Gene: DHDH

27294
2DD|HUM2DD
dihydrodiol dehydrogenase
protein-coding
19q13.33
Ensembl:ENSG00000104808 MIM:606377 Vega:OTTHUMG00000165029 UniprotKB:Q9UQ10
NG_046910.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.455e-1 (AD)  4.103e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCTPP10.694
CMSS10.693
TIGD30.687
SMIM120.686
YARS0.682
ZCCHC120.682
MAD2L1BP0.682
EBNA1BP20.68
ZNF8210.679
NPM30.678

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RY14-0.57
FMO3-0.487
ANPEP-0.437
HIGD1B-0.434
MTRNR2L9-0.429
DISC1-0.417
MTRNR2L6-0.415
CYSLTR2-0.413
ADH1B-0.411
MTRNR2L10-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of DHDH mRNA29067470
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of DHDH protein25499718
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DHDH mRNA20064835
D004958EstradiolEstradiol results in decreased expression of DHDH mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of DHDH mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DHDH mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DHDH mRNA27339419
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of DHDH mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of DHDH mRNA19770486
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA24690739
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DHDH mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHDH mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DHDH mRNA25613284
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DHDH mRNA18804290
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DHDH mRNA"26251327
D009151Mustard GasMustard Gas results in increased expression of DHDH mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DHDH mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DHDH mRNA"25554681
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DHDH mRNA18593933
D010634PhenobarbitalPhenobarbital results in decreased expression of DHDH mRNA23091169
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DHDH mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of DHDH mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of DHDH mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of DHDH mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DHDH mRNA23806026|2589566
D012834SilverSilver results in increased expression of DHDH mRNA26014281
D012834SilverSilver results in decreased expression of DHDH mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHDH mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of DHDH mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHDH mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DHDH mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DHDH mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DHDH mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of DHDH mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DHDH gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of DHDH mRNA26682919
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DHDH mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008746NAD(P)+ transhydrogenase activity-TAS10477285  
GO:0009055electron transfer activity-TAS10477285  
GO:0047115trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity-IEA-  
GO:0047837D-xylose 1-dehydrogenase (NADP+) activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-TAS10477285  
GO:0022900electron transport chain-IEA-  
GO:0042843D-xylose catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00980Metabolism of xenobiotics by cytochrome P450
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24734329[A coexistence of the Dupuytren's disease and malignant neoplasms: a review]. (2013)Zyluk AAnn Acad Med Stetin