Gene: GLI3

2737
ACLS|GCPS|GLI3-190|GLI3FL|PAP-A|PAPA|PAPA1|PAPB|PHS|PPDIV
GLI family zinc finger 3
protein-coding
7p14.1
Ensembl:ENSG00000106571 MIM:165240 Vega:OTTHUMG00000023630 UniprotKB:P10071
NG_008434.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.350e-1 (AD)  9.955e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6955604chr7:42217285 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs3801187chr7:42116764 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NHSL10.915
NOTCH20.914
ZNRF30.912
ATP13A40.896
SLC7A110.895
ARHGEF260.893
GPAM0.888
PREX20.886
PRDM160.886
EGFR0.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.488
OSBPL10-0.486
ENPP6-0.473
NELL1-0.467
AGMAT-0.467
TMEFF2-0.465
VLDLR-0.464
NRG1-0.46
HTR7-0.46
SLC7A14-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLI3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLI3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLI3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GLI3 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GLI3 gene27153756
D000728AndrogensAndrogens deficiency results in increased expression of GLI3 mRNA26710974
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GLI3 mRNA24449571
D001151ArsenicArsenic affects the expression of GLI3 mRNA28615018
D001151ArsenicArsenic affects the methylation of GLI3 gene25304211
C006632arsenic trioxidearsenic trioxide promotes the reaction [GLI3 protein binds to KIT promoter]27793025
C006632arsenic trioxidearsenic trioxide promotes the reaction [[GLI3 protein binds to KIT promoter] which results in decreased expression of KIT mRNA]27793025
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of GLI3 mRNA21714911
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GLI3 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of GLI3 mRNA19484750
D004958EstradiolEstradiol results in increased expression of GLI3 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of GLI3 mRNA15328011
C006780bisphenol Abisphenol A results in decreased expression of GLI3 mRNA28238728
C006780bisphenol AMIR107 mRNA promotes the reaction [bisphenol A results in decreased expression of GLI3 mRNA]28238728
C006780bisphenol Abisphenol A results in decreased expression of GLI3 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLI3 mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of GLI3 mRNA20971185
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GLI3 mRNA25213187|2707974
D002945CisplatinCisplatin results in decreased expression of GLI3 mRNA19561079|2160359
D019422Dietary SucroseDietary Sucrose results in increased expression of GLI3 mRNA26033743
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of GLI3 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLI3 mRNA22079256
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GLI3 gene18397875
D005492Folic AcidFolic Acid inhibits the reaction [[GLI3 gene mutant form co-treated with ochratoxin A] results in increased expression of FGF8 mRNA]17688467
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLI3 mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of GLI3 mRNA22061828
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GLI3 mRNA26378955
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GLI3 mRNA26378955
D008558MelphalanMelphalan results in decreased expression of GLI3 mRNA22363485
D008713MethimazoleMethimazole results in increased expression of GLI3 mRNA25539664
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLI3 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GLI3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GLI3 mRNA26011545
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of GLI3 mRNA26710974
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GLI3 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of GLI3 mRNA20971185
C025589ochratoxin AFolic Acid inhibits the reaction [[GLI3 gene mutant form co-treated with ochratoxin A] results in increased expression of FGF8 mRNA]17688467
C025589ochratoxin AGLI3 gene affects the susceptibility to ochratoxin A20201966
C025589ochratoxin A[GLI3 gene mutant form co-treated with ochratoxin A] results in increased expression of FGF8 mRNA17688467
C025589ochratoxin AGLI3 gene mutant form results in increased susceptibility to ochratoxin A16922921|1768846
C025589ochratoxin Aochratoxin A promotes the reaction [GLI3 gene mutant form results in increased expression of FGF8 protein]16922921
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLI3 mRNA"27188386
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLI3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GLI3 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in decreased expression of GLI3 mRNA19690047
C043680ptaquilosideptaquiloside results in decreased expression of GLI3 mRNA23274088
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GLI3 mRNA27029645
C017947sodium arsenitesodium arsenite results in increased expression of GLI3 mRNA20179202
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GLI3 mRNA26378955
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GLI3 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLI3 mRNA21570461|2405805
