Gene: TMEM97

27346
MAC30
transmembrane protein 97
protein-coding
17q11.2
Ensembl:ENSG00000109084 MIM:612912 Vega:OTTHUMG00000132497 UniprotKB:Q5BJF2
NC_000017.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.514e-1 (AD)  9.626e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL30.876
NKRF0.874
PDHX0.874
TMEM2420.872
NKIRAS10.87
KLHL120.867
RTCA0.866
GGH0.865
MAGEH10.864
TSPYL40.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.499
OR4F29-0.444
KLRB1-0.429
IL18RAP-0.395
VNN3-0.391
TTLL10-0.389
TFPI2-0.384
CEACAM4-0.383
FZD10-0.382
MTRNR2L10-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TMEM97 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TMEM97 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMEM97 mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TMEM97 mRNA"23196670
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TMEM97 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of TMEM97 mRNA11793227|2906747
D000082AcetaminophenAcetaminophen affects the expression of TMEM97 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMEM97 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMEM97 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of TMEM97 mRNA19483382
C006632arsenic trioxidearsenic trioxide results in increased expression of TMEM97 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of TMEM97 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of TMEM97 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of TMEM97 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM97 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM97 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of TMEM97 mRNA16474171|1916744
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TMEM97 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TMEM97 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of TMEM97 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of TMEM97 mRNA24136188
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TMEM97 mRNA18654764
D002110CaffeineCaffeine results in decreased expression of TMEM97 mRNA11793227
D002784CholesterolTMEM97 protein affects the metabolism of Cholesterol18070364
D002994ClofibrateClofibrate results in decreased expression of TMEM97 mRNA23811191
D002994ClofibrateClofibrate affects the expression of TMEM97 mRNA19483382
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TMEM97 mRNA18654764
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TMEM97 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMEM97 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TMEM97 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TMEM97 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of TMEM97 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TMEM97 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TMEM97 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TMEM97 mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TMEM97 mRNA21266533
D004041Dietary FatsDietary Fats affects the expression of TMEM97 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of TMEM97 mRNA18042831
D004298DopamineDopamine results in increased expression of TMEM97 mRNA21983523
D004317DoxorubicinTMEM97 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMEM97 mRNA17351261
D005001EthionineEthionine affects the expression of TMEM97 mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of TMEM97 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TMEM97 mRNA23649840
D005047EtoposideTMEM97 protein affects the susceptibility to Etoposide16217747
D018818FenoldopamFenoldopam results in increased expression of TMEM97 mRNA21983523
D018120FinasterideFinasteride results in increased expression of TMEM97 mRNA24136188
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TMEM97 mRNA28329830
D005485FlutamideFlutamide results in increased expression of TMEM97 mRNA24136188
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TMEM97 mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of TMEM97 mRNA23649840
D019833GenisteinGenistein results in increased expression of TMEM97 mRNA16474171
D005897GlafenineGlafenine results in increased expression of TMEM97 mRNA24136188
C016517indole-3-carbinolindole-3-carbinol affects the expression of TMEM97 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TMEM97 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TMEM97 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TMEM97 mRNA22904298|2479639
C410337K 7174K 7174 results in decreased expression of TMEM97 mRNA24086573
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TMEM97 mRNA18654764
C045463leflunomideleflunomide results in decreased expression of TMEM97 mRNA28988120
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TMEM97 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to TMEM97 promoter]20348232
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TMEM97 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TMEM97 mRNA"26251327
D016685MitomycinTMEM97 protein affects the susceptibility to Mitomycin16217747
D009151Mustard GasMustard Gas results in decreased expression of TMEM97 mRNA25102026
C044361M-VAC protocolTMEM97 protein results in increased susceptibility to M-VAC protocol15814643
D009532NickelNickel results in decreased expression of TMEM97 mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of TMEM97 mRNA17997037
C012655nimesulidenimesulide results in increased expression of TMEM97 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TMEM97 mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of TMEM97 mRNA19483382
D000073878Palm OilPalm Oil affects the expression of TMEM97 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of TMEM97 mRNA18042831
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of TMEM97 mRNA26678675
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMEM97 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TMEM97 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMEM97 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of TMEM97 mRNA19483382
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TMEM97 mRNA16474171
D011374ProgesteroneProgesterone results in increased expression of TMEM97 mRNA18070364
D011441PropylthiouracilPropylthiouracil affects the expression of TMEM97 mRNA19483382
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TMEM97 mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of TMEM97 mRNA20436886
D012402RotenoneRotenone results in increased expression of TMEM97 mRNA19013527
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TMEM97 mRNA21427059
C017947sodium arsenitesodium arsenite results in increased expression of TMEM97 mRNA28595984
C016104sodium bichromatesodium bichromate results in decreased expression of TMEM97 mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM97 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM97 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM97 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM97 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TMEM97 mRNA19933214
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TMEM97 mRNA28973375
D019284ThapsigarginThapsigargin results in decreased expression of TMEM97 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of TMEM97 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of TMEM97 mRNA11793227
D013853ThioacetamideThioacetamide affects the expression of TMEM97 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of TMEM97 mRNA27760801
D019772TopotecanTMEM97 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of TMEM97 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TMEM97 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of TMEM97 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMEM97 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TMEM97 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of TMEM97 mRNA22378314
D014520UrethaneUrethane results in decreased expression of TMEM97 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TMEM97 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM97 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of TMEM97 mRNA21427059
D014638VanadatesVanadates results in decreased expression of TMEM97 mRNA22714537
D014747VinblastineTMEM97 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in decreased expression of TMEM97 mRNA23034163
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA20370541
C088658zoledronic acidzoledronic acid results in increased expression of TMEM97 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19583955  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-NAS7694637  
GO:0042632cholesterol homeostasis-IDA19583955  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA19583955  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005791rough endoplasmic reticulum-IDA19583955  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA19583955  
GO:0016021integral component of membrane-IEA-  
GO:0030867rough endoplasmic reticulum membrane-IEA-  
GO:0031965nuclear membrane-IDA19583955  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29728649Small molecule modulators of sigma2R/Tmem97 reduce alcohol withdrawal-induced behaviors. (2018 Apr 20)Scott LLNeuropsychopharmacology