Gene: STK39

27347
DCHT|PASK|SPAK
serine/threonine kinase 39
protein-coding
2q24.3
Ensembl:ENSG00000198648 MIM:607648 Vega:OTTHUMG00000133745 UniprotKB:Q9UEW8
NG_052783.1
PubMed
0   ANCO-SNPs
ND
1   
5.710e-1 (AD)  3.165e-1 (ND)   (Frontal_Cortex)
6.442e-1 (AD)  5.867e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16875057chr2:169006003STK397.730e-9Maternal smoking in pregnancy27040690
cg03351487chr2:169003820STK391.260e-8Maternal smoking in pregnancy27040690
cg03351487chr2:169003820STK391.480e-11Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAP1GDS10.963
MFSD60.943
FBXO450.936
AGTPBP10.929
VAPB0.927
HBS1L0.927
ANK30.922
RUFY30.921
FAM98A0.919
PTPRD0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.536
OR4F5-0.525
EVC2-0.459
RNF135-0.455
INHBB-0.443
RREB1-0.438
RHOD-0.434
GJB2-0.431
SIX5-0.428
NHSL1-0.427

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of STK39 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of STK39 mRNA"23829299
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased expression of STK39 mRNA]17131305
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]17131305
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STK39 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STK39 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STK39 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of STK39 mRNA25458485
D000082AcetaminophenAcetaminophen affects the expression of STK39 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STK39 mRNA19770486
D013196Dihydrotestosterone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased expression of STK39 mRNA]17131305
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of STK39 mRNA17131305
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STK39 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of STK39 mRNA24449571
D001151ArsenicArsenic affects the methylation of STK39 gene25304211
D001280AtrazineAtrazine results in decreased expression of STK39 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STK39 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STK39 mRNA15034205|1977048
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]17131305
D004958EstradiolEstradiol results in increased expression of STK39 mRNA17131305|1858669
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]17131305
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]18586690
C006780bisphenol Abisphenol A results in decreased expression of STK39 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of STK39 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STK39 gene28505145
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of STK39 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK39 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of STK39 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of STK39 mRNA19549813
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] affects the expression of STK39 mRNA16322899
D016572CyclosporineCyclosporine results in decreased expression of STK39 mRNA27989131
C531198dactolisibdactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]22949526
C531198dactolisibdactolisib results in decreased phosphorylation of STK39 protein22949526
C004742daidzeindaidzein results in decreased expression of STK39 mRNA16865672
D016190CarboplatinCarboplatin results in decreased expression of STK39 mRNA18172885
D002945CisplatinCisplatin results in decreased expression of STK39 mRNA19561079
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of STK39 mRNA21858171
D002945CisplatinCisplatin results in decreased expression of STK39 mRNA18172885
D002117CalcitriolCalcitriol results in increased expression of STK39 mRNA16002434
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] affects the expression of STK39 mRNA16322899
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of STK39 protein23301498
C414690eplerenone"[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein"22949526
D060754EquolEquol results in decreased expression of STK39 mRNA16865672
D005419FlavonoidsFlavonoids results in decreased expression of STK39 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK39 gene20938992
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]17131305
C039281furanfuran results in decreased expression of STK39 mRNA25539665
C039281furanfuran results in increased expression of STK39 mRNA25539665
D019833GenisteinGenistein results in decreased expression of STK39 mRNA15378649|1686567
D005839GentamicinsGentamicins results in decreased expression of STK39 mRNA22061828
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of STK39 mRNA24680724
D017313FenretinideFenretinide results in decreased expression of STK39 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of STK39 mRNA20044591
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK39 gene20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of STK39 mRNA20864626
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of STK39 mRNA12634122
D015741MetriboloneMetribolone results in increased expression of STK39 mRNA17131305|1858669
D015741Metriboloneresveratrol inhibits the reaction [Metribolone results in increased expression of STK39 mRNA]18586690
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STK39 mRNA"25554681
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of STK39 mRNA19716841
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STK39 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of STK39 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STK39 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of STK39 mRNA18301758|2081375
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of STK39 mRNA21858171
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of STK39 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of STK39 mRNA24780913
C052785rebamipiderebamipide results in increased expression of STK39 mRNA18299717
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]18586690
C059514resveratrolresveratrol inhibits the reaction [Metribolone results in increased expression of STK39 mRNA]18586690
C059514resveratrolresveratrol results in increased expression of STK39 mRNA18586690
D012293RifampinRifampin results in increased expression of STK39 mRNA24552687
C010327salinomycinsalinomycin results in decreased expression of STK39 mRNA19682730
C017947sodium arsenitesodium arsenite affects the methylation of STK39 gene28589171
D017673Sodium Chloride, Dietary"[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein"22949526
D012969Sodium FluorideSodium Fluoride results in increased expression of STK39 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STK39 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK39 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STK39 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STK39 mRNA15034205|2015994
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK39 mRNA22298810
D013853ThioacetamideThioacetamide results in increased expression of STK39 mRNA23411599
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STK39 mRNA19042947
D014520UrethaneUrethane results in decreased expression of STK39 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of STK39 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of STK39 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of STK39 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of STK39 mRNA21427059
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of STK39 mRNA25423262
C029297vinylidene chloridevinylidene chloride results in decreased expression of STK39 mRNA26682919
D015032ZincZinc deficiency results in decreased expression of STK39 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA24393035  
GO:0004674protein serine/threonine kinase activity-IMP10980603  16669787  
GO:0005515protein binding-IPI16669787  21423148  24393035  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-ISS-  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IMP10980603  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0006468protein phosphorylation-ISS-  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0008217regulation of blood pressure-IEA-  
GO:0018105peptidyl-serine phosphorylation-IDA24393035  
GO:0018105peptidyl-serine phosphorylation-IMP10980603  
GO:0018107peptidyl-threonine phosphorylation-IDA24393035  
GO:0018107peptidyl-threonine phosphorylation-IMP10980603  16669787  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IDA24393035  
GO:0023016signal transduction by trans-phosphorylation-IMP16669787  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0032414positive regulation of ion transmembrane transporter activity-ISS-  
GO:0035556intracellular signal transduction-IDA24393035  
GO:0036438maintenance of lens transparency-ISS-  
GO:0043268positive regulation of potassium ion transport-IEA-  
GO:0046777protein autophosphorylation-IMP10980603  
GO:0046777protein autophosphorylation-ISS-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0050801ion homeostasis-IEA-  
GO:0071476cellular hypotonic response-IC24393035  
GO:0090188negative regulation of pancreatic juice secretion-IEA-  
GO:1901017negative regulation of potassium ion transmembrane transporter activity-IDA24393035  
GO:1901380negative regulation of potassium ion transmembrane transport-IDA24393035  
GO:1905408negative regulation of creatine transmembrane transporter activity-IDA25531585  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IDA25531585  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-IMP10980603  
GO:0005829cytosol-ISS-  
GO:0005856cytoskeleton-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0019898extrinsic component of membrane-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142475A meta-analytical assessment of STK39 three well-defined polymorphisms in susceptibility to hypertension. (2016 May 4)Yang HSci Rep