Gene: GLI1

2735
GLI
GLI family zinc finger 1
protein-coding
12q13.3
Ensembl:ENSG00000111087 MIM:165220 Vega:OTTHUMG00000167332 UniprotKB:P08151
NG_029564.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.472e-1 (AD)  5.740e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFATC40.721
A2ML10.709
ALDH1L1-AS20.705
PHYHD10.698
ACSS10.687
CRB10.678
ZNF4230.675
CDC42EP40.67
TNS30.659
FGFR30.657

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
L3MBTL3-0.471
RASGEF1B-0.421
VLDLR-0.417
ENPP6-0.417
MUM1L1-0.411
GSKIP-0.41
TMEFF2-0.395
SLC7A14-0.392
HTR7-0.389
SSTR2-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0889691,4-diaminocyclohexane"1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]"24973920
C0889691,4-diaminocyclohexane"1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA"24973920
C0889691,4-diaminocyclohexane"BRD4 mutant form inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0889691,4-diaminocyclohexane"HhAntag691 inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0889691,4-diaminocyclohexane"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]]"24973920
C0889691,4-diaminocyclohexane"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0889691,4-diaminocyclohexane"LDE225 inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0889691,4-diaminocyclohexane"SANT-1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GLI1 protein25945059
C5424653-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine results in decreased expression of GLI1 mRNA21625222
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of GLI1 mRNA"17109907
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLI1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GLI1 mRNA28965971
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GLI1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GLI1 mRNA16483693
D047310ApigeninApigenin results in decreased expression of GLI1 mRNA20395211
D047310ApigeninApigenin results in decreased expression of GLI1 protein20395211
D001151ArsenicArsenic affects the expression of GLI1 mRNA28615018
C006632arsenic trioxidearsenic trioxide results in decreased expression of GLI1 mRNA23861973|2594505
C006632arsenic trioxidearsenic trioxide results in decreased expression of GLI1 protein25945059
C006632arsenic trioxideGLI1 protein results in increased susceptibility to arsenic trioxide21183792
C006632arsenic trioxidearsenic trioxide binds to and results in decreased activity of GLI1 protein21183792
C006632arsenic trioxide[arsenic trioxide co-treated with Itraconazole] results in decreased expression of GLI1 mRNA27784375
C006632arsenic trioxide[arsenic trioxide co-treated with Itraconazole] results in decreased expression of GLI1 protein27784375
C006632arsenic trioxidearsenic trioxide results in decreased expression of GLI1 protein24094913
C547126AZM551248AZM551248 results in decreased expression of GLI1 mRNA22323515
C006680baicaleinbaicalein results in decreased expression of GLI1 mRNA20395211
C006680baicaleinbaicalein results in decreased expression of GLI1 protein20395211
D004958EstradiolEstradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GLI1 mRNA22958837
D004958EstradiolEstradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D004958EstradiolEstradiol results in decreased expression of GLI1 mRNA15289156
D004958EstradiolEstradiol promotes the reaction [Plant Preparations results in decreased expression of GLI1 mRNA]26945725
D004958EstradiolEstradiol results in decreased expression of GLI1 mRNA15328011|2023221
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of GLI1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of GLI1 mRNA21786754|2355768
C006780bisphenol Abisphenol A results in decreased expression of GLI1 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of GLI1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of GLI1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GLI1 protein22941245
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GLI1 mRNA19818801
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA12634122
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of GLI1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of GLI1 mRNA26033743
D019327Copper SulfateCopper Sulfate affects the expression of GLI1 mRNA19549813
D003471CuprizoneCuprizone affects the expression of GLI1 mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of GLI1 mRNA27523638
D003474CurcuminCurcumin results in decreased expression of GLI1 mRNA20395211
D003474CurcuminCurcumin results in decreased expression of GLI1 protein20395211
C000541cyclopaminecyclopamine affects the expression of GLI1 protein20032413
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
C000541cyclopaminecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
C000541cyclopaminecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
C000541cyclopaminecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]27481074
C000541cyclopaminecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]27481074
C000541cyclopaminecyclopamine inhibits the reaction [SAG compound results in increased expression of GLI1 mRNA]22923130
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20395211|2043453
C000541cyclopaminecyclopamine results in decreased expression of GLI1 mRNA20179202|2039521
C000541cyclopaminecyclopamine results in decreased expression of GLI1 protein20395211
C000541cyclopaminecyclopamine inhibits the reaction [resveratrol results in increased expression of GLI1 protein]24464877
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]21110116
C000541cyclopaminecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 mRNA]24388991
C000541cyclopaminecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 protein]24388991
C000541cyclopaminecyclopamine results in decreased expression of GLI1 mRNA21703336
C000541cyclopaminecyclopamine inhibits the reaction [SMO protein results in increased expression of GLI1 mRNA]22552772
D016572CyclosporineCyclosporine results in decreased methylation of GLI1 promoter27989131
C014347decitabine[[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of GLI1 mRNA18559595
C014347decitabinedecitabine results in increased expression of GLI1 mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GLI1 mRNA]27941970
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of GLI1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GLI1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GLI1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GLI1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GLI1 mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of GLI1 protein25386960
D003633Dichlorodiphenyl DichloroethyleneGLI1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CCND1 protein]25386960
D003633Dichlorodiphenyl DichloroethyleneGLI1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of MYC protein]25386960
