"	24355586
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]	11909699
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of GCLC protein]	20851755
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]	11820781
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]	17540521
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein]	17540521
C110923	acetyl-valyl-isoleucyl-aspartyl-aldehyde	acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein]	23377617
D000171	Acrolein	Acrolein results in increased expression of GCLC mRNA	12084617\|2810974
D000171	Acrolein	"[1,2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein"	12535742
D000171	Acrolein	Acrolein results in increased expression of GCLC mRNA	25145656
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]	20146260
D012436	S-Adenosylmethionine	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]	20146260
C560978	aegeline	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GCLC gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GCLC mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GCLC mRNA	15890375\|2363061
D000393	Air Pollutants	Air Pollutants results in increased expression of GCLC mRNA	23649983
C000188	alachlor	alachlor results in increased expression of GCLC protein	14563481
D000438	Alcohols	Alcohols results in decreased expression of GCLC mRNA	18814483
D000438	Alcohols	Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA]	18814483
D000450	Aldosterone	Aldosterone results in increased expression of GCLC protein	24512358\|2520468
D000450	Aldosterone	Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]	24512358\|2520468
D000450	Aldosterone	tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein]	24512358\|2520468
D000450	Aldosterone	Aldosterone results in increased expression of GCLC protein	24512358
D000473	Alkanes	Alkanes analog results in decreased activity of GCLC protein	12659765
D000477	Alkylating Agents	GCLC results in increased susceptibility to Alkylating Agents	8700107
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased activity of GCLC protein	24036144
C004471	allyl isothiocyanate	allyl isothiocyanate results in increased expression of GCLC mRNA	24036144
C004471	allyl isothiocyanate	NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]	24036144
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of GCLC mRNA	28522335
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased activity of GCLC protein	17092368
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased expression of GCLC mRNA	17092368
C069512	alpha-methylepinine	alpha-methylepinine promotes the reaction [sulforafan results in increased expression of GCLC mRNA]	21871945
C069512	alpha-methylepinine	alpha-methylepinine results in increased expression of GCLC mRNA	21871945
C069512	alpha-methylepinine	sulforafan promotes the reaction [alpha-methylepinine results in increased expression of GCLC mRNA]	21871945
C011512	alpha-naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of GCLC mRNA	19233942
C061621	alpha-naphthyl isocyanate	alpha-naphthyl isocyanate results in decreased expression of GCLC mRNA	17202759
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA	24530478
C050234	altertoxin II	altertoxin II affects the expression of GCLC mRNA	27178040
D019804	Mesalamine	[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA	27818126
D000638	Amiodarone	Amiodarone affects the expression of GCLC mRNA	25064622
D000667	Ampicillin	Ampicillin results in decreased expression of GCLC mRNA	21632981\|2619864
C030419	andrographolide	andrographolide results in increased expression of GCLC mRNA	25110055
C030419	andrographolide	andrographolide results in increased expression of GCLC protein	25110055
D000965	Antimony	GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony]	11560771
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of GCLC mRNA	28713220
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of GCLC protein	28713220
D047310	Apigenin	Apigenin results in increased expression of GCLC mRNA	11864778
D047310	Apigenin	Apigenin results in increased expression of GCLC mRNA	22864849
D047310	Apigenin	[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
D047310	Apigenin	Apigenin results in increased expression of GCLC protein	22864849
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of GCLC protein	17092368
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of GCLC mRNA	16704987\|1709236
C015000	arecaidine esters	arecaidine esters results in increased expression of GCLC mRNA	22851183
C015000	arecaidine esters	arecaidine esters results in increased expression of GCLC mRNA	22851183
D001149	Arsenates	[Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA	19895865
D001151	Arsenic	Arsenic results in increased expression of GCLC mRNA	19945496
D001151	Arsenic	Arsenic results in increased expression of GCLC protein	18487201
D001151	Arsenic	Arsenic results in increased expression of GCLC mRNA	23000044
D001151	Arsenic	NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA]	23000044
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of GCLC protein	25341331\|2541905
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GCLC mRNA	19417148\|2252195
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GCLC protein	23426167
C006632	arsenic trioxide	GCLC protein results in decreased susceptibility to arsenic trioxide	20707922
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GCLC mRNA	29049341
C006632	arsenic trioxide	NFE2L2 protein affects the reaction [arsenic trioxide results in increased expression of GCLC mRNA]	29049341
C006632	arsenic trioxide	arsenic trioxide results in increased activity of GCLC protein	18801422
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GCLC mRNA	18801422
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of GCLC promoter	20810208
C015001	arsenite	arsenite results in increased expression of GCLC mRNA	22476201
C015001	arsenite	arsenite results in increased expression of GCLC protein	22476201
C015001	arsenite	KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]	22476201
C015001	arsenite	KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC protein]	22476201
C015001	arsenite	NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]	22476201
C015001	arsenite	NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC protein]	22476201
C015001	arsenite	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C015001	arsenite	Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA	15894712
C015001	arsenite	arsenite results in increased activity of [GCLC protein binds to GCLM protein]	19328227
C015001	arsenite	arsenite results in increased expression of GCLC mRNA	15894712\|1932822
C015001	arsenite	arsenite results in increased expression of GCLC protein	19328227
C015001	arsenite	arsenite results in increased expression of [GCLC protein binds to GCLM protein]	19328227
C015001	arsenite	Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]]	19328227
C015001	arsenite	Cycloheximide inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C015001	arsenite	Cycloheximide inhibits the reaction [arsenite results in increased expression of [GCLC protein binds to GCLM protein]]	19328227
C015001	arsenite	pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C039726	artesunate	GCLC mRNA affects the susceptibility to artesunate	15796179
C039726	artesunate	GCLC mRNA results in decreased susceptibility to artesunate	15796179
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of GCLC mRNA"	15520183
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of GCLC protein"	15520183
D017638	Asbestos, Crocidolite	"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]"	15520183
D017638	Asbestos, Crocidolite	"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]"	15520183
D017638	Asbestos, Crocidolite	"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA]"	15520183
D017638	Asbestos, Crocidolite	"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]"	15520183
D001205	Ascorbic Acid	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA	27028516
D001205	Ascorbic Acid	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]	27028516
D001205	Ascorbic Acid	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]]	27028516
C108637	aspartyl-glutamyl-valyl-aspartal	aspartyl-glutamyl-valyl-aspartal inhibits the reaction [diphenylarsinic acid results in increased cleavage of GCLC protein]	17628625
D001379	Azathioprine	Azathioprine results in increased expression of GCLC mRNA	22623647\|2619864
C051597	Bandrowski's base	Bandrowski's base results in increased expression of GCLC mRNA	20566472
C025485	basic fuchsin	basic fuchsin results in increased expression of GCLC mRNA	25727789
C416282	BAY 11-7085	BAY 11-7085 results in increased expression of GCLC mRNA	22851183
D001554	Benzene	Benzene affects the expression of GCLC mRNA	15878777
C029876	benzidine	benzidine results in increased expression of GCLC mRNA	26198647
D019324	beta-Naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of GCLC mRNA	19233942
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GCLC mRNA	16426233
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GCLC mRNA	16426233\|2399433
D019817	Benzoic Acid	Benzoic Acid results in increased expression of GCLC mRNA	20566472
C022921	benzo(k)fluoranthene	AHR2 mutant form inhibits the reaction [benzo(k)fluoranthene results in increased expression of GCLC mRNA]	21600235
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of GCLC mRNA	21600235
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GCLC mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA	25170436
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GCLC mRNA	14625279\|1503420
D001564	Benzo(a)pyrene	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLC mRNA	25820237
D001564	Benzo(a)pyrene	[chromium hexavalent ion co-treated with Benzo(a)pyrene] results in increased expression of GCLC protein	25820237
D001564	Benzo(a)pyrene	GCLM gene mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA]	24291350
D001564	Benzo(a)pyrene	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA]	14625279
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GCLC mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GCLC mRNA"	19150397
D016227	Benzoquinones	Benzoquinones analog results in increased expression of GCLC protein	21651925
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]	25263748
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]	25263748
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of GCLC mRNA	22154832
D004958	Estradiol	Estradiol results in increased expression of GCLC mRNA	22154832
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA	26496021
C031463	beta-glycerophosphoric acid	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA	27028516
C031463	beta-glycerophosphoric acid	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]	27028516
C031463	beta-glycerophosphoric acid	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]]	27028516
D001688	Biological Products	Biological Products results in increased expression of GCLC mRNA	23266269
C452139	BIRB 796	BIRB 796 results in increased expression of GCLC mRNA	21328587
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of GCLC mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of GCLC mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of GCLC mRNA	27750016
C006780	bisphenol A	bisphenol A affects the expression of GCLC mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of GCLC mRNA	28796629
C006780	bisphenol A	bisphenol A results in increased expression of GCLC protein	28796629
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of GCLC mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of GCLC	20924222
C025703	bleomycetin	bleomycetin results in increased expression of GCLC mRNA	21040473
D001761	Bleomycin	Bleomycin results in decreased expression of GCLC protein	23570914
D001761	Bleomycin	caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein]	23570914
C013418	bromfenacoum	bromfenacoum results in increased expression of GCLC protein	28903499
C032036	bromobenzene	bromobenzene results in increased expression of GCLC protein	18078705
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA	24910943
C020237	brusatol	brusatol results in decreased expression of GCLC protein	27639429
D002065	Buspirone	Buspirone results in decreased expression of GCLC mRNA	24136188
D003931	Diacetyl	Diacetyl results in increased expression of GCLC mRNA	25145656
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in decreased activity of GCLC protein] promotes the reaction [Diamide affects the abundance of Calcium]	21148766
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GCLC protein	12659765
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]	18556457
