Gene: PCSK1N

27344
BigLEN|PEN|PROSAAS|SAAS|SCG8|SgVIII
proprotein convertase subtilisin/kexin type 1 inhibitor
protein-coding
Xp11.23
Ensembl:ENSG00000102109 MIM:300399 Vega:OTTHUMG00000034502 UniprotKB:Q9UHG2
NC_000023.11
PubMed
0   ANCO-SNPs
OD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC85B0.944
TRAPPC50.922
TMEM1600.902
MRPL410.9
YDJC0.893
ZNF4280.887
FBXL150.887
TPGS10.886
ABHD17A0.883
FAM173A0.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.665
OR4F29-0.641
CR1-0.316
ITGA1-0.3
FCGR3B-0.3
CP-0.3
FLVCR2-0.287
SULT1B1-0.285
SLFN12-0.285
REST-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of PCSK1N mRNA"28073004
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCSK1N mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PCSK1N mRNA"19446018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCSK1N mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCSK1N mRNA21839799
C006780bisphenol Abisphenol A affects the expression of PCSK1N mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PCSK1N mRNA26079696
D002104CadmiumCadmium results in increased expression of PCSK1N mRNA24376830
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PCSK1N mRNA20360939
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCSK1N gene20938992
D003024ClozapineClozapine affects the expression of PCSK1N mRNA14647396
D003042CocaineCocaine results in decreased expression of PCSK1N mRNA15009677
D016572CyclosporineCyclosporine results in decreased expression of PCSK1N mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of PCSK1N mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PCSK1N mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PCSK1N mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PCSK1N mRNA28412506
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PCSK1N mRNA20360939
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCSK1N gene20938992
D006220HaloperidolHaloperidol results in increased expression of PCSK1N mRNA14647396
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PCSK1N mRNA27392435
D007854LeadLead affects the expression of PCSK1N mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCSK1N gene20938992
D009020MorphineMorphine results in increased expression of PCSK1N mRNA20144693
C568376MT19c compoundMT19c compound results in decreased expression of PCSK1N mRNA21781307
C028007nickel monoxidenickel monoxide results in increased expression of PCSK1N mRNA19167457
D005996NitroglycerinNitroglycerin results in decreased expression of PCSK1N mRNA12102619
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCSK1N mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of PCSK1N mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCSK1N mRNA24680724
D014635Valproic AcidValproic Acid affects the expression of PCSK1N mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCSK1N mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of PCSK1N gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-IBA21873635  
GO:0004866endopeptidase inhibitor activity-TAS10632593  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005102signaling receptor binding-TAS10632593  
GO ID GO Term Qualifier Evidence PubMed
GO:0002021response to dietary excess-IEA-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0009409response to cold-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0016486peptide hormone processing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005802trans-Golgi network-IEA-  
GO:0030141secretory granule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
26298082Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation. (2016 Feb)Wu WCell Tissue Res