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of GLI1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of GLI1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GLI1 mRNA28123099
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GLI1 mRNA27058323
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GLI1 protein27058323
D004052Diethylnitrosamineepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]27058323
D004052Diethylnitrosamineepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]27058323
D004052Diethylnitrosaminetheaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]27058323
D004052Diethylnitrosaminetheaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]27058323
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of GLI1 mRNA15289156
C010945embelinembelin results in decreased expression of GLI1 protein24694877
C010945embelinembelin results in decreased expression of GLI1 protein24694877
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]27058323
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]27058323
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of GLI1 mRNA20395211
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of GLI1 protein20395211
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GLI1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GLI1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GLI1 mRNA17109907
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GLI1 mRNA27776689
C082360fipronilfipronil results in increased methylation of GLI1 gene28536466
D005472FluorouracilFluorouracil results in decreased expression of GLI1 mRNA18776995
D005472FluorouracilGLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein]18776995
C070081fulvestrantfulvestrant results in increased expression of GLI1 mRNA20232216
C551027GANT 61GANT 61 results in decreased activity of GLI1 protein22265815
C551027GANT 61GANT 61 results in decreased expression of GLI1 mRNA22265815
C551027GANT 61GANT 61 results in decreased expression of GLI1 protein24094913
D019833GenisteinGenistein inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20395211
D019833GenisteinGenistein results in decreased expression of GLI1 mRNA15289156|2039521
D019833GenisteinGenistein results in decreased expression of GLI1 protein20395211
D019833GenisteinGenistein results in increased expression of GLI1 mRNA21810550
D005947Glucosecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
D005947Glucosecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
D005947Glucosecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]27481074
D005947Glucosecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein27481074
D005947Glucosepolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
D005947Glucosepolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]22087285
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]22087285
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]22087285
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]22087285
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]22087285
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag69122087285
C538724HhAntag691HhAntag691 results in decreased expression of GLI1 mRNA22087285
C538724HhAntag691HhAntag691 results in decreased expression of GLI1 mRNA24973920|2758588
C538724HhAntag691"HhAntag691 inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GLI1 mRNA26846883
C082359imidaclopridimidacloprid results in decreased expression of GLI1 mRNA27444676
C018986ipriflavoneipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
C018986ipriflavoneipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D017964ItraconazoleItraconazole analog results in decreased expression of GLI1 mRNA21936514
D017964Itraconazole[arsenic trioxide co-treated with Itraconazole] results in decreased expression of GLI1 mRNA27784375
D017964Itraconazole[arsenic trioxide co-treated with Itraconazole] results in decreased expression of GLI1 protein27784375
D017964ItraconazoleItraconazole results in decreased expression of GLI1 protein24094913
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GLI1 mRNA27392435
C525593JK184JK184 affects the activity of GLI1 protein19222062
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GLI2 protein results in increased expression of GLI1 mRNA]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GLI1 mRNA26752646|2700647
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to GLI1 promoter]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GLI2 protein results in increased expression of GLI1 mRNA]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [SUFU gene mutant form results in increased expression of GLI1 mRNA]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [SUFU gene mutant form results in increased expression of GLI1 protein]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GLI1 mRNA24973920
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GLI1 protein24973920
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]]"24973920
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C561435LDE225LDE225 results in decreased expression of GLI1 mRNA24973920
C561435LDE225"LDE225 inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA12634122
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GLI1 protein25069516
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of GLI1 protein]25069516
D008070Lipopolysaccharidescyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]21110116
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein21110116
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GLI1 mRNA21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]21110116
D008555MelittenMelitten results in decreased expression of GLI1 protein26189965
D008694MethamphetamineMethamphetamine results in decreased expression of GLI1 mRNA19564919
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GLI1 mRNA"26251327
C523799MRK 003MRK 003 inhibits the reaction [HES1 protein binds to GLI1 intron]21169257
C523799MRK 003MRK 003 results in increased expression of GLI1 mRNA21169257
C523799MRK 003NOTCH2 inhibits the reaction [MRK 003 results in increased expression of GLI1 mRNA]21169257
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of GLI1 mRNA"25487280
C025589ochratoxin Aochratoxin A results in decreased expression of GLI1 mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of GLI1 mRNA]21703336
D010100Oxygencyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
D010100Oxygencyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
D010100Oxygencyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]27481074
D010100Oxygencyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]27481074
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA27481074
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein27481074
D010100Oxygenpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
D010100Oxygenpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
D010882Piperonyl ButoxidePiperonyl Butoxide inhibits the reaction [SMO protein results in increased expression of GLI1 mRNA]22552772
D010936Plant ExtractsPlant Extracts results in decreased expression of GLI1 mRNA23557933
D028321Plant PreparationsEstradiol promotes the reaction [Plant Preparations results in decreased expression of GLI1 mRNA]26945725
D028321Plant PreparationsPlant Preparations results in decreased expression of GLI1 mRNA26945725
C058229polydatincyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]27481074
C058229polydatincyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]27481074
C058229polydatinpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]27481074
C058229polydatinpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]27481074
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GLI1 mRNA22958837
D011441PropylthiouracilPropylthiouracil results in decreased expression of GLI1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of GLI1 mRNA20395211
D011794QuercetinQuercetin results in decreased expression of GLI1 protein20395211
D011796QuinacrineGSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]28720477
D011796QuinacrineQuinacrine results in decreased expression of GLI1 protein28720477
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of GLI1 protein]25069516
C059514resveratrolresveratrol results in decreased activity of GLI1 protein22397755
C059514resveratrolresveratrol results in decreased expression of GLI122301921
C059514resveratrolresveratrol results in decreased expression of GLI1 mRNA20395211
C059514resveratrolresveratrol results in decreased expression of GLI1 protein20395211
C059514resveratrolcyclopamine inhibits the reaction [resveratrol results in increased expression of GLI1 protein]24464877
C059514resveratrolresveratrol results in increased expression of and affects the localization of GLI1 protein24464877
C468918SAG compoundcyclopamine inhibits the reaction [SAG compound results in increased expression of GLI1 mRNA]22923130
C468918SAG compoundSAG compound results in increased expression of GLI1 mRNA22923130
C468918SAG compoundSAG compound results in increased expression of GLI1 protein24464877
C010327salinomycinsalinomycin results in decreased expression of GLI1 mRNA25499043
C010327salinomycinsalinomycin results in decreased expression of GLI1 protein25499043
C468919SANT-1 compound"SANT-1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C468920SANT-2 compoundSANT-2 compound results in decreased expression of GLI1 mRNA22265815
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GLI1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GLI1 mRNA23806026
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of GLI1 mRNA20179202
C017947sodium arsenitesodium arsenite results in increased expression of GLI1 protein20179202
D012969Sodium Fluoridecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 mRNA]24388991
D012969Sodium Fluoridecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 protein]24388991
D012969Sodium FluorideSodium Fluoride results in increased expression of GLI1 mRNA24388991
D012969Sodium FluorideSodium Fluoride results in increased expression of GLI1 protein24388991
D013629TamoxifenTamoxifen affects the expression of GLI1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLI1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLI1 mRNA17942748
C056068theaflavintheaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]27058323
C056068theaflavintheaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]27058323
C479163tofacitinibtofacitinib results in increased expression of GLI1 mRNA25487280
D014047TolnaftateTolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D014047TolnaftateTolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D014118Toxins, Biological"Toxins, Biological affects the expression of GLI1 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA17085092
D014212TretinoinTretinoin affects the expression of GLI1 mRNA22262565
D014212TretinoinTretinoin results in increased expression of GLI1 mRNA20488242
D014635Valproic AcidValproic Acid results in increased expression of GLI1 mRNA19101580
D014750VincristineGLI1 gene SNP results in increased susceptibility to Vincristine20864405

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA18298960  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA9118802  
GO:0003682chromatin binding-IEA-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI10564661  10806483  11238441  20818436  22439934  23395608  
24217340  24311597  25241761  25416956  25609649  25910212  
28965847  
GO:0008017microtubule binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IDA17035233  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-IDA12165851  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007224smoothened signaling pathway-IDA19878745  
GO:0007224smoothened signaling pathway-TAS11001584  
GO:0007283spermatogenesis-IEA-  
GO:0007418ventral midline development-IEA-  
GO:0008284positive regulation of cell proliferation-IMP12165851  
GO:0008589regulation of smoothened signaling pathway-TAS11238441  
GO:0009611response to wounding-IEA-  
GO:0009913epidermal cell differentiation-IDA12165851  
GO:0009953dorsal/ventral pattern formation-IEA-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0021696cerebellar cortex morphogenesis-IEA-  
GO:0021938smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0030324lung development-IEA-  
GO:0030850prostate gland development-IEA-  
GO:0045667regulation of osteoblast differentiation-IEA-  
GO:0045740positive regulation of DNA replication-IDA12165851  
GO:0045880positive regulation of smoothened signaling pathway-IDA17035233  
GO:0045893positive regulation of transcription, DNA-templated-IDA11238441  12165851  17035233  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9118802  10693759  12165851  
GO:0048546digestive tract morphogenesis-TAS11001584  
GO:0060032notochord regression-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IDA28583401  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP17035233  
GO:0097421liver regeneration-IEA-  
GO:1902808positive regulation of cell cycle G1/S phase transition-IDA28583401  
GO:2000345regulation of hepatocyte proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10806483  11238441  19878745  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10504446  11238441  16229683  19878745  
GO:0005829cytosol-IDA18559511  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-IEA-  
GO:0097542ciliary tip-TAS-  
GO:0097546ciliary base-TAS-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5635851GLI proteins bind promoters of Hh responsive genes to promote transcriptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep
28652248GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. (2017 Aug 15)Kasiri SCancer Res
24856810Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. (2014 Jul)Sverrisson EFUrol Oncol