Gene info: ID 27343

Gene: POLL

GENE ID: 27343

Synonyms: BETAN|POLKAPPA

Description: DNA polymerase lambda

Gene type: protein-coding

Location: 10q24.32

dbXrefs: Ensembl:ENSG00000166169 MIM:606343 Vega:OTTHUMG00000018933 UniprotKB:Q9UGP5

RefSeq: NG_017063.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.968e-1 (AD) 4.056e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RECQL5	0.93
STRADA	0.926
TMUB2	0.924
PPOX	0.921
ANAPC2	0.912
MAN1B1	0.911
CCDC22	0.911
PRMT7	0.911
USP20	0.911
XRCC1	0.909

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.588
OR4F29	-0.541
MTRNR2L6	-0.4
MTRNR2L9	-0.396
MTRNR2L10	-0.363
KLRB1	-0.345
PABPC4L	-0.317
KCNJ15	-0.315
TTLL10	-0.305
C9orf153	-0.303

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of POLL mRNA"	19114083
C027576	4-hydroxy-2-nonenal	POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]	22331492
C027576	4-hydroxy-2-nonenal	POLL protein affects the susceptibility to 4-hydroxy-2-nonenal	22331492
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of POLL mRNA	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of POLL gene	28458013
D016604	Aflatoxin B1	decitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of POLL mRNA]	28458013
D000638	Amiodarone	Amiodarone results in increased expression of POLL mRNA	19774075
C072019	benzo(a)pyrene diolepoxide I	benzo(a)pyrene diolepoxide I results in increased expression of POLL mRNA	27694624
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of POLL mRNA	27694624
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of POLL mRNA	19428948
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"POLL protein affects the susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"	22331492
D004958	Estradiol	Estradiol results in decreased expression of POLL mRNA	19167446
C006780	bisphenol A	bisphenol A affects the expression of POLL mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of POLL mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of POLL mRNA	23741332
C014347	decitabine	decitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of POLL mRNA]	28458013
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of POLL mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of POLL mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLL mRNA	17942748
C005499	honokiol	honokiol results in decreased activity of POLL protein	28067485
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of POLL mRNA	19376150
C056493	imiquimod	imiquimod results in decreased expression of POLL mRNA	21878529
D008694	Methamphetamine	Methamphetamine results in decreased expression of POLL mRNA	19564919
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of POLL mRNA	26924002
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of POLL mRNA	24642059
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of POLL mRNA	19244175
D012643	Selenium	Selenium results in increased expression of POLL mRNA	19244175
D012645	Selenomethionine	Selenomethionine affects the expression of POLL mRNA	17222674
C017947	sodium arsenite	sodium arsenite results in decreased expression of POLL mRNA	16014739
D013629	Tamoxifen	Tamoxifen affects the expression of POLL mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of POLL mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLL mRNA	17942748
D014635	Valproic Acid	Valproic Acid affects the expression of POLL mRNA	17292431
C025643	vinclozolin	vinclozolin results in increased expression of POLL mRNA	20566332
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of POLL mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	NAS	10982892
GO:0003887	DNA-directed DNA polymerase activity	-	IBA	21873635
GO:0003887	DNA-directed DNA polymerase activity	-	IDA	19806195
GO:0003887	DNA-directed DNA polymerase activity	-	NAS	10982892
GO:0003887	DNA-directed DNA polymerase activity	-	TAS	-
GO:0046872	metal ion binding	-	IEA	-
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	-	IDA	19806195

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000724	double-strand break repair via homologous recombination	-	IMP	20693240
GO:0006260	DNA replication	-	NAS	10982892
GO:0006287	base-excision repair, gap-filling	-	IDA	19806195
GO:0006289	nucleotide-excision repair	-	IDA	10982892
GO:0006303	double-strand break repair via nonhomologous end joining	-	IMP	19806195
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	-
GO:0016446	somatic hypermutation of immunoglobulin genes	-	NAS	10982892
GO:0071897	DNA biosynthetic process	-	IDA	19806195

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	NAS	10982892
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term
hsa03410	Base excision repair
hsa03450	Non-homologous end-joining

Reactome ID	Reactome Term	Evidence
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
7881852	[Role of carcinogenic polycyclic aromatic hydrocarbons in the etiology of lung cancer morbidity among the population a of a large industrial city]. (1994)	Kireeva IS	Med Tr Prom Ekol
21477967	Patient preference survey in the management of asymptomatic carotid stenosis. (2011 Jun)	Jayasooriya GS	J Vasc Surg
12341093	The misunderstood pill: thirty years of testing and development have reduced pill's major, minor side effects. (1986 Summer)	-	Netw Res Triangle Park N C