Gene: GCLM

2730
GLCLR
glutamate-cysteine ligase modifier subunit
protein-coding
1p22.1
Ensembl:ENSG00000023909 MIM:601176 Vega:OTTHUMG00000010562 UniprotKB:P48507
NG_012072.1
PubMed
ND
4   
NA (AD)  9.916e-2 (ND)   (Frontal_Cortex)
4.496e-1 (AD)  5.755e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TXNRD10.883
CLIP10.847
LARP40.842
SEC24A0.837
PDE120.837
TMF10.835
NAA500.831
MARCH50.827
DNAJB90.826
COPB10.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.465
OR4F29-0.422
RSPO1-0.276
MUSTN1-0.274
KLRK1-0.273
RERGL-0.262
SNX22-0.259
GPR17-0.252
FCRL1-0.25
HIGD1B-0.244

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLM mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLM mRNA]"27071940
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of GCLM mRNA"26198647
C0394111,2-dibromo-2,4-dicyanobutane"1,2-dibromo-2,4-dicyanobutane results in increased expression of GCLM mRNA"23999411|2796514
C0493251,2-dithiol-3-thione"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA"22495766
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione affects the expression of GCLM mRNA"19162173
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of GCLM mRNA25596134
C0334891,3-dichloro-2-propanol"1,3-dichloro-2-propanol results in increased expression of GCLM mRNA"26143167
C4030081,4-dihydroquinone"1,4-dihydroquinone results in increased expression of GCLM mRNA"27965148
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA"24211530
C1187011-bromohexane1-bromohexane results in increased expression of GCLM mRNA27965148
C1185591-bromopropane1-bromopropane results in increased expression of GCLM mRNA20211940
C1185591-bromopropaneNFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA]20211940
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GCLM mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLM mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2-tert-butylhydroquinone] results in increased expression of GCLM mRNA"25305463
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLM mRNA"25305463
C5112952,2',4,4'-tetrabromodiphenyl ether"GCLM protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of CASP3 protein]"25797475
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of GCLM mRNA"27965148
C0630022,3-dimethoxy-1,4-naphthoquinone"[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone"23315585
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]26577515|2668657
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA]19073151
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of GCLM protein16972261
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLM mRNA19073151
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]25895139
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GCLM mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GCLM mRNA"20406850
C4993262-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide results in decreased expression of GCLM mRNA20159942
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide results in increased expression of GCLM mRNA22851183
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide results in increased expression of GCLM mRNA22851183
C0914232-chloromethylpyridine2-chloromethylpyridine results in increased expression of GCLM mRNA26198647
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLM mRNA"22746536
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLM protein"22746536
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"NFE2L2 gene mutant form inhibits the reaction [2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLM mRNA]"22746536
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLM mRNA"22746536
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased expression of GCLM protein"22746536
C568680(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLM mRNA"22746536
C568680(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide"NFE2L2 gene mutant form inhibits the reaction [(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLM mRNA]"22746536
C568680(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLM mRNA"22746536
C568680(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased expression of GCLM protein"22746536
C0367582-ethylhexyl acrylate2-ethylhexyl acrylate results in increased expression of GCLM mRNA27965148
C0188552-tert-butylhydroquinone"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2-tert-butylhydroquinone] results in increased expression of GCLM mRNA"25305463
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]24632381
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GCLM mRNA12081989|2500366
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GCLM mRNA12007577|1601473
C0188552-tert-butylhydroquinoneNFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA]19328227
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GCLM mRNA10978506
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GCLM promoter20810208
C5610552-trifluoromethyl-2'-methoxychalone2-trifluoromethyl-2'-methoxychalone results in increased expression of GCLM mRNA21539383
C5610552-trifluoromethyl-2'-methoxychalone2-trifluoromethyl-2'-methoxychalone results in increased expression of GCLM mRNA21539383
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of GCLM protein"22649188
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM protein23535287
C0213383-hydroxybenzo(a)pyrene3-hydroxybenzo(a)pyrene results in increased expression of GCLM mRNA26238291
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of GCLM mRNA28790194
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-oneNFE2L2 protein affects the reaction [3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of GCLM mRNA]28790194
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of GCLM mRNA"20159942
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of GCLM mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GCLM mRNA19191707
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine results in decreased expression of GCLM mRNA"20159942
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of GCLM mRNA23883479
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of GCLM mRNA]23883479
C0275634-nitrobenzyl bromide4-nitrobenzyl bromide results in increased expression of GCLM mRNA23999411
C1144594-phenyl-2-propionamidotetraline4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]25550330
C0909334-phenyl-3-furoxancarbonitrile4-phenyl-3-furoxancarbonitrile results in increased expression of GCLM mRNA22851183
C0297284-phenylenediamine4-phenylenediamine results in increased expression of GCLM mRNA16314067|2399941
C0293704-toluidine4-toluidine results in increased expression of GCLM mRNA27638505
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GCLM protein"19121294
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GCLM protein"19121294
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C1119846-methylsulfinylhexyl isothiocyanate6-methylsulfinylhexyl isothiocyanate results in increased expression of GCLM protein21382770
C0776467,12-benz(a)anthraquinone"7,12-benz(a)anthraquinone results in increased expression of GCLM mRNA"23684558
C0307357-aminocephalosporanic acid7-aminocephalosporanic acid results in increased expression of GCLM mRNA24211530
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of GCLM mRNA"26238291
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM mRNA18332871
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM protein18332871
C023710abietic acidabietic acid results in increased expression of GCLM mRNA27965148
D000082AcetaminophenAcetaminophen affects the expression of GCLM mRNA25064622
D000082Acetaminophen[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA25881548
D000082AcetaminophenAcetaminophen results in increased expression of GCLM mRNA21420995|2906747
D000082Acetaminophenpyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]25881548
D000082AcetaminophenAcetaminophen affects the expression of GCLM mRNA17562736
D000082AcetaminophenAcetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]]16840778
D000082AcetaminophenAcetaminophen results in decreased expression of GCLM mRNA25818464
D000082AcetaminophenAcetaminophen results in increased expression of GCLM mRNA25499718|2932517