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GLI3 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of GLI3 mRNA22723015|2493525
C012589trichostatin Atrichostatin A results in increased expression of GLI3 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of GLI3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GLI3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GLI3 mRNA24935251|2800136
D014635Valproic AcidGLI3 gene mutant form results in increased susceptibility to Valproic Acid16359493
D014635Valproic AcidGLI3 protein results in decreased susceptibility to Valproic Acid16359493
D014635Valproic AcidValproic Acid promotes the reaction [GLI3 gene mutant form affects the expression of FGF8 mRNA]16359493
D014638VanadatesVanadates results in increased expression of GLI3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GLI3 gene25487561

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA18298960  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA2118997  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IDA10077605  17000779  17764085  
GO:0005515protein binding-IPI10564661  10806483  11238441  12435627  16371461  17000779  
17764085  19389374  19592253  19955409  23955340  24311597  
25241761  28965847  
GO:0008013beta-catenin binding-IPI17331723  
GO:0035035histone acetyltransferase binding-IPI10075717  
GO:0042826histone deacetylase binding-IDA12435627  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10693759  12435627  19084012  
GO:0001656metanephros development-IEA-  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007224smoothened signaling pathway-TAS11001584  
GO:0007411axon guidance-IEA-  
GO:0007442hindgut morphogenesis-IEA-  
GO:0007507heart development-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0016485protein processing-IEA-  
GO:0021631optic nerve morphogenesis-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021775smoothened signaling pathway involved in ventral spinal cord interneuron specification-IEA-  
GO:0021776smoothened signaling pathway involved in spinal cord motor neuron cell fate specification-IEA-  
GO:0021798forebrain dorsal/ventral pattern formation-IEA-  
GO:0021819layer formation in cerebral cortex-IEA-  
GO:0021861forebrain radial glial cell differentiation-IEA-  
GO:0022018lateral ganglionic eminence cell proliferation-IEA-  
GO:0030318melanocyte differentiation-IEA-  
GO:0030324lung development-IEA-  
GO:0030850prostate gland development-IEA-  
GO:0032332positive regulation of chondrocyte differentiation-IEA-  
GO:0033077T cell differentiation in thymus-ISS-  
GO:0035108limb morphogenesis-IMP9354785  18478223  
GO:0042060wound healing-IEA-  
GO:0042307positive regulation of protein import into nucleus-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042733embryonic digit morphogenesis-TAS11001584  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043585nose morphogenesis-TAS11001584  
GO:0043586tongue development-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0045060negative thymic T cell selection-ISS-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045879negative regulation of smoothened signaling pathway-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12435627  16254602  19084012  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17000779  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18559511  
GO:0046638positive regulation of alpha-beta T cell differentiation-ISS-  
GO:0046639negative regulation of alpha-beta T cell differentiation-ISS-  
GO:0048557embryonic digestive tract morphogenesis-IEA-  
GO:0048566embryonic digestive tract development-TAS11001584  
GO:0048589developmental growth-IEA-  
GO:0048593camera-type eye morphogenesis-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060364frontal suture morphogenesis-IEA-  
GO:0060366lambdoid suture morphogenesis-IEA-  
GO:0060367sagittal suture morphogenesis-IEA-  
GO:0060594mammary gland specification-IEA-  
GO:0060831smoothened signaling pathway involved in dorsal/ventral neural tube patterning-IEA-  
GO:0060840artery development-IEA-  
GO:0060873anterior semicircular canal development-IEA-  
GO:0060875lateral semicircular canal development-IEA-  
GO:0061005cell differentiation involved in kidney development-IEA-  
GO:0070242thymocyte apoptotic process-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA17331723  
GO:0097421liver regeneration-IEA-  
GO:1903010regulation of bone development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10693759  11238441  12435627  16254602  18559511  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10077605  11238441  12435627  
GO:0005829cytosol-IDA18559511  
GO:0005829cytosol-TAS-  
GO:0005929cilium-IDA16254602  19592253  
GO:0005930axoneme-IEA-  
GO:0016592mediator complexcolocalizes_withIDA17000779  
GO:0016607nuclear speck-IEA-  
GO:0017053transcriptional repressor complex-IEA-  
GO:0097542ciliary tip-TAS-  
GO:0097546ciliary base-TAS-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5635851GLI proteins bind promoters of Hh responsive genes to promote transcriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8940973RUNX2 regulates osteoblast differentiationIEA
R-HSA-8941326RUNX2 regulates bone developmentIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal