Gene: MOCS3

27304
UBA4
molybdenum cofactor synthesis 3
protein-coding
20q13.13
Ensembl:ENSG00000124217 MIM:609277 Vega:OTTHUMG00000032741 UniprotKB:O95396
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.621e-1 (AD)  3.977e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMIGO10.916
GPRASP20.912
ATL10.911
ELMOD10.91
ATP6V1C10.91
LZTFL10.908
NCEH10.907
KIF3A0.906
WDR470.905
MTMR90.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.539
MYL3-0.505
HEY2-0.493
RAI14-0.483
YES1-0.481
MTRNR2L9-0.478
MTRNR2L6-0.478
MTRNR2L10-0.474
EBF1-0.473
MAGEA12-0.473

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MOCS3 mRNA"27291303
D000082AcetaminophenAcetaminophen affects the expression of MOCS3 mRNA17562736
C006780bisphenol Abisphenol A results in decreased expression of MOCS3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MOCS3 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MOCS3 mRNA23741332
D019327Copper SulfateCopper Sulfate results in decreased expression of MOCS3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MOCS3 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MOCS3 mRNA23914054
D007213IndomethacinIndomethacin results in increased expression of MOCS3 mRNA28201806
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MOCS3 mRNA26011545
D010416PentachlorophenolPentachlorophenol results in increased expression of MOCS3 mRNA24642059
D014520UrethaneUrethane results in decreased expression of MOCS3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of MOCS3 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of MOCS3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004792thiosulfate sulfurtransferase activity-IBA21873635  
GO:0004792thiosulfate sulfurtransferase activity-IMP15073332  17459099  
GO:0005515protein binding-IPI18650437  21209336  
GO:0005524ATP binding-IEA-  
GO:0016779nucleotidyltransferase activity-IBA21873635  
GO:0016779nucleotidyltransferase activity-IDA19017811  
GO:0016783sulfurtransferase activity-IDA15910006  18650437  19017811  
GO:0016783sulfurtransferase activity-TAS-  
GO:0042292URM1 activating enzyme activity-IBA21873635  
GO:0042292URM1 activating enzyme activity-IDA19017811  
GO:0046872metal ion binding-IEA-  
GO:0061604molybdopterin-synthase sulfurtransferase activity-IEA-  
GO:0061605molybdopterin-synthase adenylyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002098tRNA wobble uridine modification-IDA19017811  
GO:0002143tRNA wobble position uridine thiolation-IBA21873635  
GO:0006777Mo-molybdopterin cofactor biosynthetic process-IDA15073332  
GO:0018192enzyme active site formation via cysteine modification to L-cysteine persulfide-IDA15910006  
GO:0032324molybdopterin cofactor biosynthetic process-TAS-  
GO:0032447protein urmylation-IBA21873635  
GO:0034227tRNA thio-modification-IDA19017811  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA15073332  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04122Sulfur relay system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-947581Molybdenum cofactor biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26917578Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. (2016 Jun)Jackson VEThorax