D000082AcetaminophenAcetaminophen results in increased expression of GCLM protein18468992
D000082Acetaminophen[GCLC protein binds to GCLM protein] which results in decreased susceptibility to Acetaminophen16840778
D000082AcetaminophenGCLM protein affects the susceptibility to Acetaminophen17584759
D000082AcetaminophenGCLM protein results in decreased susceptibility to Acetaminophen18642143
D000082AcetaminophenOGT gene mutant form promotes the reaction [Acetaminophen results in increased expression of GCLM mRNA]29325178
D000082Acetaminophensulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]25818464
D000082AcetaminophenAcetaminophen results in increased expression of GCLM mRNA11245408|1720275
D000082AcetaminophenAcetaminophen results in decreased expression of GCLM mRNA25818464
D000082Acetaminophen[GCLC protein co-treated with GCLM protein] affects the susceptibility to Acetaminophen17584759
D000082Acetaminophensulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]25818464
D000109AcetylcholineGCLM gene SNP affects the susceptibility to Acetylcholine12975258
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA]19350554
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA]18723479
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
D000111AcetylcysteineGCLM protein affects the susceptibility to Acetylcysteine17584759
D000171AcroleinAcrolein results in increased expression of GCLM mRNA24211530
D000171AcroleinAcrolein results in increased expression of GCLM mRNA12763045
D020106AcrylamideAcrylamide results in decreased expression of GCLM mRNA28159594
D020106Acrylamidesalvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]28159594
C010013adriamycinol[GCLM gene mutant form results in increased metabolism of Doxorubicin] which results in increased abundance of adriamycinol25446851
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GCLM mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GCLM mRNA23630614
D000393Air PollutantsAir Pollutants results in increased expression of GCLM mRNA23649983
D000393Air PollutantsAir Pollutants results in increased expression of GCLM protein23649983
D000393Air PollutantsGCLM gene mutant form promotes the reaction [Air Pollutants results in increased expression of IL3 protein]27865893
D000393Air PollutantsGCLM gene mutant form promotes the reaction [Air Pollutants results in increased expression of IL6 protein]27865893
C000188alachloralachlor results in increased expression of GCLM protein14563481
C496116alpha-damasconealpha-damascone results in increased expression of GCLM mRNA27965148
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA24530478
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]22389237
D019804MesalamineMesalamine promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA]27818126
D000638AmiodaroneAmiodarone affects the expression of GCLM mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GCLM mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in increased expression of GCLM mRNA24211530
D000667AmpicillinAmpicillin results in decreased expression of GCLM mRNA21632981
D000667AmpicillinAmpicillin results in increased expression of GCLM mRNA22609641
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA19737545
C030419andrographolideandrographolide results in increased expression of GCLM mRNA25110055
C030419andrographolideandrographolide results in increased expression of GCLM protein25110055
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of GCLM mRNA28713220
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GCLM mRNA24449571
D047310ApigeninApigenin results in increased expression of GCLM mRNA22864849
D047310Apigenin[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide22864849
D047310ApigeninApigenin results in increased expression of GCLM protein22864849
D016718Arachidonic AcidArachidonic Acid results in increased expression of GCLM mRNA16704987
C015000arecaidine estersarecaidine esters results in increased expression of GCLM mRNA22851183
C015000arecaidine estersarecaidine esters results in increased expression of GCLM mRNA22851183
D001151ArsenicArsenic results in increased expression of GCLM mRNA19945496
D001151ArsenicArsenic results in increased expression of GCLM protein18487201|2741310
D001152ArsenicalsArsenicals promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]24632381
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA]19350554
C006632arsenic trioxidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of GCLM mRNA]23883479
C006632arsenic trioxidearsenic trioxide results in decreased expression of GCLM protein25341331
C006632arsenic trioxidearsenic trioxide results in increased expression of GCLM mRNA15725085|1912883
C006632arsenic trioxideEthionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA]26708503
C006632arsenic trioxidearsenic trioxide results in decreased expression of GCLM promoter20810208
C015001arsenitearsenite results in increased expression of GCLM mRNA22476201|2568028
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of GCLM mRNA]22476201
C015001arseniteNFE2L2 protein affects the reaction [arsenite results in increased expression of GCLM mRNA]22476201
C015001arsenite4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
C015001arseniteAcetylcysteine inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLM mRNA15894712
C015001arsenitearsenite results in increased activity of [GCLC protein binds to GCLM protein]19328227
C015001arsenitearsenite results in increased expression of [GCLC protein binds to GCLM protein]19328227
C015001arsenitearsenite results in increased expression of GCLM mRNA15894712|1932822
C015001arsenitearsenite results in increased expression of GCLM protein19328227
C015001arsenitearsenite results in increased stability of GCLM mRNA19328227
C015001arseniteCycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]]19328227
C015001arseniteCycloheximide inhibits the reaction [arsenite results in increased expression of [GCLC protein binds to GCLM protein]]19328227
C015001arseniteCycloheximide inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
C039726artesunateGCLM mRNA results in decreased susceptibility to artesunate15796179
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GCLM mRNA"15520183
D017638Asbestos, Crocidolite"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]"15520183
D017638Asbestos, Crocidolite"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]"15520183
D017638Asbestos, Crocidolite"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA]"15520183
D017638Asbestos, Crocidolite"[GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]"15520183
D017638Asbestos, Crocidolite"GCLM protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]"15520183
D017638Asbestos, Crocidolite"GCLM protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA]"15520183
D001379AzathioprineAzathioprine results in increased expression of GCLM mRNA18222062|2262364
C051597Bandrowski's baseBandrowski's base results in increased expression of GCLM mRNA20566472
C416282BAY 11-7085BAY 11-7085 results in increased expression of GCLM mRNA22851183
D001554BenzeneBenzene results in increased expression of GCLM mRNA21843810
C029876benzidinebenzidine results in increased expression of GCLM mRNA26198647
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of GCLM mRNA19737606
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA19737545
D019817Benzoic AcidBenzoic Acid results in increased expression of GCLM mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCLM mRNA20064835|2010694
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLM mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of FASN mRNA]24291350
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of SREBF1 mRNA]24291350
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [GCLM gene mutant form results in increased expression of SOD2 mRNA]24291350
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GCLM mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCLM mRNA15034205|1589471
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLM mRNA25820237
D001564Benzo(a)pyreneGCLM gene mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA]24291350
D001564Benzo(a)pyrene[GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene24107266
D001564Benzo(a)pyreneGCLM gene mutant form results in decreased susceptibility to Benzo(a)pyrene24291350
D001564Benzo(a)pyreneGCLM gene mutant form results in increased susceptibility to Benzo(a)pyrene23135907|2827969
D001564Benzo(a)pyreneGCLM protein affects the susceptibility to Benzo(a)pyrene22253057
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCLM mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GCLM mRNA"19150397
D016227BenzoquinonesBenzoquinones analog results in increased expression of GCLM protein21651925
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLM mRNA20061341
D004958EstradiolEstradiol results in increased expression of GCLM mRNA20106945
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GCLM mRNA22154832
D004958EstradiolEstradiol results in increased expression of GCLM mRNA22154832
D004958Estradiol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]22389237
D004958EstradiolEstradiol affects the expression of GCLM mRNA22389237
D024503beta-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]22389237
D001688Biological ProductsBiological Products results in increased expression of GCLM mRNA23266269
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in increased expression of GCLM mRNA19188863
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in increased expression of GCLM protein19188863
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in increased expression of GCLM mRNA17535857
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in increased expression of GCLM mRNA27965148
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of GCLM mRNA15912405
C006780bisphenol Abisphenol A affects the expression of GCLM mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GCLM mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of GCLM mRNA25181051|2698221
C006780bisphenol Abisphenol A results in increased methylation of GCLM gene28505145
C006780bisphenol Abisphenol A results in increased expression of GCLM20924222
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of GCLM mRNA26198647
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of GCLM mRNA21601586
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of GCLM mRNA21601586
C032036bromobenzenebromobenzene results in increased expression of GCLM mRNA12628495
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]17724089
D019328Buthionine Sulfoximine[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]22864849
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of GCLM mRNA10978506|1901038
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GCLM mRNA12414654|2341063
D020122tert-Butylhydroperoxide[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide22864849
D020122tert-Butylhydroperoxide[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]22864849
D020122tert-Butylhydroperoxide[chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide22864849
D002104CadmiumCadmium results in increased expression of GCLM mRNA21120746|2117241
D002104CadmiumCadmium results in increased expression of GCLM mRNA25388156
C028031cadmium acetatecadmium acetate results in increased expression of GCLM protein29140578
C028031cadmium acetateTrehalose inhibits the reaction [cadmium acetate results in increased expression of GCLM protein]29140578
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [NFE2L2 protein binds to GCLM promoter]26827822
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GCLM protein26827822
D019256Cadmium ChlorideNFE2L2 protein promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]26827822
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GCLM mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GCLM mRNA20061341
D019256Cadmium ChlorideNFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of GCLM protein]26827822
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GCLM mRNA19010381
D002185CannabidiolCannabidiol results in increased expression of GCLM mRNA21542829
C005563captaxcaptax results in increased expression of GCLM mRNA23999411|2421153
D002220CarbamazepineCarbamazepine affects the expression of GCLM mRNA24752500|2597931
D012721CarbarylCarbaryl results in increased expression of GCLM mRNA27829164
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GCLM mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GCLM mRNA17484886|2747729
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GCLM protein27477297
D002251Carbon TetrachlorideNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]27477297
D002251Carbon TetrachlorideNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]27477297
D002251Carbon Tetrachloridetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]27477297
D002251Carbon Tetrachloridetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]27477297
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GCLM mRNA15963342
C068623carnosolcarnosol results in increased expression of GCLM mRNA20116392
C026690cerous chloridecerous chloride results in decreased expression of GCLM mRNA28954213
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of GCLM protein17724089
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione17724089
D002699Chlorambucil[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil10900222
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of GCLM mRNA18636392
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of GCLM mRNA25596134
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of GCLM mRNA29136249
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GCLM mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of GCLM mRNA24211530
D002737ChloropreneChloroprene results in increased expression of GCLM mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of GCLM mRNA25064622
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of GCLM mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GCLM mRNA20938992
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLM mRNA25820237
C043561chrysin[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]22864849
C043561chrysinchrysin results in increased expression of GCLM mRNA22864849
C043561chrysin[chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide22864849
C043561chrysinchrysin results in increased expression of GCLM protein22864849
C043561chrysinMAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]22864849
C043561chrysinNFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]22864849
C059262cidofovircidofovir results in increased expression of GCLM mRNA25596134
C012843cinnamic aldehyde[cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA20351055
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of GCLM mRNA17178418|2399941
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of GCLM mRNA20566472|2399941
C073341citraconic acidcitraconic acid results in increased expression of GCLM mRNA27277809
C073341citraconic acidcitraconic acid results in increased expression of GCLM protein27277809
C007076citralcitral results in increased expression of GCLM mRNA27965148
C028677clivorineclivorine results in decreased expression of GCLM mRNA25881548
C028677clivorinepyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]25881548
C028677clivorineQuercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]25881548
D004002Clodronic AcidClodronic Acid results in increased expression of GCLM mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of GCLM protein16470657
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of GCLM mRNA23052192
C018021cobaltous chloridecobaltous chloride results in increased expression of GCLM mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of GCLM mRNA19320972|2294125
C018021cobaltous chloridecobaltous chloride results in increased expression of GCLM mRNA24386269
C018021cobaltous chloridecobaltous chloride results in increased expression of GCLM protein24386269
D003042CocaineCocaine affects the expression of GCLM mRNA20187946
C075384coniferaldehydeconiferaldehyde results in increased expression of GCLM mRNA26275128
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GCLM mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of GCLM mRNA25167922
D003300CopperCopper analog results in increased expression of GCLM protein23882024
