Gene: AMPH

273
AMPH1
amphiphysin
protein-coding
7p14.1
Ensembl:ENSG00000078053 MIM:600418 Vega:OTTHUMG00000023725 UniprotKB:P49418
NC_000007.14
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.039e-1 (AD)  7.945e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELL20.978
OPCML0.972
PCSK20.972
TMEM2460.97
GABRG20.969
DYNC1I10.968
SH3GL20.968
AAK10.967
NMNAT20.967
SLC4A100.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.56
YES1-0.53
RAI14-0.525
REST-0.524
MYL3-0.513
CSAG1-0.508
FZD10-0.505
RNF135-0.504
LRAT-0.503
COPZ2-0.499

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of AMPH protein"21673325
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AMPH mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of AMPH mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AMPH gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMPH mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AMPH mRNA24449571
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of AMPH mRNA15912405
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AMPH mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of AMPH mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AMPH mRNA12419474|1533650
C018475butyraldehydebutyraldehyde results in increased expression of AMPH mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AMPH mRNA18636176
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of AMPH mRNA12734012
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of AMPH mRNA18636392
D016572CyclosporineCyclosporine results in decreased expression of AMPH mRNA20106945|2798913
D003907DexamethasoneDexamethasone results in increased expression of AMPH mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AMPH mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of AMPH mRNA25016146
D004147DioxinsDioxins affects the expression of AMPH mRNA20463971
D000431EthanolEthanol results in decreased expression of AMPH protein20621659
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMPH mRNA17942748
D004397FonofosFonofos results in increased methylation of AMPH promoter22847954
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of AMPH mRNA21782745
D003932HeroinHeroin results in decreased expression of AMPH mRNA16710320
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of AMPH mRNA12419474
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AMPH mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AMPH mRNA28628672
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of AMPH mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AMPH protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AMPH mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AMPH mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AMPH mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AMPH mRNA"25554681
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of AMPH mRNA18636392
D010269ParaquatParaquat results in decreased expression of AMPH mRNA18198484
D010278ParathionParathion results in increased methylation of AMPH promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of AMPH mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of AMPH mRNA19429403
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of AMPH mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of AMPH mRNA17950772
C006253pirinixic acidpirinixic acid results in increased expression of AMPH mRNA20813756
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of AMPH mRNA]17950772
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AMPH mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of AMPH mRNA22238285
C005556propionaldehydepropionaldehyde results in decreased expression of AMPH mRNA26079696
C012568terbufosterbufos results in increased methylation of AMPH promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMPH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMPH mRNA22808131
D014212TretinoinTretinoin results in decreased expression of AMPH mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMPH mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of AMPH mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of AMPH mRNA24935251
D017974Uranium CompoundsUranium Compounds results in increased expression of AMPH mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of AMPH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AMPH mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AMPH gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9148966  10542231  12057195  15834155  16696976  17762867  
20946875  21044950  25416956  
GO:0005543phospholipid binding-IDA22750946  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-TAS9182667  
GO:0007268chemical synaptic transmission-TAS9182667  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0008021synaptic vesicle-TAS1628617  
GO:0015629actin cytoskeleton-TAS9182667  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0031256leading edge membrane-IDA22750946  
KEGG ID KEGG Term
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20735880Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction. (2011 Jun)Velazquez-Sanchez CInt J Neuropsychopharmacol