Gene: GLO1

2739
GLOD1|GLYI|HEL-S-74
glyoxalase I
protein-coding
6p21.2
Ensembl:ENSG00000124767 MIM:138750 Vega:OTTHUMG00000014636 UniprotKB:Q04760
NG_012074.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.414e-1 (AD)  7.315e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIGD1A0.943
PRDX30.939
ITM2B0.938
RHEB0.935
C11orf580.935
METTL90.933
PSMD100.932
NDUFB50.93
RAB180.93
ASAH10.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.843
OR4F29-0.808
MTRNR2L6-0.189
MTRNR2L10-0.178
OR6C74-0.176
FCRL1-0.17
HMHB1-0.166
TRPV5-0.164
MTRNR2L3-0.163
MTRNR2L9-0.163

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTarget
DB03130S-P-NitrobenzyloxycarbonylglutathioneSmall MoleculeExperimentalTarget
DB03330S-(N-Hydroxy-N-Iodophenylcarbamoyl)GlutathioneSmall MoleculeExperimentalTarget
DB03345Beta-MercaptoethanolSmall Molecule60-24-2ExperimentalTarget
DB03602S-Benzyl-GlutathioneSmall MoleculeExperimentalTarget
DB04132S-HexylglutathioneSmall MoleculeExperimentalTarget
DB08179methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GLO1 mRNA"15302862
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GLO1 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLO1 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of GLO1 mRNA"18343893
C026784acemetacinacemetacin results in decreased activity of GLO1 protein17243824
D000082AcetaminophenAcetaminophen affects the expression of GLO1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GLO1 mRNA19770486
D000447AldehydesGLO1 protein affects the metabolism of Aldehydes11719831
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of GLO1 protein26597043
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GLO1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of GLO1 mRNA20458559
D001205Ascorbic AcidAscorbic Acid affects the expression of GLO1 protein19224539
D001280AtrazineAtrazine results in increased expression of GLO1 mRNA23358194
D001280AtrazineAtrazine results in increased expression of GLO1 protein23358194
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of GLO1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GLO1 protein22138271
D001564Benzo(a)pyreneMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GLO1 protein]22138271
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLO1 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of GLO1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GLO1 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of GLO1 mRNA25181051
D003931DiacetylDiacetyl affects the activity of GLO1 protein11513095
D003931Diacetylhexylglutathione inhibits the reaction [Diacetyl affects the activity of GLO1 protein]11513095
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GLO1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GLO1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GLO1 mRNA27339419
C007020chlorophyllinchlorophyllin analog results in decreased expression of GLO1 protein22852132
C100187chloropicrinchloropicrin affects the expression of GLO1 mRNA26352163
D003300CopperCopper results in increased expression of GLO1 mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of GLO1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of GLO1 protein21641295
C029892cupric chloridecupric chloride results in increased expression of GLO1 mRNA24650576
C030973cupric oxidecupric oxide results in decreased expression of GLO1 protein25470785
D003474CurcuminCurcumin results in decreased activity of GLO1 protein18946510
D016572CyclosporineCyclosporine results in decreased expression of GLO1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of GLO1 mRNA19770486
D003676DeferoxamineDeferoxamine results in increased expression of GLO1 protein19515424
D003676Deferoxamineferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein]19515424
C000944dicrotophosdicrotophos results in decreased expression of GLO1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GLO1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GLO1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GLO1 mRNA]17942915
D004047Diethyl PyrocarbonateDiethyl Pyrocarbonate affects the activity of GLO1 protein11513095
D004047Diethyl Pyrocarbonatehexylglutathione inhibits the reaction [Diethyl Pyrocarbonate affects the activity of GLO1 protein]11513095
D004317DoxorubicinGLO1 mRNA results in decreased susceptibility to Doxorubicin16085563
D004317Doxorubicintroglitazone inhibits the reaction [GLO1 mRNA results in decreased susceptibility to Doxorubicin]16085563
D004317Doxorubicin[troglitazone results in decreased expression of GLO1 mRNA] which results in increased susceptibility to Doxorubicin16085563
D004317DoxorubicinGLO1 protein results in decreased susceptibility to [Indomethacin co-treated with Doxorubicin]17243824
D004317Doxorubicin[Indomethacin results in decreased activity of GLO1 protein] which results in increased susceptibility to Doxorubicin17243824
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GLO1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GLO1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GLO1 mRNA17108234
C013531ferric ammonium citrateferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein]19515424
D005473FluoxetineGLO1 protein results in increased susceptibility to Fluoxetine22113448
D005690GalactoseGalactose results in decreased expression of and results in decreased activity of GLO1 protein22687555
D005690Galactoseprotocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein]22687555