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]	17724089
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]	12805647
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]	10900227
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GCLC protein	15707499\|7955076
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]	7955076
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione	15707499
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased activity of GCLC protein	10915739
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of GCLC mRNA	17980396\|1844945
D019328	Buthionine Sulfoximine	[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein	11019651
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein	12967637
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]	23585199
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA]	24964298
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GCLC protein	12433058
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]	22864849
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of GCLC mRNA	10978506\|2358519
D019328	Buthionine Sulfoximine	[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein	16288907
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]	20732396
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GCLC protein	20732396
C065566	buthionine sulfoximine ethyl ester	GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]	12504668
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GCLC mRNA	16426233
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GCLC mRNA	16426233\|2592207
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GCLC protein	16426233
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of GCLC protein	21536018
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of GCLC mRNA	9535746
D020122	tert-Butylhydroperoxide	NFE2L2 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of GCLC mRNA]	19233942
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GCLC mRNA	19233942
D020122	tert-Butylhydroperoxide	"[Linoleic Acids, Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide"	17092368
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GCLC mRNA	23410634\|2750901
D020122	tert-Butylhydroperoxide	[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
D020122	tert-Butylhydroperoxide	[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]	22864849
D020122	tert-Butylhydroperoxide	[chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
D020122	tert-Butylhydroperoxide	GCLC protein results in decreased susceptibility to tert-Butylhydroperoxide	12425961
D020122	tert-Butylhydroperoxide	[Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
C018475	butyraldehyde	butyraldehyde results in decreased expression of GCLC mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of GCLC mRNA	21120746
D002104	Cadmium	[GCLC results in decreased uptake of Cadmium] which results in decreased expression of SLC39A8	18556457
D002104	Cadmium	Cadmium results in increased expression of GCLC mRNA	16769250
D002104	Cadmium	Cadmium results in increased expression of GCLC	19879314
D002104	Cadmium	Cadmium results in increased expression of GCLC mRNA	25388156
C028031	cadmium acetate	cadmium acetate results in increased expression of GCLC protein	29140578
C028031	cadmium acetate	Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein]	29140578
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	23174481
D019256	Cadmium Chloride	NFE2L2A mutant form inhibits the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]	23174481
D019256	Cadmium Chloride	sulforafan promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]	23174481
D019256	Cadmium Chloride	Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]	18556457
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA	25170436
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	25596134\|2652539
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC protein	24291162
D019256	Cadmium Chloride	GCLC results in decreased susceptibility to Cadmium Chloride	18556457
D019256	Cadmium Chloride	GCLC results in decreased uptake of Cadmium Chloride	18556457
D019256	Cadmium Chloride	[GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride	18556457
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	16769250
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	22677785
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GCLC mRNA	25993096
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of and results in increased activity of GCLC protein	11254161
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GCLC mRNA	11254161
D019256	Cadmium Chloride	GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride]	19682480
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA	18654764
C037123	cadmium sulfate	cadmium sulfate results in increased expression of GCLC mRNA	12064557
C037123	cadmium sulfate	cadmium sulfate results in increased expression of GCLC mRNA	16221973
C034939	cadmium sulfide	cadmium sulfide results in decreased expression of GCLC mRNA	27866839
C053400	cafestol	[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein]	17110534
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein]	23570914
D002110	Caffeine	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D002118	Calcium	[Buthionine Sulfoximine results in decreased activity of GCLC protein] promotes the reaction [Diamide affects the abundance of Calcium]	21148766
D002118	Calcium	[Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA	15913539
C005563	captax	captax results in increased expression of GCLC mRNA	20491607
D002220	Carbamazepine	Carbamazepine affects the expression of GCLC mRNA	24752500
D002246	Carbon Disulfide	Carbon Disulfide results in increased expression of GCLC mRNA	27530093
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GCLC mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of GCLC protein	10915739
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GCLC mRNA	27477297
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GCLC protein	27477297
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GCLC mRNA	10915739\|2733941
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GCLC protein	10915739\|1807870
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]	27477297
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]	27477297
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]	27477297
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]	27477297
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GCLC mRNA	24293383
D002251	Carbon Tetrachloride	diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]	24293383
D002330	Carmustine	[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein	12967637
D002330	Carmustine	[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein	16288907
C068623	carnosol	carnosol results in increased expression of GCLC mRNA	20116392
C006923	carvone	carvone results in increased expression of GCLC mRNA	27750016
C026690	cerous chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA	28954213
C026690	cerous chloride	cerous chloride results in increased expression of GCLC mRNA	28954213
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of GCLC protein	17724089
D002635	Chenodeoxycholic Acid	[Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione	17724089
D002699	Chlorambucil	[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil	10900222
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of GCLC mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of GCLC mRNA	23650126
D002726	Chlorogenic Acid	Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]	29136249
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of GCLC mRNA	29136249
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of GCLC mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of GCLC mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of GCLC mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of GCLC mRNA	25064622
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of GCLC mRNA	25596134
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein"	27394961
D002791	Cholesterol, Dietary	"MET gene mutant form inhibits the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein]"	27394961
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA	20350562
D002794	Choline	NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA]	20350562
C074702	chromium hexavalent ion	[Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA	19895865
C074702	chromium hexavalent ion	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLC mRNA	25820237
C074702	chromium hexavalent ion	[chromium hexavalent ion co-treated with Benzo(a)pyrene] results in increased expression of GCLC protein	25820237
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of GCLC protein	18306314
C041167	chromium nitrate	chromium nitrate results in increased expression of GCLC mRNA	20491607
C043561	chrysin	[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]	22864849
C043561	chrysin	chrysin results in increased expression of GCLC mRNA	22864849
C043561	chrysin	[chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
C043561	chrysin	chrysin results in increased expression of GCLC protein	22864849
C043561	chrysin	MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]	22864849
C043561	chrysin	NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]	22864849
C059262	cidofovir	cidofovir results in decreased expression of GCLC mRNA	25596134
C012843	cinnamic aldehyde	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C012843	cinnamic aldehyde	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C012843	cinnamic aldehyde	[cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	20351055
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of GCLC mRNA	17178418
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of GCLC protein	21469739
C012843	cinnamic aldehyde	NFE2L2 mRNA affects the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C012843	cinnamic aldehyde	pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of GCLC mRNA	20566472
C019304	ciprofibrate	ciprofibrate results in decreased activity of GCLC protein	7676460
C019304	ciprofibrate	ciprofibrate results in decreased expression of GCLC mRNA	7676460
C073341	citraconic acid	citraconic acid results in increased expression of GCLC mRNA	27277809
C073341	citraconic acid	citraconic acid results in increased expression of GCLC protein	27277809
C028677	clivorine	[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA	25881548
C028677	clivorine	pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]	25881548
D002990	Clobetasol	Clobetasol results in decreased expression of GCLC mRNA	16882163
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of GCLC mRNA	25596134
D003033	Coal Tar	Coal Tar results in increased expression of GCLC mRNA	16882163
D003033	Coal Tar	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GCLC mRNA	22935520
D003033	Coal Tar	[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GCLC mRNA	22935520
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GCLC mRNA	24612858
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GCLC mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GCLC mRNA	24386269
C004690	coclaurine	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D003069	Coffee	Coffee affects the expression of GCLC mRNA	21448860
D003069	Coffee	Coffee results in increased expression of GCLC mRNA	18028974
D003069	Coffee	NFE2L2 protein promotes the reaction [Coffee results in increased expression of GCLC mRNA]	18028974
C075384	coniferaldehyde	coniferaldehyde results in increased expression of GCLC mRNA	26275128
D003300	Copper	Copper results in increased expression of GCLC mRNA	25119852
D003300	Copper	Copper results in increased expression of GCLC mRNA	19747488
D003300	Copper	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA]"	19747488
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of GCLC mRNA	20971185
D003300	Copper	RELA mRNA affects the reaction [Copper results in increased expression of GCLC mRNA]	19747488
D003300	Copper	Copper results in decreased expression of GCLC mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GCLC mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of GCLC mRNA	20116453
C030123	coumarin	coumarin results in increased expression of GCLC mRNA	18480146
C013453	cresidine	cresidine results in increased expression of GCLC mRNA	26198647
C029892	cupric chloride	cupric chloride results in increased expression of GCLC mRNA	17211630
D003474	Curcumin	Curcumin analog results in increased expression of GCLC mRNA	23954767
D003474	Curcumin	Curcumin results in increased activity of GCLC protein	10514034
D003474	Curcumin	Curcumin results in increased expression of GCLC mRNA	23710286\|2395476
D003474	Curcumin	NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]	23954767
D003474	Curcumin	NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]	23954767
D003474	Curcumin	Curcumin results in increased expression of GCLC mRNA	21256849
D003474	Curcumin	Curcumin results in increased expression of GCLC mRNA	19168576\|1918325
D003474	Curcumin	Curcumin results in increased activity of [GCLC protein binds to GCLM protein]	17602960
D003474	Curcumin	Curcumin results in increased expression of GCLC mRNA	17602960\|1829998
D003474	Curcumin	Curcumin results in increased expression of GCLC protein	17602960\|1833287
D003474	Curcumin	Curcumin results in decreased expression of GCLC	18462866
C114438	cyanidin 3-O-glucoside	[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin 3-O-glucoside] results in increased expression of GCLC mRNA	27818126
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GCLC mRNA	17654400
D003513	Cycloheximide	"Cycloheximide inhibits the reaction [2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GCLC mRNA]"	7943345
D003513	Cycloheximide	Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]]	19328227
D003513	Cycloheximide	Cycloheximide inhibits the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
D003513	Cycloheximide	Cycloheximide inhibits the reaction [arsenite results in increased expression of [GCLC protein binds to GCLM protein]]	19328227
D003513	Cycloheximide	Cycloheximide inhibits the reaction [diphenylarsinic acid results in increased expression of GCLC protein]	17628625
D003513	Cycloheximide	Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
D003520	Cyclophosphamide	Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]	27633142
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of GCLC mRNA	27633142
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of GCLC protein	27633142
D016572	Cyclosporine	Cyclosporine affects the expression of GCLC mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of GCLC mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in decreased expression of GCLC mRNA	11589784\|2559613
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of GCLC mRNA	23726867
D003538	Cystamine	Cystamine results in decreased activity of GCLC protein	12659765
D003543	Cysteamine	Cysteamine results in decreased activity of GCLC protein	15282320
D003543	Cysteamine	[Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione	15282320
D003545	Cysteine	Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
D003609	Dactinomycin	"Dactinomycin inhibits the reaction [2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GCLC mRNA]"	7943345
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA]	11972604
D003609	Dactinomycin	Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C515055	darinaparsin	darinaparsin results in increased expression of GCLC protein	23426167
D003634	DDT	DDT results in increased expression of GCLC mRNA	26198647
C017180	decamethrin	decamethrin results in decreased expression of GCLC mRNA	23401056
C017180	decamethrin	Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]	17540521
C017180	decamethrin	Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein]	17540521
C017180	decamethrin	Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]	23585199
C017180	decamethrin	decamethrin affects the expression of GCLC mRNA	16758951
C017180	decamethrin	decamethrin results in increased expression of GCLC mRNA	17540521\|2358519
C017180	decamethrin	decamethrin results in increased expression of GCLC protein	17540521
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA	28659758
D003840	Deoxycholic Acid	[Deoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	17724089
D064791	Desoxycorticosterone Acetate	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA"	22228705
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GCLC mRNA]	27941970
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA]	16054899
D003907	Dexamethasone	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA	27028516
D003907	Dexamethasone	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]	27028516
D003907	Dexamethasone	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]]	27028516
C028009	diallyl disulfide	diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]	24293383
D003958	Diamide	[Buthionine Sulfoximine results in decreased activity of GCLC protein] promotes the reaction [Diamide affects the abundance of Calcium]	21148766
D003958	Diamide	Diamide results in increased activity of GCLC protein	15115889
D003958	Diamide	Diamide results in increased expression of GCLC mRNA	15115889
D003958	Diamide	Diamide results in increased expression of GCLC protein	15115889
D003959	Diamines	Diamines analog results in decreased activity of GCLC protein	12659765
D003976	Diazinon	Diazinon results in increased expression of GCLC mRNA	26198647
C061481	dibenzoylmethane	dibenzoylmethane results in increased expression of GCLC mRNA	17942926
C061481	dibenzoylmethane	[sulforafan co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA	17942926
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GCLC mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of GCLC mRNA	24535708
D002945	Cisplatin	Cisplatin promotes the reaction [MYC protein binds to GCLC promoter]	17628013
D002945	Cisplatin	Cisplatin results in decreased expression of GCLC mRNA	25596134
D002945	Cisplatin	Cisplatin results in increased expression of GCLC mRNA	27480280\|2895953
D002945	Cisplatin	sulforafan promotes the reaction [Cisplatin results in increased expression of GCLC mRNA]	28959534
D002945	Cisplatin	Cisplatin results in increased expression of GCLC mRNA	20605904
D002945	Cisplatin	Cisplatin results in increased expression of GCLC protein	20605904
D002945	Cisplatin	Cisplatin results in increased phosphorylation of GCLC protein	22006019
D002945	Cisplatin	NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of GCLC mRNA]	20605904
D002945	Cisplatin	NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of GCLC protein]	20605904
D002945	Cisplatin	Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]	20732396
D002945	Cisplatin	sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]	20732396
D003633	Dichlorodiphenyl Dichloroethylene	Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]	25263748
D003633	Dichlorodiphenyl Dichloroethylene	Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]	25263748
D003633	Dichlorodiphenyl Dichloroethylene	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]	25263748
D003633	Dichlorodiphenyl Dichloroethylene	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]	25263748
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA	25263748
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein	25263748
D004006	Dichlorvos	Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of GCLC protein]	14568351
D004006	Dichlorvos	Dichlorvos results in decreased activity of GCLC protein	14568351
D004008	Diclofenac	Diclofenac affects the expression of GCLC mRNA	24752500
D004008	Diclofenac	Diclofenac results in decreased expression of GCLC mRNA	17202759
D004008	Diclofenac	GCLC protein affects the susceptibility to Diclofenac	19481141
D018119	Stavudine	Stavudine results in increased expression of GCLC mRNA	18299183
D004026	Dieldrin	Dieldrin results in increased expression of GCLC mRNA	23041725
D004041	Dietary Fats	Dietary Fats results in decreased expression of GCLC mRNA	25016146
C058705	diethyl malate	diethyl malate affects the expression of GCLC mRNA	24814887
C014476	diethyl maleate	diethyl maleate results in increased activity of GCLC protein	10915739
C014476	diethyl maleate	diethyl maleate results in increased expression of GCLC mRNA	10915739\|2527062
C014476	diethyl maleate	diethyl maleate results in increased expression of GCLC protein	10915739
C014476	diethyl maleate	diethyl maleate results in increased activity of GCLC protein	15115889
C014476	diethyl maleate	diethyl maleate results in increased expression of GCLC mRNA	10978506\|1511588
C014476	diethyl maleate	diethyl maleate results in increased expression of GCLC protein	15115889\|2146525
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA	16158176
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA	14656948
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GCLC mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GCLC mRNA	26198647
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GCLC mRNA	15890375
C011612	diethyl sulfate	diethyl sulfate results in increased expression of GCLC mRNA	20491607
D002117	Calcitriol	[Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA	15913539
C552122	dimerumic acid	dimerumic acid results in increased activity of GCLC protein	24036144
C552122	dimerumic acid	dimerumic acid results in increased expression of GCLC mRNA	24036144
C552122	dimerumic acid	NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA]	24036144
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GCLC mRNA"	22485181
D000069462	Dimethyl Fumarate	Dimethyl Fumarate results in increased expression of GCLC mRNA	27277809
D000069462	Dimethyl Fumarate	NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]	27277809
D000069462	Dimethyl Fumarate	Dimethyl Fumarate results in increased expression of GCLC protein	27277809
C018522	dimethyl-N-acetylmuramyl-alanylglutamate	dimethyl-N-acetylmuramyl-alanylglutamate results in decreased expression of GCLC mRNA	16806111
C018522	dimethyl-N-acetylmuramyl-alanylglutamate	gypenoside inhibits the reaction [dimethyl-N-acetylmuramyl-alanylglutamate results in decreased expression of GCLC mRNA]	16806111
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of GCLC mRNA	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of GCLC protein	23485615
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of GCLC mRNA	14600272\|1589037
D004128	Dimethylnitrosamine	Plant Extracts inhibits the reaction [Dimethylnitrosamine results in decreased expression of GCLC protein]	23485615
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GCLC mRNA	20146380\|2056647
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of GCLC mRNA	23999411
C493087	diphenylarsinic acid	aspartyl-glutamyl-valyl-aspartal inhibits the reaction [diphenylarsinic acid results in increased cleavage of GCLC protein]	17628625
C493087	diphenylarsinic acid	Cycloheximide inhibits the reaction [diphenylarsinic acid results in increased expression of GCLC protein]	17628625
C493087	diphenylarsinic acid	[diphenylarsinic acid results in increased activity of CASP3 protein] which results in increased cleavage of GCLC protein	17628625
C493087	diphenylarsinic acid	diphenylarsinic acid results in increased cleavage of GCLC protein	17628625
C493087	diphenylarsinic acid	diphenylarsinic acid results in increased expression of GCLC protein	17628625
D004178	Diquat	Diquat results in increased expression of GCLC mRNA	16962985
D004178	Diquat	[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA	22762311
D004178	Diquat	Diquat results in decreased activity of GCLC protein	7676460
D004178	Diquat	Diquat results in decreased expression of GCLC mRNA	7676460
D004221	Disulfiram	Disulfiram results in increased expression of GCLC mRNA	20566472
D004237	Diuron	Diuron results in increased expression of GCLC mRNA	21551480
D004281	Docosahexaenoic Acids	"[Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNA]"	25659769
C012301	domoic acid	domoic acid results in increased expression of GCLC mRNA	23315585
C012301	domoic acid	domoic acid results in increased expression of GCLC protein	23315585
D004298	Dopamine	Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein]	23377617
D004317	Doxorubicin	[GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin]	10900222
D004317	Doxorubicin	GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]	11560771
D004317	Doxorubicin	ABCC1 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GCLC protein]	26822305
D004317	Doxorubicin	Doxorubicin results in increased expression of GCLC protein	26822305
D004317	Doxorubicin	Doxorubicin promotes the reaction [tyrphostin AG 1478 results in decreased expression of GCLC protein]	18371937
D004317	Doxorubicin	Doxorubicin results in decreased expression of GCLC protein	18371937\|2516900
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Ethanol results in decreased expression of GCLC mRNA]"	27983966
D004391	Dust	Dust results in increased expression of GCLC mRNA	17805423
D015118	Eicosapentaenoic Acid	"[Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNA]"	25659769
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in increased activity of GCLC protein	17092368
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in increased expression of GCLC mRNA	17092368
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GCLC protein	23301498
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GCLC mRNA	25585349
C048498	erdosteine	erdosteine results in increased expression of GCLC protein	26193055
D004976	Ethacrynic Acid	[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid	10900222
D000431	Ethanol	CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA]	19133322
D000431	Ethanol	Ethanol results in increased expression of GCLC mRNA	19133322
D000431	Ethanol	"Drugs, Chinese Herbal inhibits the reaction [Ethanol results in decreased expression of GCLC mRNA]"	27983966
D000431	Ethanol	Ethanol results in decreased expression of GCLC mRNA	27983966
D000431	Ethanol	Ethanol results in increased expression of GCLC mRNA	10978506
D000431	Ethanol	[Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA	10830784
D000431	Ethanol	[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein	16792574
D000431	Ethanol	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA	16792574
D000431	Ethanol	Ethanol results in increased activity of GCLC protein	16792574
D000431	Ethanol	Ethanol results in increased expression of GCLC mRNA	16792574
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GCLC mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GCLC mRNA	20170705\|2686566
C040833	ethyl acrylate	ethyl acrylate results in increased expression of GCLC mRNA	26198647
D005047	Etoposide	[GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]	10900222
D005047	Etoposide	[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide	10900222
C496966	Eudragit RSPO	Eudragit RSPO results in increased expression of GCLC mRNA	22119964
D005054	Eugenol	Eugenol results in increased expression of GCLC mRNA	20566472\|2619864
D018683	Excitatory Amino Acid Agents	Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
C074031	exenatide	exenatide results in increased expression of GCLC mRNA	27939242
C074031	exenatide	exenatide results in increased expression of GCLC protein	27939242
C074031	exenatide	GLP1R protein affects the reaction [exenatide results in increased expression of GCLC mRNA]	27939242
C074031	exenatide	PRKCD protein affects the reaction [exenatide results in increased expression of GCLC mRNA]	27939242
C074031	exenatide	rottlerin inhibits the reaction [exenatide results in increased expression of GCLC protein]	27939242
C084519	farnesal	farnesal results in increased expression of GCLC mRNA	20491607
C015881	farrerol	farrerol results in increased expression of GCLC mRNA	26111761
D011345	Fenofibrate	Fenofibrate results in decreased expression of GCLC mRNA	25596134
C024555	ferric chloride	[ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein	19900513
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of GCLC mRNA	18617210
C020748	ferrous sulfate	ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]	27424009
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of GCLC protein	27424009
C082360	fipronil	fipronil results in increased expression of GCLC mRNA	23962444
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of GCLC mRNA	16426233
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of GCLC mRNA	16426233
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA	16158176
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA	14656948
D005485	Flutamide	Flutamide results in increased expression of GCLC mRNA	17702527
D005485	Flutamide	Flutamide results in increased expression of GCLC mRNA	24136188
D005485	Flutamide	GCLC protein affects the susceptibility to Flutamide	19481141
D005492	Folic Acid	[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein	16792574
D005492	Folic Acid	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA	16792574
D005557	Formaldehyde	Formaldehyde results in increased expression of GCLC mRNA	20491607
C070081	fulvestrant	fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C039281	furan	[Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA	24910943
C039281	furan	furan results in increased expression of GCLC mRNA	24183702\|2491094
C039281	furan	furan results in increased expression of GCLC mRNA	27402187
D005690	Galactose	Galactose results in decreased expression of GCLC mRNA	25892055
D005690	Galactose	Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA]	25892055
C017341	gamma-glutamylcysteine	Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
C017341	gamma-glutamylcysteine	Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
C017341	gamma-glutamylcysteine	Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	15115889
C017341	gamma-glutamylcysteine	GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine	15115889
C017341	gamma-glutamylcysteine	GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine	19073151
D017965	gamma-Linolenic Acid	gamma-Linolenic Acid results in increased activity of GCLC protein	17092368
D017965	gamma-Linolenic Acid	gamma-Linolenic Acid results in increased expression of GCLC mRNA	17092368
C419708	gefitinib	GCLC protein affects the susceptibility to gefitinib	15496427
D019833	Genistein	Genistein affects the expression of GCLC mRNA	26865667
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA	21782745
D019833	Genistein	Genistein results in increased expression of GCLC mRNA	21782745
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in increased expression of GCLC mRNA	11673643
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in increased expression of GCLC protein	11673643
C063170	Ginkgo biloba extract	[Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione	11673643
D005907	Gliclazide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
D005907	Gliclazide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
D005944	Glucosamine	Glucosamine analog results in increased expression of GCLC mRNA	21825963
D005961	Glucosinolates	Glucosinolates results in increased expression of GCLC protein	15570060
D005978	Glutathione	Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]	17724089
D005978	Glutathione	[Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione	17724089
D005978	Glutathione	GCLC polymorphism affects the chemical synthesis of Glutathione	16599007
D005978	Glutathione	GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]	12504668
D005978	Glutathione	GCLC results in increased abundance of Glutathione	18556457
D005978	Glutathione	[GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride	18556457
D005978	Glutathione	[Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione	11673643
D005978	Glutathione	[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	21728338
D005978	Glutathione	[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione	21728338
D005978	Glutathione	[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione	21833590
D005978	Glutathione	[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione	17724089
D005978	Glutathione	[2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione	7955076
D005978	Glutathione	[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]	7955076
D005978	Glutathione	[Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione	15707499
D005978	Glutathione	[Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione	15282320
D005978	Glutathione	[FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione	23628456
D005978	Glutathione	[FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione	23628456
D005978	Glutathione	GCLC mRNA results in increased abundance of Glutathione	26187465
D005978	Glutathione	[GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein	26187465
D005978	Glutathione	GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]	14978233
D005978	Glutathione	GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]	19914271
D005978	Glutathione	GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]	20159942
D005978	Glutathione	GCLC protein results in increased abundance of Glutathione	19914271\|7955076
D005978	Glutathione	[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA	22762311
D005978	Glutathione	Glutathione deficiency results in increased expression of GCLC mRNA	15345336\|2062111
D005978	Glutathione	[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione	10544272
D005978	Glutathione	GCLC protein affects the chemical synthesis of Glutathione	21728338
D005978	Glutathione	[GCLC protein co-treated with GCLM protein] results in increased chemical synthesis of Glutathione	17584759
D005978	Glutathione	GCLC protein results in increased abundance of Glutathione	22914438
D005978	Glutathione	GCLC protein results in increased chemical synthesis of Glutathione	19798679\|2366541
D005978	Glutathione	GCLC results in increased abundance of Glutathione	21833590
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in increased expression of GCLC mRNA	20471814
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins inhibits the reaction [titanium dioxide results in decreased expression of GCLC protein]	28780322
C474918	gypenoside	gypenoside inhibits the reaction [dimethyl-N-acetylmuramyl-alanylglutamate results in decreased expression of GCLC mRNA]	16806111
C474918	gypenoside	gypenoside results in increased expression of GCLC mRNA	16806111
D006427	Hemin	Hemin results in increased expression of GCLC mRNA	16631525
C001335	hexachlorobutadiene	hexachlorobutadiene results in decreased expression of GCLC mRNA	21905055
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of GCLC mRNA	21905055
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of GCLC mRNA	20566472
C012348	higenamine	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D017313	Fenretinide	[Fenretinide co-treated with scriptaid] results in increased expression of GCLC mRNA	21319187
D017313	Fenretinide	[Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA	21319187
D017313	Fenretinide	Fenretinide results in increased expression of GCLC mRNA	21319187
D017313	Fenretinide	Fenretinide results in increased expression of GCLC mRNA	28973697
D006843	Hydrocarbons, Chlorinated	"Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of GCLC protein]"	24355586
D006843	Hydrocarbons, Chlorinated	"Hydrocarbons, Chlorinated analog results in decreased activity of GCLC protein"	24355586
D006854	Hydrocortisone	Hydrocortisone results in increased expression of GCLC mRNA	10978506
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GCLC mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of GCLC protein	24866057
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GCLC mRNA	12598062\|1663152
D006861	Hydrogen Peroxide	MIR153 mRNA affects the reaction [Hydrogen Peroxide results in decreased expression of GCLC protein]	24866057
D006861	Hydrogen Peroxide	GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]	19914271
D006861	Hydrogen Peroxide	GCLC protein results in decreased susceptibility to Hydrogen Peroxide	19914271
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GCLC protein	24437944
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]	27028516
D006861	Hydrogen Peroxide	notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of GCLC protein]	24437944
D006861	Hydrogen Peroxide	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]]	27028516
D047348	Hydrolyzable Tannins	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D006894	Hydroxyestrones	[Hydroxyestrones results in increased expression of and results in increased localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	19952498
D006997	Hypochlorous Acid	Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D006997	Hypochlorous Acid	Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D006997	Hypochlorous Acid	CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D006997	Hypochlorous Acid	Hypochlorous Acid affects the expression of GCLC mRNA	18648578
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of GCLC mRNA	17980396
D006997	Hypochlorous Acid	S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
D007052	Ibuprofen	Ibuprofen results in increased expression of GCLC mRNA	11909699
D007069	Ifosfamide	Ifosfamide results in decreased expression of GCLC mRNA	25596134
C093581	indene	indene results in increased expression of GCLC mRNA	27750016
C057286	indenoindole	[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]	7955076
C057286	indenoindole	[CYP1A1 protein results in increased metabolism of indenoindole] which results in increased activity of GCLC protein	7955076
D007213	Indomethacin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]	11909699
D007213	Indomethacin	Acetylcysteine inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]	11909699
D007213	Indomethacin	Indomethacin results in increased expression of GCLC mRNA	11909699
D007213	Indomethacin	Indomethacin results in increased expression of GCLC protein	11820781
D007213	Indomethacin	KEAP1 protein inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]	11909699