D003300CopperCopper results in increased expression of GCLM protein23882024
D019327Copper SulfateCopper Sulfate results in increased expression of GCLM mRNA19549813
C030123coumarincoumarin results in increased expression of GCLM mRNA18480146
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of GCLM mRNA19167446
C013453cresidinecresidine results in increased expression of GCLM mRNA26198647
C029892cupric chloridecupric chloride results in increased expression of GCLM mRNA17211630|2434327
C030973cupric oxidecupric oxide results in increased expression of GCLM mRNA24343273
C030973cupric oxidecupric oxide analog results in increased expression of GCLM protein23882024
D003474CurcuminCurcumin analog results in increased expression of GCLM mRNA23954767
D003474CurcuminCurcumin results in increased expression of GCLM mRNA17198877|1799999
D003474CurcuminCurcumin results in increased expression of GCLM protein19188863
D003474CurcuminNFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]23954767
D003474CurcuminNFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]23954767
D003474CurcuminCurcumin results in increased expression of GCLM mRNA17535857|1916857
D003474CurcuminCurcumin results in increased activity of [GCLC protein binds to GCLM protein]17602960
D003474CurcuminCurcumin results in increased expression of GCLM mRNA17602960
D003474CurcuminCurcumin results in increased expression of GCLM protein17602960|1833287
C114438cyanidin 3-O-glucosidecyanidin 3-O-glucoside promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA]27818126
D003513CycloheximideCycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]]19328227
D003513CycloheximideCycloheximide inhibits the reaction [arsenite results in increased expression of [GCLC protein binds to GCLM protein]]19328227
D003513CycloheximideCycloheximide inhibits the reaction [arsenite results in increased expression of GCLM mRNA]19328227
D016572CyclosporineCyclosporine affects the expression of GCLM mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of GCLM mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of GCLM mRNA11589784|2559613
C515055darinaparsindarinaparsin results in increased expression of GCLM mRNA19417148
D003634DDTDDT results in increased expression of GCLM mRNA26198647
C017180decamethrindecamethrin results in decreased expression of GCLM mRNA16737586
C017180decamethrindecamethrin results in increased expression of GCLM mRNA16758951
D013759DronabinolDronabinol results in increased expression of GCLM mRNA21542829
D013759DronabinolDronabinol results in decreased expression of GCLM mRNA17578508
C479072delta-tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]22389237
D003703DemecolcineDemecolcine results in decreased expression of GCLM mRNA23649840
C050229demethoxycurcumindemethoxycurcumin results in increased expression of GCLM mRNA19188863|2338626
C050229demethoxycurcumindemethoxycurcumin results in increased expression of GCLM protein19188863
C050229demethoxycurcumindemethoxycurcumin results in increased expression of GCLM mRNA17535857
D003840Deoxycholic Acid[Deoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA17724089
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GCLM mRNA]27941970
D003958DiamideDiamide results in increased expression of GCLM mRNA15115889
D003958DiamideDiamide results in increased expression of GCLM protein15115889
D003976DiazinonDiazinon results in increased expression of GCLM mRNA26198647
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GCLM mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GCLM mRNA24535708
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of GCLM mRNA]27392435
D002945CisplatinCisplatin promotes the reaction [MYC protein binds to GCLM promoter]17628013
D002945CisplatinCisplatin results in increased expression of GCLM mRNA25450742|2559613
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]27392435
D004008DiclofenacDiclofenac affects the expression of GCLM mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of GCLM mRNA18042831
D004041Dietary FatsGCLM results in increased susceptibility to Dietary Fats21967773
C058705diethyl malatediethyl malate affects the expression of GCLM mRNA24814887
C058705diethyl malateS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]24814887
C014476diethyl maleatediethyl maleate results in increased expression of GCLM mRNA25270620
C014476diethyl maleatediethyl maleate results in increased expression of GCLM mRNA10978506|1511588
C014476diethyl maleatediethyl maleate results in increased expression of GCLM protein15115889|2146525
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA16158176
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GCLM mRNA27638505
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of GCLM mRNA27277809
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]27277809
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of GCLM protein27277809
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of GCLM mRNA20146380|2056647
D004137DinitrochlorobenzeneNFE2L2 protein affects the reaction [Dinitrochlorobenzene results in increased expression of GCLM mRNA]27965148
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of GCLM mRNA23999411
D004147DioxinsDioxins affects the expression of GCLM mRNA20463971
C062963diphenylcarboxylatediphenylcarboxylate results in increased expression of GCLM mRNA27965148
D004178DiquatDiquat results in increased expression of GCLM mRNA21172416
D004178DiquatDiquat results in increased expression of GCLM mRNA16962985|2082654
D004221DisulfiramDisulfiram results in increased expression of GCLM mRNA20566472
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of GCLM mRNA25545062
D007851DodecanolDodecanol analog results in increased expression of GCLM mRNA27965148
C012301domoic aciddomoic acid results in increased expression of GCLM mRNA23315585
C012301domoic aciddomoic acid results in increased expression of GCLM protein23315585
C012301domoic acidGCLM affects the susceptibility to domoic acid17804861
C012301domoic acidGCLM protein results in decreased susceptibility to domoic acid23315585
C012301domoic acid"[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone"23315585
C012301domoic acid[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide23315585
C012301domoic acidGCLM results in decreased susceptibility to domoic acid19200344
D004298Dopamine[GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine23704229
D004317Doxorubicin[GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin]10900222
D004317DoxorubicinABCC1 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GCLM protein]26822305
D004317DoxorubicinDoxorubicin results in increased expression of GCLM protein26822305
D004317DoxorubicinGCLM gene mutant form results in increased metabolism of Doxorubicin25446851
D004317Doxorubicin[GCLM gene mutant form results in increased metabolism of Doxorubicin] which results in increased abundance of adriamycinol25446851
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of GCLM mRNA"23811387
D015118Eicosapentaenoic Acid[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA22169119
D015118Eicosapentaenoic Acid[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA22169119
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA]18723479
C512195elesclomolelesclomol results in increased expression of GCLM mRNA18723479
C118739entinostatentinostat results in increased expression of GCLM mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GCLM protein23301498
D004811EpichlorohydrinEpichlorohydrin results in increased expression of GCLM mRNA24211530
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of GCLM mRNA25585349
C031365epomediol[Ethinyl Estradiol co-treated with epomediol] results in increased activity of GCLM protein12071332
C048498erdosteineerdosteine results in increased expression of GCLM protein26193055
D004976Ethacrynic Acid[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid10900222
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GCLM mRNA25064622
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with epomediol] results in increased activity of GCLM protein12071332
D005000EthionamideEthionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA]26708503