C435770gambierol[Okadaic Acid co-treated with gambierol] results in decreased expression of GLO1 protein19397276
D005907GliclazideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A12 promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A8 promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [RELA protein binds to AGER promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of AGER protein]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]19833897
D005947GlucoseGlucose results in decreased expression of GLO1 protein19833897
D005947GlucoseSOD2 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]19833897
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [HIF1A protein binds to NOS3 promoter]]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [HIF1A protein binds to CXCR4 promoter]]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCL12 protein]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of NOS3 mRNA]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of NOS3 protein]18227068
C010972glycolaldehydeglycolaldehyde results in decreased activity of GLO1 protein21378371
C033550hexylglutathionehexylglutathione inhibits the reaction [Diacetyl affects the activity of GLO1 protein]11513095
C033550hexylglutathionehexylglutathione inhibits the reaction [Diethyl Pyrocarbonate affects the activity of GLO1 protein]11513095
C005499honokiolhonokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]26723916
D007213IndomethacinGLO1 protein results in decreased susceptibility to [Indomethacin co-treated with Doxorubicin]17243824
D007213IndomethacinIndomethacin binds to and results in decreased activity of GLO1 protein17243824
D007213Indomethacin[Indomethacin results in decreased activity of GLO1 protein] which results in increased susceptibility to Doxorubicin17243824
D007213IndomethacinIndomethacin results in increased expression of GLO1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GLO1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of GLO1 mRNA27392435
D019344Lactic Acid[GLO1 protein results in increased metabolism of Pyruvaldehyde] which results in increased abundance of Lactic Acid23954466
C008281limonenelimonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28986142
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GLO1 mRNA"24972896
C005498magnololmagnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28919305
C013592mangiferinmangiferin results in increased expression of and results in increased activity of GLO1 protein24036348
C013592mangiferinmangiferin results in increased expression of GLO1 mRNA24036348
D008694MethamphetamineMethamphetamine results in increased expression of GLO1 protein19826936
D008715MethionineMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GLO1 protein]22138271
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GLO1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GLO1 protein26558463
D008777MethyltestosteroneMethyltestosterone results in increased expression of GLO1 mRNA29191790
C517880monascinmonascin results in increased expression of GLO1 protein23954466
C028007nickel monoxidenickel monoxide results in increased expression of GLO1 mRNA19167457
D019319Okadaic Acid[Okadaic Acid co-treated with gambierol] results in decreased expression of GLO1 protein19397276
D019319Okadaic AcidOkadaic Acid results in decreased expression of GLO1 protein19397276
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GLO1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of GLO1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of GLO1 protein25937538
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [HIF1A protein binds to NOS3 promoter]]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [HIF1A protein binds to CXCR4 promoter]]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCL12 protein]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of NOS3 mRNA]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of NOS3 protein]18227068
C004479pimagedinepimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]26723916
C004479pimagedinepimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28919305
C006253pirinixic acidpirinixic acid results in decreased expression of GLO1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of GLO1 mRNA18301758
C009091protocatechuic acidprotocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein]22687555
D011765PyruvaldehydeGLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]20093988
D011765PyruvaldehydeGLO1 protein affects the susceptibility to Pyruvaldehyde20093988
D011765PyruvaldehydeNFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]22917016
D011765PyruvaldehydePyruvaldehyde affects the expression of GLO1 protein22917016
D011765PyruvaldehydePyruvaldehyde results in decreased expression of GLO1 protein25933243
D011765Pyruvaldehyderesveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]22917016
D011765Pyruvaldehyderosiglitazone affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]22917016
D011765Pyruvaldehydesulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]25933243
D011765Pyruvaldehydehonokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]26723916
D011765Pyruvaldehydelimonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28986142
D011765Pyruvaldehydepimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]26723916
D011765PyruvaldehydePyruvaldehyde results in decreased activity of GLO1 protein26723916|2898614
D011765Pyruvaldehydemagnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28919305