D007306	Insecticides	Insecticides results in decreased expression of GCLC mRNA	23401056
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GCLC mRNA	25613284
D007501	Iron	Iron results in decreased expression of GCLC mRNA	19073151
D007501	Iron	Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]	19073151
D007501	Iron	Iron results in increased activity of GCLC protein	17189828
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA]	16054899
C036643	isoeugenol	isoeugenol results in increased expression of GCLC mRNA	20566472
D007538	Isoniazid	Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]	24128855
D007538	Isoniazid	Isoniazid results in decreased expression of GCLC mRNA	24128855
D007545	Isoproterenol	Isoproterenol results in decreased expression of GCLC mRNA	21335049
D017879	Isothiocyanates	Isothiocyanates results in increased expression of GCLC protein	15570060
D017879	Isothiocyanates	Isothiocyanates results in increased expression of GCLC protein	15570060
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of GCLC mRNA	27233051
C561695	(+)-JQ1 compound	oltipraz promotes the reaction [(+)-JQ1 compound results in increased expression of GCLC mRNA]	27233051
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of GCLC mRNA	23430699\|2473384
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of GCLC protein	24733848
C410337	K 7174	K 7174 results in increased expression of GCLC mRNA	24086573
C006552	kaempferol	kaempferol results in increased expression of GCLC mRNA	11864778
C053401	kahweol	[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein]	17110534
D007649	Ketamine	Ketamine results in increased expression of GCLC mRNA	20080153
D007660	Ketoprofen	Ketoprofen results in increased expression of GCLC mRNA	11909699
D019344	Lactic Acid	Lactic Acid results in increased expression of GCLC mRNA	20566472
C028521	lanthanum chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA	28954213
C028521	lanthanum chloride	lanthanum chloride results in increased expression of GCLC mRNA	24142884
C028521	lanthanum chloride	lanthanum chloride results in increased expression of GCLC protein	24142884
C008261	lead acetate	lead acetate results in increased expression of GCLC mRNA	26498409
C008261	lead acetate	NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA]	26498409
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA	18654764
C029891	lead chloride	lead chloride results in increased expression of GCLC mRNA	18654764
C045463	leflunomide	leflunomide results in increased expression of GCLC mRNA	24136188
D064704	Levofloxacin	Levofloxacin results in decreased expression of GCLC mRNA	24136188
C018584	linalool	linalool results in increased expression of GCLC mRNA	20491607
D001556	Lindane	Lindane results in increased expression of GCLC mRNA	26198647
D044243	Linoleic Acids, Conjugated	"Linoleic Acids, Conjugated results in increased activity of GCLC protein"	17092368
D044243	Linoleic Acids, Conjugated	"[Linoleic Acids, Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide"	17092368
D044243	Linoleic Acids, Conjugated	"Linoleic Acids, Conjugated results in increased expression of GCLC mRNA"	17092368
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA"	18930950
D008095	Lithocholic Acid	Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]	17724089
D008095	Lithocholic Acid	Lithocholic Acid affects the expression of GCLC mRNA	20146260
D008095	Lithocholic Acid	Lithocholic Acid affects the expression of GCLC protein	20146260
D008095	Lithocholic Acid	[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	17724089
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of GCLC protein	17724089
D008095	Lithocholic Acid	[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione	17724089
D008095	Lithocholic Acid	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]	20146260
D008095	Lithocholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]	20146260
D008095	Lithocholic Acid	[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	17724089
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of GCLC mRNA	20977460
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of GCLC protein	20977460
D008095	Lithocholic Acid	NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]	20977460
D008095	Lithocholic Acid	NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]	20977460
D047311	Luteolin	Luteolin results in increased expression of GCLC mRNA	22864849
D047311	Luteolin	[Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide	22864849
D047311	Luteolin	Luteolin results in increased expression of GCLC protein	22864849
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLC mRNA	26378955
D008344	Maneb	[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA	21402726
D008344	Maneb	Maneb results in increased activity of GCLC protein	15527874
C001687	maytenonic acid	maytenonic acid results in increased expression of GCLC mRNA	27751938
C001687	maytenonic acid	maytenonic acid results in increased expression of GCLC mRNA	27751938
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
C065757	meloxicam	meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein]	20851755
C042720	mercuric bromide	mercuric bromide results in increased expression of GCLC mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
D008627	Mercuric Chloride	GCLC protein results in decreased susceptibility to Mercuric Chloride	24118919
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of GCLC mRNA	24118919
D008628	Mercury	GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]	19515364
D008628	Mercury	GCLC gene SNP affects the susceptibility to Mercury	22236634
D008628	Mercury	Mercury results in increased expression of GCLC mRNA	17547211
D008687	Metformin	Metformin results in increased expression of GCLC mRNA	25596134
D008701	Methapyrilene	Methapyrilene results in increased expression of GCLC mRNA	15890375\|2893558
D008701	Methapyrilene	Methapyrilene results in increased expression of GCLC protein	19523481
D008713	Methimazole	Methimazole results in increased expression of GCLC mRNA	20144635
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA	20350562
D008715	Methionine	NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA]	20350562
D008727	Methotrexate	Methotrexate affects the expression of GCLC mRNA	18502557
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of GCLC mRNA	21782745
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased expression of GCLC mRNA"	27480280
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased expression of GCLC protein"	27480280
D008753	Methylenebis(chloroaniline)	Methylenebis(chloroaniline) results in increased expression of GCLC mRNA	26198647
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA	24556215
D008751	Methylene Blue	Methylene Blue results in increased expression of GCLC mRNA	24556215
D008751	Methylene Blue	NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]	24556215
C002950	methylformamide	methylformamide affects the expression of GCLC mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of GCLC mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GCLC mRNA	23458150
C004925	methylmercuric chloride	GCLC protein results in decreased susceptibility to methylmercuric chloride	24118919
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GCLC mRNA	24118919\|2800136
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GCLC mRNA	20061341
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GCLC mRNA	27298056
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GCLC protein	27298056
C004925	methylmercuric chloride	Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]	27298056
C004925	methylmercuric chloride	Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]	27298056
D008767	Methylmercury Compounds	GCLC gene polymorphism affects the metabolism of Methylmercury Compounds	24696865
D008767	Methylmercury Compounds	GCLC polymorphism affects the metabolism of Methylmercury Compounds	16599007
C020771	methylmercury hydroxide	GCLC protein affects the susceptibility to methylmercury hydroxide	8806884
C020771	methylmercury hydroxide	methylmercury hydroxide results in increased expression of GCLC mRNA	8806884
C020771	methylmercury hydroxide	methylmercury hydroxide results in increased expression of GCLC mRNA	1351382\|8917676
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GCLC mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]"	21871945
D008743	Methyl Parathion	[Methyl Parathion co-treated with Verapamil] results in increased expression of GCLC mRNA	25286004
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA]"	20230807
C033069	methyl salicylate	methyl salicylate results in increased expression of GCLC mRNA	20566472
C076881	methysticin	methysticin results in increased expression of GCLC mRNA	28448946
D052998	Microcystins	Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA]	24964298
D052998	Microcystins	Microcystins analog results in increased expression of GCLC mRNA	24964298
D015735	Mifepristone	Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]]	16840778
D015735	Mifepristone	Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]	16840778
D015735	Mifepristone	Mifepristone results in increased expression of GCLC protein	16840778
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of GCLC mRNA	19945496\|2088654
C523799	MRK 003	GCLC results in decreased susceptibility to MRK 003	19903844
C492919	N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA]"	19747488
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GCLC mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GCLC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GCLC mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GCLC mRNA"	25554681
C031721	naphthalene	Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]	12805647
C031721	naphthalene	Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]	10900227
C031721	naphthalene	GCLC protein results in decreased susceptibility to naphthalene	10900227\|1280564
C031721	naphthalene	naphthalene results in increased activity of GCLC protein	10900227
C031721	naphthalene	naphthalene results in increased expression of and results in increased activity of GCLC protein	12805647
C031721	naphthalene	naphthalene analog results in increased expression of GCLC mRNA	24976557
C031721	naphthalene	naphthalene results in increased expression of GCLC mRNA	24563378
C005503	naphthazarin	naphthazarin results in increased activity of GCLC protein	12379427
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GCLC mRNA	20551477
D009288	Naproxen	Naproxen results in increased expression of GCLC mRNA	11909699
C529068	naringenin-7-O-glucoside	naringenin-7-O-glucoside results in increased expression of GCLC mRNA	18652870
C005274	naringin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C005274	naringin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C005274	naringin	[naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA	22871521
C005274	naringin	naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]	25773745
C005274	naringin	naringin results in increased expression of GCLC mRNA	22871521
C005274	naringin	naringin results in increased expression of GCLC protein	25773745
C005274	naringin	rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of GCLC mRNA	19812364
C524653	nectandrin-B	nectandrin-B results in increased expression of GCLC mRNA	27511913
C524653	nectandrin-B	nectandrin-B results in increased expression of GCLC protein	27511913
C524653	nectandrin-B	GSK3B protein inhibits the reaction [nectandrin-B results in increased expression of GCLC mRNA]	27511913
C524653	nectandrin-B	GSK3B protein inhibits the reaction [nectandrin-B results in increased expression of GCLC protein]	27511913
C524653	nectandrin-B	nectandrin-B results in increased expression of GCLC mRNA	27511913
C524653	nectandrin-B	nectandrin-B results in increased expression of GCLC protein	27511913
C524653	nectandrin-B	U 0126 inhibits the reaction [nectandrin-B results in increased expression of GCLC mRNA]	27511913
C524653	nectandrin-B	U 0126 inhibits the reaction [nectandrin-B results in increased expression of GCLC protein]	27511913
C051752	nefazodone	nefazodone results in increased expression of GCLC mRNA	24136188
C026385	n-hexane	n-hexane results in increased expression of GCLC mRNA	20566472
C022838	nickel chloride	nickel chloride results in increased expression of GCLC mRNA	17547211\|2111180
C022838	nickel chloride	nickel chloride affects the expression of GCLC mRNA	22110744
C029938	nickel sulfate	nickel sulfate results in increased expression of GCLC mRNA	20491607\|2056647
C029938	nickel sulfate	nickel sulfate results in increased expression of GCLC mRNA	16100012
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of GCLC mRNA	24136188
