Gene info: ID 27329

Gene: ANGPTL3

GENE ID: 27329

Synonyms: ANG-5|ANGPT5|ANL3|FHBL2

Description: angiopoietin like 3

Gene type: protein-coding

Location: 1p31.3

dbXrefs: Ensembl:ENSG00000132855 MIM:604774 Vega:OTTHUMG00000009146 UniprotKB:Q9Y5C1

RefSeq: NG_028169.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.935e-1 (AD) 8.049e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LMX1B	0.711
OR4K3	0.701
OR13C3	0.696
PSG3	0.695
CD1B	0.69
POU5F2	0.683
OR1I1	0.674
OR10A5	0.673
MTRNR2L5	0.672
OR9Q2	0.66

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SAC3D1	-0.313
WFDC1	-0.311
SIRT4	-0.307
CCL27	-0.306
CHST8	-0.304
MYADML2	-0.302
CRTAC1	-0.295
B9D2	-0.295
CHAC1	-0.293
GALNT14	-0.29

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ANGPTL3 mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ANGPTL3 mRNA"	25380136
D000082	Acetaminophen	Acetaminophen results in decreased expression of ANGPTL3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ANGPTL3 mRNA	17562736
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of ANGPTL3 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ANGPTL3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ANGPTL3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ANGPTL3 mRNA	19770486
D000638	Amiodarone	Amiodarone results in decreased expression of ANGPTL3 mRNA	27089845
D001241	Aspirin	Aspirin results in decreased expression of ANGPTL3 mRNA	27089845
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANGPTL3 mRNA	19770486
D004958	Estradiol	Estradiol results in decreased expression of ANGPTL3 mRNA	20106945
C006780	bisphenol A	bisphenol A results in decreased expression of ANGPTL3 mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of ANGPTL3 mRNA	24067728
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ANGPTL3 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ANGPTL3 mRNA	27339419
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of ANGPTL3 mRNA	27174168
D019343	Citric Acid	Citric Acid results in increased expression of ANGPTL3 mRNA	27089845
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ANGPTL3 mRNA	24386269
D016572	Cyclosporine	Cyclosporine results in decreased expression of ANGPTL3 mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of ANGPTL3 mRNA	19770486\|2383089
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ANGPTL3 mRNA	23914054
C000944	dicrotophos	dicrotophos results in decreased expression of ANGPTL3 mRNA	28302478
D004967	Estrogens	[Progesterone co-treated with Estrogens] results in decreased expression of ANGPTL3 mRNA	22350948
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ANGPTL3 mRNA	16872691
C082360	fipronil	fipronil results in increased expression of ANGPTL3 mRNA	23962444
D005485	Flutamide	Flutamide results in increased expression of ANGPTL3 mRNA	24793618
D005897	Glafenine	Glafenine results in decreased expression of ANGPTL3 mRNA	24136188
D017313	Fenretinide	Fenretinide results in decreased expression of ANGPTL3 mRNA	28973697
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of ANGPTL3 mRNA	20353558
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ANGPTL3 mRNA	26011545
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of ANGPTL3 mRNA	25380136
C051752	nefazodone	nefazodone results in decreased expression of ANGPTL3 mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of ANGPTL3 mRNA	24136188
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANGPTL3 mRNA"	25510870
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ANGPTL3 mRNA	27153767
D010634	Phenobarbital	Phenobarbital affects the expression of ANGPTL3 mRNA	19159669
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ANGPTL3 mRNA	19710929
D017035	Pravastatin	Pravastatin results in decreased expression of ANGPTL3 mRNA	27225895
D017035	Pravastatin	Pravastatin results in decreased expression of ANGPTL3 mRNA	27225895
D011374	Progesterone	[Progesterone co-treated with Estrogens] results in decreased expression of ANGPTL3 mRNA	22350948
D011374	Progesterone	Progesterone results in decreased expression of ANGPTL3 mRNA	22350948
D019821	Simvastatin	Simvastatin results in decreased expression of ANGPTL3 mRNA	25055962
C075117	squalestatin 1	squalestatin 1 results in decreased expression of ANGPTL3 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in decreased expression of ANGPTL3 mRNA	27225895
D013629	Tamoxifen	Tamoxifen results in decreased expression of ANGPTL3 mRNA	27089845
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANGPTL3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ANGPTL3 mRNA	17949056
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ANGPTL3 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of ANGPTL3 mRNA	24489787
D013853	Thioacetamide	Thioacetamide results in decreased expression of ANGPTL3 mRNA	23411599
C050504	tianeptine	tianeptine results in decreased expression of ANGPTL3 mRNA	27089845
D014241	Trichloroethylene	Trichloroethylene results in decreased methylation of ANGPTL3 gene	27618143
D014635	Valproic Acid	Valproic Acid results in decreased expression of ANGPTL3 mRNA	27089845\|2915479
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ANGPTL3 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of ANGPTL3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ANGPTL3 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004857	enzyme inhibitor activity	-	ISS	-
GO:0004859	phospholipase inhibitor activity	-	IDA	17110602
GO:0005178	integrin binding	-	IPI	11877390
GO:0008083	growth factor activity	-	IDA	11877390
GO:0008201	heparin binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0006071	glycerol metabolic process	-	IDA	12565906
GO:0006631	fatty acid metabolic process	-	IDA	12565906
GO:0006644	phospholipid metabolic process	-	IDA	17110602
GO:0007160	cell-matrix adhesion	-	IPI	11877390
GO:0007165	signal transduction	-	IDA	11877390
GO:0007229	integrin-mediated signaling pathway	-	NAS	11877390
GO:0008203	cholesterol metabolic process	-	IDA	17110602
GO:0009395	phospholipid catabolic process	-	IDA	17110602
GO:0009725	response to hormone	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010519	negative regulation of phospholipase activity	-	IDA	17110602
GO:0019915	lipid storage	-	IDA	12565906
GO:0030335	positive regulation of cell migration	-	IDA	11877390
GO:0042632	cholesterol homeostasis	-	IDA	17110602
GO:0045766	positive regulation of angiogenesis	-	IDA	11877390
GO:0048844	artery morphogenesis	-	ISS	-
GO:0050996	positive regulation of lipid catabolic process	-	IDA	12565906
GO:0051004	regulation of lipoprotein lipase activity	-	TAS	-
GO:0051005	negative regulation of lipoprotein lipase activity	-	IDA	17110602 19542565
GO:0055088	lipid homeostasis	-	IDA	17110602
GO:0055090	acylglycerol homeostasis	-	IDA	17110602
GO:0055091	phospholipid homeostasis	-	IDA	17110602
GO:0070328	triglyceride homeostasis	-	IGI	23150577
GO:0070328	triglyceride homeostasis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	17110602
GO:0005769	early endosome	-	IEA	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0009986	cell surface	-	IDA	12565906
GO:0030027	lamellipodium	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	TAS
R-HSA-8963899	Plasma lipoprotein remodeling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17191020	Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects. (2007)	Hatsuda S	J Vasc Res
29538435	Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study. (2018)	Morinaga J	PLoS One