D011765Pyruvaldehydepimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]28919305
D011765PyruvaldehydePyruvaldehyde results in decreased activity of GLO1 protein28919305
D011765PyruvaldehydeGLO1 protein affects the metabolism of Pyruvaldehyde20093988
D011765PyruvaldehydeGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]]18227068
D011765PyruvaldehydeGLO1 protein results in increased metabolism of Pyruvaldehyde18227068|2395446
D011765Pyruvaldehyde[GLO1 protein results in increased metabolism of Pyruvaldehyde] which results in increased abundance of Lactic Acid23954466
D011794QuercetinQuercetin results in increased expression of GLO1 protein17292933
C059514resveratrolNFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]22917016
C059514resveratrolresveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]22917016
C059514resveratrolresveratrol results in increased expression of GLO1 protein22917016
C059514resveratrolresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
C059514resveratrolresveratrol results in increased activity of GLO1 protein21439372
C089730rosiglitazonerosiglitazone affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]22917016
D012524SarinSarin results in increased expression of GLO1 protein28973502
D012715Sesame OilSesame Oil results in decreased expression of GLO1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased activity of GLO1 protein19679115
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GLO1 mRNA19679115
C017947sodium arsenitesodium arsenite results in decreased expression of GLO1 protein21925251
C017947sodium arsenitesodium arsenite results in increased expression of GLO1 protein21925251
D012969Sodium FluorideSodium Fluoride results in decreased expression of GLO1 protein28918527
D012969Sodium FluorideSodium Fluoride results in increased expression of GLO1 mRNA27862939
D013311StreptozocinGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
D013311Streptozocinresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
D013311Streptozocin[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein21439372
C016766sulforafansulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]25933243
C016766sulforafansulforafan results in increased expression of GLO1 protein25933243
D013467SulindacSulindac results in decreased activity of GLO1 protein17243824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLO1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLO1 mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLO1 mRNA16922920|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLO1 mRNA15328365
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GLO1 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of GLO1 protein"25852303
D019284ThapsigarginThapsigargin results in decreased expression of GLO1 protein24648495
D014046TolmetinTolmetin results in decreased activity of GLO1 protein17243824
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GLO1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GLO1 mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of GLO1 mRNA15901671
C057693troglitazonetroglitazone inhibits the reaction [GLO1 mRNA results in decreased susceptibility to Doxorubicin]16085563
C057693troglitazonetroglitazone results in decreased activity of GLO1 mRNA11719831
C057693troglitazonetroglitazone results in decreased activity of GLO1 protein11719831|1257285
C057693troglitazonetroglitazone results in decreased expression of GLO1 mRNA12572858
C057693troglitazone[troglitazone results in decreased expression of GLO1 mRNA] which results in increased susceptibility to Doxorubicin16085563
C057693troglitazonetroglitazone results in decreased activity of GLO1 mRNA11719831
C057693troglitazonetroglitazone results in decreased activity of GLO1 protein11719831
C057693troglitazonetroglitazone results in decreased expression of GLO111719831
D014501UraniumUranium affects the expression of GLO1 mRNA15672453
D017974Uranium CompoundsUranium Compounds results in decreased expression of GLO1 mRNA19654044
C005460uranyl acetateuranyl acetate affects the expression of GLO1 mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of GLO1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of GLO1 mRNA25979313
D009536NiacinamideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
D009536Niacinamideresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]21439372
D009536Niacinamide[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein21439372
C020549zomepiraczomepirac results in decreased activity of GLO1 protein17243824

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004462lactoylglutathione lyase activity-IDA9705294  11489834  
GO:0004462lactoylglutathione lyase activity-TAS-  
GO:0008270zinc ion binding-IDA9705294  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006090pyruvate metabolic process-TAS-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006749glutathione metabolic process-IEA-  
GO:0009438methylglyoxal metabolic process-IEA-  
GO:0030316osteoclast differentiation-ISS-  
GO:0043066negative regulation of apoptotic process-IDA11489834  
GO:0043066negative regulation of apoptotic process-IMP10807791  
GO:0043066negative regulation of apoptotic process-TAS16130169  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-TAS16130169  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00620Pyruvate metabolism
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29505808Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. (2018 Apr)de Guglielmo GPharmacol Biochem Behav