D015376	Nimustine	Nimustine results in increased expression of GCLC mRNA	9393752
C077073	nitisinone	[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA	12899938
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased expression of GCLC mRNA	19631198
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased expression of GCLC protein	19631198
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of GCLC mRNA	26552463
C025256	nonylphenol	nonylphenol results in increased expression of GCLC mRNA	22982499
C072936	notoginsenoside R1	Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C072936	notoginsenoside R1	Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C072936	notoginsenoside R1	fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C072936	notoginsenoside R1	NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]	24437944
C072936	notoginsenoside R1	notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of GCLC protein]	24437944
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of GCLC protein	24437944
C570897	NSC668394	NSC668394 results in increased expression of GCLC mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of GCLC mRNA	20971185
C025589	ochratoxin A	[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein]	17110534
C025589	ochratoxin A	ochratoxin A results in decreased expression of GCLC mRNA	16251485\|1841718
C025589	ochratoxin A	ochratoxin A results in decreased expression of GCLC protein	16251485\|1711053
C025589	ochratoxin A	ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]	18547363
C025589	ochratoxin A	ochratoxin A results in decreased expression of GCLC mRNA	18547363
D016627	Oxidopamine	Oxidopamine results in decreased expression of GCLC protein	25446857
D016627	Oxidopamine	salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]	25446857
D016627	Oxidopamine	Oxidopamine results in decreased expression of GCLC protein	25446857
D016627	Oxidopamine	Oxidopamine results in increased expression of GCLC mRNA	21397656
D016627	Oxidopamine	Oxidopamine results in increased expression of GCLC protein	21397656
D016627	Oxidopamine	salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]	25446857
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of GCLC mRNA	18706400\|1928389
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of GCLC protein	25280775
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of GCLC mRNA	18706400
C026209	oltipraz	oltipraz promotes the reaction [(+)-JQ1 compound results in increased expression of GCLC mRNA]	27233051
C016340	o,p'-DDT	"o,p'-DDT affects the expression of GCLC mRNA"	17984292
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of GCLC mRNA	25729387
C030110	oxaliplatin	[Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of GCLC mRNA	25596134
D010100	Oxygen	[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC mRNA	25922074
D010100	Oxygen	naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]	25773745
D010100	Oxygen	NFE2L2 mutant form inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]	25773745
D010100	Oxygen	[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein	25773745
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GCLC mRNA	25658374
D010126	Ozone	Ozone results in increased expression of GCLC mRNA	17095637
D010126	Ozone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA]	17460151
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of GCLC mRNA]	19555225
D019308	Palmitic Acid	Palmitic Acid results in increased expression of GCLC mRNA	28027979
D010269	Paraquat	Paraquat affects the expression of GCLC mRNA	25064622
D010269	Paraquat	Paraquat results in increased expression of GCLC mRNA	27288846
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of GCLC protein]	20851755
D010269	Paraquat	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA	24530478
D010269	Paraquat	CAT protein inhibits the reaction [Paraquat results in decreased expression of GCLC protein]	24866057
D010269	Paraquat	meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein]	20851755
D010269	Paraquat	Paraquat results in decreased expression of GCLC mRNA	24866057
D010269	Paraquat	Paraquat results in decreased expression of GCLC protein	20851755\|2486605
D010269	Paraquat	Paraquat results in increased expression of GCLC mRNA	17215068
D010269	Paraquat	Paraquat results in increased expression of GCLC mRNA	20116453
D010269	Paraquat	Paraquat affects the expression of GCLC mRNA	16854511
D010269	Paraquat	Paraquat results in increased expression of GCLC mRNA	26598004\|2846789
D052638	Particulate Matter	Particulate Matter results in decreased expression of GCLC mRNA	17987463
D052638	Particulate Matter	NFE2L2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of GCLC mRNA]	18614404
D052638	Particulate Matter	Particulate Matter results in increased expression of GCLC mRNA	18614404
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GCLC mRNA	24642059
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of GCLC mRNA	21503142
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of GCLC mRNA	23567314
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of GCLC mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GCLC mRNA	26548598
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GCLC mRNA	23567314
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GCLC mRNA	27750016
D026023	Permethrin	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA	28659758
D010578	Petroleum	GCLC gene SNP affects the susceptibility to Petroleum	21716162
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of GCLC mRNA	20442190
D010634	Phenobarbital	Phenobarbital results in increased expression of GCLC mRNA	21896655
D010634	Phenobarbital	Phenobarbital results in decreased expression of GCLC mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in decreased expression of GCLC mRNA	19162173
D019800	Phenol	Phenol results in increased expression of GCLC mRNA	26198647
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of GCLC mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of GCLC mRNA	22538082
D010696	Phloroglucinol	Phloroglucinol results in increased expression of GCLC protein	20188716
D010696	Phloroglucinol	Phloroglucinol results in increased expression of GCLC protein	20188716
D010705	Phosgene	Phosgene affects the expression of GCLC mRNA	16300373
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GCLC mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in decreased expression of GCLC mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of GCLC mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of GCLC mRNA	15890375\|1916217
D010936	Plant Extracts	Plant Extracts results in increased activity of GCLC protein	23485615
D010936	Plant Extracts	Plant Extracts results in increased expression of GCLC mRNA	11864778\|2192041
D010936	Plant Extracts	Plant Extracts results in increased expression of GCLC mRNA	27163856
D010936	Plant Extracts	Plant Extracts results in increased expression of GCLC protein	15570060
D010936	Plant Extracts	Plant Extracts results in increased expression of GCLC protein	15570060
D010936	Plant Extracts	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA]	20399244
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dimethylnitrosamine results in decreased expression of GCLC protein]	23485615
D010936	Plant Extracts	Plant Extracts results in increased expression of GCLC mRNA	20399244
D010936	Plant Extracts	U 0126 inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA]	20399244
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of GCLC mRNA	22579512
D011189	Potassium Chloride	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA"	22228705
C027373	potassium chromate(VI)	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA]	14625279
D011192	Potassium Dichromate	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA]	14625279
D045542	PQQ Cofactor	PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA]	26276080
D017035	Pravastatin	Pravastatin results in increased expression of GCLC mRNA	27225895
D017035	Pravastatin	Pravastatin results in decreased expression of GCLC mRNA	27225895
D011224	Prazosin	Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA]	18071297
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA"	22851183
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA"	22851183
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of GCLC mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GCLC mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of GCLC mRNA	22154832
D011374	Progesterone	Progesterone results in decreased expression of GCLC mRNA	22238285
D019840	2-Propanol	2-Propanol results in increased expression of GCLC mRNA	20566472
C005556	propionaldehyde	propionaldehyde results in decreased expression of GCLC mRNA	26079696
C034912	puag-haad	puag-haad results in increased expression of GCLC protein	26102008
D011710	Pyocyanine	Pyocyanine results in increased expression of GCLC mRNA	24015256
D011710	Pyocyanine	[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA	24015256
D011710	Pyocyanine	trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]	24015256
D011719	Pyrazines	Pyrazines analog results in increased expression of GCLC mRNA	25056784
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]	21469739
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]	25881548
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]	25881548
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC mRNA]	25881548
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC protein]	25881548
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA]	17460151
C432165	pyrazolanthrone	pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA]	19328227
C031280	pyrazole	pyrazole results in increased expression of GCLC mRNA	17945193
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA	28659758
D011794	Quercetin	[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA	25881548
D011794	Quercetin	pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]	25881548
D011794	Quercetin	pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]	25881548
D011794	Quercetin	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC mRNA]	25881548
D011794	Quercetin	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC protein]	25881548
D011794	Quercetin	Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]	25881548
D011794	Quercetin	Quercetin results in increased expression of GCLC mRNA	11864778\|2125695
D011794	Quercetin	Quercetin results in increased expression of GCLC protein	25881548
D011794	Quercetin	Quercetin results in increased expression of GCLC mRNA	19183254
D011794	Quercetin	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA	25716194
D011794	Quercetin	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein	25716194
D011794	Quercetin	Quercetin affects the expression of GCLC mRNA	18178720
D011794	Quercetin	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA]]	27028516
D011794	Quercetin	Quercetin promotes the reaction [EGR1 protein binds to GCLC promoter]	19798679\|2217404
D011794	Quercetin	Quercetin results in increased expression of GCLC mRNA	19798679\|2055401
D011794	Quercetin	Quercetin results in increased expression of GCLC protein	25716194
C428865	quercetin 3-arabinopyranoside	[quercetin 3-arabinopyranoside results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	16574296
C428865	quercetin 3-arabinopyranoside	quercetin 3-arabinopyranoside results in increased expression of GCLC protein	16574296
C443401	quercetin 3-O-glucuronide	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA	25716194
C443401	quercetin 3-O-glucuronide	[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein	25716194
D017382	Reactive Oxygen Species	[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	21728338
D017382	Reactive Oxygen Species	[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione	21728338
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of GCLC mRNA	25800948
D017382	Reactive Oxygen Species	[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]	22864849
C059514	resveratrol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of GCLC mRNA]	11909699
C059514	resveratrol	[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with resveratrol] results in increased expression of GCLC mRNA	27818126
C059514	resveratrol	NFE2L2 protein affects the reaction [resveratrol results in increased expression of GCLC mRNA]	20418481
C059514	resveratrol	[resveratrol results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA	20418481
C059514	resveratrol	resveratrol results in increased expression of GCLC mRNA	11909699\|2006092
C059514	resveratrol	resveratrol results in increased expression of GCLC mRNA	21520053
C059514	resveratrol	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
C059514	resveratrol	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
C059514	resveratrol	resveratrol results in increased expression of GCLC mRNA	15882976
C059514	resveratrol	KEAP1 protein inhibits the reaction [resveratrol results in increased expression of GCLC mRNA]	20418481
D012172	Retinaldehyde	Retinaldehyde results in increased expression of GCLC mRNA	25331497\|2775175
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA]	16054899
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium results in increased expression of GCLC mRNA	18154958
D000068718	Rosuvastatin Calcium	[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA	18154958
D012402	Rotenone	Rotenone results in increased expression of GCLC mRNA	17657281
D012402	Rotenone	PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA]	26276080
D012402	Rotenone	Rotenone results in decreased expression of GCLC mRNA	26276080
D012402	Rotenone	[safranal co-treated with Rotenone] affects the expression of GCLC	28145852
C085746	rottlerin	rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]	24211276
C085746	rottlerin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]	25895139
C085746	rottlerin	rottlerin inhibits the reaction [exenatide results in increased expression of GCLC protein]	27939242
C085746	rottlerin	rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]	25895139
C085746	rottlerin	rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]	25773745
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GCLC mRNA"	16678137
C079198	S 1 (combination)	GCLC protein results in increased susceptibility to S 1 (combination)	16734730
C087963	safranal	[safranal co-treated with Rotenone] affects the expression of GCLC	28145852
C018381	salvin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]	26577515\|2668657
C018381	salvin	NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]	26577515
C018381	salvin	NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]	26686574
C018381	salvin	salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]	25446857
C018381	salvin	salvin results in increased expression of GCLC protein	26577515\|2668657
C018381	salvin	salvin results in increased expression of GCLC mRNA	18329808
C018381	salvin	salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]	25446857
D012503	Saponins	Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA]	25892055
C093642	SB 203580	SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein]	25201354
C015499	schizandrin B	schizandrin B analog results in increased activity of GCLC protein	21328628
C410733	scriptaid	[Fenretinide co-treated with scriptaid] results in increased expression of GCLC mRNA	21319187
C410733	scriptaid	scriptaid results in increased expression of GCLC mRNA	21319187
D012643	Selenium	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA	11444866
C009226	selenocystine	NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]	22807314
C009226	selenocystine	selenocystine results in increased expression of GCLC mRNA	22807314
D012645	Selenomethionine	Selenomethionine results in increased expression of GCLC mRNA	22807314
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in decreased activity of GCLC protein	19010315
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]	17980396
C040115	shogaol	shogaol metabolite results in increased expression of GCLC protein	25148906
C040115	shogaol	shogaol results in increased expression of GCLC protein	25148906
C040115	shogaol	NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]	25148906
C040115	shogaol	shogaol results in increased expression of GCLC mRNA	25148906
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GCLC mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of GCLC mRNA	23221170
D012834	Silver	NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA]	22546375
D012834	Silver	Silver results in increased expression of GCLC mRNA	22036727\|2254637
D012834	Silver	Silver results in increased expression of GCLC mRNA	27131904
D018030	Silver Compounds	Silver Compounds results in decreased expression of GCLC protein	21182908
D012835	Silver Nitrate	Silver Nitrate results in decreased expression of GCLC mRNA	19733233
D012838	Silymarin	Silymarin results in increased expression of GCLC mRNA	28137608
D012838	Silymarin	Silymarin results in increased expression of GCLC protein	28137608
C403258	si-wu-tang	si-wu-tang results in increased expression of GCLC mRNA	21464939
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
C009277	sodium arsenate	sodium arsenate results in increased expression of GCLC mRNA	12727804
C017947	sodium arsenite	NFE2L2A protein affects the reaction [sodium arsenite results in increased expression of GCLC mRNA]	27306194
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC mRNA	27306194
C017947	sodium arsenite	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of GCLC protein]	25201354
C017947	sodium arsenite	CARM1 mutant form promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]	23699174
C017947	sodium arsenite	NFE2L1 protein affects the reaction [sodium arsenite results in increased expression of GCLC mRNA]	20805060
C017947	sodium arsenite	NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]	28125038
C017947	sodium arsenite	PRMT1 mutant form promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]	23699174
C017947	sodium arsenite	SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein]	25201354
C017947	sodium arsenite	sodium arsenite affects the methylation of GCLC gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased activity of GCLC protein	12441363
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC mRNA	12441363\|2010067
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC protein	25201354\|2871322
C017947	sodium arsenite	SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]	28125038
C017947	sodium arsenite	[GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein]	20006689
C017947	sodium arsenite	[GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]	20006689
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC mRNA	16014739\|2139691
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC protein	26371860\|2647389
C017947	sodium arsenite	sodium arsenite affects the expression of GCLC mRNA	25625412
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC mRNA	12210719\|2146525
C017947	sodium arsenite	sodium arsenite results in increased expression of GCLC protein	21465251
C016104	sodium bichromate	sodium bichromate results in decreased expression of GCLC mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GCLC mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GCLC mRNA	22561333
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [uranyl acetate results in decreased expression of GCLC protein]	26523793
D017673	Sodium Chloride, Dietary	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA"	22228705
D020358	Sodium Cholate	"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein"	27394961
D020358	Sodium Cholate	"MET gene mutant form inhibits the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein]"	27394961
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of GCLC mRNA	20566472
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GCLC mRNA	27862939
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GCLC mRNA	24383545
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GCLC mRNA	18449455
D053260	Soot	Soot results in increased expression of GCLC mRNA	19165387\|2246145
D053260	Soot	Soot results in decreased expression of GCLC mRNA	23065132
D053260	Soot	Soot results in increased expression of GCLC protein	23065132
D013148	Spironolactone	Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]	24512358\|2520468
C539817	S-sulindac	S-sulindac results in increased expression of GCLC mRNA	19276279
D019311	Staurosporine	Staurosporine promotes the reaction [MYC protein binds to GCLC promoter]	17628013
D013311	Streptozocin	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
D013311	Streptozocin	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
D013311	Streptozocin	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
D013311	Streptozocin	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA	21439372
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein	21439372
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of GCLC mRNA	16214533
D020058	Styrene	Styrene results in increased activity of GCLC protein	16971035
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLC mRNA	26378955
C016766	sulforafan	sulforafan promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]	23174481
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	27306194
C016766	sulforafan	alpha-methylepinine promotes the reaction [sulforafan results in increased expression of GCLC mRNA]	21871945
C016766	sulforafan	NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]	22807314
C016766	sulforafan	sulforafan promotes the reaction [alpha-methylepinine results in increased expression of GCLC mRNA]	21871945
C016766	sulforafan	sulforafan promotes the reaction [Cisplatin results in increased expression of GCLC mRNA]	28959534
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	20442190\|2187194
C016766	sulforafan	sulforafan results in increased expression of GCLC protein	22558124
C016766	sulforafan	NFE2L2 protein promotes the reaction [sulforafan results in increased expression of GCLC mRNA]	20932822
C016766	sulforafan	[sulforafan co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA	17942926
C016766	sulforafan	sulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]	25818464
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	17942926\|1907115
C016766	sulforafan	sulforafan results in increased expression of GCLC protein	19303893\|2777701
C016766	sulforafan	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]"	21871945
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	21871945
C016766	sulforafan	sulforafan results in increased expression of GCLC protein	22558124
C016766	sulforafan	Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]	20732396
C016766	sulforafan	ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]	18547363
C016766	sulforafan	sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]	20732396
C016766	sulforafan	sulforafan results in increased activity of GCLC protein	20732396
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	18547363
C016766	sulforafan	sulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]	25818464
C016766	sulforafan	sulforafan results in increased expression of GCLC mRNA	25818464
D013467	Sulindac	Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]	11820781
D013467	Sulindac	Sulindac affects the expression of GCLC mRNA	15946948
D013467	Sulindac	Sulindac results in increased expression of GCLC protein	11820781
D013496	Suprofen	Suprofen results in increased expression of GCLC mRNA	11909699
C458508	T 0070907	T 0070907 results in increased expression of GCLC mRNA	22851183
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA"	16426233
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA"	16426233
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of GCLC mRNA	20854872
D013629	Tamoxifen	Tamoxifen affects the expression of GCLC mRNA	20937368
C001803	tempol	tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein]	24512358\|2520468
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA	19542225\|2180250
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GCLC mRNA	20702594\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of GCLC mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC mRNA]	21846477
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA	15328365\|1580003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GCLC mRNA	21215274\|2323856
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA	16960034
D013752	Tetracycline	Tetracycline affects the expression of GCLC mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA	18154958
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA	18154958\|2619864
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA	17200146
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GCLC mRNA	25613284
C017953	tetramethylpyrazine	tetramethylpyrazine analog results in increased expression of GCLC mRNA	25056784
C017953	tetramethylpyrazine	tetramethylpyrazine analog results in increased expression of GCLC protein	25056784
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]	27477297
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]	27477297
D013827	Thiabendazole	[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein	11019651
D013827	Thiabendazole	Thiabendazole results in increased activity of GCLC protein	11019651
D013853	Thioacetamide	Thioacetamide affects the expression of GCLC mRNA	25064622