C004919ethylene dimethacrylateethylene dimethacrylate results in increased expression of GCLM mRNA27965148
D005047Etoposide[GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]10900222
D005047Etoposide[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide10900222
D005054EugenolEugenol results in increased expression of GCLM mRNA20566472|2619864
D011345FenofibrateFenofibrate results in increased expression of GCLM mRNA25596134
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA16158176
D005472FluorouracilGCLM protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in increased expression of GCLM mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GCLM mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of GCLM mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of GCLM mRNA19167457
D008299Maleic AnhydridesMaleic Anhydrides results in increased expression of GCLM mRNA24211530
D005688Galactosamine"[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GCLM mRNA"28887131
D024504gamma-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]22389237
C106014geduningedunin results in increased expression of GCLM mRNA17010675
D019833GenisteinGenistein results in decreased expression of GCLM mRNA12075121
D005897GlafenineGlafenine results in decreased expression of GCLM mRNA24136188
D005978GlutathioneButhionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]17724089
D005978Glutathione[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione17724089
D005978GlutathioneGCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione12975258
D005978Glutathione[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione17724089
D005978GlutathioneGCLM gene mutant form results in decreased abundance of Glutathione20417186|2370422
D005978Glutathione[GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene24107266
D005978Glutathione[GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein25446851
D005978GlutathioneGCLM protein affects the metabolism of Glutathione22253057
D005978GlutathioneGCLM protein affects the susceptibility to Glutathione17584759
D005978GlutathioneGCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]20159942
D005978GlutathioneGCLM protein mutant form results in decreased abundance of Glutathione22253057
D005978GlutathioneGCLM protein results in increased chemical synthesis of Glutathione22253057|2313590
D005978GlutathioneGlutathione deficiency results in increased expression of GCLM mRNA15345336|2062111
D005978Glutathione[GCLC protein co-treated with GCLM protein] results in increased chemical synthesis of Glutathione17584759
C071834glycidamideglycidamide results in increased expression of GCLM mRNA17822822
D006037GlyoxalGlyoxal results in increased expression of GCLM mRNA27965148
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in increased expression of GCLM mRNA20471814
C412815GW 4064GW 4064 results in increased expression of GCLM mRNA26655953
D055768Halogenated Diphenyl EthersGCLM protein results in decreased susceptibility to Halogenated Diphenyl Ethers19150461
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of GCLM mRNA15159207
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of GCLM mRNA20566472
D017313FenretinideFenretinide results in increased expression of GCLM mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GCLM mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GCLM mRNA18951874|2927443
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GCLM mRNA12414654|1990215
D006861Hydrogen PeroxideSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLM mRNA]29274434
D006861Hydrogen Peroxide[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide23315585
C031927hydroquinonehydroquinone results in increased expression of GCLM protein21059386
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of GCLM mRNA18156441
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of GCLM mRNA19376150
D007052IbuprofenIbuprofen results in increased expression of GCLM mRNA11909699|2559613
D007069IfosfamideIfosfamide results in increased expression of GCLM mRNA25596134
D007213IndomethacinIndomethacin results in increased expression of GCLM mRNA11909699
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCLM mRNA25613284
D007501IronIron results in decreased expression of GCLM mRNA19073151
D007501IronUrsodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA]19073151
C036643isoeugenolisoeugenol results in increased expression of GCLM mRNA20566472|2399941
D007529IsoflavonesIsoflavones results in increased expression of GCLM mRNA17374662
D007545IsoproterenolIsoproterenol results in decreased expression of GCLM mRNA21335049
D007545IsoproterenolIsoproterenol results in increased expression of GCLM mRNA20003209
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of GCLM mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]27392435
C410337K 7174K 7174 results in increased expression of GCLM mRNA24086573
D007660KetoprofenKetoprofen results in increased expression of GCLM mRNA11909699
D019344Lactic AcidLactic Acid results in increased expression of GCLM mRNA20566472
D007854LeadGCLM gene polymorphism affects the abundance of Lead25728017
C008261lead acetatelead acetate results in increased expression of GCLM mRNA26498409
C008261lead acetateNFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLM mRNA]26498409
C008261lead acetatelead acetate results in increased expression of GCLM mRNA25270620
C052901lemongrass oillemongrass oil affects the expression of GCLM mRNA25976427
C008281limonenelimonene results in increased expression of GCLM mRNA27965148
D001556LindaneLindane results in increased expression of GCLM mRNA26198647
C482199lipopolysaccharide, E coli O55-B5"[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GCLM mRNA"28887131
D008070Lipopolysaccharides[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA22169119
D008070Lipopolysaccharides[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA22169119
D008070LipopolysaccharidesLipopolysaccharides affects the expression of GCLM mRNA22169119
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GCLM mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of GCLM mRNA]19339665
D008095Lithocholic AcidButhionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]17724089
D008095Lithocholic AcidLithocholic Acid affects the expression of GCLM mRNA20146260
D008095Lithocholic AcidLithocholic Acid affects the expression of GCLM protein20146260
D008095Lithocholic Acid[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA17724089
D008095Lithocholic AcidLithocholic Acid results in increased expression of GCLM protein17724089
D008095Lithocholic Acid[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione17724089
D008095Lithocholic Acid[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA17724089
D047311LuteolinLuteolin results in increased expression of GCLM mRNA22864849
D047311LuteolinLuteolin results in increased expression of GCLM protein22864849
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GCLM mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLM mRNA26378955
D008315MalondialdehydeGCLM gene polymorphism affects the abundance of Malondialdehyde25728017
D008550Melatonin4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]25550330
D008550MelatoninMelatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]25550330
D008550MelatoninSL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]25550330
D015122MercaptopurineMercaptopurine results in increased expression of GCLM mRNA18222062
C042720mercuric bromidemercuric bromide results in increased expression of GCLM mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of GCLM mRNA20353558
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D008627Mercuric ChlorideABCC2 gene mutant form promotes the reaction [Mercuric Chloride results in increased expression of GCLM mRNA]24039982
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GCLM mRNA24039982
D008628MercuryGCLM gene polymorphism affects the abundance of Mercury21925580
D008628MercuryGCLM polymorphism affects the metabolism of Mercury16961004
D008628MercuryGCLM protein affects the abundance of Mercury18560528
D008628MercuryMercury results in decreased expression of GCLM mRNA19937285