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of GCLC mRNA	10486302\|1097850
D013853	Thioacetamide	Thioacetamide results in increased expression of GCLC protein	10486302
D008063	Thioctic Acid	Thioctic Acid results in increased expression of GCLC mRNA	16249512\|1794088
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]	27298056
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]	27298056
C009495	titanium dioxide	Grape Seed Proanthocyanidins inhibits the reaction [titanium dioxide results in decreased expression of GCLC protein]	28780322
C009495	titanium dioxide	titanium dioxide results in decreased expression of GCLC protein	28780322
C009495	titanium dioxide	titanium dioxide results in increased expression of GCLC mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GCLC mRNA	27576004
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GCLC mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	[Acetaminophen co-treated with Tobacco Smoke Pollution] results in increased expression of GCLC mRNA	26452297
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GCLC mRNA	26452297
D014028	Tobacco Smoke Pollution	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GCLC mRNA	22935520
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA	25729387
D019772	Topotecan	[Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of GCLC mRNA	25729387
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA	22851183
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA	22851183
D014199	Trehalose	Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein]	29140578
C034613	triacsin C	triacsin C results in increased expression of GCLC mRNA	16704987
C011559	tributyltin	PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]	25895139
C012589	trichostatin A	trichostatin A results in increased expression of GCLC mRNA	15901671
C012589	trichostatin A	[Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA	21319187
C012589	trichostatin A	trichostatin A results in increased expression of GCLC mRNA	21319187
C009560	trigonelline	trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]	24015256
C046488	trimethyltin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]	25895139
C046488	trimethyltin	rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]	25895139
C046488	trimethyltin	trimethyltin results in increased expression of GCLC mRNA	25895139
D014302	Trinitrobenzenesulfonic Acid	[Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA	10830784
C001899	triptolide	triptolide results in decreased expression of GCLC protein	25169008
C001899	triptolide	NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]	25169008
C001899	triptolide	triptolide results in decreased expression of GCLC protein	25169008
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GCLC mRNA"	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GCLC mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of GCLC mRNA	19140230
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA"	18930950
C080163	trovafloxacin	trovafloxacin results in decreased expression of GCLC mRNA	24136188
D014415	Tunicamycin	NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of GCLC mRNA]	22959925
D014415	Tunicamycin	Tunicamycin results in increased expression of GCLC mRNA	22959925
C101044	tyrphostin AG 1478	Doxorubicin promotes the reaction [tyrphostin AG 1478 results in decreased expression of GCLC protein]	18371937
C101044	tyrphostin AG 1478	tyrphostin AG 1478 results in decreased expression of GCLC protein	18371937
C113580	U 0126	U 0126 inhibits the reaction [nectandrin-B results in increased expression of GCLC mRNA]	27511913
C113580	U 0126	U 0126 inhibits the reaction [nectandrin-B results in increased expression of GCLC protein]	27511913
C113580	U 0126	U 0126 inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA]	20399244
C005460	uranyl acetate	sodium bisulfide inhibits the reaction [uranyl acetate results in decreased expression of GCLC protein]	26523793
C005460	uranyl acetate	uranyl acetate results in decreased expression of GCLC protein	26523793
D014520	Urethane	Urethane results in increased expression of GCLC mRNA	28818685
D014580	Ursodeoxycholic Acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]	19073151
D014580	Ursodeoxycholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]	19073151
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of GCLC mRNA	19073151
D014580	Ursodeoxycholic Acid	NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]	18687751
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of GCLC mRNA	18687751
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of GCLC protein	18687751
C073339	usnic acid	NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]	27369375
C073339	usnic acid	usnic acid results in increased expression of GCLC mRNA	27369375
C073339	usnic acid	usnic acid results in increased expression of GCLC protein	27369375
C406224	valdecoxib	valdecoxib results in increased expression of GCLC mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of GCLC mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in increased expression of GCLC mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased expression of GCLC mRNA	25716160
C100058	vanillin	vanillin results in increased expression of GCLC mRNA	17178418
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of GCLC mRNA	17987463
D001335	Vehicle Emissions	NFE2L2 gene mutant form inhibits the reaction [Vehicle Emissions results in increased expression of GCLC mRNA]	18614404
D001335	Vehicle Emissions	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GCLC mRNA	22935520
D001335	Vehicle Emissions	[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GCLC mRNA	22935520
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of GCLC mRNA	18614404\|2192043
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of GCLC protein	21920430
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GCLC gene	25560391
D014700	Verapamil	[Methyl Parathion co-treated with Verapamil] results in increased expression of GCLC mRNA	25286004
C059141	verlukast	"[verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]"	21728338
D014750	Vincristine	[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine	10900222
D009536	Niacinamide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
D009536	Niacinamide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
D009536	Niacinamide	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]	21439372
D009536	Niacinamide	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]	21439372
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA	21439372
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein	21439372
D014810	Vitamin E	Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA]	18814483
D014810	Vitamin E	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA	11444866
D014810	Vitamin E	Vitamin E affects the expression of GCLC mRNA	16298738
D014810	Vitamin E	Vitamin E affects the expression of GCLC protein	16298738
D014810	Vitamin E	Vitamin E affects the reaction [[REL binds to GCLC promoter] which affects the expression of GCLC mRNA]	16298738\|1629873
D024483	Vitamin K 3	Vitamin K 3 results in increased activity of GCLC protein	7943345
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GCLC mRNA	7943345
D024483	Vitamin K 3	Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA]	11972604
D024483	Vitamin K 3	Vitamin K 3 results in increased activity of GCLC protein	11972604
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GCLC mRNA	11972604\|2341063
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GCLC mRNA	25270620
D014994	Xylose	Xylose analog results in decreased activity of GCLC protein	12659765
D015016	Yohimbine	[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA	28843594
D015032	Zinc	acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein]	23377617
D015032	Zinc	Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein]	23377617
D015032	Zinc	Zinc deficiency results in decreased expression of and results in increased cleavage of GCLC protein	23377617
D015032	Zinc	Zinc deficiency results in decreased expression of GCLC mRNA	23377617
D015032	Zinc	Zinc deficiency results in decreased expression of GCLC mRNA	23377617
D015032	Zinc	Zinc deficiency results in decreased expression of GCLC protein	23377617
C016837	zinc chloride	zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA]	18385089
D015054	Zymosan	Zymosan results in increased expression of GCLC mRNA	17200146

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IDA	24639
GO:0004357	glutamate-cysteine ligase activity	-	IBA	21873635
GO:0004357	glutamate-cysteine ligase activity	-	IDA	8104187 11972604
GO:0004357	glutamate-cysteine ligase activity	-	IMP	16183645
GO:0005524	ATP binding	-	IEA	-
GO:0016595	glutamate binding	-	IDA	9841880
GO:0043531	ADP binding	-	IDA	24639
GO:0046982	protein heterodimerization activity	-	IEA	-
GO:0050662	coenzyme binding	-	IPI	9675072 9841880

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006534	cysteine metabolic process	-	IDA	2294991
GO:0006536	glutamate metabolic process	-	IDA	2294991 12663448
GO:0006750	glutathione biosynthetic process	-	IBA	21873635
GO:0006750	glutathione biosynthetic process	-	IDA	8104187 10395918
GO:0006750	glutathione biosynthetic process	-	IEA	-
GO:0006750	glutathione biosynthetic process	-	IMP	12663448
GO:0006979	response to oxidative stress	-	IDA	10395918 11972604
GO:0007568	aging	-	IEA	-
GO:0007584	response to nutrient	-	IEA	-
GO:0008637	apoptotic mitochondrial changes	-	IEA	-
GO:0009408	response to heat	-	IDA	8104187
GO:0009410	response to xenobiotic stimulus	-	IEA	-
GO:0009725	response to hormone	-	IDA	8104187
GO:0014823	response to activity	-	IEA	-
GO:0019852	L-ascorbic acid metabolic process	-	IEA	-
GO:0031397	negative regulation of protein ubiquitination	-	IEA	-
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0032869	cellular response to insulin stimulus	-	IEA	-
GO:0035729	cellular response to hepatocyte growth factor stimulus	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IDA	10439045
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	-
GO:0044344	cellular response to fibroblast growth factor stimulus	-	IEA	-
GO:0044752	response to human chorionic gonadotropin	-	IEA	-
GO:0045454	cell redox homeostasis	-	IDA	10439045
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10439045
GO:0046685	response to arsenic-containing substance	-	IEA	-
GO:0046686	response to cadmium ion	-	IEA	-
GO:0050880	regulation of blood vessel size	-	IMP	12598062
GO:0051409	response to nitrosative stress	-	IEA	-
GO:0051900	regulation of mitochondrial depolarization	-	IEA	-
GO:0070555	response to interleukin-1	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEA	-
GO:0071333	cellular response to glucose stimulus	-	IEA	-
GO:0071372	cellular response to follicle-stimulating hormone stimulus	-	IEA	-
GO:0097069	cellular response to thyroxine stimulus	-	IEA	-
GO:2000490	negative regulation of hepatic stellate cell activation	-	IEA	-
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0017109	glutamate-cysteine ligase complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-1643685	Disease	TAS
R-HSA-174403	Glutathione synthesis and recycling	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-5578999	Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22044695	Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer. (2012 Mar)	de Andrade M	Cancer Prev Res (Phila)
16409822	[Cigarette smoking coacervate up-regulates the expression of gamma-glutamylcysteine synthetase in alveolar epithelial cells mediated by activator protein-1]. (2005 Dec 7)	Zou ZX	Zhonghua Yi Xue Za Zhi
22610501	A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers. (2013 Oct)	Nichenametla SN	Mol Carcinog
18062829	Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) pilot study. (2008 Jun)	Ravn-Haren G	Br J Nutr
18420959	Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. (2008 Jul 1)	Siedlinski M	Am J Respir Crit Care Med
23688726	Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)	Tang W	Free Radic Biol Med
12882455	Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers. (2003 Jul)	Neurohr C	Eur Respir J
26087411	Cigarette Smoke-Induced Hypermethylation of the GCLC Gene Is Associated With COPD. (2016 Feb)	Cheng L	Chest
27207918	Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel. (2016 Sep)	Gitik M	Int J Neuropsychopharmacol
26681403	The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial. (2016 Mar)	Wang Z	J Pineal Res
25524402	Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)	Reszka E	J Trace Elem Med Biol
22272327	Serum oxidative stress-induced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokers. (2012)	Fratta Pasini A	PLoS One