D008687MetforminMetformin results in increased expression of GCLM mRNA25596134
D008687MetforminMetformin results in decreased expression of GCLM mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GCLM mRNA20938992
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased expression of GCLM"21723306
C008435methyldithiocarbamatemethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of GCLM mRNA]19339665
D008753Methylenebis(chloroaniline)Methylenebis(chloroaniline) results in increased expression of GCLM mRNA26198647
D008751Methylene Blue[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA24556215
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GCLM mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GCLM mRNA20061341
D008767Methylmercury CompoundsGCLM protein affects the metabolism of Methylmercury Compounds18560528
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of GCLM protein26558463
D020366MethylmethacrylateMethylmethacrylate results in increased expression of GCLM mRNA16916219
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GCLM mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GCLM mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GCLM protein26558463
C033069methyl salicylatemethyl salicylate results in increased expression of GCLM mRNA20566472
D015735MifepristoneAcetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]]16840778
D015735MifepristoneMifepristone results in increased activity of [GCLC protein binds to GCLM protein]16840778
D015735MifepristoneMifepristone results in increased expression of GCLM protein16840778
C517880monascinmonascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]23331247
C517880monascinNFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]23331247
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GCLM mRNA19945496
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GCLM protein24625837
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of GCLM mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GCLM protein"23026733
D009285NaphthoquinonesNaphthoquinones results in increased expression of GCLM mRNA23811387
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of GCLM mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GCLM mRNA20551477
D009288NaproxenNaproxen results in increased expression of GCLM mRNA11909699
C529068naringenin-7-O-glucosidenaringenin-7-O-glucoside results in increased expression of GCLM mRNA18652870
C022794n-butyl glycidyl ethern-butyl glycidyl ether results in increased expression of GCLM mRNA27965148
C524653nectandrin-Bnectandrin-B results in increased expression of GCLM mRNA27511913
C524653nectandrin-Bnectandrin-B results in increased expression of GCLM mRNA27511913
C051752nefazodonenefazodone results in increased expression of GCLM mRNA24136188
C026385n-hexanen-hexane results in increased expression of GCLM mRNA20566472
D009532NickelNickel results in increased expression of GCLM mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of GCLM mRNA22110744
C028007nickel monoxidenickel monoxide results in decreased expression of GCLM mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of GCLM mRNA16314067|2056647
C012655nimesulidenimesulide results in increased expression of GCLM mRNA24136188
C077073nitisinone[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA12899938
D009569Nitric OxideGCLM gene SNP affects the abundance of and affects the activity of and affects the susceptibility to Nitric Oxide12975258
D009585Nitrogen DioxideNitrogen Dioxide results in decreased expression of GCLM mRNA16049373
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of GCLM mRNA17616710
C014112N-methyl-4-aminophenolN-methyl-4-aminophenol results in increased expression of GCLM mRNA27965148
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GCLM protein19716841
C010615Nonidet P-40Nonidet P-40 results in increased expression of GCLM mRNA26552463
C570897NSC668394NSC668394 results in increased expression of GCLM mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GCLM mRNA20971185
C464660obeticholic acidobeticholic acid results in increased expression of GCLM mRNA26655953
C025589ochratoxin Aochratoxin A results in decreased expression of GCLM mRNA16251485|1841718
D019787Linoleic AcidLinoleic Acid metabolite results in increased expression of GCLM mRNA26879219
D016627OxidopamineOxidopamine results in decreased expression of GCLM protein25446857
D016627Oxidopaminesalvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]25446857
D016627OxidopamineOxidopamine results in decreased expression of GCLM protein25446857
D016627Oxidopaminesalvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]25446857
D009828Oleanolic AcidOleanolic Acid results in increased expression of GCLM mRNA18706400
C016340o,p'-DDT"o,p'-DDT affects the expression of GCLM mRNA"18925944
C016340o,p'-DDT"o,p'-DDT affects the expression of GCLM mRNA"17984292
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of GCLM mRNA25167922
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GCLM mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of GCLM mRNA25729387
D010081OxazoloneOxazolone results in increased expression of GCLM mRNA23999411
D010100OxygenOxygen deficiency results in decreased expression of GCLM mRNA25596134|2651600
D010126OzoneGCLM gene mutant form affects the susceptibility to Ozone20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of MT1 mRNA]20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of MT2 mRNA]20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of SLC23A1 mRNA]20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of SLC23A2 mRNA]20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of SOD2 mRNA]20417186
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of TTPA mRNA]20417186
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of GCLM mRNA18636392
D000073878Palm OilPalm Oil results in decreased expression of GCLM mRNA18042831
D010261ParaoxonParaoxon results in increased expression of GCLM mRNA24413757
D010269ParaquatParaquat affects the expression of GCLM mRNA25064622
D010269ParaquatParaquat results in increased expression of GCLM mRNA27288846
D010269Paraquat[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA24530478
D010269ParaquatGCLM gene mutant form results in increased susceptibility to Paraquat23704229
D010269Paraquat[GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine23704229
D010269Paraquat[GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased activity of ACO2 protein23704229
D010269ParaquatParaquat results in increased expression of GCLM mRNA28467894
D052638Particulate MatterGCLM gene mutant form affects the susceptibility to Particulate Matter23808636
D052638Particulate MatterGCLM gene mutant form promotes the reaction [Particulate Matter results in increased expression of IL3 protein]27865893
D052638Particulate MatterGCLM gene mutant form promotes the reaction [Particulate Matter results in increased expression of IL6 protein]27865893
D052638Particulate MatterGCLM protein results in decreased susceptibility to Particulate Matter21967497
D052638Particulate MatterNFE2L2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of GCLM mRNA]18614404
D052638Particulate MatterParticulate Matter analog results in increased expression of GCLM mRNA15322212
D052638Particulate MatterParticulate Matter results in increased expression of GCLM mRNA18614404|2187364
D010400Penicillin GPenicillin G results in increased expression of GCLM mRNA22609641
D010404Penicillin VPenicillin V results in increased expression of GCLM mRNA22609641
D010416PentachlorophenolPentachlorophenol results in increased expression of GCLM mRNA23892564
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of GCLM mRNA21503142
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of GCLM mRNA23567314
D010634PhenobarbitalPhenobarbital affects the expression of GCLM mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of GCLM mRNA19162173
D019800PhenolPhenol results in increased expression of GCLM mRNA26198647
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GCLM mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of GCLM mRNA20345932
D010695PhlorhizinPhlorhizin results in decreased expression of GCLM mRNA22538082
C018637phoronephorone affects the expression of GCLM mRNA18198479
D010705PhosgenePhosgene affects the expression of GCLM mRNA16300373
C004479pimagedinepimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA]12763045
D010938Plant OilsPlant Oils results in increased expression of GCLM mRNA23370395
C014758plumbaginplumbagin results in increased expression of GCLM mRNA20028456
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of GCLM mRNA22579512
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA"22851183
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA"22851183
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GCLM mRNA19162173
C479581procyanidin B3[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA22169119
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GCLM mRNA22154832
D0198402-Propanol2-Propanol results in increased expression of GCLM mRNA20566472
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of GCLM mRNA25626140
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]25881548
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]25881548
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]25881548
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]25881548
C432165pyrazolanthronepyrazolanthrone results in decreased activity of GCLM protein16972261
D011794Quercetin[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA25881548
D011794Quercetinpyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]25881548
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]25881548
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]25881548
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]25881548
D011794QuercetinQuercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]25881548
D011794QuercetinQuercetin results in increased expression of GCLM mRNA19576171|2163298
D011794QuercetinQuercetin results in increased expression of GCLM protein25881548
D011794QuercetinSB 203580 inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]22197970
D011794QuercetinQuercetin analog results in increased activity of GCLM protein27777014
D011794QuercetinQuercetin results in increased expression of GCLM mRNA19183254
D011794QuercetinQuercetin results in increased expression of GCLM protein27777014
C004532quinonequinone results in increased expression of GCLM protein21059386
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of GCLM mRNA25800948
D017382Reactive Oxygen Species[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]22864849
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of GCLM mRNA19167446
C059514resveratrolresveratrol promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA]27818126
C059514resveratrolresveratrol results in increased expression of GCLM mRNA25808216
D015474IsotretinoinIsotretinoin results in decreased expression of GCLM mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of GCLM mRNA25572481|2559613
C089730rosiglitazonerosiglitazone results in increased expression of GCLM mRNA25596134
D012402RotenoneRotenone affects the expression of GCLM mRNA23186747
D012402RotenoneRotenone results in increased expression of GCLM mRNA17657281
C085746rottlerin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]25895139
C085746rottlerinrottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]25895139
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GCLM mRNA"16678137
C018381salvin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]26577515|2668657
C018381salvinNFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]26577515
C018381salvinNFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]26686574
C018381salvinsalvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]28159594
C018381salvinsalvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]25446857
C018381salvinsalvin results in increased expression of GCLM protein26577515|2668657
C018381salvinsalvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]25446857
D012503SaponinsSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLM mRNA]29274434
C093642SB 203580SB 203580 inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]22197970
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]24814887
C040115shogaolshogaol metabolite results in increased expression of GCLM protein25148906
C040115shogaolshogaol results in increased expression of GCLM protein25148906
D012834SilverNFE2L2 protein affects the reaction [Silver results in increased expression of GCLM mRNA]22546375
D012834SilverSilver results in increased expression of GCLM mRNA22036727|2254637
D012834SilverSilver results in increased expression of GCLM mRNA27131904
D012838SilymarinNFE2L2 mutant form inhibits the reaction [Silymarin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]23331247
D012838SilymarinSilymarin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]23331247
D012838SilymarinSilymarin results in increased expression of GCLM mRNA28137608
D012838SilymarinSilymarin results in increased expression of GCLM protein28137608
C403258si-wu-tangsi-wu-tang results in increased expression of GCLM mRNA21464939
C424127SL 327SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]25550330
C017947sodium arseniteNFE2L1 protein affects the reaction [sodium arsenite results in increased expression of GCLM mRNA]20805060
C017947sodium arsenitesodium arsenite results in increased expression of GCLM mRNA12679051|2010067
C017947sodium arsenitesodium arsenite results in increased expression of GCLM protein27413109
C017947sodium arsenite[GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein]20006689
C017947sodium arsenite[GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]20006689
C017947sodium arseniteGCLM gene mutant form results in increased susceptibility to sodium arsenite16014739
C017947sodium arsenitesodium arsenite results in increased expression of GCLM mRNA16014739|2139691
C017947sodium arsenitesodium arsenite results in increased expression of GCLM protein26371860
C017947sodium arsenitesodium arsenite affects the expression of GCLM mRNA25625412
C017947sodium arsenitesodium arsenite results in increased expression of GCLM mRNA21465251
C017947sodium arsenitesodium arsenite results in increased expression of GCLM protein21465251
C016104sodium bichromatesodium bichromate results in decreased expression of GCLM mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of GCLM mRNA22155349
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of GCLM mRNA20566472
D053260SootSoot results in increased expression of GCLM protein23065132
D013095Spermidinepimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA]12763045
D013095SpermidineSpermidine results in increased expression of GCLM mRNA12763045
C539817S-sulindacS-sulindac results in increased expression of GCLM mRNA19276279
D019311StaurosporineStaurosporine promotes the reaction [MYC protein binds to GCLM promoter]17628013
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GCLM mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLM mRNA26378955
C016766sulforafansulforafan results in increased expression of GCLM21723306
C016766sulforafansulforafan results in increased expression of GCLM mRNA20442190|2153938
C016766sulforafanNFE2L2 protein promotes the reaction [sulforafan results in increased expression of GCLM mRNA]20932822
C016766sulforafansulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]25818464
C016766sulforafansulforafan results in increased expression of GCLM mRNA19071154|1930389
C016766sulforafansulforafan results in increased expression of GCLM protein19303893|2777701
C016766sulforafansulforafan inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]25818464
C016766sulforafansulforafan results in increased expression of GCLM mRNA25818464
D013496SuprofenSuprofen results in increased expression of GCLM mRNA11909699
D013605T-2 ToxinT-2 Toxin results in decreased expression of GCLM mRNA20854872
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCLM mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GCLM mRNA11489354|1755586
D013749TetrachlorodibenzodioxinGCLM results in decreased susceptibility to Tetrachlorodibenzodioxin22082335
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCLM mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of GCLM mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GCLM mRNA18163543
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GCLM mRNA21215274
D013752TetracyclineTetracycline affects the expression of GCLM mRNA25064622
D013755Tetradecanoylphorbol Acetate2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]24632381
D013755Tetradecanoylphorbol AcetateArsenicals promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]24632381
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GCLM mRNA24632381
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCLM mRNA25613284
C017953tetramethylpyrazineNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]27477297
C017953tetramethylpyrazineNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]27477297
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]27477297
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]27477297
D013853ThioacetamideThioacetamide affects the expression of GCLM mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of GCLM mRNA10486302|1097850
D013853ThioacetamideThioacetamide results in increased expression of GCLM protein10486302
D008063Thioctic AcidThioctic Acid results in increased expression of GCLM mRNA16249512
D013893ThiramThiram results in increased expression of GCLM mRNA23999411|2421153
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GCLM mRNA22363418|2740439
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of GCLM mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GCLM mRNA20133372
D014050TolueneToluene results in increased expression of GCLM mRNA28245982
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GCLM mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GCLM mRNA25729387
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA22851183
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA22851183
D014199TrehaloseTrehalose inhibits the reaction [cadmium acetate results in increased expression of GCLM protein]29140578
C034613triacsin Ctriacsin C results in increased expression of GCLM mRNA16704987
C011559tributyltinPRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]25895139
D014241TrichloroethyleneTrichloroethylene results in increased expression of GCLM mRNA19448997
C012589trichostatin Atrichostatin A affects the expression of GCLM mRNA28542535
C046488trimethyltin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]25895139
C046488trimethyltinrottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]25895139
C046488trimethyltintrimethyltin results in increased expression of GCLM mRNA25895139
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GCLM mRNA22609641
C050414tripterinetripterine results in increased expression of GCLM mRNA17010675
C013320tris(2-butoxyethyl) phosphateGCLM protein results in decreased susceptibility to tris(2-butoxyethyl) phosphate25797475
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of GCLM mRNA23052192
D014415TunicamycinTunicamycin results in decreased expression of GCLM mRNA17127020
C479548undecanalundecanal analog results in increased expression of GCLM mRNA27965148
C538763undecylenic acidundecylenic acid results in increased expression of GCLM mRNA27965148
D014580Ursodeoxycholic Acid2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA]19073151
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA]19073151
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of GCLM mRNA19073151
C406224valdecoxibvaldecoxib results in increased expression of GCLM mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of GCLM mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLM mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of GCLM mRNA23179753|2438349
C100058vanillinvanillin results in increased expression of GCLM mRNA17178418
D001335Vehicle EmissionsGCLM gene mutant form affects the susceptibility to Vehicle Emissions23808636
D001335Vehicle EmissionsGCLM gene mutant form promotes the reaction [Vehicle Emissions results in increased expression of IL3 protein]27865893
D001335Vehicle EmissionsGCLM gene mutant form promotes the reaction [Vehicle Emissions results in increased expression of IL6 protein]27865893
D001335Vehicle EmissionsGCLM protein results in decreased susceptibility to Vehicle Emissions21967497
D001335Vehicle EmissionsNFE2L2 gene mutant form inhibits the reaction [Vehicle Emissions results in increased expression of GCLM mRNA]18614404
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of GCLM mRNA15322212
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GCLM gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of GCLM mRNA18614404
D001335Vehicle EmissionsVehicle Emissions results in increased expression of GCLM protein21920430
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of GCLM mRNA15541757
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of GCLM mRNA21503142
D014750Vincristine[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine10900222
D014750VincristineVincristine results in decreased expression of GCLM mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of GCLM mRNA26682919
D014810Vitamin EVitamin E affects the expression of GCLM mRNA16298738|2044732
D014810Vitamin EVitamin E affects the reaction [[REL binds to GCLM promoter] which affects the expression of GCLM mRNA]16298738|1629873
D024483Vitamin K 3Vitamin K 3 results in increased expression of GCLM mRNA12414654|2341063
D024483Vitamin K 3Vitamin K 3 results in increased expression of GCLM mRNA25270620
D015032ZincZinc deficiency results in decreased expression of GCLM mRNA23377617
D015032ZincZinc deficiency results in decreased expression of GCLM protein23377617
D015032ZincZinc deficiency results in decreased expression of GCLM mRNA23377617
D015032ZincZinc deficiency results in decreased expression of GCLM protein23377617
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of GCLM mRNA16357179
C016837zinc chloridezinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLM mRNA]18385089

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004357glutamate-cysteine ligase activitycontributes_toIDA9841880  
GO:0004357glutamate-cysteine ligase activitycontributes_toIMP16183645  
GO:0030234enzyme regulator activity-IBA21873635  
GO:0035226glutamate-cysteine ligase catalytic subunit binding-IPI9675072  9841880  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006534cysteine metabolic process-IEA-  
GO:0006536glutamate metabolic process-IDA9841880  9895302  
GO:0006750glutathione biosynthetic process-IBA21873635  
GO:0006750glutathione biosynthetic process-IDA10395918  
GO:0006750glutathione biosynthetic process-IEA-  
GO:0006750glutathione biosynthetic process-IMP12081989  
GO:0006979response to oxidative stress-IDA10395918  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0008637apoptotic mitochondrial changes-IEA-  
GO:0014823response to activity-IEA-  
GO:0035229positive regulation of glutamate-cysteine ligase activity-IBA21873635  
GO:0035729cellular response to hepatocyte growth factor stimulus-IEA-  
GO:0035733hepatic stellate cell activation-IEA-  
GO:0042493response to drug-IDA9895302  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0044344cellular response to fibroblast growth factor stimulus-IEA-  
GO:0044752response to human chorionic gonadotropin-IEA-  
GO:0050880regulation of blood vessel size-IMP12975258  
GO:0051409response to nitrosative stress-IEA-  
GO:0051900regulation of mitochondrial depolarization-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071372cellular response to follicle-stimulating hormone stimulus-IEA-  
GO:0097069cellular response to thyroxine stimulus-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-NAS9895302  
GO:0005829cytosol-TAS-  
GO:0017109glutamate-cysteine ligase complex-IBA21873635  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-174403Glutathione synthesis and recyclingTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23827356Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury. (2013 Oct 1)Barcelos GRSci Total Environ
18420959Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. (2008 Jul 1)Siedlinski MAm J Respir Crit Care Med
25524402Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)Reszka EJ Trace Elem Med Biol
12882455Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers. (2003 Jul)Neurohr CEur Respir J